«Tit» «Name» «Fam_Nam» «Organization» «Address1» «Address_2» «PO_Box» «City». «Country» Sevilla, February, 2016

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1 «Tit» «Name» «Fam_Nam» «Organization» «Address» «Address_» «PO_Box» «City». «Country» Proficiency Test 5- Laboratory Code: «Lab_code» Sevilla, February, 6 Dear participants, Enclosed you will find the report of the Proficiency Test 5- on Drugs of Abuse in Hair, organized by the Society of Hair Testing. Each of the participating laboratories received an identifying code. Your particular code is «Lab_code». Sets of three samples were sent to forty four participating laboratories. Forty one of them sent the report forms back. Sample contents were as follows: Sample A contained opiates (6-MAM, morphine, codeine, acetylcodeine and heroin), cocainics (cocaine, BE, norcocaine and traces of cocaethylene) and cannabis (THC, CBD, CBN and THC-COOH). It also contained methadone, dihydrocodeine, diazepam, nordiazepam, tramadol, EME and AEME. Sample B contained contained traces of cocainics (cocaine, BE). Median concentration of cocaine is below the cut-off proposed by SoHT. Sample C opiates (6-MAM, morphine, codeine, acetylcodeine and heroin), cocainics (cocaine, BE, cocaethylene and norcocaine) traces of amphetamine compounds (amphetamine methamphetamine and MDMA) and cannabis (THC, CBD, CBN and THC-COOH). It also contained dihydrocodeine, diazepam, nordiazepam, tramadol, EME, AEME and traces of methadone.

2 has been calculated based on robust estimators (median instead of mean and interquartile instead of standard deviation). has been calculated as follows: = (x - χ) / IQR Where: x: Concentration reported by the participant χ: Median concentration obtained from the participating laboratories IQR: Interquartile range: It is calculated as: Q-Q (the upper quartile minus the lower quartile) Q: Third quartile (percentile 75) Q: First quartile (percentile 5) Decision criteria The following criteria have been adopted: Satisfactory results: ± Questionable results: < Unsatisfactory results: Yours faithfully, Carmen Jurado

3 Laboratory Code: Lab QUALITATIVE RESULTS Sample A Sample B Sample C Substances A T F Substances A T F Substances A T F MAM P D N MAM P Morphine P Morphine P Codeine P Codeine P Cocaine P Cocaine P BE P BE P THC P Amphetamine* P THC-COOH P Methamphetamine* P MDMA* THC P P THC-COOH * The median concentrations of amphetamine, methamphetamine and MDMA in Sample C are.6 ng/mg,. ng/mg and. ng/mg, respectively. All of them are lower than the cut-off proposed by SoHT (. ng/mg). P A: Your answer T: True answer F: False answer P: Positive N: Negative NR: Not reported NA: Not analyzed FN: False Negative FP: False Positive Comments: Sample A contains methadone, CBD, CBN, norcocaine, dihydrocodeine, diazepam, tramadol and traces of cocaethylene (. ng/mg, median concentration). Sample B contains traces of cocaine (.6 ng/mg, median concentration) and benzoylecgonine (.7 ng/mg, median concentration). Sample C contains CBD, CBN, norcocaine, cocaethylene, dihydrocodeine, diazepam and tramadol and traces of methadone

4 MAM conc. (ng/mg) MAM- Sample A Lab. MAM (ng/mg) Result Lab. MAM (ng/mg) Result 9,75 -,5 Questionable,,5 Satisfactory,9 -, Questionable,7, Satisfactory 5, -,9 Satisfactory 5,,7 Satisfactory Average,5 Satisfactory Satisfactory 9 6,6 -,5 6 5,5,7 SD, 6, -, Satisfactory 5,76,5 Satisfactory CV% 5, 5 7, -, Satisfactory 6,,5 Satisfactory Median,9 6 7, -, Satisfactory 5 6,,66 Satisfactory Minimum,75 9, -, Satisfactory 6,5,69 Satisfactory Quartile 5,7 6 9, -,7 Satisfactory 7 6,7,76 Satisfactory Quartile 75,95 9,9 -,67 Satisfactory 7,77,9 Satisfactory Maximum 9,7 7,5 -,55 Satisfactory 6,9,7 Satisfactory Iqr,6 5,7 -,5 Satisfactory 9,7, Satisfactory, -, Satisfactory >,5 -, Satisfactory > 5 5, -,9 Satisfactory P, -, Satisfactory,56 -, Satisfactory,97 -, Satisfactory,9 -, Satisfactory 7,, Satisfactory 6,6, Satisfactory,95,6 Satisfactory,,7 Satisfactory,,7 Satisfactory,, Satisfactory,, Satisfactory

5 5 Morphine- Sample A Morphine conc. (ng/mg) Lab. Morphine (ng/mg Result Lab. Morphine (ng/mg) Result,9 -,6 Satisfactory 7,,6 Satisfactory,9 -, Satisfactory,,96 Satisfactory 5, -,9 Satisfactory,5,5 Satisfactory Average,95 9,5 -,9 Satisfactory,79,67 Satisfactory SD, 5,6 -, Satisfactory,9,7 Satisfactory CV% 57, 6,6 -, Satisfactory 6,9,7 Satisfactory Median,7,7 -,79 Satisfactory 7 5,,79 Satisfactory Minimum,9 6, -,7 Satisfactory 9 5,6, Satisfactory Quartile 5,7,57 -, Satisfactory 5,5,9 Satisfactory Quartile 75,,6 -, Satisfactory 5 5,7, Satisfactory Maximum,,7 -, Satisfactory 6,5, Satisfactory Iqr,, -,7 Satisfactory 5 6,6,5 Satisfactory, -,7 Satisfactory 7,, Questionable 6,5 -, Satisfactory,,7 Unsatisfactory,9 -, Satisfactory P 7, -, Satisfactory 9, -, Satisfactory, -, Satisfactory,6 -, Satisfactory,7 Satisfactory,, Satisfactory,7,5 Satisfactory,5,6 Satisfactory,5, Satisfactory 5,59, Satisfactory 6,, Satisfactory

6 ,5 Codeine- Sample A Codeine conc. (ng/mg),5, Lab. Codeine (ng/mg Result Lab. Codeine (ng/mg) Result,6 -, Satisfactory,9, Satisfactory 5, -, Satisfactory 6,,9 Satisfactory, -, Satisfactory 7,5,6 Satisfactory Average, 9, -,7 Satisfactory 7,5,6 Satisfactory SD,5 6, -,9 Satisfactory,9,7 Satisfactory CV%,75 6, -,9 Satisfactory 6,,79 Satisfactory Median,79,9 -,7 Satisfactory,,79 Satisfactory Minimum,6 5,9 -,7 Satisfactory 9,, Satisfactory Quartile 5,6,5 -,6 Satisfactory 5,,9 Satisfactory Quartile 75, 9,6 -, Satisfactory,,7 Satisfactory Maximum,6 -, Satisfactory 5,,7 Satisfactory Iqr,,6 -,5 Satisfactory,, Questionable,65 -, Satisfactory,67 -, Satisfactory,6 -,6 Satisfactory,7 -, Satisfactory 7,7 -, Satisfactory,75 -, Satisfactory,7 -, Satisfactory 6,, Satisfactory,, Satisfactory 5,,7 Satisfactory,,7 Satisfactory,,7 Satisfactory,7,9 Satisfactory,9, Satisfactory

7 Cocaine conc. (ng/mg) 6 Cocaine- Sample A Lab. Cocaine (ng/mg Result Lab. Cocaine (ng/mg) Result,6 -, Questionable 7,5, Satisfactory,9 -,7 Satisfactory 6 7,5, Satisfactory 5, -,7 Satisfactory 7,6,5 Satisfactory Average 6, 9, -,6 Satisfactory 5 7,69,55 Satisfactory SD, 6, -,5 Satisfactory 7,7,56 Satisfactory CV%,6 5,6 -,6 Satisfactory 7,5,69 Satisfactory Median 6,,9 -,95 Satisfactory,, Satisfactory Minimum,6, -,7 Satisfactory 6,5,9 Satisfactory Quartile 5 5,, -,59 Satisfactory,75,97 Satisfactory Quartile 75 7,65 5,9 -,56 Satisfactory,,99 Satisfactory Maximum, 6 5,6 -,7 Satisfactory 9,77, Satisfactory Iqr,5 9 5, -,5 Satisfactory,,7 Satisfactory 9 5,5 -, Satisfactory,,55 Satisfactory 5,6 -,6 Satisfactory P 5 5,9 -, Satisfactory 6, -, Satisfactory 6 6, -, Satisfactory 6, -, Satisfactory 7 6, -, Satisfactory 6, Satisfactory 6,5,9 Satisfactory 6,7,6 Satisfactory 7,, Satisfactory 7,,6 Satisfactory 7 7,,6 Satisfactory 7,, Satisfactory

8 BE conc. (ng/mg) 6 6 BE- Sample A Lab. BE (ng/mg) Result Lab. BE (ng/mg) Result, -,7 Satisfactory,,5 Satisfactory 7,7 -,7 Satisfactory,,5 Satisfactory 5,5 -, Satisfactory,5,6 Satisfactory Average 7,9, -,7 Satisfactory,66,67 Satisfactory SD, 9, -, Satisfactory,9,7 Satisfactory CV%,5 5,6 -, Satisfactory,5,77 Satisfactory Median, 5, -,75 Satisfactory 7,, Satisfactory Minimum, 6 5, -,75 Satisfactory,9,99 Satisfactory Quartile 5 6, 6 5,67 -,6 Satisfactory,, Satisfactory Quartile 75, 6, -,5 Satisfactory 6,, Satisfactory Maximum 6, 6,6 -, Satisfactory 6,, Questionable Iqr,9 5 6,9 -,9 Satisfactory >5 6,9 -, Satisfactory P 6,95 -, Satisfactory 5 7, -,6 Satisfactory 9 7, -,5 Satisfactory 7, -, Satisfactory 7, -,9 Satisfactory 9, Satisfactory,,5 Satisfactory 6,,7 Satisfactory,, Satisfactory,7, Satisfactory 7,9, Satisfactory,95, Satisfactory 6 9,,7 Satisfactory

9 ,9 THC- Sample A 9, 6 THC conc. (ng/mg),7,6,5,,,, Lab. THC Result 5, -, Satisfactory, -,7 Satisfactory 9, -,6 Satisfactory Average, 7, -,6 Satisfactory SD, 6, -,56 Satisfactory CV% 9,7, -,5 Satisfactory Median,6 7, -, Satisfactory Minimum,,7 -,6 Satisfactory Quartile 5,,5 -, Satisfactory Quartile 75,,6 Satisfactory Maximum,9,69, Satisfactory Iqr,5,7, Satisfactory 5,7, Satisfactory,, Satisfactory 5,9,6 Satisfactory 5,, Satisfactory,, Satisfactory 9,9 7, Unsatisfactory P 6 P

10 6 MAM conc. (ng/mg) 5 MAM- Sample C Lab. MAM (ng/mg) Result Lab. MAM (ng/mg) Result 5, -, Satisfactory,7,9 Satisfactory,5 -,9 Satisfactory,,6 Satisfactory 9, -, Satisfactory 7,,6 Satisfactory Average,75 9,6 -,9 Satisfactory,9, Satisfactory SD, 9,6 -,9 Satisfactory,9, Satisfactory CV%, 6, -, Satisfactory 6,9,6 Satisfactory Median,5 5,5 -, Satisfactory 5,97,9 Satisfactory Minimum, 5, -,7 Satisfactory,99, Satisfactory Quartile 5,56 6,5 -,7 Satisfactory,5,5 Satisfactory Quartile 75,9,5 -,6 Satisfactory,69,9 Satisfactory Maximum 5,5,57 -,66 Satisfactory,9,9 Satisfactory Iqr,,5 -,65 Satisfactory 5,,6 Satisfactory,6 -,6 Satisfactory 5,,6 Satisfactory,7 -,5 Satisfactory 6 5,5,56 Satisfactory 5,9 -, Satisfactory P,9 -, Satisfactory, -,6 Satisfactory,6 -, Satisfactory, -,9 Satisfactory, -, Satisfactory 7,, Satisfactory,5, Satisfactory,5, Satisfactory 7,5,6 Satisfactory,57,9 Satisfactory 6,6, Satisfactory

11 ,5 Morphine- Sample C 5 5 Morphine conc. (ng/mg),5, Lab. Morphine (ng/mg) Result Lab. Morphine (ng/mg) Result, -,6 Satisfactory 6,, Satisfactory 5, -, Satisfactory 7,, Satisfactory 6, -, Satisfactory 9,, Satisfactory Average,95, -, Satisfactory 7,5, Satisfactory SD,5 9, -,6 Satisfactory,7,5 Satisfactory CV% 5,6,6 -,99 Satisfactory,,75 Satisfactory Median, 6,5 -,9 Satisfactory 5,9,96 Satisfactory Minimum,,5 -,9 Satisfactory,,99 Satisfactory Quartile 5,6,5 -, Satisfactory 6,7,5 Satisfactory Quartile 75,55 5,5 -, Satisfactory,5, Satisfactory Maximum,7,66 -,5 Satisfactory,9, Satisfactory Iqr,5 9,67 -,9 Satisfactory,67,6 Satisfactory,7 -, Satisfactory 5,5, Unsatisfactory,7 -, Satisfactory,7, Unsatisfactory,75 -, Satisfactory P,77 -,6 Satisfactory 5,7 -, Satisfactory, -, Satisfactory, Satisfactory 7, Satisfactory,9, Satisfactory 6,9,7 Satisfactory,9,9 Satisfactory,9, Satisfactory,99,6 Satisfactory,, Satisfactory

12 ,6,5 Codeine- Sample C 5 Codeine conc. (ng/mg),,,, Lab. Codeine (ng/mg) Result Lab. Codeine (ng/mg) Result, -,9 Satisfactory 7,6,7 Satisfactory, -,9 Satisfactory,7,56 Satisfactory, -, Satisfactory 6,9,7 Satisfactory Average, 9, -, Satisfactory,,9 Satisfactory SD,9 6, -, Satisfactory,,7 Satisfactory CV%, 9, -,7 Satisfactory,,7 Satisfactory Median,5 5, -,6 Satisfactory,,75 Satisfactory Minimum,, -,6 Satisfactory 5,56, Unsatisfactory Quartile 5,, -,56 Satisfactory 6 P Quartile 75,57, -,56 Satisfactory Maximum,56,5 -,7 Satisfactory Iqr,7, -, Satisfactory,9 -, Satisfactory 7,9 -, Satisfactory,9 -, Satisfactory, -, Satisfactory, -, Satisfactory,, Satisfactory 7,, Satisfactory 6,, Satisfactory,, Satisfactory,, Satisfactory,, Satisfactory 6,, Satisfactory,5, Satisfactory 9,6,7 Satisfactory

13 Cocaine conc. (ng/mg) Cocaine- Sample C Lab. Cocaine (ng/mg) Result Lab. Cocaine (ng/mg) Result 9, -, Satisfactory 6,5,6 Satisfactory 5, -,7 Satisfactory 7 6,5,6 Satisfactory, -,6 Satisfactory 6,6,6 Satisfactory Average 5,5 9,5 -,5 Satisfactory 6 6,7,6 Satisfactory SD,7 6,7 -,5 Satisfactory 9 6,,7 Satisfactory CV%,,7 -,9 Satisfactory 6,9,77 Satisfactory Median 5,, -,7 Satisfactory 5 6,96,7 Satisfactory Minimum,, -, Satisfactory 7,7,9 Satisfactory Quartile 5,55, -, Satisfactory 6,5,6 Satisfactory Quartile 75 6,65 6, -,6 Satisfactory,7, Satisfactory Maximum 9, 6, -, Satisfactory 9,5,6 Satisfactory Iqr,95, -, Satisfactory 9,,6 Satisfactory 5,6 -,6 Satisfactory 9,,6 Satisfactory,7 -, Satisfactory P,5 -, Satisfactory,5 -,7 Satisfactory,6 -,6 Satisfactory,6 -,5 Satisfactory,99 -, Satisfactory 5, Satisfactory 5 5,5,6 Satisfactory 7 5,6,6 Satisfactory 7 5,77, Satisfactory 5,9,6 Satisfactory 5 6,, Satisfactory 6,,5 Satisfactory

14 6 BE conc. (ng/mg) 6 BE- Sample C Lab. BE (ng/mg) Result Lab. BE (ng/mg) Result 5,69 -, Satisfactory 5,, Satisfactory 7, -,9 Satisfactory 7 9,6, Satisfactory,6 -,9 Satisfactory 5 9,5,5 Satisfactory Average 7,5 9,9 -, Satisfactory 9 9,76,57 Satisfactory SD, 9, -, Satisfactory,55,76 Satisfactory CV% 7,6 5, -,7 Satisfactory,5,9 Satisfactory Median 7,,5 -,69 Satisfactory,, Satisfactory Minimum,69,7 -,65 Satisfactory,, Satisfactory Quartile 5,9 6, -,6 Satisfactory,, Satisfactory Quartile 75 9,6,9 -,6 Satisfactory 6,, Satisfactory Maximum,7 5,7 -,9 Satisfactory,7,6 Satisfactory Iqr,6 6 6, -, Satisfactory >5 6,9 -, Satisfactory P 6, -,7 Satisfactory 6,6 -, Satisfactory 6,5 -, Satisfactory 7, -, Satisfactory 6 7, -, Satisfactory 7, Satisfactory 7,5, Satisfactory 7 7,9, Satisfactory 7,, Satisfactory 6 7,9, Satisfactory,, Satisfactory,, Satisfactory,, Satisfactory

15 Amphetamine conc. (ng/mg),5,,5,,5, Amphetamine- Sample C , Lab. Amphetamine (ng/mg) Result Lab. Amphetamine (ng/mg) Result 9,7 -, Satisfactory,5,5 Satisfactory,6 -, Satisfactory 5,,6 Satisfactory 6,9 -,75 Satisfactory 9, Questionable Average,6,95 -,69 Satisfactory SD,6, -,6 Satisfactory CV% 6,9, -,5 Satisfactory Median,5, -,5 Satisfactory Minimum,7, -,5 Satisfactory Quartile 5,, -,5 Satisfactory Quartile 75,9 7, -,5 Satisfactory Maximum,, -,5 Satisfactory Iqr,, -,5 Satisfactory 7, -,5 Satisfactory,5 Satisfactory The median Amphetamine concentration is below the,5 Satisfactory cut-off proposed by SoHT,6, Satisfactory (. ng/mg),6, Satisfactory 6,7,5 Satisfactory,7,5 Satisfactory 6,5,75 Satisfactory 5,9,5 Satisfactory,9,5 Satisfactory,9,5 Satisfactory,,6 Satisfactory,,7 Satisfactory 6,, Satisfactory

16 Methamphetamine conc. (ng/mg),5,5,,5,,5,,5,,5 Methamphetamine- Sample A Lab. Methamphet. (ng/mg) Result 9,5 -, Satisfactory,56 -,9 Satisfactory,6 -, Satisfactory Average, 9,7 -,67 Satisfactory SD,7 6,7 -,6 Satisfactory CV% 56,, -,5 Satisfactory Median,, -,5 Satisfactory Minimum,5 6, -,7 Satisfactory Quartile 5,9 7, -,7 Satisfactory Quartile 75,5, Satisfactory Maximum,, Satisfactory Iqr,6, Satisfactory, Satisfactory, Satisfactory The median Methamphetamine,,7 Satisfactory concentration is below the,,7 Satisfactory cut-off proposed by SoHT 5,, Satisfactory (. ng/mg),, Satisfactory 7,,5 Satisfactory,5,67 Satisfactory,5,67 Satisfactory 6,7 Satisfactory,,7 Satisfactory,9, Satisfactory 6,9, Satisfactory 5, 5, Unsatisfactory

17 ,5, MDMA- Sample C 5 MDMA conc. (ng/mg),5,, Lab. MDMA (ng/mg) Result Lab. MDMA (ng/mg) Result 6,6 -,7 Satisfactory 5,, Unsatisfactory,6 -,9 Satisfactory,7 -, Satisfactory Average,,7 -, Satisfactory SD,, -, Satisfactory CV%,97 9, -, Satisfactory Median,, -, Satisfactory Minimum,6, -,6 Satisfactory Quartile 5,,9 -,56 Satisfactory Quartile 75,,9 -,56 Satisfactory Maximum, 7,9 -,56 Satisfactory Iqr,6,9 -, Satisfactory,9 -, Satisfactory 6, Satisfactory The median MDMA concentration is below the, Satisfactory cut-off proposed by SoHT, Satisfactory (. ng/mg), Satisfactory 7, Satisfactory,, Satisfactory,, Satisfactory,, Satisfactory 9,,56 Satisfactory 6,,56 Satisfactory,5, Satisfactory 6,59,6 Satisfactory 5,6,9 Satisfactory

18 , 5,5 THC- Sample C 5, THC conc. (ng/mg),5,,5,, Lab. THC (ng/mg) Result 5, -,67 Satisfactory,6 -,7 Satisfactory 7,7 -, Satisfactory Average,,76 -,9 Satisfactory SD,7 6,77 -, Satisfactory CV% 5,5 9, -, Satisfactory Median,,9 -,6 Satisfactory Minimum,, -,5 Satisfactory Quartile 5,9, -,5 Satisfactory Quartile 75,5, -, Satisfactory Maximum, 6, -,7 Satisfactory Iqr,6, -,7 Satisfactory 7, Satisfactory, Satisfactory,,7 Satisfactory 5,,7 Satisfactory,,7 Satisfactory,5, Satisfactory 6,5, Satisfactory,56, Satisfactory,, Satisfactory 9,,7 Satisfactory,,5 Satisfactory 7,,5 Satisfactory 5,, Satisfactory 5,,7 Unsatisfactory