UNC Board of Trustees March 25, 2010
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1 UNC Board of Trustees March 25, 2010
2 UNC Lineberger: The Public Comprehensive Cancer Center Basic research: Molecular discovery Clinical Research: Diagnostics & Therapeutics Clinical Care: Patient-centered Excellence Economic Development Health Disparities Research Rural African American Populations Expanding Hispanic Population Dissemination & Outreach AHEC, community & clinical practice State Health Dept. Population Sciences Epidemiology & Health Outcomes
3 UNC Lineberger Growth Clinical 125,000 Patient Visits 3,500 New Patients 850 on Therapeutic Trials Research 300 Members $220 M Total Costs Training 26 pre and postdoctoral training grants
4 Extraordinary Support from the People of North Carolina UCRF NC Cancer Hospital Imaging Research Building
5 UCRF Oversight Committee Erskine Bowles, Chair only for the purpose of cancer research under UNC Hospitals, the Lineberger Comprehensive Cancer Center or both.
6 Clinical Excellence Team Science The Legislature Prevention & Detection Research Research Infrastructure Rising Cancer Incidence UCRF Becoming College & Other Schools Tech Transfer Flat NIH Funding the Best Academic Culture: College/Health Affairs Enhancing Faculty Research Patient Care CTSA Opening Cancer Hospital Changing Technology Service to the State
7 UCRF Strategic Plan Tier III Optimizing NC Cancer Outcomes Cancer Genetics/ Genomics Developing New Cancer Treatments Tier II Opportunity Fund Innovation, Technology & Recruitment Tier I Infrastructure Clinical Excellence & Outreach, Clinical/Translational Research Cores, Tissue Procurement & Informatics, Population & Basic Science Cores
8 Multidisciplinary Cancer Care BMT Breast Genetics Bone & Soft Tissue GI Urologic GYN Thoracic Leukemia & Lymphoma Pediatrics Brain Tumor Melanoma Head & Neck Skull-Base Tumors Ocular Tumors Psycho- Geriatric Oncology Oncology
9 Clinical Excellence & Outreach Multidisciplinary Care How do we best export to the state? Quality of Care: Disease-Specific Tumor Boards by Telemedicine Communities: 13 Sites: 18 Oncologist Offices: 28
10 Recruitment: The Key to the Future
11 Award-Winning Junior Recruits Paul Armistead, MD, PhD Derek Chiang, PhD Two Morehead Scholars BMT/Immunobiology Bioinformatics Billy Kim, MD Ryan Miller, MD, PhD 2 Damon Runyons Washington University Dana Farber/Harvard Angelique Whitehurst, PhD UT Southwestern Functional Genomic Screening
12 UCRF Recruits Computer Science Biology Psychology Cell & Developmental Biology Sociology Chemistry Microbiology Pharmacology Pharmacy Genetics Health Behavior & Health Education Epidemiology Health Policy & Management Biostatistics
13 UCRF Clinical Recruits Pediatric Oncology Radiation Oncology Urologic Oncology GYN Oncology Surgical Oncology Medical Oncology Clinical Genetics Psycho Oncology Pathology
14 UCRF Strategic Plan Cancer Genetics/ Genomics
15 Developing Novel Therapies Drug delivery innovation Nanomedicine Novel delivery systems Target identification Target validation NOVEL THERAPIES Preclinical Cancer Models Predict efficacy Test UNC compounds Analyze PK/PD Early-phase human clinical trials Novel drug discovery Small molecules High Throughput Screening Computational Approaches Medicinal Chemistry Mouse Phase I Unit
16 UCRF Clinical Applications of Nanotechnology Extramural funding & economic development Otto Zhou Carbon Nanotube Electron Source Xintek & Siemens IGRT Prototype: NC Cancer Hospital 2010 Joe DeSimone Liquidia Nanoparticle chemotherapy Desktop Synchrotron
17 Lineberger Partnerships: UCRF and School of Pharmacy Howard McLeod, PharmD Washington University Pharmacogenetics/ Individualized therapy: $10M Bill Zamboni, PharmD, PhD University of Pittsburgh Pharmacoanalytic labs: $3M Stephen Frye, PhD Former head, GSK world-wide med chem Chemical biology/medicinal chemistry center: $10M
18 UCRF Strategic Plan Developing New Cancer Treatments
19 The Cancer Genome Atlas Next Generation Sequencing UCRF Investment: $10M Development of Clinical Applications Neil Hayes, MD Chuck Perou, PhD Lisa Carey, MD Katie Hoadley, PhD Ian Davis, MD, PhD
20 Parental Inbred Strains A C57BL/6 129S1 NOD NZO PWK CAST WSB One Representative Chromosome F1 G1 G2 G2:F1 G2:F2 One of 1,000 Independent Collaborative Cross Strains G2:F20
21 UCRF Innovation Awards: Dog Lymphoma Genetics Team UNC Medical Oncology/Genetics NC State Vet School/Genetics
22 UCRF Strategic Plan Optimizing NC Cancer Outcomes
23 North Carolina: A Laboratory Research ICSIS Quality of Care Comparative effectiveness Outcomes state-wide database Prevention & early detection Service & Comprehensiveness
24 Integrated Cancer Surveillance and Information System (ICSIS) State tumor registry 44,000 cases yearly GIS localization NC Oncology workforce analysis Cancer care claims data Medicare Medicaid State Employees BCBS NC Quality of care and comparative effectiveness research
25 Carolina Breast Cancer Study: Phase III Population-based Molecular etiology to clinical outcomes 2,000 cases 50% African American 50% under age 50 Clinical follow-up in the community setting Senator Jeanne Lucas
26 UNC Cancer Survivorship Cohort Target accrual: 10,000 patients Hospital-based Collect epi, psychosocial, demographic data Informatics, clinical and treatment data Genomic DNA and tumor tissue Consent to follow yearly Consent to reconsent for additional studies
27 UCRF & UNC-CH Funding: Impact of Recruitment, Retention, & Investment Cancer Genome Atlas: $20 M Virology & Prostate P01s: $12 M Collaborative Cross: $13 M Biostatistics P01: $10 M ARRA Stimulus Funding: 40% LCCC members Innovation Awardees/R01s: >$10M Cancer & Nanotechnology: $17 M
28 Why we do what we do! Aaron Mervin Sam McConkey Esten Maxwell Christi McCall Billie Ann Peterson Karla Werner Kenneth Harris Florence Myers James Hardin Mike Creed
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