Membrane Structure and Function
|
|
- Kristin West
- 5 years ago
- Views:
Transcription
1 LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson Chapter 7 Membrane Structure and Function Lectures by Erin Barley Kathleen Fitzpatrick
2 Why do cells need a plasma membrane?
3 Overview: Life at the Edge The plasma membrane is the boundary that separates the living cell from its surroundings The plasma membrane exhibits selective permeability, allowing some substances to cross it more easily than others
4 Concept 7.1: Cellular membranes are fluid mosaics of lipids and proteins Phospholipids are the most abundant lipid in the plasma membrane Phospholipids are amphipathic molecules, containing hydrophobic and hydrophilic regions The fluid mosaic model states that a membrane is a fluid structure with a mosaic of various proteins embedded in it
5 Figure 7.2 Hydrophilic head WATER Hydrophobic tail WATER
6 In 1935, Hugh Davson and James Danielli proposed a sandwich model in which the phospholipid bilayer lies between two layers of globular proteins Later studies found problems with this model, particularly the placement of membrane proteins, which have hydrophilic and hydrophobic regions In 1972, S. J. Singer and G. Nicolson proposed that the membrane is a mosaic of proteins dispersed within the bilayer, with only the hydrophilic regions exposed to water
7 Figure 7.3 Phospholipid bilayer Hydrophobic regions of protein Hydrophilic regions of protein Why are there proteins embedded in the phospholipid bilayer?
8 The Fluidity of Membranes Phospholipids in the plasma membrane can move within the bilayer Most of the lipids, and some proteins, drift laterally Rarely does a molecule flip-flop transversely across the membrane
9 Figure 7.5 Fibers of extracellular matrix (ECM) Glycoprotein Carbohydrate Glycolipid EXTRACELLULAR SIDE OF MEMBRANE Cholesterol Microfilaments of cytoskeleton Peripheral proteins Integral protein CYTOPLASMIC SIDE OF MEMBRANE
10 Figure 7.6 Lateral movement occurs 10 7 times per second. Flip-flopping across the membrane is rare ( once per month). If the phospholipids move, does that mean membrane proteins move too?
11 Figure 7.7 RESULTS Membrane proteins Mouse cell Human cell Hybrid cell Mixed proteins after 1 hour
12 As temperatures cool, membranes switch from a fluid state to a solid state The temperature at which a membrane solidifies depends on the types of lipids Membranes rich in unsaturated fatty acids are more fluid than those rich in saturated fatty acids Membranes must be fluid to work properly; they are usually about as fluid as salad oil Compare and Contrast Saturated and Unsaturated Fats.
13 The steroid cholesterol has different effects on membrane fluidity at different temperatures At warm temperatures (such as 37 C), cholesterol restrains movement of phospholipids At cool temperatures, it maintains fluidity by preventing tight packing
14 Figure 7.8 Fluid Viscous Unsaturated hydrocarbon tails Saturated hydrocarbon tails (a) Unsaturated versus saturated hydrocarbon tails (b) Cholesterol within the animal cell membrane helps maintain fluidity by preventing tight packing Cholesterol
15 Evolution of Differences in Membrane Lipid Composition Variations in lipid composition of cell membranes of many species appear to be adaptations to specific environmental conditions Ability to change the lipid compositions in response to temperature changes has evolved in organisms that live where temperatures vary
16 Membrane Proteins and Their Functions A membrane is a collage of different proteins, often grouped together, embedded in the fluid matrix of the lipid bilayer Proteins determine most of the membrane s specific functions
17 Peripheral proteins are bound to the surface of the membrane Integral proteins penetrate the hydrophobic core Integral proteins that span the membrane are called transmembrane proteins The hydrophobic regions of an integral protein consist of one or more stretches of nonpolar amino acids, often coiled into alpha helices
18 Figure 7.9 EXTRACELLULAR SIDE N-terminus helix C-terminus CYTOPLASMIC SIDE
19 Six major functions of membrane proteins Transport Enzymatic activity Signal transduction Cell-cell recognition Intercellular joining Attachment to the cytoskeleton and extracellular matrix (ECM)
20 Figure 7.10a Signaling molecule Enzymes Receptor ATP Signal transduction (a) Transport (b) Enzymatic activity (c) Signal transduction
21 Figure 7.10b Glycoprotein (d) Cell-cell recognition (e) Intercellular joining (f) Attachment to the cytoskeleton and extracellular matrix (ECM)
22 The Role of Membrane Carbohydrates in Cell-Cell Recognition Cells recognize each other by binding to surface molecules, often containing carbohydrates, on the extracellular surface of the plasma membrane Sugar Label Membrane carbohydrates may be covalently bonded to lipids (forming glycolipids) or more commonly to proteins (forming glycoproteins) Carbohydrates on the external side of the plasma membrane vary among species, individuals, and even cell types in an individual
23 Figure 7.11 HIV Receptor (CD4) Co-receptor (CCR5) Receptor (CD4) but no CCR5 Plasma membrane HIV can infect a cell that has CCR5 on its surface, as in most people. HIV cannot infect a cell lacking CCR5 on its surface, as in resistant individuals.
24 Synthesis and Sidedness of Membranes Membranes have distinct inside and outside faces The asymmetrical distribution of proteins, lipids, and associated carbohydrates in the plasma membrane is determined when the membrane is built by the ER and Golgi apparatus
25 Figure 7.12 Transmembrane glycoproteins Secretory protein Golgi apparatus ER ER lumen Vesicle Glycolipid Plasma membrane: Cytoplasmic face Extracellular face Transmembrane glycoprotein Membrane glycolipid Secreted protein
26 Concept 7.2: Membrane structure results in selective permeability A cell must exchange materials with its surroundings, a process controlled by the plasma membrane Plasma membranes are selectively permeable, regulating the cell s molecular traffic Gate
27 The Permeability of the Lipid Bilayer Hydrophobic (nonpolar) molecules, such as hydrocarbons, can dissolve in the lipid bilayer and pass through the membrane rapidly Polar molecules, such as sugars, do not cross the membrane easily
28 Transport Proteins Transport proteins allow passage of hydrophilic substances across the membrane Some transport proteins, called channel proteins, have a hydrophilic channel that certain molecules or ions can use as a tunnel Channel proteins called aquaporins facilitate the passage of water
29 Other transport proteins, called carrier proteins, bind to molecules and change shape to shuttle them across the membrane A transport protein is specific for the substance it moves
30 Concept 7.3: Passive transport is diffusion of a substance across a membrane with no energy investment Diffusion is the tendency for molecules to spread out evenly into the available space Although each molecule moves randomly, diffusion of a population of molecules may be directional At dynamic equilibrium, as many molecules cross the membrane in one direction as in the other Think of putting a few drops of dye into a cup of water. What happens over time?
31 Animation: Membrane Selectivity Right-click slide / select Play
32 Animation: Diffusion Right-click slide / select Play
33 Figure 7.13 Molecules of dye Membrane (cross section) WATER Net diffusion Net diffusion Equilibrium (a) Diffusion of one solute Net diffusion Net diffusion Equilibrium Net diffusion (b) Diffusion of two solutes Net diffusion Equilibrium
34 Substances diffuse down their concentration gradient, the region along which the density of a chemical substance increases or decreases No work must be done to move substances down the concentration gradient The diffusion of a substance across a biological membrane is passive transport because no energy is expended by the cell to make it happen If you are a passive person, you let things slide by
35 Effects of Osmosis on Water Balance Osmosis is the diffusion of water across a selectively permeable membrane Water diffuses across a membrane from the region of lower solute concentration to the region of higher solute concentration until the solute concentration is equal on both sides LOW solute HIGH solute Water follows the highly concentrated solute.
36 Figure 7.14 Lower concentration of solute (sugar) Higher concentration of solute Same concentration of solute Sugar molecule H 2 O Selectively permeable membrane Sugar (green dots) cannot cross the selectively permeable membrane. Osmosis
37 Water Balance of Cells Without Walls Tonicity is the ability of a surrounding solution to cause a cell to gain or lose water Isotonic solution: Solute concentration is the same as that inside the cell; no net water movement across the plasma membrane Hypertonic solution: Solute concentration is greater than that inside the cell; cell loses water (hyper = high) The water follows the solute, which is higher outside the cell, so the water leaves the cell, so the cell shrinks. Hypotonic solution: Solute concentration is less than that inside the cell; cell gains water (hypo = low) The water follows the solute, which is higher inside the cell, so the cell gets bigger.
38 Figure 7.15 (a) Animal cell Hypotonic solution Isotonic solution Hypertonic solution H 2 O H 2 O H 2 O H 2 O Lysed Normal Shriveled (b) Plant cell H 2 O Cell wall H 2 O H 2 O H 2 O Turgid (normal) Flaccid Plasmolyzed Osmosis
39 Hypertonic or hypotonic environments create osmotic problems for organisms Osmoregulation, the control of solute concentrations and water balance, is a necessary adaptation for life in such environments The protist Paramecium, which is hypertonic to its pond water environment, has a contractile vacuole that acts as a pump
40 Water Balance of Cells with Walls Cell walls help maintain water balance A plant cell in a hypotonic solution swells until the wall opposes uptake; the cell is now turgid (firm) If a plant cell and its surroundings are isotonic, there is no net movement of water into the cell; the cell becomes flaccid (limp), and the plant may wilt
41 In a hypertonic environment, plant cells lose water; eventually, the membrane pulls away from the wall, a usually lethal effect called plasmolysis
42 Video: Plasmolysis
43 Video: Turgid Elodea
44 Animation: Osmosis Right-click slide / select Play
45 Facilitated Diffusion: Passive Transport Aided by Proteins In facilitated diffusion, transport proteins speed the passive movement of molecules across the plasma membrane Facilitate = proteins help move molecules across Channel proteins provide corridors that allow a specific molecule or ion to cross the membrane Channel proteins include Aquaporins, for facilitated diffusion of water Ion channels that open or close in response to a stimulus (gated channels)
46 Figure 7.17 EXTRACELLULAR FLUID (a) A channel protein Channel protein CYTOPLASM Solute Carrier protein Solute (b) A carrier protein
47 Carrier proteins undergo a subtle change in shape that translocates the solute-binding site across the membrane There are numerous diseases associated with ion channel dysfunction. Search for a disease caused by ion channel dysfunction. How does it lead directly to a disease? Extra Credit!
48 Concept 7.4: Active transport uses energy to move solutes against their gradients Facilitated diffusion is still passive because the solute moves down its concentration gradient, and the transport requires no energy Some transport proteins, however, can move solutes against their concentration gradients
49 The Need for Energy in Active Transport Active transport moves substances against their concentration gradients Active transport requires energy, usually in the form of ATP Active transport is performed by specific proteins embedded in the membranes You need energy to be active person that exercises.
50 Active transport allows cells to maintain concentration gradients that differ from their surroundings The sodium-potassium pump is one type of active transport system
51 Figure EXTRACELLULAR FLUID [ ] high [K ] low CYTOPLASM 1 [ ] low [K ] high Cytoplasmic sodium binds to the sodium-potassium pump. The protein likes to bind sodium when it has this particular shape. *Notice that the sodium is being pumped against its concentration gradient. From a low cytoplasmic side to a high extracellular side.
52 Figure EXTRACELLULAR FLUID [ ] high [K ] low CYTOPLASM [ ] low 1 [K ] high 2 P ADP ATP Sodium binding then stimulates the phosphorylation by ATP. ATP gives up one of its phosphates to the protein, so ATP becomes ADP (tri to di phosphate)
53 Figure EXTRACELLULAR FLUID [ ] high [K ] low [ ] low ATP CYTOPLASM P 1 [K ] high 2 ADP 3 P Phosphorylation causes the protein to change its shape, causing it to no longer like to bind to sodium. So it is released to the extracellular side.
54 Figure EXTRACELLULAR FLUID [ ] high [K ] low [ ] low ATP CYTOPLASM P 1 [K ] high 2 ADP 3 P The new shape now likes to bind potassium. It binds on the extracellular side and triggers the release of the phosphate. K K 4 P P i
55 Figure EXTRACELLULAR FLUID [ ] high [K ] low [ ] low ATP CYTOPLASM P 1 [K ] high 2 ADP 3 P Loss of the phosphate restores the proteins original shape, which now no longer likes to bind to potassium. K K K K 5 4 P P i
56 Figure EXTRACELLULAR FLUID [ ] high [K ] low [ ] low ATP CYTOPLASM P 1 [K ] high 2 3 ADP Potassium is released, and now the protein s shape likes to bind sodium again. The cycle repeats. P K K K K K 6 K 5 4 P P i
57 Animation: Active Transport Right-click slide / select Play
58 Figure 7.19 Passive transport Active transport Diffusion Facilitated diffusion ATP
59 How Ion Pumps Maintain Membrane Potential Membrane potential is the voltage difference across a membrane Voltage is created by differences in the distribution of positive and negative ions across a membrane
60 Two combined forces, collectively called the electrochemical gradient, drive the diffusion of ions across a membrane A chemical force (the ion s concentration gradient) An electrical force (the effect of the membrane potential on the ion s movement)
61 An electrogenic pump is a transport protein that generates voltage across a membrane The sodium-potassium pump is the major electrogenic pump of animal cells The main electrogenic pump of plants, fungi, and bacteria is a proton pump Electrogenic pumps help store energy that can be used for cellular work
62 Figure 7.20 ATP H Proton pump EXTRACELLULAR FLUID H H H H CYTOPLASM H Proton pumps are electrogenic pums that store energy by generating a voltage across the membrane. It moves positive charges in the form of hydrogens. The voltage and the hydrogen concentration gradient represent a dual energy source that can drive other processes, such as the uptake of nutrients. Most are powered by ATP!
63 Cotransport: Coupled Transport by a Membrane Protein Cotransport occurs when active transport of a solute indirectly drives transport of other solutes Plants commonly use the gradient of hydrogen ions generated by proton pumps to drive active transport of nutrients into the cell
64 ATP H H H Proton pump H H H H H Sucrose-H cotransporter Diffusion of H Sucrose Sucrose A carrier protein such as the sucrose-proton cotransporter in a plant cell is able to use the diffusion of protons down its electrochemical gradient into the cell to drive the uptake of sucrose. The proton gradient is maintained by an ATP-driven proton pump that concentrates protons outside the cell, thus storing energy that can be used for active transport of the sucrose. So, ATP indirectly provides the energy necessary for cotransport.
65 Concept 7.5: Bulk transport across the plasma membrane occurs by exocytosis and endocytosis Small molecules and water enter or leave the cell through the lipid bilayer or via transport proteins Large molecules, such as polysaccharides and proteins, cross the membrane in bulk via vesicles Bulk transport requires energy
66 Exocytosis In exocytosis, transport vesicles migrate to the membrane, fuse with it, and release their contents Many secretory cells use exocytosis to export their products Exo = exit
67 Animation: Exocytosis Right-click slide / select Play
68 Endocytosis In endocytosis, the cell takes in macromolecules by forming vesicles from the plasma membrane Endocytosis is a reversal of exocytosis, involving different proteins There are three types of endocytosis Phagocytosis ( cellular eating ) Pinocytosis ( cellular drinking ) Receptor-mediated endocytosis
69 Animation: Exocytosis and Endocytosis Introduction Right-click slide / select Play
70 In phagocytosis a cell engulfs a particle in a vacuole The vacuole fuses with a lysosome to digest the particle
71 1 m Figure 7.22a Phagocytosis Pseudopodium of amoeba EXTRACELLULAR FLUID Solutes Pseudopodium Bacterium Food vacuole An amoeba engulfing a bacterium via phagocytosis (TEM). Food or other particle Food vacuole CYTOPLASM
72 Animation: Phagocytosis Right-click slide / select Play
73 In pinocytosis, molecules are taken up when extracellular fluid is gulped into tiny vesicles
74 0.5 m Figure 7.22b Pinocytosis Plasma membrane Pinocytosis vesicles forming in a cell lining a small blood vessel (TEM). Vesicle
75 Animation: Pinocytosis Right-click slide / select Play
76 In receptor-mediated endocytosis, binding of ligands to receptors triggers vesicle formation A ligand is any molecule that binds specifically to a receptor site of another molecule
77 0.25 m Figure 7.22c Receptor-Mediated Endocytosis Plasma membrane Coat proteins Ligand Receptor Coat proteins Top: A coated pit. Bottom: A coated vesicle forming during receptor-mediated endocytosis (TEMs). Coated pit Coated vesicle
78 Animation: Receptor-Mediated Endocytosis Right-click slide / select Play
79 Figure 7.UN01 Passive transport: Facilitated diffusion Channel protein Carrier protein
80 Figure 7.UN02 Active transport ATP
Membrane Structure and Function
LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson Chapter 7 Membrane Structure and Function
More informationMembrane Structure and Function
Chapter 7 Membrane Structure and Function PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from
More informationBIOLOGY. Membrane Structure and Function CAMPBELL. Reece Urry Cain Wasserman Minorsky Jackson
CAMPBELL BIOLOGY TENTH EDITION Reece Urry Cain Wasserman Minorsky Jackson 7 Membrane Structure and Function Lecture Presentation by Nicole Tunbridge and Kathleen Fitzpatrick Life at the Edge The plasma
More informationMembrane Structure and Function
Chapter 7 Membrane Structure and Function PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from
More informationMembrane Structure and Function
LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson Chapter 7 Membrane Structure and Function
More informationMembrane Structure and Function
Chapter 7 LECTURE RESENTATIONS For CAMBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, eter V. Minorsky, Robert B. Jackson Membrane Structure and Function
More informationMembrane Structure and Function
Chapter 7 LECTURE RESENTATIONS For CAMBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, eter V. Minorsky, Robert B. Jackson Membrane Structure and Function
More informationCh. 7 Cell Membrane BIOL 222
Ch. 7 Cell Membrane BIOL 222 Overview: Plasma Membrane Plasma boundary that separates the living cell from its surroundings Selec4ve permeability Allowance of some substances to cross more easily than
More informationMembrane Structure and Function
Chapter 7 Membrane Structure and Function PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from
More informationMEMBRANE STRUCTURE & FUNCTION
MEMBRANE STRUCTURE & FUNCTION Chapter 8 KEY CONCEPTS Cellular s are fluid mosaics of lipids and proteins Membrane structure results in selective permeability Passive transport is diffusion of a substance
More informationChapter 7: Membrane Structure & Function
Chapter 7: Membrane Structure & Function 1. Membrane Structure 2. Transport Across Membranes 1. Membrane Structure Chapter Reading pp. 125-129 What are Biological Membranes? Hydrophilic head WATER They
More informationChapter 7: Membrane Structure & Function. 1. Membrane Structure. What are Biological Membranes? 10/21/2015. Why phospholipids? 1. Membrane Structure
Chapter 7: Membrane Structure & Function 1. Membrane Structure 2. Transport Across Membranes 1. Membrane Structure Chapter Reading pp. 125-129 What are Biological Membranes? Hydrophilic head WATER They
More informationMembrane Structure and Function
Chapter 7 Membrane Structure and Function PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from
More informationMembrane Structure and Function
Membrane Structure and Function Chapter 7 Objectives Define the following terms: amphipathic molecules, aquaporins, diffusion Distinguish between the following pairs or sets of terms: peripheral and integral
More informationMEMBRANE STRUCTURE AND FUNCTION
MEMBRANE STRUCTURE AND FUNCTION selective permeability permits some substances to cross it more easily than others Figure 7.1 Scientists studying the plasma Reasoned that it must be a phospholipid bilayer
More informationCONCEPT 5.1: Cellular membranes are fluid mosaics of lipids and proteins
Ch 5 Membrane Transport and Signaling Overview The plasma separates the living cell from its surroundings The plasma exhibits selective permeability, allowing some substances to cross it more easily than
More informationConcept 7.1: Cellular membranes are fluid mosaics of lipids and proteins
Concept 7.1: Cellular membranes are fluid mosaics of lipids and proteins Lipids: Non-polar substances such as fat that contain C, H, O. Phospholipids: Lipid with phosphate group, very abundant in plasma
More informationChapter 7: Membrane Structure and Function. Key Terms:
Key Terms: Selectively permeable Fluid mosaic model Amphipathic Phospholipid Bilayer Hydrophilic Hydrophobic Phosphate head Fatty acid tail Davson-Danielli Singer-Nicolson Freeze-Fracture EM Unsaturated
More informationMembrane Transport and Cell Signaling
CAMPBELL BIOLOGY IN FOCUS URRY CAIN WASSERMAN MINORSKY REECE 5 Membrane Transport and Cell Signaling Lecture Presentations by Kathleen Fitzpatrick and Nicole Tunbridge, Simon Fraser University SECOND EDITION
More informationBSC Exam I Lectures and Text Pages
BSC 2010 - Exam I Lectures and Text Pages I. Intro to Biology (2-29) II. Chemistry of Life Chemistry review (30-46) Water (47-57) Carbon (58-67) Macromolecules (68-91) III. Cells and Membranes Cell structure
More information5 Membrane Transport and Cell Signaling
CAMPBELL BIOLOGY IN FOCUS Urry Cain Wasserman Minorsky Jackson Reece 5 Membrane Transport and Cell Signaling Lecture Presentations by Kathleen Fitzpatrick and Nicole Tunbridge Overview: Life at the Edge
More informationCHAPTER 8 MEMBRANE STUCTURE AND FUNCTION
CHAPTER 8 MEMBRANE STUCTURE AND FUNCTION Plasma Membrane Plasma membrane is selectively permeable, (allowing some substances to cross more easily than others) PM is flexible bends and changes shape
More informationMembrane Structure and Function. Cell Membranes and Cell Transport
Membrane Structure and Function Cell Membranes and Cell Transport 1895 1917 1925 Membrane models Membranes are made of lipids Phospholipids can form membranes Its actually 2 layers - there are proteins
More informationMEMBRANE STRUCTURE AND FUNCTION
MEMBRANE STRUCTURE AND FUNCTION 2.4.2 Membranes organize the chemical activities of cells Membranes provide structural order for metabolism Form most of the cell's organelles Compartmentalize chemical
More informationCHAPTER 8 MEMBRANE STRUCTURE AND FUNCTION
CHAPTER 8 MEMBRANE STRUCTURE AND FUNCTION Section B: Traffic Across Membranes 1. A membrane s molecular organization results in selective permeability 2. Passive transport is diffusion across a membrane
More informationChapter 7: Membrane Structure and Function
Chapter 7: Membrane Structure and Function Concept 7.1 Cellular membranes are fluid mosaics of lipids and proteins 1. Phospholipids are amphipathic. Explain what this means. Name Period Amphipathic means
More informationLecture Series 4 Cellular Membranes
Lecture Series 4 Cellular Membranes Reading Assignments Read Chapter 11 Membrane Structure Review Chapter 21 pages 709-717 717 (Animal( Cell Adhesion) Review Chapter 12 Membrane Transport Review Chapter
More informationLecture Series 5 Cellular Membranes
Lecture Series 5 Cellular Membranes Cellular Membranes A. Membrane Composition and Structure B. Animal Cell Adhesion C. Passive Processes of Membrane Transport D. Active Transport E. Endocytosis and Exocytosis
More informationA. Membrane Composition and Structure. B. Animal Cell Adhesion. C. Passive Processes of Membrane Transport. D. Active Transport
Cellular Membranes A. Membrane Composition and Structure Lecture Series 5 Cellular Membranes B. Animal Cell Adhesion E. Endocytosis and Exocytosis A. Membrane Composition and Structure The Fluid Mosaic
More informationPlasma Membrane Structure and Function
Plasma Membrane Structure and Function Chapter 7 Image from: http://www.biologie.uni-hamburg.de/b-online/ge22/03.gif Slide show modified from: http://www.explorebiology.com/pptap/2005/ http://facstaff.bloomu.edu/gdavis/links%20100.htm
More informationCh. 7 Cell Membrane BIOL 222
Ch. 7 Cell Membrane BIOL 222 Overview: Plasma Membrane Plasma membrane boundary that separates the living cell from its surroundings Selec4ve permeability Allowance of some substances to cross more easily
More informationCell Membrane Structure and Function. What is the importance of having a cell membrane?
Cell Membrane Structure and Function What is the importance of having a cell membrane? I. Membrane Structure a. Membranes contain proteins, lipids, and carbohydrates (which are all types of macromolecules)
More informationMembrane Structure and Function
Chapter 7 Membrane Structure and Function Lecture Outline Overview: Life at the Edge The plasma membrane separates the living cell from its nonliving surroundings. This thin barrier, 8 nm thick, controls
More informationWhat kind of things must pass into and out of cells?? Be careful not to go too fast.
1. A membrane s molecular organization results in selective permeability What kind of things must pass into and out of cells?? Be careful not to go too fast. Permeability of a molecule through a membrane
More informationCell Membranes and Signaling
5 Cell Membranes and Signaling Concept 5.1 Biological Membranes Have a Common Structure and Are Fluid A membrane s structure and functions are determined by its constituents: lipids, proteins, and carbohydrates.
More informationWhat kind of things must pass into and out of cells?? Be careful not to go too fast.
1. A membrane s molecular organization results in selective permeability What kind of things must pass into and out of cells?? Be careful not to go too fast. Permeability of a molecule through a membrane
More informationChapter 7 Membrane Structure and Function. The plasma membrane surrounds the living cells from their surroundings.
Chapter 7 Membrane Structure and Function The plasma membrane surrounds the living cells from their surroundings. Only 8 nm thick (8,000 to equal the thickness of a sheet of paper) Controls passage of
More informationMembrane Structure & Function (Learning Objectives)
Membrane Structure & Function (Learning Objectives) Review the basic function and biochemical composition of the plasma membrane. Learn the fluid state of membranes and the movement of its lipids and proteins.
More informationChapter 7 Membrane Structure and Function
Chapter 7 Membrane Structure and Function CELL MEMBRANE: Basics: Regulates flow in and out of the cell Composed of phospholipids and proteins - some carbohydrates and lipids SELECTIVELY PERMEABLE - allows
More informationMembrane Structure and Function. Selectively permeable membranes are key to the cell's ability to function
Membrane Structure and Function Selectively permeable membranes are key to the cell's ability to function Amphipathic Molecules Have both hydrophilic and hydrophobic regions Phospholipids have hydrophilic
More informationMembrane Structure and Function
Membrane Structure and Function What You Must Know: Why membranes are selectively permeable. The role of phospholipids, proteins, and carbohydrates in membranes. How water will move if a cell is placed
More informationLecture Series 4 Cellular Membranes. Reading Assignments. Selective and Semi-permeable Barriers
Lecture Series 4 Cellular Membranes Reading Assignments Read Chapter 11 Membrane Structure Review Chapter 12 Membrane Transport Review Chapter 15 regarding Endocytosis and Exocytosis Read Chapter 20 (Cell
More informationChapter 7: Membrane Structure and Function
Chapter 7: Membrane Structure and Function Name Period Concept 7.1 Cellular membranes are fluid mosaics of lipids and proteins 1. The large molecules of all living things fall into just four main classes.
More informationChapter 7-3 Cell Boundaries
Chapter 7-3 Cell Boundaries The Plasma Membrane: Cell Membrane Regulates what enters and leaves the cell. Provides protection and support. Highly selective barrier!!!! What the plasma membrane is made
More informationConcept 7.5: Bulk transport across the plasma membrane occurs by exocytosis and endocytosis
Concept 7.5: Bulk transport across the plasma membrane occurs by exocytosis and endocytosis Small molecules and water enter or leave the cell through the lipid bilayer or by transport proteins Large molecules,
More informationPhospholipids. Extracellular fluid. Polar hydrophilic heads. Nonpolar hydrophobic tails. Polar hydrophilic heads. Intracellular fluid (cytosol)
Module 2C Membranes and Cell Transport All cells are surrounded by a plasma membrane. Eukaryotic cells also contain internal membranes and membrane- bound organelles. In this module, we will examine the
More informationChapter 5. The Working Cell. Lecture by Richard L. Myers
Chapter 5 The Working Cell PowerPoint Lectures for Biology: Concepts & Connections, Sixth Edition Campbell, Reece, Taylor, Simon, and Dickey Lecture by Richard L. Myers MEMBRANE STRUCTURE AND FUNCTION
More informationThe Cell Membrane. Cell membrane separates living cell from nonliving surroundings. Controls traffic in & out of the cell
The Cell Membrane 1 Overview Cell membrane separates living cell from nonliving surroundings thin barrier = 8nm thick Controls traffic in & out of the cell selectively permeable allows some substances
More informationWhat do you remember about the cell membrane?
Cell Membrane What do you remember about the cell membrane? Cell (Plasma) Membrane Separates the internal environment of the cell from the external environment All cells have a cell membrane Selectively
More informationMembrane Structure and Function
Membrane Structure and Function Check Your Gummy Bears Ø Take Day One measurements l Same measurements you took yesterday Ø What type solution was the gummy bear in? Hyper, Hypo, or Isotonic? Ø Put your
More informationThe Cell Membrane & Movement of Materials In & Out of Cells PACKET #11
1 February 26, The Cell Membrane & Movement of Materials In & Out of Cells PACKET #11 Introduction I 2 Biological membranes are phospholipid bilayers with associated proteins. Current data support a fluid
More informationLecture Series 4 Cellular Membranes
Lecture Series 4 Cellular Membranes Reading Assignments Read Chapter 11 Membrane Structure Review Chapter 12 Membrane Transport Review Chapter 15 regarding Endocytosis and Exocytosis Read Chapter 20 (Cell
More informationCell Transport & the Cell Membrane
Cell Transport & the Cell Membrane I. Cell Membrane A. Structure Structure of the cell membrane is referred to as the Fluid Mosaic Model. It is made up of lipids, proteins and carbohydrates. The membrane
More informationThe Cell Membrane AP Biology
The Cell Membrane AP Biology! 2007-2008 Overview! Cell membrane separates living cell from nonliving surroundings " thin barrier = 8nm thick! Controls traffic in & out of the cell " selectively permeable
More informationThe Cell Membrane. Phospholipids. Chapter 7: Arranged as a Phospholipid bilayer. Cell membrane defines cell! Cell membrane separates living cell from
Chapter 7: The Cell Membrane Phospholipids! Amphipathic Molecules: " Phosphate head! hydrophilic " Fatty acid tails! Hydrophobic! Arranged as a bilayer Phosphate attracted to water Fatty acid repelled
More informationMembrane Structure and Function
BIOL1040 Page 1 Membrane Structure and Function Friday, 6 March 2015 2:58 PM Cellular Membranes Fluid mosaics of lipids and proteins Phospholipids - abundant Phospholipids are amphipathic molecules (has
More informationMembrane Structure and Function
Chapter 7 Membrane Structure and Function Lecture Outline Overview: Life at the Edge The plasma membrane separates the living cell from its surroundings. This thin barrier, 8 nm thick, controls traffic
More informationHow Things Get In and Out of Cells, or gummy bears, zip lock bags or whatever!
How Things Get In and Out of Cells, or gummy bears, zip lock bags or whatever! SC.912.L.14.3 Benchmark Clarifications: Students will compare and/or contrast the structures found in plant cells and in animal
More informationBio 111 Study Guide Chapter 5 Membrane Transport and Cell Signaling
Bio 111 Study Guide Chapter 5 Membrane Transport and Cell Signaling BEFORE CLASS: Reading: Read the whole chapter from pp. 100-119. There are many great figures in this chapter. Make sure you study all
More informationAP Biology. Overview. The Cell Membrane. Phospholipids. Phospholipid bilayer. More than lipids. Fatty acid tails. Phosphate group head
Overview The Cell Membrane Cell separates living cell from nonliving surroundings thin barrier = 8nm thick Controls traffic in & out of the cell selectively permeable allows some substances to cross more
More informationPlasma Membrane Structure and Function
Plasma Membrane Structure and Function The plasma membrane separates the internal environment of the cell from its surroundings. The plasma membrane is a phospholipid bilayer with embedded proteins. The
More informationMembrane Structure and Function - 1
Membrane Structure and Function - 1 The Cell Membrane and Interactions with the Environment Cells interact with their environment in a number of ways. Each cell needs to obtain oxygen and other nutrients
More informationThe Cell Membrane. Usman Sumo Friend Tambunan Arli Aditya Parikesit. Bioinformatics Group Faculty of Mathematics and Science University of Indonesia
The Cell Membrane Usman Sumo Friend Tambunan Arli Aditya Parikesit Bioinformatics Group Faculty of Mathematics and Science University of Indonesia Overview Cell membrane separates living cell from nonliving
More informationChapter 7. Movement across the Cell Membrane
Chapter 7 Movement across the Cell Membrane 2005-2006 Diffusion 2nd Law of Thermodynamics governs biological systems u Universe tends towards disorder Diffusion u movement from high low concentration Diffusion
More informationBiology Kevin Dees. Chapter 7 Membrane Structure and Function
Chapter 7 Membrane Structure and Function The plasma membrane surrounds the living cells from their surroundings. Only 8 nm thick (8,000 to equal the thickness of a sheet of paper) Controls passage of
More informationDiffusion across cell membrane
The Cell Membrane and Cellular Transport Diffusion across cell membrane Cell membrane is the boundary between inside & outside separates cell from its environment Can it be an impenetrable boundary? NO!
More informationMonday, September 30 th :
Monday, September 30 th : QUESTION TO PONDER: Differentiate between a pro- and eukaryotic organism. List 4 organelles that each type of organism has in common. The Cell Membrane Modified from Kim Foglia
More informationWhat is the Surface Area to Volume Ratio of a sphere with a radius of 5mm? Of 10 mm? What sphere can eliminate wastes and move materials quicker?
Warm Up What is the Surface Area to Volume Ratio of a sphere with a radius of 5mm? Of 10 mm? What sphere can eliminate wastes and move materials quicker? Cell Membrane and Function Chapter 7 Big Idea #2:
More informationCWDHS Mr. Winch Grade 12 Biology
The Cell Membrane Overview Cell separates living cell from nonliving surroundings thin barrier = 8nm thick Controls traffic in & out of the cell selectively permeable allows some substances to cross more
More informationChapter 8. Cell Membranes
Chapter 8 Cell Membranes Composition of cell membrane: the fluid mosaic model 流體鑲嵌模型 ---structural element (lipid脂質) Page 197 ---carry out the specific functions (protein蛋白質) Phospholipids 磷脂質 Are the
More informationCh7: Membrane Structure & Function
Ch7: Membrane Structure & Function History 1915 RBC membranes studied found proteins and lipids 1935 membrane mostly phospholipids 2 layers 1950 electron microscopes supported bilayer idea (Sandwich model)
More informationThe Cell Membrane & Movement of Materials In & Out of Cells PACKET #11
1 The Cell Membrane & Movement of Materials In & Out of Cells PACKET #11 Introduction I 2 Biological membranes are phospholipid bilayers with associated proteins. Current data support a fluid mosaic model
More informationMovement across the Membrane
Chapter 8. Movement across the Membrane 2003-2004 1 Cell membrane Cells have an inside & an outside Cell membrane is the boundary Can it be an impenetrable boundary? NO! Why not? The cell needs materials
More informationPhospholipid Bilayer Hydrophilic head Hydrophobic tail Molecules with hydrophilic and hydrophobic parts are called Ampipathic molecules
Plasma Membrane The membrane at the boundary of every cell Functions as a selective barrier for the passage of materials in and out of cells Membrane Composition Phospholipids Proteins Carbohydrates Cholesterol
More informationThe Plasma Membrane. 5.1 The Nature of the Plasma Membrane. Phospholipid Bilayer. The Plasma Membrane
5.1 The Nature of the Plasma Membrane The Plasma Membrane Four principal components in animals Phospholipid bilayer Molecules of cholesterol interspersed within the bilayer. Membrane proteins embedded
More informationDivision Ave High School Ms. Foglia AP Biology
The Cell Membrane Phospholipids Phosphate head hydrophilic Fatty acid tails hydrophobic Arranged as a bilayer Phosphate attracted to water Fatty acid repelled by water 2007-2008 Aaaah, one of those structure
More informationChapter 8. Movement across the Cell Membrane. diffusion. Diffusion of 2 solutes. Cell (plasma) membrane. Diffusion 9/7/2012
Chapter 8. Movement across the Cell Membrane Diffusion Diffusion of 2 solutes Each substance diffuses down its own concentration gradient, independent of concentration gradients of other substances Diffusion
More informationDiffusion. Chapter 7. Movement across the Cell Membrane. Cell (plasma) membrane. diffusion. Building a membrane. Diffusion of 2 solutes
WH Chapter 7 Diffusion Move for HIGH to LOW concentration passive transport no energy needed Movement across the Cell Membrane 2005-2006 diffusion osmosis Diffusion 2nd Law of Thermodynamics governs biological
More informationPhospholipids. Phosphate head. Fatty acid tails. Arranged as a bilayer. hydrophilic. hydrophobic. Phosphate. Fatty acid. attracted to water
The Cell Membrane Phospholipids Phosphate head hydrophilic Fatty acid tails hydrophobic Arranged as a bilayer Phosphate attracted to water Fatty acid repelled by water I want you to remember: Structure
More informationMembranes. Chapter 5. Membrane Structure
Membranes Chapter 5 Membrane Structure Lipid Bilayer model: - double phospholipid layer - Gorter & Grendel: 1925 Fluid Mosaic model: consist of -phospholipids arranged in a bilayer -globular proteins inserted
More informationComprehensive and Easy Course Notes for BIOL1040 Exams and Assessment
Comprehensive and Easy Course Notes for BIOL1040 Exams and Assessment MODULE 1: PRINCIPLES OF CELL FUNCTION Membrane Structure & Function Cellular membranes are fluid mosaics of lipids and proteins Phospholipids
More informationOutline. Membrane Structure and Function. Membrane Models Fluid-Mosaic. Chapter 5
Membrane Structure and Function Chapter 5 Membrane Models Fluid-Mosaic Outline Plasma Membrane Structure and Function Protein Functions Plasma Membrane Permeability! Diffusion! Osmosis! Transport Via Carrier
More informationTRANSPORT ACROSS MEMBRANES
Unit 2: Cells, Membranes and Signaling TRANSPORT ACROSS MEMBRANES Chapter 5 Hillis Textbook TYPES OF TRANSPORT ACROSS THE CELL (PLASMA) MEMBRANE: What do you remember? Complete the chart with what you
More informationBio 111 Study Guide Chapter 7 Membrane Structure and Function
Bio 111 Study Guide Chapter 7 Membrane Structure and Function BEFORE CLASS: Reading: Read the whole chapter from p. 124 138. Note the differences between Figures 7.2 and 7.3. We have come a long way in
More informationChapter 5. The Working Cell. Lecture by Richard L. Myers
Chapter 5 The Working Cell PowerPoint Lectures for Biology: Concepts & Connections, Sixth Edition Campbell, Reece, Taylor, Simon, and Dickey Copyright 2009 Pearson Education, Inc. Lecture by Richard L.
More informationMembrane Structure and Membrane Transport of Small Molecules. Assist. Prof. Pinar Tulay Faculty of Medicine
Membrane Structure and Membrane Transport of Small Molecules Assist. Prof. Pinar Tulay Faculty of Medicine Introduction Cell membranes define compartments of different compositions. Membranes are composed
More informationMembranes. Chapter 5
Membranes Chapter 5 Membrane Structure The fluid mosaic model of membrane structure contends that membranes consist of: -phospholipids arranged in a bilayer -globular proteins inserted in the lipid bilayer
More informationChapter 7: Membranes
Chapter 7: Membranes Roles of Biological Membranes The Lipid Bilayer and the Fluid Mosaic Model Transport and Transfer Across Cell Membranes Specialized contacts (junctions) between cells What are the
More informationMembrane Structure. Membrane Structure. Membrane Structure. Membranes
Membrane Structure Membranes Chapter 5 The fluid mosaic model of membrane structure contends that membranes consist of: -phospholipids arranged in a bilayer -globular proteins inserted in the lipid bilayer
More informationTransport: Cell Membrane Structure and Function. Biology 12 Chapter 4
Transport: Cell Membrane Structure and Function Biology 12 Chapter 4 FLUID-MOSAIC MODEL OF MEMBRANE STRUCTURE The cell membrane (plasma membrane) is made of two layers of phospholipid molecules (bilayer)
More informationChapter 5. The Working Cell. PowerPoint Lectures for Campbell Biology: Concepts & Connections, Seventh Edition Reece, Taylor, Simon, and Dickey
Chapter 5 The Working Cell PowerPoint Lectures for Campbell Biology: Concepts & Connections, Seventh Edition Reece, Taylor, Simon, and Dickey Lecture by Edward J. Zalisko Lesson Plans Flipped Classroom
More informationChapter 4 Skeleton Notes: Membrane Structure & Function
Chapter 4 Skeleton Notes: Membrane Structure & Function Overview/Objectives 4.1 Plasma Membrane Structure & Function o Structure and Function of the PM o Major functions of proteins 4.2- Permeability of
More informationCH 7.2 & 7.4 Biology
CH 7.2 & 7.4 Biology LABEL THE MEMBRANE Phospholipids Cholesterol Peripheral proteins Integral proteins Cytoskeleton Cytoplasm Extracellular fluid Most of the membrane A phospholipid bi-layer makes up
More informationCell Membranes Valencia college
6 Cell Membranes Valencia college 6 Cell Membranes Chapter objectives: The Structure of a Biological Membrane The Plasma Membrane Involved in Cell Adhesion and Recognition Passive Processes of Membrane
More informationUnit 1 Matter & Energy for Life
Unit 1 Matter & Energy for Life Chapter 2 Interaction of Cell Structure Biology 2201 Primary Membrane Function: Homeostasis Conditions in the cell must remain more or less constant under many different
More informationDelve AP Biology Lecture 4: 10/9/11 Melissa Ko and Anne Huang
Today s Agenda: I. Review of organelles II. More important organelles III. Plasma membrane structure IV. Diffusion and transport Delve AP Biology Lecture 4: 10/9/11 Melissa Ko and Anne Huang I. Review
More informationCytoskeleton. Provide shape and support for the cell. Other functions of the cytoskeleton. Nucleolus. Nucleus
Chapter 4: Cell Structure and Function Cytoskeleton The cytoskeleton is a network of fibers that organizes structures and activities in the cell. Microtubules (the largest) Intermediate fibers Microfilaments
More informationCellular membranes are fluid mosaics of lipids and proteins.
Study Guide e Plasma Membrane You should be able to write out the definitions to each of the following terms in your own words: plasma membrane fluid mosaic integral proteins peripheral proteins receptor
More informationMovement across the Cell Membrane
Movement across the Cell Membrane Diffusion 2nd Law of Thermodynamics governs biological systems universe tends towards disorder (entropy) Diffusion u movement from HIGH LOW concentration Simple Diffusion
More information