Special Topic: Radiological Dispersal Device or Dirty Bomb EXPLOSION AND BLAST INJURIES

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Angelina Gray
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1 Special Topic: Radiological Dispersal Device or Dirty Bomb EXPLOSION AND BLAST INJURIES

2 Scenario Presentation

3 Possible Scenarios Simple radiological device Improvised nuclear device (IND) Nuclear weapon detonation Nuclear power plant accident Radioactive dispersal device (RDD) including the Dirty Bomb scenario Photo Credit Sandia National Laboratories and Wikipedia

4 Dirty Bomb Conventional explosive + radioactive material = dirty bomb Dispersal pattern variable Combined blast and burn injuries External and internal contamination Potentially large population affected

5 MECHANISM OF DISEASE

Directly Indirectly Non-ionizing radiation (microwaves, UV):

6 Ionizing Versus Non-ionizing Radiation Ionizing radiation interacts with human body through direct and indirect effects: Directly Indirectly Non-ionizing radiation (microwaves, UV): Does not ionize other atoms or lead to the formation of free radicals

7 Radiation Damage Deterministic Threshold dose Local radiation injury Acute radiation syndrome Stochastic Random Oncogenensis Teratogenesis

8 Radiation Physics 101

9 Radioactive Decay Atoms decay to reach a more stable state by emitting inonizing radiation in the form of particles or penetrating radiation (Gamma rays).

10 Different Types of Radiation

11 Types of Ionizing Radiation

12 Types of Ionizing Radiation Alpha particles Positively charged, easily stopped by a thin paper, do not present an external hazard. Inhaled/ingested, can result in significant organ damage.

13 Types of Ionizing Radiation Beta particles Negatively charged electrons, can travel several centimeters through air. Stopped by clothes. If internalized will cause problems. beta burn

14 Types of Ionizing Radiation Gamma rays Electromagnetic waves. Gamma rays are the same as x-rays -- the difference is their source from within the atom: nuclear for gamma, extranuclear for X-rays. Are a significant hazard (depending on duration of exposure, distance from the source, and type of shielding).

15 Types of Ionizing Radiation Neutrons Neutron irradiation can turn previously nonradioactive materials radioactive. Uncharged. Causes whole body irradiation like Gamma rays. Emitted from fission reactions.

16 Radiation Units: S.I. Versus USA S.I. Formula USA 1 Gray (Gy) = 100 x RAD 1 Sievert (Sv) = 100 x REM

17 2 Different yet Possible Overlapping Entities Exposure Whole body Partial body Contamination External Internal

19 Contamination External Routes of Internalization Inhalation Ingestion Injection or Wounds

20 Some Externally Contaminated Patients are Exposed Contaminated Victims Exposed Victims

21 All Internally Contaminated Patients are Potentially Exposed Internally Contaminated Victims Exposed Victims

22 Radiation Protection in Whole Body Exposure Distance Time Shielding

23 Pick the Appropriate Personal Protective Equipment (PPE)! WHEN CARING FOR THESE PATIENTS

24 A B C D

taking care of patients in the predecontamination and

25 Respiratory Protection Commonly available protective masks are generally sufficient predecontamination OSHA/NIOSH: Hospital staff taking care of patients in the predecontamination and decontamination areas, PAPRs or HEPA filter negative pressure masks are described as minimum

26 Personal Protection Standard Precautions

27 Radiation Detection in the ED Victims should be surveyed with Geiger-Muller counters.

28 Radiation Detection in the ED Survey patient for radiological contamination and mark areas on body diagram. Remove contaminated clothes and label them. Except for an instance of highly-radioactive shrapnel, contamination should NOT deter medical staff from treating life-threatening injuries.

29 Radiation Survey in the ED and Decontamination

31 DIAGNOSIS OF INTERNAL CONTAMINATION

32 Nasal Swabs A swab is collected from each nostril of individuals who have potentially inhaled radionuclides in the form of particulate matter. Each swab gets tested for the detection of radiation. The radiation present in the nasal cavities will reflect the presence of radionuclides in lower air spaces and subsequent internal contamination.

33 In Vivo Measurements Whole body counters Chest counters for Plutonium and Uranium Wound monitoring instruments

34 Whole Body Dosimetry Using whole body counters or scanners that are potentially available at nuclear medicine departments. It is crucial to know when the contamination occurs as well as which radionuclide is involved. p

35 Diagnosis By Excretion (Bioassay) Sampling Collect urine or feces to measure excretion rates Challenging interpretation Time when contaminationoccured Charcteristics of inhaled or internalized radionuclides

36 Internal Contamination Acute Radiation Syndrome CLINICAL IMPACT AND CONSEQUENCES

37 Clinical Consequences of Internal Contamination Acute and subacute End organ dammage Acute Radiation Syndrome Multiorgan failure Chronic Solid tumors Leukemias

38 Management Strategies Supportive care Decreasing absorption Decorporation and enhance elimination Long term monitoring

39 Internal Contamination Iodine Radionuclide Medication KI (potassium iodide) Transuranics such as Plutonium & Americium Uranium Zn-DTPA Ca-DTPA Bicarbonate Cesium Rubidium Thallium Tritium Prussian Blue* [Ferrihexacyano- Ferrate (II)] Water

40 Used for Transuranics such as Plutonium and Americium. First dose should be Calcium DTPA followed by Zinc DTPA. Duration of therapy will be guided by urine or feces transuranic concentrations. Transuranics

Cesium-137 46 Goiania pts contaminated with Cs-137 treated with Prussian Blue. Less than 1% is absorbed.

41 Cesium Goiania pts contaminated with Cs-137 treated with Prussian Blue. Less than 1% is absorbed. Exchanges a cation and binds Cesium or Thallium. Decreases GI absorption and interruts enterohepatic circulation.

42 Radioactive Iodine Exposure Iodine Prophylaxis and Treatment Potassium iodide (KI) is an effective, inexpensive thyroid-blocking agent.

43 Radioactive Iodine Exposure 131 I I 131 I 131 I THYROID 131 I Saturate the Critical Organ with the Stable Isotope

44 ACUTE RADIATION SYNDROME (ARS)

45 Acute Radiation Syndrome Deterministic effect Prodrome phase Hematopoetic syndrome Gastrointestinal syndrome CV/CNS syndrome (ARS)

46 Prodrone Vague Sx: nausea, vomiting, headache. Help predict the dose: the higher the absorbed dose the earlier and the more frequent the Sx occur. 15 June 2004 Annals of Internal Medicine Volume 140 Number 12

47 Hematopoetic Syndrome (2-6 Gy)

48 Lymphocyte Depletion Kinetics Andrew s nomogram helps estimate the dose of radiation. WBC with differential every 6 hrs for first hours.

49 Rate of dicentric chromosomes in peripheral lymphocytes. Available at REAC/TS. Takes a few days. Cytogenetics

50 Management of the Hematopoetic Syndrome Complications: infection and bleeding. Treatment is supportive: Reverse isolation IVF Blood products Antibiotics Colony stimulating factors such as filgrastim or G-CSF (300 mcg s/c per day) Stem cell transplant

Population Monitoring The process to screen people for radioactive contamination or exposure to radiation, assist with decontamination, register, and prioritize for further

51 Population Monitoring The process to screen people for radioactive contamination or exposure to radiation, assist with decontamination, register, and prioritize for further follow up. Primary objective is to identify people who are in immediate danger. It is a local/state effort; similar to PODs.

52 Community Reception Centers (CRC) The place to conduct population monitoring Primary services include: external contamination screening; external decontamination; prioritizing people for further care Benefits include: providing needed services to affected and concerned people; reducing burden on hospitals; managing scarce medical resources; supporting public shelters Staffing: Health physics (radiation safety), nursing/medical, and general staff

53 REMM Website Useful Resource

55 CDC Radiation Studies Branch Fact sheets Educational materials

57 Thank You!

Radiological Preparedness & Emergency Response. Session V. Objectives. Clinical Evaluation and Management of Internal Contamination

Radiological Preparedness & Emergency Response Session V Clinical Evaluation and Management of Internal Contamination Objectives Discuss the diagnosis of internal contamination. Describe the health effects