Detection of Drugs-of-Abuse by Tandem Mass Spectrometry.
|
|
- Meghan O’Brien’
- 5 years ago
- Views:
Transcription
1 Detection of Drugs-of-Abuse by Tandem Mass Spectrometry. Dr Tim Laurens MSc.Chem(Pretoria), Ph.D. Chem (Pretoria), MSc.Toxicology (Surrey,UK) FRSChem, MFSSoc / Mobile:
2 Introduction What are drugs of Abuse?. Any substance that due to desirable effect is misused for purposes other than intended Effect on CNS Any substance of which the possession or supply of which is restricted by law due to potential harmful effects on the user Schedules of the Medicines and Related Substances Control Act, Act 101 of 1965 Drugs and Drug Trafficking Act, Act 140 of 1992
3 CNS Depressants Benzodiazepines piods Flunitrazepam, Diazepam Codeine, Heroine, methadone, morphine, pethidine etc Marijuana Various forms of Cannabis sativa containing tetrahydrocannabinol (THC) Barbiturates Alcohol Phenobarbital, secobarbital Alcoholic Beverages
4 Amphetamines Cocaine ther stimulants Inhalants Halocinogens PCP Anabolic steroids CNS Stimulants Speed methamphetamine Ecstacy (methylenedioxymethamphetamine) Free base crack and hydrochloride Ephidrine, Pseudoephidrine, ther substances Petrol, solvents, propane (LPG), LSD, Ecstacy, mescaline, psilocybin, scopolamine Phencyclidine Testosterone, stanozol
5 range Juice HUBLY-BUBLY
6 Routes of Administration ral intake - Amphetamines, EXTACY, Barbitirates, tricyclic antidepressants Inhalation - Cannabis, Methaqualone, Metcathinone, Methamphetamine, Cocaine Intravenous -Heroin, piates ral intake First pass metabolism Liver Inhalation / Intravenous directly in the bloodstream
7 Pharmacology Absorbtion Distrubution Metabolism (Liver, Lungs) Excretion A.D.M.E. Metabolism takes place to increase water solubility of a compound in the body to enhance urinary excretion
8 Drug Half Life Half-Life Concentration (mg/l) Time (days)
9 The Cell
10 Microsomes and Lysosomes
11 Metabolism Cannabis CH 3 H C H 3 C H 3 CH 3 Delta-9-Tetrahydrocannabinol (THC) CH 2 H CH H H C H 3 C H 3 CH 3 C H 3 C H 3 CH 3 11-Hydroxy-delta-9-THC 11-nor-9-Carboxy-delta-9-THC Conjugation
12 Metabolism- piates NCH 3 CH 3 C CCH 3 Heroin NCH 3 NCH 3 NCH 3 H CCH 3 H H CH 3 H 6-Acetylmorphine Morphine Codeine Conjugation
13 Metabolism Cocaine Me Me CH 3 N CH 3 N H Cocaine Ecgonine Methyl Ester CH 3 N H CH 3 N H H Benzoylecgonine Ecgonine
14 Metabolism Amphetamines H N H H N H N Methcathinone Ephedrine Methamphetamine H NH 2 NH 2 NH 2 Cathinone Norephedrine Amphetamine H p-hydrolation and Conjugation Benzoic acid Glucuronide and Glycine conjugation H N H N H N MDMA MDEA MBDB CH 3 H N NH 2 NH 2 H HMMA MDA BDB Conjugation
15 Choice of Bio sample Matrix Blood (Plasma, Serum) Mandatory in cases of driving under the influence. Hair Sweat Saliva Nails Urine: Still the sample of choice since the concentration levels are relatively high and samples can be taken non-invasively
16 Relative Abundance in Biological Matrices Relative abundance of Cannabinoids in biological matrices [Staub et al J Chromatog B 733(1999)119] % THC THC-CH THC-H CBD CBN Blood Saliva Sweat Hair
17 Drugs of Abuse in Saliva Concentrations of Drugs of Abuse in Saliva Schramm et al, Journal of Analytical Toxicology, 16(1992)1 Drug Class Analyte ng/ml Time of detection Cannabinoids Delta 9 - THC hours Cocaine Cocaine h 10 days piods Morphine 0.6 3h 24 h Codeine h - 36 h Barbiturates Amobarbital Hexobarbital h Methaqualone Methaqualone h 3 days Diazepines Diazepam h 50 h Amphetamine Amphetamine h
18 Reported time during which drugs of abuse can be measured in URINE Drug Comment Approximate time of detection Cannabinoids Moderate smoker 10 days Chronic use 30 days Cocaine Benzoyecgonine metabolite 1 4 days Phencyclidine Moderate use 8 days Chronic use 8 30 days piates: Codeine, Heroin, Morphine, pium Poppy, xycodone, xymorphone, Barbiturates: Amobarbital, Butabarbital, Butalbital, Pentobarbital, Phenobarbital, Secobarbital Short acting Long acting 2 days 1 day 2-3 weeks Benzodiazepines Therapeutic dose 2 weeks Amphetamines, Metamphetamines, Methylenedioxyamphetamines(MDA, MDMA, MDEA), Pseudoephidrine and Ephidrine 2-4 days
19 Hair Drug incorporation in hair depends on: Lipophilicity of drug Melanine affinity Membrane permeability Subjected to environmental contamination Establish use weeks to months before collection Pre employment investigations
20 Sampling procedure Steps to ensure that the specimen is freshly voided. Steps to protect against tampering and adulteration. Identification of the individual giving the specimen. Evidence of the written informed consent of the individual to the analysis of the specimen Disclosure of recent medication, or evidence that the individual was advised of the significance of recent medication
21 Example of a Donor s Statement of Informed Consent I confirm that I have provided a freshly voided urine specimen to the specimen collector. I have observed the specimen being placed and sealed in the specimen bottles and confirm that the information on this form and on the specimen labels is correct. I hereby give permission for a minimum of two sealed specimen containers to be sent to the laboratory and I consent that they be tested for evidence of drug use and for tests to be carried out to confirm the validity of the sample. I understand that the results will be communicated confidentially to the employer or a designated representative. I consent to the above. Donor s Name (Block Capitals) Donor s Signature: Date: Donor s identifier on the specimen labels (if different from above)
22 Transport to Laboratory 1. Chain of custody 2. The minimum information required on the Chain of Custody Form is: a) Information identifying the donor. b) Date and time of collection. c) Name of testing laboratory. d) Names and signatures of all individuals who had custody of the sample during the collection process. 3. Document proceedings as close as possible, try to have a witness with you all the time.
23 Flaws in the Chain of Custody 1. Barcode mismatch or absent 2. No documentation received with the sample 3. No written consent to test from the donor 4. Seals broken or tampered with on any bottle 5. No seals 6. nly 1 sample received 7. Insufficient sample for complete analysis 8. Leaking sample
24 Laboratory Analysis Test for adulteration To check that the sample submitted for testing is in fact urine. ph (Normal 4-9) Creatinine (5-20 mg/dl) utside this range Specific Gravity must be determined. Sample not suitable for analysis due to an unidentified interferant or poor sample quality such as turbidity.
25 Testing Philosophy Screening test first (Toxicology Lab/ Industrial Lab) then confirmation at specialized lab competent to give evidence in a court of law
26 Analytical Techniques Screening Immuno assays, RIA, Enzyme-based assays, LC-DAD, GC Selective detection Tandem Mass spectrometry does show some potential 200 drugs simultaneously NB!!! Quantitatively With direct infusion and no chromatographic separation Confirmation by GC-MS
27 peration of a tandem MS
28
29 Compounds included in LC MS/MS drug screen
30 Examples Ritalin Pseudo and nor-pseudo ephedrine
31 Conclusions Tandem Mass Spectroscopy (MS/MS) provides a fast cost effective selective and sensitive method to reliably analyse a large number of drugs simultaneously.
Effective Date: Approved by: Laboratory Executive Director, Ed Hughes (electronic signature)
1 Policy #: 803 (PLH-803-02) Effective Date: NA Reviewed Date: 4/11/2008 Subject: URINE DRUG SCREENS Approved by: Laboratory Executive Director, Ed Hughes (electronic signature) Approved by: Laboratory
More informationUrine drug testing it s not always crystal clear
Urine drug testing it s not always crystal clear Kirk Moberg, MD, PhD, FASAM Executive Medical Director, UnityPoint Health Illinois Institute for Addiction Recovery Clinical Professor of Internal Medicine
More informationTest Definition: PDSOX Pain Clinic Drug Screen, Chain of Custody, Urine
Reporting Title: Pain Clinic Drug Screen, CoC, U Performing Location: Rochester Specimen Requirements: Container/Tube: Chain-of-Custody Kit (Supply T282) containing the specimen containers, seals, and
More informationTest Definition: PCDSO Pain Clinic Drug Screen, Urine
Reporting Title: Pain Clinic Drug Screen, U Performing Location: Rochester Specimen Requirements: Collection Container/Tube: Plastic urine container Submission Container/Tube: Plastic, 60-mL urine bottle
More informationThe Drug Testing Process. Employer or Practice
Disclosures Clinical Professor, Jefferson Medical College BOD MROCC [Medical Review Officer Certification Council] BOD National Sleep Foundation BOD POEMS [Pennsylvania Occupational & Environmental Medicine
More informationEDUCATIONAL COMMENTARY rd TEST EVENT Chemistry Urine Drug Testing
EDUCATIONAL COMMENTARY 2003 3 rd TEST EVENT Chemistry Urine Drug Testing Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE
More informationDrug Testing Basics. by Erowid
Drug Testing Basics by Erowid INDEX 1. What do they Test for? 2. Test Types 3. Test Sensitivity 4. Detection Periods WHAT DO THEY TEST FOR? The first thing to know about drug testing is what the standard
More information1/27/ New Release, Quest Diagnostics Nichols Institute, Valencia
NEW TESTS Please Note: Not all test codes assigned to each assay are listed in the table of contents. Please refer to the complete listing on the page numbers indicated. Test Code Test Name Effective Date
More informationFastect II Drug Screen Dipstick Test Training and Certification Program
Fastect II Drug Screen Dipstick Test Training and Certification Program Fastect II Training Page 1 of 7 Rev. B Fastect II Drug Screen Dipstick Test Training and Certification for Test Administrators The
More informationSeptember HCMC Toxicology Transition: Additional information and Frequently Asked Questions
September 2016 HCMC Toxicology Transition: Additional information and Frequently Asked Questions Many clinicians have asked for more information about the Urine Drug Compliance Analysis (LAB8742) switch
More informationLaboratory Service Report
4 05/25/19 Client C702884-DLP ROCHESTER Amphetamines, Confirmation Positive Confirmed POSITIVE by LC-S/S for the following: Amphetamine = 52 ethamphetamine = 124 ethamphetamine exists in the d- and l-isomeric
More informationFrequently Asked Questions: Opiate Dependency and Methadone Maintenance Treatment program follow-up
Frequently Asked Questions: Opiate Dependency and Methadone Maintenance Treatment program follow-up Dr. Bhushan M. Kapur Associate Professor Department of Laboratory Medicine and Pathobiology, Faculty
More informationContract No. 952-M1 Collection Service Requirements Texas Department of Criminal Justice (TDCJ)
The services and requirements referenced are specific to Texas Department of Criminal Justice (TDCJ) and are in addition to and may include the services and must be in compliance with the requirements
More informationLearning Objectives. Drug Testing 10/17/2012. Utilization of the urine drug screen: The good, the bad, and the ugly
Utilization of the urine drug screen: The good, the bad, and the ugly Jennifer A. Lowry, MD Chief, Section of Medical Toxicology Children s Mercy Hospital Kansas City, MO Learning Objectives Describe the
More informationRapid Alcohol Screening Devices. p19
CLIA-WAIVED Product Catalog RAPID DRUG SCREENING DEVICES Rapid Urine Drug Screening Devices. p5 Rapid Alcohol Screening Devices. p19 Complementary Products. p23 HELPING YOU MAKE INFORMED DECISIONS ABOUT
More informationQuickTox Drug Screen Dipcard (with and without Adulteration Tests)
QuickTox Drug Screen Dipcard (with and without Adulteration Tests) Training and Certification Program Presented by CLIAwaived.com, San Diego, CA Distributed by CLIAwaived.com www.cliawaived.com 1-858-481-5031
More informationCase Plan Drug Testing: Myths, Best Practices, and Strategies
Case Plan Drug Testing: Myths, Best Practices, and Strategies Children s Law Institute, Albuquerque, New Mexico January 13, 2017 Presenters Jennifer Olson, Attorney, Respondents Contract Counsel, Solo
More informationWhat Your Drug Test Really Means. Krista Beiermann, RN, OHS Occupational Health Services, Columbus Hospital
What Your Drug Test Really Means Krista Beiermann, RN, OHS Occupational Health Services, Columbus Hospital Disclosure There are no relevant financial relationships with commercial interests associated.
More informationSubstance Abuse Testing Electronic Result Reporting Layout Specifications. Version 3.2 January 2004
Substance Abuse Testing Electronic Result Reporting Layout Specifications Version 3.2 January 2004 Copyright Notice This publication is produced and distributed by LabOne, Inc. to specify the content and
More informationQuickTox Drug Screen Dipcard (with and without Adulteration Tests)
QuickTox Drug Screen Dipcard (with and without Adulteration Tests) Training and Certification Program Presented by Branan Medical Corporation Branan Medical Corporation 10015 Muirlands Road Irvine, California
More informationUrine Drug Testing Methods 3-5
Urine Drug Testing Methods 3-5 Type of Test Logistics Pearls Initial Screening Test: Immunoassay Confirmatory Test: Gas chromatography-mass spectrometry (GCMS) + or Liquid chromatography-mass spectrometry
More informationControlled Substance Monitoring in the Age of the Opioid Epidemic
Controlled Substance Monitoring in the Age of the Opioid Epidemic Paul E. Hilliard, MS, MD Hospital Pain Committee Chair Department of Anesthesiology CME housekeeping I have no financial disclosures AKA,
More informationLABORATORY TECHNICAL SPECIFICATIONS MANUAL
LABORATORY TECHNICAL SPECIFICATIONS MANUAL Produced by Synergy Health Laboratory Services Controlled Document ID 103.00250 January 2015 - Version 9 Purpose of Procedure This document outlines the technical
More informationLABORATORY TECHNICAL SPECIFICATIONS MANUAL
LABORATORY TECHNICAL SPECIFICATIONS MANUAL Produced by Synergy Health Laboratory Services Controlled Document ID 103.00250 August 2015 - Version 12 Purpose of Procedure This document outlines the technical
More informationNeoSal Oral Fluid Collection System Solutions for Forensic Drug Detection
PERFORMANCE OF THE NEOSAL ORAL FLUID COLLECTION SYSTEM Neogen develops and manufactures a comprehensive range of ELISA test kits and accessories for forensic drug detection. Neogen offers solutions to
More informationSECTION 1 LEARNING OBJECTIVES:
CHAPTER 5 DRUGS SECTION 1 LEARNING OBJECTIVES: 1. Define psychological and physical dependence. 2. Name and classify the commonly abused drugs. 3. Describe the tendency to develop psychological and physical
More informationYou Can t Fool the Bladder Police. Effective Use of Urine Drug Screening
You Can t Fool the Bladder Police Effective Use of Urine Drug Screening Why Test? Accountability Create and maintain safe treatment environment Compliance with licensing or policy Collection Supervised
More informationDrugSmartCup & DrugSmartDip Accuracy Report as produced by Ameditech, Inc.
Accuracy The accuracy of the DrugSmart Drugs of Abuse Tests was evaluated in comparison to commercially available drug screen tests. Sixty (60) negative urine samples collected from presumed non-user volunteers
More informationQuest Diagnostics Drug Testing Index Full Year 2015 Tables
Quest Diagnostics Drug Testing Index Full Year 2015 Tables Table 1. Annual Positivity Rates Urine Drug Tests (For Combined U.S. Workforce) (More than 9.5 million tests from January to December 2015) Year
More informationLaboratory Testing to Support Pain Management: Methods, Concepts and Case Studies
Laboratory Testing to Support Pain Management: Methods, Concepts and Case Studies Frederick G. Strathmann, PhD, DABCC, (CC,TC) Medical Director, Toxicology Associate Scientific Director of MS ARUP Laboratories
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
Schedule of ccreditation United Kingdom ccreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK ccredited to Laboratory locations: Gavenny Court Brecon Road bergavenny Monmouthshire
More informationUrine Drug Screening: The Essentials of Interpretation
Urine Drug Screening: The Essentials of Interpretation Loralie J Langman, PhD DABCC (CC, MD, TC), F-ABFT Director Clinical and Forensic Toxicology Laboratory, Mayo Clinic Professor, Mayo Clinic College
More informationT R A I N I N G G U I D E
TRAINING GUIDE InstaCube Oral Fluid Drug Test For Forensic Use Only Powered By: Contents 3 The information in this presentation is a general overview on performing and interpreting the InstaCube Oral Fluid
More information2013 Clinical drug and alcohol testing solutions. Product Catalog. CLIA-waived point of care test devices
2013 Clinical drug and alcohol testing solutions Product Catalog CLIA-waived point of care test devices HELPING YOU MAKE INFORMED DECISIONS ABOUT ABUSE. Substance abuse testing with more substance. 2 of
More informationCDIA TM Marijuana Colloidal Gold Test Cassette (Saliva)
CDIA TM Marijuana Colloidal Gold Test Cassette (Saliva) Cat. No.: DTSJZ023 Pkg. Size: Intended Use The CDIA TM Marijuana Colloidal Gold Test Cassette (Saliva) is an immunochromatography based one step
More informationNARCOTIC NOTES FLIPBOOK BY: PER:
NARCOTIC NOTES FLIPBOOK BY: PER: 1 https://www.youtube. com/watch?v=lolb21bii-a 2 Laws, Collection, & Preservation Narcotic Drugs = natural or synthetic substance that produces bodily (physiological) or
More informationToxCup Drug Screen Cup (with and without Adulteration Tests) Training and Certification Program
ToxCup Drug Screen Cup (with and without Adulteration Tests) Training and Certification Program ToxCup Training Page 1 of 8 Rev. B ToxCup Drug Screen Cup ToxCup Drug Screen Cup with Adulteration Tests
More informationDrug & Alcohol Testing
Drug & Alcohol Testing Health & Wellbeing in your workplace 1300 453 688 ClinicalLabs.com.au Drug & Alcohol Testing Drug and alcohol misuse is estimated to cost Australian businesses billions of dollars
More informationToxCup Drug Screen Cup (with and without Adulteration Tests) Training and Certification Program
ToxCup Drug Screen Cup (with and without Adulteration Tests) Training and Certification Program ToxCup Training Page 1 of 8 Rev. B ToxCup Drug Screen Cup ToxCup Drug Screen Cup with Adulteration Tests
More informationAlcohol. Ethanol Highlands Parkway, Suite 100 Smyrna, GA 30082
Alcohol The alcohol of interest is ethanol. Ethanol has a sedative effect in the brain. Ethanol intoxication symptoms include blurred vision, slurred speech, poor coordination and difficulty thinking depending
More informationDrug Testing: How to Evaluate Results
Drug Testing: How to Evaluate Results Prepared for you by the West Virginia Drug Testing Laboratory Drug testing, whether for an individual or a large corporation, consists of two necessary steps - specimen
More informationDrugConfirm Advanced Urine Dip Cards.
DrugConfirm Advanced Urine Dip Cards The information in this presentation is a general overview on using the Confirm BioSciences DrugConfirm Advanced drug test cup but can be applied to many similarly
More informationUsing Liquid Chromatography Tandem Mass Spectrometry Urine Drug Testing to Identify Licit and Illicit Drug-Use in a Community-based Patient Population
Using Liquid Chromatography Tandem Mass Spectrometry Urine Drug Testing to Identify Licit and Illicit Drug-Use in a Community-based Patient Population Adam S. Ptolemy 1, Colleen Murray 2, Edward Dunn 3,
More informationPayment Policy: Urine Specimen Validity Testing Reference Number: CC.PP.056 Product Types: ALL Effective Date: 11/01/2017 Last Review Date:
Payment Policy: Reference Number: CC.PP.056 Product Types: ALL Effective Date: 11/01/2017 Last Review Date: Coding Implications Revision Log See Important Reminder at the end of this policy for important
More informationControlled Substances. Forensic Science
Controlled Substances Forensic Science Copyright and Terms of Service Copyright Texas Education Agency, 2011. These materials are copyrighted and trademarked as the property of the Texas Education Agency
More informationDrugs of Abuse I Serum
Drugs of Abuse I Serum 2017-11 1.10 For quality monitoring of quantitative measurements by chromatographic methods These reference materials are produced on the basis of human matrices. The highly accurate
More informationLABORATORY TECHNICAL SPECIFICATIONS MANUAL
LABORATORY TECHNICAL SPECIFICATIONS MANUAL Produced by Controlled Document ID 103.0025 November 2017 Version 17 Ltd Gavenny Court, Brecon Road, Abergavenny, Monmouthshire NP7 7RX, United Kingdom Limited
More informationPOINT OF CARE TESTING
POINT OF CARE TESTING POINT OF CARE INSTANT TESTING Randox Testing Services offers a wide range of products to enable you to carry out on-site drug and alcohol testing for instant results. Our products
More informationInterpretation of Workplace Tests for Cannabinoids
J. Med. Toxicol. (2017) 13:106 110 DOI 10.1007/s13181-016-0587-z PROCEEDINGS Interpretation of Workplace Tests for Cannabinoids Ken Kulig 1 Received: 17 May 2016 /Revised: 16 August 2016 /Accepted: 6 September
More informationCozart DDS Drug Detection System On-site Saliva Drug Testing
Cozart DDS Drug Detection System On-site Saliva Drug Testing www.siemens.com Siemens Healthcare Diagnostics Drug Testing, under the Cozart brand name, has more than a 10-year legacy of providing an extensive
More informationThe Drug Evaluation and Classification Program
The Drug Evaluation and Classification Program International Association of Chiefs of Police Drug Evaluation and Classification (DEC) Program The Drug Evaluation and Classification (DEC) Program is a transportation
More informationClearing Up The Confusion About Substance Abuse Testing
Clearing Up The Confusion About Substance Abuse Testing 2018 Indiana Safety and Health Conference and Expo Presented by Tiffany Ellefson, DISA/Midwest Toxicology Services Items to cover Latest Trends in
More informationMulti-Drug Screen Test
Multi-Drug Screen Test Package Insert for OTC/CLIA-Waived- and Professional Use For in vitro diagnostic use only The Multi-Drug Screen Test offers a variety of solutions for fast and reliable drug testing
More informationUrine Drug Testing to Monitor Opioid Use In Managing Chronic Pain
Faculty Disclosure Henry C. Nipper, PhD, DABCC Dr. Nipper has listed no financial interest/arrangement that would be considered a conflict of interest. Urine Drug Testing to Monitor Opioid Use In Managing
More informationLC Application Note. Dangerous driver?
LC Application Note Dangerous driver? www.palsystem.com Dangerous driver? Robert M. Sears 1 ; Kenneth C. Lewis 2 ; and Kim Gamble 3 1 SC Law Enforcement Division, Columbia, SC 29221; 2 OpAns LLC, Durham
More informationPatient-Centered Urine Drug Testing. Douglas Gourlay, MD, MSc, FRCPC, FASAM
Patient-Centered Urine Drug Testing Douglas Gourlay, MD, MSc, FRCPC, FASAM Declaration of Potential Conflict of Interest The content of this presentation is non- commercial and does not represent any conflict
More informationConflict of Interest Disclosure
Patient Rx Drug Misuse and Abuse: Compliance Toxicology Monitoring in Clinical Practice Toxicology Staff Andrea Terrell, Ph.D., DABCC Chief Scientific Officer George Behonick, Ph.D., DABFT, Manager, FBU
More informationTest Name Results Units Bio. Ref. Interval
135091312 Age 30 Years Gender Male 15/9/2017 122400M 15/9/2017 11729M 19/9/2017 40644M Ref By Final Test Results Units Bio. Ref. Interval DRUGS OF ABUSE, URINE AMHETAMINE SCREEN, URINE results indicate
More informationMEDICAL POLICY Drug Testing
POLICY: PG0069 ORIGINAL EFFECTIVE: 01/01/11 LAST REVIEW: 11/13/18 MEDICAL POLICY Drug Testing GUIDELINES This policy does not certify benefits or authorization of benefits, which is designated by each
More informationPolicy Writing and Advice 2 Manager Training 2 Employee Awareness 3 Rehabilitation 3
The way forward To implement a successful programme a full complement of services are required. Knowledge and understanding are key requirements. Employers have 'a duty of care' to equip their staff with
More informationORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS
ORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS Barry K Logan PhD, DABFT National Director of Forensic Services, NMS Labs Willow Grove PA Disclaimer
More information2. DEFINITIONS. For the purposes of this policy the following terms are defined herein:
SECTION IV: ALCOHOL AND DRUG FREE WORKPLACE 1. GENERAL POLICY. The purpose of this policy is to implement the Federal Drug Free Workplace Act of 1988 by providing for a safe and productive work environment
More informationToxicological Investigation of Drug Impaired Driving Toxicology Laboratory Survey
Toxicological Investigation of Drug Impaired Driving Toxicology Laboratory Survey Kayla J. Lowrie, MS, Jennifer Turri, BS, Jill Yeakel, MSFS, Barry K. Logan, PhD, DABFT, Arcadia University, 450 S. Easton
More informationHallucinogens Marijuana
Introduction A drug is defined as a natural or synthetic substance that is used to produce physiological or psychological effects in humans or other higher order animals. Narcotic drugs are analgesics,
More informationYour Results are Our Priority.
Your Results are Our Priority. Enzyme Linked Immunosorbent Assay (ELISA) One year shelf life Ready to use, color coded reagents and bottles Single dilution factor Adaptable for all forensic matrices Forensic
More informationDrugConfirm Advanced Instant Urine Drug Test Cups Training Guide.
DrugConfirm Advanced Instant Urine Drug Test Cups Training Guide The information in this presentation is a general overview on using Confirm BioSciences DrugConfirm Advanced urine drug test cup; however,
More informationBeating Drug Tests and Defending Positive Results
Beating Drug Tests and Defending Positive Results Amitava Dasgupta Beating Drug Tests and Defending Positive Results A Toxicologist s Perspective Amitava Dasgupta Department of Pathology and Laboratory
More informationDriving Under The Influence Of Drugs In Ireland: A Growing And Significant Danger
Driving Under The Influence Of Drugs In Ireland: A Growing And Significant Danger D.A.Cusack, G.Harrington, P.Furney, K.Flynn and C.P.Leavy Medical Bureau of Road Safety, Department of Forensic Medicine,
More informationSchedule of Accreditation
Schedule of Accreditation Organisation Name Trading As INAB Reg No Contact Name Address Medical Bureau Of Road Safety 30T Helen Kearns Contact Phone No 01-7165555 Email Website Accreditation Standard Health
More informationEuropean Guidelines for Workplace Drug Testing in UrineandOral fluid
EWDTS European Workplace Drug Testing Society European Guidelines for Workplace Drug Testing in UrineandOral fluid 9th EWDTS Symposium in Lisbon Sanna Taskinen Michaela Neuhofer Updating project # 2 Current
More informationControlled Substances: Drugs. Chapter 5
Controlled Substances: Drugs Chapter 5 1 Introduction 2 You hear about drugs on TV and in the movies, on the radio, in books and magazines, on the Internet, and in daily conversation with friends and peers.
More informationDRUGS OF ABUSE TEST CUPS 14-DRUG PANEL WITH ADULTERANTS Step by Step Instructions
DRUGS OF ABUSE TEST CUPS 14-DRUG PANEL WITH ADULTERANTS Step by Step Instructions For in vitro diagnostic use The McKesson Consult Drugs of Abuse Test Cup is a screening test for the rapid qualitative
More information«Tit» «Name» «Fam_Nam» «Organization» «Address1» «Address_2» «PO_Box» «City». «Country» Sevilla, February, 2016
«Tit» «Name» «Fam_Nam» «Organization» «Address» «Address_» «PO_Box» «City». «Country» Proficiency Test 5- Laboratory Code: «Lab_code» Sevilla, February, 6 Dear participants, Enclosed you will find the
More informationORAL FLUID DRUG TESTING
detection technologies for the new millennium ORAL FLUID DRUG TESTING Dean F. Fritch, Ph.D., DABFT, DABCC-TC Manager of Technical & Analytical Services TESTING FOR DRUGS OF ABUSE Tests for imairment/drug-induced
More informationEuropean Guidelines for Workplace Drug Testing in Blood and Blood Spots
EWDTS European Workplace Drug Testing Society European Guidelines for Workplace Drug Testing in Blood and Blood Spots 9th EWDTS Symposium in Lisbon Wim Schielen 29-5-2015, Lisbon Updating project # 2 Current
More informationDrug Profiles of Apprehended Drivers in Victoria
Drug Profiles of Apprehended Drivers in Victoria J Gerostamoulos, P McCaffrey, O H. Drummer and M Odell*. Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, 57-83
More informationDrug and Alcohol Testing
Drug and Alcohol Testing A comprehensive approach Safeguard your staff, business and customers from irresponsible use of alcohol and illicit drugs. Alcohol and drugs misuse in the workplace is a growing
More informationProof of Concept for Automated SPE/HPLC/MS/MS Methods to Replace Traditional Immunoassay with MS Confirmation of Driving Under the Influence Samples
Proof of Concept for Automated SPE/HPLC/MS/MS Methods to Replace Traditional Immunoassay with MS Confirmation of Driving Under the Influence Samples Robert M. Sears, Toxicology Technical Leader 1, Kenneth
More informationA substance that reduces pain and may or may not have psychoactive properties.
GLOSSARY OF TERMS AMPHETAMINE-TYPE STIMULANTS (ATS) A group of substances, mostly synthetic, with closely related chemical structure which have, to varying degrees, a stimulating effect on the central
More informationUrine Opioid Dependency Panel (UODP) 1
Drug Testing Panels Urine Opioid Dependency Panel (UODP) 1 Amphetamines Amphetamine Methamphetamine Methylenedioxyamphetamine Adderall, Dexedrine, Vyvanse, Lisdexamfetamine (Speed, Bennies, Crystal Meth,
More informationTypes of Drugs by Physical Effect- Narcotics
Illegal Drugs Types of Drugs by Physical Effect- Narcotics Narcotics depress the CNS, releive pain, produce sleep Morphine, heroin, and codeine. Morphine comes from the poppy plant Heroin is acetylated
More information3/8/2018. Reasons for Doing UDT. UDT: A Tool in Risk Assessment. Faculty/Presenter Disclosure. Urine Drug Testing in Chronic Pain Management
Urine Drug Testing in Chronic Pain Management March 8, 2018 Faculty/Presenter Disclosure Faculty: Andrew J Smith, MDCM Relationships with commercial interests: None to report Andrew J Smith, MDCM Staff
More informationToxCup Drug Screen Cup Step-by Step Instructions
ToxCup Drug Screen Cup Step-by Step Instructions This is a preliminary screening test that detects drug-of-abuse in urine at specified detection levels. To confirm preliminary positive results, a more
More informationCutoff levels for hydrocodone in a blood test
Cutoff levels for hydrocodone in a blood test The premier DNA and drug testing company in the North Texas area. Specializing in legal cases but also provide testing for employers and private individuals.
More informationBENZODIAZEPINES / BZO
DrugCheck Waive TM (FP) Multiple Drug Screen Cup Package Insert for testing any combination of the following drugs: AMP/BAR/BZO/COC/THC/MTD/MET/MDMA/OPI300/OPI/OXY/PCP/PPX/TCA Including Specimen Validity
More informationORAL FLUID DRUG TESTING Dean F. Fritch, Ph.D., DABFT, DABCC-TC Manager of Technical & Analytical Services
detection technologies for the new millennium ORAL FLUID DRUG TESTING Dean F. Fritch, Ph.D., DABFT, DABCC-TC Manager of Technical & Analytical Services TESTING FOR DRUGS OF ABUSE Tests for imairment/drug-induced
More informationTesting for Controlled Substances
Testing for illicit drugs Testing for Controlled Substances 1 Purposes: Employment Sports Screening medical eval. Legal Monitoring Treatment Probation Prescribing controlled substances Forensics 2 Drug
More informationProduct Catalog. May We are Toxicology. Tel Toll Free Fax
Product Catalog May 2014 www.immunalysis.com We are Toxicology. Tel 909.482.0840 Toll Free 888.664.8378 Fax 909.482.0850 Comprehensive Drug Testing Solutions 21 Urine HEIA Assays 37 ELISA Assays for Multiple
More informationINSTANT DRUG SCREENING
................................ INSTANT DRUG SCREENING Rapid tests for the detection of drugs and their metabolites in urine and saliva A CEuropean Background NHS Supply Chain Approved Reliable, quick
More informationDRUGS OF ABUSE
DRUGS OF ABUSE www.btnx.com 1-888-339-9964 Rapid Response Drugs of Abuse and Alcohol Screening Devices BTNX Inc. prides itself in offering quality drug detection tests for accurate, safe and rapid testing.
More informationProcedure for Toxicology Analysis Version 7 Toxicology Unit Effective Date: 03/14/2014 Issued by Drug Chemistry Forensic Scientist Manager
Toxicology Analysis 1.0 Purpose - This procedure specifies the required elements for analyzing toxicology submissions and reporting drug testing results. 2.0 Scope This procedure applies to all submissions
More informationDRUG & ALCOHOL TESTING YOUR QUESTIONS ANSWERED
DRUG & ALCOHOL TESTING YOUR QUESTIONS ANSWERED Need some advice on testing? Call us free on: 0800 036 2522 Cellmark s Hair Testing Service Cellmark s ISO17025 accredited hair drug & alcohol testing service
More information3703 Camino del Rio South 100-A San Diego, CA, Phone Fax CLIA# 05D Director: David J.
Drug Adherence Assessment Report Prescribed Medications: NO MEDICATION LIST PROVIDED CONSISTENT RESULTS - REPORTED MEDICATION DETECTED (PARENT DRUG AND/OR METABOLITE) REPORTED PRESCRIPTION FLAG ANTICIPATED
More informationPrepared by Date Adopted Supersedes Procedure # Review Date Revision Date Signature. Distributed to # of Copies Distributed to # of Copies
Procedure: Status DS Prepared by Date Adopted Supersedes Procedure # Review Date Revision Date Signature Distributed to # of Copies Distributed to # of Copies PRINCIPLE: The Status DS 10 Panel (MET/OPI/COC/THC/PCP/BZO/BAR/MTD/TCA/AMP)
More informationMEDICAL POLICY Drug Testing
POLICY: PG0069 ORIGINAL EFFECTIVE: 01/01/11 LAST REVIEW: 04/10/18 MEDICAL POLICY Drug Testing GUIDELINES This policy does not certify benefits or authorization of benefits, which is designated by each
More informationAnnual Reports Questionnaire (ARQ) Part III: Extent, patterns and trends in drug use
Annual Reports Questionnaire (ARQ) Part III: Extent, patterns and trends in drug use Report of the Government of: Reporting Year: Completed on (date): Please return completed questionnaire to: arq@unodc.org
More informationForensic Toxicology Scope of Testing and Detection Limits
Forensic Toxicology Scope of Testing and Detection Limits Table of Contents QUALITATIVE ANALYSES... 2 Volatile Screen by GC/FID... 2 Carbon Monoxide by Microdiffusion... 2 Ethylene Glycol by GC/MS... 2
More informationSmartNotes. Understanding the SAMHSA Guidelines for Drugs of Abuse Testing
DIAGNOSTICS SAMHSA Guidelines SmartNotes Understanding the SAMHSA Guidelines for Drugs of Abuse Testing The Substance Abuse and Mental Health Services Administration (SAMHSA) is an agency within the US
More informationOverview of the AACC Academy s LMPG: Using clinical laboratory tests to monitor drug therapy in pain management patients
Overview of the AACC Academy s LMPG: Using clinical laboratory tests to monitor drug therapy in pain management patients Gwen McMillin, PhD, DABCC(CC,TC) Professor, University of Utah Medical Director,
More informationWorkflow for Screening and Quantification of the SAMHSA (NIDA) Panel in Serum Using UHPLC-TOF
APPLICATIO OTE Liquid Chromatography/ Mass Spectrometry Authors: Avinash Dalmia Bonnie Marmor PerkinElmer, Inc. Shelton, CT Workflow for Screening and Quantification of the SAMHSA (IDA) Panel in Serum
More information