Lipinutragen: InnovAction for the market of molecular medicine

Transcription

1 Lipinutragen: InnovAction for the market of molecular medicine Dr. Carla Ferreri, Company co-founder & Dr. Arianna Salati, CEO

2 MOLECULAR BASIS Organic synthesis, kinetics, mechanisms STRESS-OMICS Stress of biological molecules (DNA, proteins, lipids): analytical methodologies and biomimetic models MOLECULAR MEDICINE BIOMARKER DISCOVERY (cyclopurines, trans lipids, desulfurated peptides and proteins), transfer to biology-medicinebiotechnology

3 MOLECULAR BASIS Organic synthesis, kinetics, mechanisms STRESS-OMICS Stress of biological molecules (DNA, proteins, lipids): analytical methodologies and biomimetic models MOLECULAR MEDICINE BIOMARKER DISCOVERY (cyclopurines, trans lipids, desulfurated peptides and proteins), transfer to biology-medicinebiotechnology

4 Focus on this compartment: cells cannot exist without MEMBRANES that are necessary for ORGANIZATION and FUNCTIONING

5 MEMBRANE REACTIVITY: The UNSATURATED FATTY ACID are REACTIVE to STRESS We envisaged it as a new field of chemical biology

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7 Oleic acid 9c C18:1 H O O 9 Linoleic acid 9c,12c C18:2 H O O Arachidonic acid 5c,8c,11c,14c C20:4 H O O

8 Lipid isomerization (MUFA & PUFA) 9 9 RS Dramatic change of the NATURAL geometry

9 Biomimetic model Liposomes as models for pharmacological, nutraceutical and biological studies Studied by the COST Action CM Leader position and coordination activity of 20 research groups in the Working group (WG3) of the Action ( Membrane stress, signaling and defences

10 Vol 114, pag (2014)

11 MOLECULAR BASIS Competitive isomerization and peroxidation Role of antioxidant synergies STRESS-OMICS Analytical and molecular libraries for recognition in biological fluids New models of cellular stress MOLECULAR MEDICINE Development of a new discipline regarding lipids

12 Lipidome monitoring for the MEMBRANE fatty acid asset S - M - P DIET METABOLISM Response to stress and stimuli NEW INSIGHTS IN BIOLOGICAL AND PHARMACOLOGICAL PATHWAYS

13 LIPIDOMICS in humans Children atopic dermatitis (TRANS) Chem. Phys. Lipids 2002, Lipids 2005 Longevity - Centenarian offspring (TRANS) Int. J. Cell Biochem. 2008, Rejuven. Res Human atrial fibrillation J. Interv. Card. Electrophysiol Children autism, PLoS ONE, 2013 Celiac disease, Br. J. Nutr 2014 Man infertility, submitted 2015 Lipidomics in animals Rats fed a trans-free diet Free Radic Biol Med 2005 Environmental radiation to animals Rad. Res Sportive rats Lipids in Health and Disease, 2012 LIPIDOMICS in cells Leukemia cell lines (TRANS) Free Radic Biol Med 2005 Beta pancreatic cell lines, Diabetes 2011 Neuroblastoma cell lines, PLoS ONE 2013 Bleomycin treated cell, Org. Biomol. Chem. 2015

14 Erythrocyte membrane lipidome

15 All important fatty acids represented (arachidonic, omega-3, saturated FA, trans FA) Representative of other tissues

16 CHOOSE the MATURE ERYTHROCYTE for the best REPORTER capacity (original protocol high-throughput device) SELECT A FATTY ACID CLUSTER (12 ELEMENTS) TO DESCRIBE THE MEMBRANE BALANCE (MEMBRANE UNBALANCE INDEX MUI PATENT WO A1) EXPERT REV. MOL. DIAGN. 2012, 12, )

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18 Born in Dec as CNR spin off company Co-founders: Carla Ferreri and Chryssostomos Chatgilialoglu + 2 private partners Fund raising: private funds from the 4 partners In the partners changed and now they are: FERRERI 40% CHATGILIALOGLU 50% MARANINI 10% In 2011 it was proposed to CNR to enter as partner No INTEREST

19 Is the first italian company, born as CNR spin-off, applying in a real market, Research, Innovation and Internationalization Vision Mission Value Life Balance through Membrane Balance To become the world s pioneer and leader in nutrilipidomic research and development Human first Research Disruptive innovation Quality Ethics Devotion

20 Strategic development Overcome the DEATH VALLEY End of the spin-off status Market preparation and scientific background Pre-Launch Product development Start of sales EARLY ADOPTERS Launch Expansion and Market development Post-Launch Consolidating client portfolio Further expansion Market survey Development scientific background CME courses Formation First business model: Fat Profile Nutragenika line PARTNERSHIPS Development FAT PHARMACY R&D and Marketing reinforce Nutrilipidomics: functional foods FUND raising Development Lipidomic Laboratory Lipidomic profile data base and software Patent and trade marks LIPIDOMIC DIET software ROBOTICS: International Research program (EUROSTARS H2020) FIRST FUNDING from INSTITUTIONS (EU) Highthroughput development and brand International Market GREECE SPAIN POLAND Dec

21 BILLING COMPANY Lipinutragen s idea of expansion in Europe Lodz EMPLOYEES years 9 BILBAO BOLOGNA ATHENS EXPANSION of the IDEA to bring SCIENCE to MARKET Entrepreneurship founded by researchers, incubated in institutions/universities Entering the market to bring innovation made of scientific advancements in life sciences (SCIENCE ETHICS)

22 LIPINUTRAGEN, DIVISIONS AND CUSTOMERS PREVENTION & QUALITY LIFE MOLECULAR DIAGNOSTICS NUTRA - THERAPY HUMAN FIRST RESEARCH & INNOVATION BE ETHICS QUALITY & DEVOTION

23 FATHARMACY PREVENTION AND QUALITY LIFE CUSTOMERS: 92 SELECTED PHARMACIES AS CUSTOMERS MORE THAN 150 ANALYSES per MONTH MORE THAN PERSONS ANALYZED IN 3 YEARS( ) ACTIVITIES CME COURSES FOR PHARAMCISTS 3 COMMUNICATION TRAINING DISLOCATED COURSES SOFTWARE DEDICATED IN EACH OF 92 PHARMACIES CONSULTING BOARD OF PHARMACISTS TRAINING AND AWARENESS PAPERS, CAMPAIGN and web strategy

24 FATPROFILE MOLECULAR DIAGNOSIS CUSTOMERS 250 SPECIALISTS: MEDICAL DOCTORS AND NUTRITIONISTS MORE THAN 200 ANALYSES per MONTH MORE THAN PERSONS ANALYZED IN 4 YEARS ( ) ACTIVITIES 3 NATIONAL CME COURSES PER YEAR CASE HISTORY AND CUSTOMER DATABASE STUDY INTERNAL RESEARCH PROJECT (ON GOING) Co-funded by Lipinutragen & Medical partners and published Ospedale Maggiore Autism IRCCS _ Istituto delle Scienze Neurologiche di Bologna - Duchenne De Bellis Celiac disease The Hebrew University Diabetes

25 NUTRAGENIKA, PESONALIZED NUTRITIONAL THERAPY OBJECTIVE TO PROVIDE THE MARKET WITH HIGH QUALITY PRODUCTS RESULT OF STUDIES THAT INVOLVED ABOUT ANALYSES DELIVERED: 4 NUTRACEUTICAL PRODUCTS SALES TURNOVER OF ABOUT MORE THAN UNITS SOLD IN 2014 FUNCTIONAL FOODS NUTRANUT: NUT S CREAM WITH CACAO, EV OLIVE OIL AND LINESEEDS VERY LOW SATURED FATTY ACID CONTENT AND BALANCED W3-W6 CONTENT

26 LIPINUTRAGEN & CNR EU PROJECTS APPLICATIVE RESEARCH APPROCH Project: E!7348 LIPIDOMEL Title: New nutritional approach to develop a dietary ingredient against excess weight- and oxidative stress-induced disorders Partners: BIONOV (France), LIPINUTRAGEN (Italy), ISOF-CNR (Italy) Scientist in charge: Dr. Carla Ferreri Period: Apr Mar % LIPINUTRAGEN 50% MIUR % CNR (salaries of permanent researchers) 50% MIUR Marie Sklodowska Curie Actions Innovation Training Networks (ITN)-ETN- H2020 Title: Click Chemistry for future gene therapies to benefit citizens, researches and industry Responsible: dr. Valentina Sunda Period: % EC FUNDS (1 PhD student) ISOF CNR Scientist in charge: Dr. Carla Ferreri % EC FUNDS (1 PhD student)

27 LIPINUTRAGEN & CNR SYNERGY APPLICATIVE R&D APPROACH FOCUS ON REAL MARKET SCIENTIFIC BASIS for RESEARCH AND DEVELOPEMENT NATIONAL AND INTERNATIONAL PROJECTS

28 GRAZIE!! If you like, you can taste it