IVC History, Cancer Research

Transcription

1 Riordan Clinic IVC Academy 5 IVC History, Cancer Research O (slides 41-80)

2 Pharmacokinetics of Oral Vitamin C using Liposomal Form* To test whether plasma vitamin C levels, following oral doses in supplemented volunteers are tightly controlled and subject to a maximum in the region of 220 mm/l, as suggested by previous researchers for depleted subjects. *Hickey, Roberts, and Miller (unpublished)

3 ??? mm/l Phase 3? 220 mm/l Phase 2 AA is rapidly excreted 70 mm/l Phase 1 AA is actively reabsorbed

4 36 Grams of Liposomal C (Two Subjects) Is This Phase 3 of Vitamin C? (BioCenter Lab 6634 plasma C levels - only 50 > 120 mmol/l) 450 { Phase { { Phase ref. range Phase grL 36grL2

5 450 mm/l Phase 3 Bowel tolerance dosing or frequent liposomal packs 220 mm/l Phase 2 AA is rapidly excreted 70 mm/l Phase 1 AA is actively reabsorbed

6 Dynamic Flow Definition repeated Ascorbic Acid doses, at an interval of less than 5 half-lives, produce a high, steady-state value in blood plasma. Hickey, Roberts, Cathcart J Orthomol Med 2005; 20: Note: Phase 2 Ascorbic Acid halflife is about 30 minutes x 5 = 2.5 hours

7 Applied Dynamic Flow (over extended time) Irwin Stone 1982 letter to Albert Szent- Gyorgyi Nobel Prize winner Joe Kieninger achieved a plasma level of 1817 mm/l 32 mg/dl (USA units) Note: mm/l is Mid-Dose Joe built up to 80 grams of AA/day over a 2½ year period

8 Phase 5 High Dose Intermittent IVC Targeting 10,000 30,000 mm/l Phase 4 Mid-Dose Continuous IVC Target range of mm/l Phase 3 Dynamic Flow Oral Dosing mm/l Phase 2 AA is actively excreted Phase 1 AA is actively reabsorbed

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10 1 square = growth in 1 week

11 High dose IVC kills tumor cells each treatment. But surviving chemo-resistant cells grow back stronger each time.

12 Low dose, continuous IVC solves the problem of resistant cancer cell selection with intermittent high dose IVC

13 The Yellow Line = continuous recovery. Intermittent IVC controls cancer, but often does not defeat cancer.

14 Mid-Dose-Continuous-IVC can also be AUGMENTED with standard Riordan Protocol Dosage infusions. Hybrid IVC high dose mid

15 Effects of human serum removed from patient before and at intervals after intravenous infusion of vitamin C (60 grams) on cultured human prostate tumor cells Survival % (bars) Serum ascorbate (mg/dl) (line) T=0 T=35 T=65 T=95 T=125 T=185 T=245 T=305 Time (minutes) 0

16 Mid-Dose-Continuous IVC will spark a continuously positive rate of chronic illness recovery by imitating the way ascorbate is made in injured animals

17 Tumor Inhibition by Vitamin C (animal studies) 10 Clin Cancer Res January 15; 16(2): Surviving Animals Ascorbate Control Time (days) Survival time of sarcoma bearing mice control and treated with IP ascorbate 700 mg/kg

18 Effect of Ascorbic Acid on Angiogenesis Ascorbic acid inhibits migration and angiogenesis of the endothelial cells. AA at 1-3 mg/ml caused the reduction of the growth of sprouts from aortic rings. Mikirova NA, Casciari JJ, Riordan NH. Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo. Journal of Angiogenesis Research 2010, 2:2

19 Ascorbic Acid is Amazing dosing is crucial! Corrects scurvy in cancer patients (less fatigue) Supports detoxification systems in the body Relieves pain and promotes well-being Boosts cellular immunity (to prevent secondary infections) Stimulates collagen formation (to wall off tumor) Inhibits hyaluronidase (to retard metastasis) Relieves cellular hypoxia/restores aerobic metabolism Restores mitochondrial functioning, improves apoptosis Inhibits angiogenesis and reduces tumor nutrient supply Potentiates chemotherapy and radiation Reduces side effects & toxicity of conventional therapy Plausible oncologic adjunct in cancer patient care

20 Effects of IVC on Inflammation

21 Inflammation and Cancer Inflammation is a critical component of tumor progression. Cancers arise from sites of chronic injury. Inflammatory component is present and contributes to tumor proliferation angiogenesis metastasis resistance to chemotherapy. Nature December 19; 420, 6917

22 The Seven Hallmarks of Cancer 1. Self-sufficiency of growth signals 2. Insensitivity to antigrowth signals 3. Evasion of apoptosis 4. Unlimited proliferation potential 5. Enhanced angiogenesis 6. Tissue invasion and metastasis 7. Inflammatory microenvironment Molecular Cancer Research; 4(4). April 2006

23 Cytokines, inflammation and tumor growth Tumors that produce little or no cytokines induce limited inflammatory and vascular responses, resulting in constrained tumor growth. In contrast, production of an abundance of pro-inflammatory cytokines potentiates angiogenesis, thus favoring neoplastic growth. Nature December 19; 420(6917), Coussens et al.

24 Effect of high-dose intravenous vitamin C on inflammation in cancer patients. The high dose intravenous ascorbic acid therapy affects C-reactive protein levels and pro-inflammation cytokines in cancer patients. Modulation of inflammation by IVC correlated with decreases in tumor marker levels. Mikirova et al. Journal of Translational Medicine 2012, 10:189

25 Inflammation: a driving force of cancer metastasis Inflammatory cells produce TNFα, TGFβ, IL-6, IL-1 activate NFκB STAT3 pathways induce epithelial-to-mesenchymal transition (EMT) and metastasis. Wu Y et al. Cell Cycle 8:20, ; October 15, 2009

26 CRP in Inflammation and Cancer Patients with increased CRP had a higher risk of dying from cancer than from other causes independent of acute infection. The relation of CRP to cancer death was stronger than to vascular death. Clinical Chemistry 54:2, , 2008, Claudia Marsik et al

27 CRP a Prognostic Indicator CRP Predicts Cancer Survival in Multiple myeloma Melanoma Lymphoma Ovarian Ca Renal Ca Pancreatic Ca GI Cancers Prostate ca Mahmoud FA, Rivera NI. Current Oncology Report 2002;4:250 5

28 Does high dose IVC therapy suppress inflammation in cancer patients? Patients followed the Riordan IVC Protocol IVC doses ranged from 7.5 g 50 g Median follow-up time was 7.2 years CRP and tumor markers were measured as a routine analysis Pro-inflammatory cytokines were measured before and after IVC

29 CRP values before and after IVC treatments Most of the cancer patients, 70 ± 13 % showed a reduction in CRP during IVC therapy.

30 Serum C-Reactive Protein as Independent Prognostic Variable Kaplan-Meier curves for overall survival of patients with ovarian cancer broken down by serum CRP. Hefer et al. Clin Cancer Res 2008;14(3): 210

31 The Effects of IVC on PSA

32 The effects of IVC therapy on PSA 70 % of patients showed reduced PSA levels during IVC treatment. Mikirova et al. 2015

33 Tracking of PSA levels over time in subjects with prostate cancer Subject A: initial Gleason score =6; treatments given weekly or twice weekly at doses of 25 g; PSA levels decreased from initial values of 60 ng/ml to final values in the normal range. Subject B: Gleason score = 6 9; treatments typically given weekly at doses of either 7.5 g or 25 g (40 IVC); PSA levels decreased from maximum values of 1500 ng/ml to a final value of 7 ng/ml.

34 Tracking of PSA levels over time in subjects with prostate cancer Subject A: initial Gleason score =6; treatments given weekly or twice weekly at doses of 25 g; PSA levels decreased from initial values of 60 ng/ml to final values in the normal range. Subject B: Gleason score = 6 9; treatments typically given weekly at doses of either 7.5 g or 25 g (40 IVC); PSA levels decreased from maximum values of 1500 ng/ml to a final value of 7 ng/ml.

35 PSA IVC (grams C) Changes of the rate of PSA progression during IVC treatment PSA IVC (grams C) PSA frequency IVC ra te of change IVC frequency of IVC rate of chang e PSA days 40 IVC d ays DAYS days

36 The effect of IVC on the suppression of ALP As ALP is a marker of bone formation and the most often site of metastasis for prostate cancer patients is bone, the analysis of the ALP may be helpful tools to evaluate the effectiveness of the IVC therapy on metastatic site. 140 ALP PSA IVC ALP (U/L) PSA (ng/ml) Vitamin C (grams-ivc) Vitamin C (grams - Chelation) ALP PSA ALP days DAYS

37 Effect of IVC on Bone Regeneration

38 Effect of vitamin C on bone regeneration AA deficiency inhibits bone formation osteoblasts differentiation bone matrix growth Immunohistochemical analyses of collagen I (a, b), and osteoblast cells. Urban et al. Head & Face Medicine 2012, 8:25

39 Effect of IVC on Cell Signaling

40 Unified Theory Of Sustained Reserves Illness Depletion Adapted eos External Oxidative Stress ios internal Oxidative Stress Genetic Expression Repair Damage DNA Membranes AOS Structural ROS Signaling Chemical

41 Cellular Injury Inadequate nutrient reserves The damage cannot be repaired Cytokine Signaling Cytokine signaling intensifies the inflammatory response