Style of practice (1) Private clinic 77 % (282) Hospital 21 % ( 46 ) Others 2 % ( 11 ) Style of practice (2)

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1 Style of practice (1) Private clinic 77 % (282) Hospital 21 % ( 46 ) Others 2 % ( 11 ) Style of practice (2) Oncologist (standard treatment) 4 % ( 14 ) Oncologist (non-standard) 5 % ( 17 ) Non-oncologist 91 % (308) 1

2 Q-1: Assuming that you are diagnosed with cancer and have to select anticancer agents for chemotherapy, which of the following items would you give high priority to? Please choose 3 items from the following. Severity of adverse reactions 77 % Response rate* 67 % extension of survival period 56 % Probability of complete remission 47 % Trusting relationship with your doctor 23 % Opinions of your family 11 % *The response rate is the proportion of patients in whom the tumor has either disappeared (complete remission) or become smaller (partial remission) 2

3 Q-2: Would you undergo chemotherapy if you were diagnosed with "cancer for which radical surgery is not possible and chemotherapy is the only treatment option? I would. 14 % ( 49 ) 58% I probably would. 42 % (143 ) I probably would not. 30 % (100) 44% I would not. 14 % ( 47 ) 3

4 Q-3: Would you undergo non-standard therapy if you were diagnosed with cancer? * Standard therapy : surgery, radiotherapy, and chemotherapy. I would. 58 % ( 198 ) 89% I probably would. 31 % (104 ) I probably would not. 9 % ( 29 ) 11% I would not. 2 % ( 8 ) 4

5 List of selected non-standard therapy (1) 1 High-doseIVC therapy 68 % ( 204 ) 2 Immunotherapy* 50 % ( 152 ) 3 Nutritional supplements 42 % ( 128 ) 4 Nutrition therapy** 29 % ( 87 ) 5 Hyperthermia 25 % ( 75 ) 6 Palliative care 23 % ( 70 ) 7 Ozone therapy (Major Hemotherapy) 21 % ( 63 ) 8 Chinese herb medicine 20 % ( 61 ) 9 IV lipoic acid therapy 18 % ( 53 ) 10 Hydrogen therapy (oral and IV) 14% ( 41 ) * NK-cell, vaccine, Dendritic cell based immunotherapy, T cell based adoptive immunotherapy, Autologous Immune Enhancement Therapy (AIET) **Organic food, Gerson therapy, etc 5

6 List of selected non-standard therapy (2) 11 Gene therapy 19 % ( 43 ) 12 Home medical care 18 % ( 40 ) 13 Laughter therapy 18 % ( 39 ) 14 Low dose Naltrexone (LDN) 18 % ( 38 ) 15 Stress reduction and healing therapy 16 % ( 35 ) 16 Musictherapy 15 % ( 34 ) 17 Physical exercise therapy 15 % ( 34 ) 18 Hospice 14 % ( 31 ) 19 Psychotherapy 11 % ( 25 ) 20 Yoga 10 % ( 23 ) Others: IPT, IV-Ukrain, Hospice, Umbilical Cord Stem Cell Therapy, Pillates, etc. 6

7 Conclusions 1 62% of doctors (MD and DDS) said that they would choose firstline chemotherapy if they were diagnosed with cancer and chemotherapy is the only treatment option: while 38% said they would not. 2 If their first-line chemotherapy is ineffective or has to be discontinued due to the adverse reactions, 46% would choose second-line chemotherapy, but 54% would not. 3 92% of doctors would undergo non-standard cancer therapy along with or without standard therapy. 4 For the patients, oncologist should show not only treatment with chemotherapy, but also therapeutic option without chemotherapy. Moreover, oncologist also should show patients non-standard therapies such as IVC, Immunotherapy, etc. 7

8 CMAJ 2006 Intravenously Administered Vitamin C as Cancer Therapy: Three cases. Renal cancer, Bladder cancer and Malignant lymphoma CMAJ 2006;174(7): By National Institute of Health (USA) National Cancer Institute (USA) McGill University (Canada) 8

9 Renal Cancer (1month after IVC) 9 Padayatty, S. J. et al. CMAJ 2006;174: Copyright 2006 CMA Media Inc. or its licensors

10 Copyright 2006 CMA Media Inc. or its licensors 7 month after IVC Padayatty, S. J. et al. CMAJ 2006;174:

11 62 yrs. Breast cancer

12 54 yrs. female, stomach cancer

13

14 14

15 Hugh D. Riordan, M.D

16 Riordan IVC Protocol (PDF file) Riordan IVC protocol

17 Indication of IVC 1. Patients who have failed standard therapy 2. Enhance effectiveness of standard therapy 3. Reduce side effects of standard therapy 4. Patients who refuse standard therapy and wish to receive alternative treatment. 5. Prolong remission period 6. Prevention of metastasis

18 Type of Cancer for IVC stomach cancer colon cancer pancreatic cancer Liver cancer lung cancer ovarian cancer cervical cancer breast cancer prostate cancer leukemia lymphoma bladder cancer kidney cancer brain cancer and others Patients at any stage can try IVC!

19 Contraindications (1) G6P Deficiency (2) Severe congestive heart failure (3) Renal insufficiency or failure

20 Riordan IVC Protocol Vitamin C (A.A.) # Grams (# cc) Diluent Type 20% MgCl Added Infusion Time (~0.5 gram/minute) Osmolality (calculated) 15 grams (30cc) 250cc Ringer's Lactate 1cc ~30 minutes* 827 mosm/l 25 grams (50cc) 250cc Sterile Water 1cc ~50 minutes 800 mosm/l 50 grams (100cc) 500cc Sterile Water 2cc ~100 minutes 900 mosm/l 75 grams (150cc) 750cc Sterile Water 2cc ~150 minutes 703 mosm/l 100 grams (200cc) 1000cc Sterile Water 2cc ~200 minutes 893 mosm/l The Riordan IVC Protocol dosing schedule depicted above has served as a safe start for cancer patients new to IVC. The Riordan Clinic in Wichita, Kansas, since 1990, has administered over 30,000 onsite IVC infusions according to this protocol. Zero fatalities and rare side effects a testament to its remarkable safety.

21 Let s start IVC Therapy 1. Begin with a series of three consecutive IVC infusions at the 15, 25, and 50 gram dosages 2. Measure post IVC plasma levels of Vitamin C. 3. Find the IVC dosage that gets the patient to a post IVC therapeutic range of mg/dl

22 Goal of Plasma IVC Levels mg/dl 140 Survival % Mia PaCa-2 SK-MEL-28 SW-620 U-2-OS Ascorbate (mg/dl)

23 Today s topics 1. Intravenous High-dose Vitamin C Therapy for Cancer Treatment in Japan 2. Nutrition supplements along with IVC for cancer patients 23

24 Effect of orthomolecular oral nutrition therapy on survival in cancer patients (Hoffer A.) Survival (%) Standard + Orthomolecular (n=457) 標準治療 + 栄養療法 (457 人 ) Standard only (n=52) 標準治療単独 (52 人 ) Years 24

25 Orthomolecular Medicine For Everyone By Abram Hoffer and Andrew Saul I have Cancer: What should I do? Michael J. Gonzales and Andrew Saul 25

26 Orthomolecular basic nutritional supplements for cancer patients Vitamin B (B1,2,3,5,6) 100mg each x 1-2 Vitamin C 2-5g x 3-6 Vitamin D IU x 1 Selenium 200 μg x 2-3 alpha lipoic acid 200 mg x 2-3 Zinc 50mg x 1 Magnesium 500mg x 3 Salvestrol 3-6cap x 1-2 Also consider to add Vitamin A, E, coenzyme Q10, probiotics, omega-3 etc. 26

27 Salvestrols... natural plant polyphenols... from... FRUIT Apples Blackcurrants Cranberries Grapes (& wine) Oranges Strawberries etc. VEGETABLES Avocados Brussels Sprouts Capsicums Cabbage Cauliflower Olives... etc. HERBS Artichoke Basil Dandelion Milk Thistle Parsley Rosemary Thyme... etc.

28

29

30 There is always a key to stop the progression of cancer and it might not be limited to a single key. It could very well be two or more. Each time a key is discovered the progression of a cancer can be curtailed. It is our responsibility to work step-bystep with our patients to discover these keys. 30

31 Those Keys Include: Proper Nutrition Immune System Mobilization Stress Management Spiritual Well-Being + I V Vitamin C, ALA, etc 31

32 As a physician on a quest for these keys, we must work with the families to impart courage and hope upon our patients for the entirety of their long and arduous journey. 32

33 Japanese College of Intravenous Therapy

34

35 JCIT Board Member 2016 International Board Great network of influential doctors, contributing to the success in our

36 Overview of JCIT ØEstablished in 2007 ØPresident - Atsuo Yanagisawa MD., PhD. Ø Over 690 members practicing IV therapy ØMission: Contribute to people s health by creating a society where everyone can choose to get safe and effective orthomolecular IV therapy ØMain Activity: Educating doctors and the society

37 Variety of IV-Therapy in Japan Vitamin C (High-dose:15-100g) Myers Cocktail Laennec (Placenta) EDTA Chelation Therapy Glutathione (High-dose) Alpha-Lipoic Acid Ozone Therapy (MAH) Variety of IV Nutrient Cocktails

38 The Facts about Members Number of Members doctors in total, including dentists in 2016 Covering all prefectures in Japan

39 IVC Network in Japan

40 Let us work together to establish The Worldwide IVC Network in this world, and make a better, healthier, and safer place one country at a time.

41 Thank you!

Dr. Atsuo Yanagisawa President Japanese College of Intravenous Therapy International Society for Orthomolecular Medicine

Dr. Atsuo Yanagisawa President Japanese College of Intravenous Therapy International Society for Orthomolecular Medicine Intravenous Vitamin C Therapy In Japan Dr. Atsuo Yanagisawa President Japanese College of Intravenous Therapy International Society for Orthomolecular Medicine 1 Dr. Atsuo Yanagisawa, MD, PhD Director

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