2 Bio/Agro Security Enterprise Historical Context and Scope

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1 ` Field to Fork

2 2 Bio/Agro Security Enterprise Historical Context and Scope

3 Bio/Agro Security Enterprise Historical Context and Scope 3

4 4 Bio/Agro Security Enterprise Historical Context and Scope

5 Bio/Agro Security Enterprise Historical Context and Scope 5

6 6 Bio/Agro Security Enterprise Historical Context and Scope

7 Bio/Agro Security Enterprise Biothreats Over the Horizon 7

8 8 Bio/Agro Security Enterprise Biothreats Over the Horizon

9 BSL 3/3E/3Ag Facility Livestock/Crops/Food 9

10 10 BSL 3/3E/3Ag Facility Livestock/Crops/Food

11 BSL 3/3E/3Ag Facility Livestock/Crops/Food 11

12 12 BSL 3/3E/3Ag Facility Livestock/Crops/Food

13 BSL 3/3E/3Ag Facility Livestock/Crops/Food 13

14 14 BSL 3/3E/3Ag Facility Livestock/Crops/Food

15 BSL 3/3E/3Ag Facility Livestock/Crops/Food 15

16 16 Unique in the World Livestock/Crops/Food BSL 3/3E/3Ag Facility BIOSECURITY RESEARCH INSTITUTE Status: Start / End Date Principal Investigators Infectious Disease/ Disease Pathogen BRI R&D Area Select Agent (CDC or USDA) Registration Transfer (or Permit) Approval Projects Pending Start Date Pending Wilson: USDA Richt: Rift Valley Fever (NBAF Disease Project) Vector-Borne Transmission A/E/I Approved NA Start Date Pending Faburay Ehrlichia ruminantium Lab R&D and in Livestock A/E/P NA Approved Start Date Pending Stack Raythayibacter toxicus Lab R&D E Approved Approved PPQ Start Date Pending Shi African Swine Fever (NBAF Disease Project) Lab R&D and in Livestock A/E Approved NA Start Date ~10/24/17 Wilson: USDA Richt: Rift Valley Fever (NBAF Disease Project) In White Tailed Deer A/E Approved NA Start Date ~11/01/17 Ganta Ehrlichia ruminantium Lab R&D and in Livestock A/E/P NA Approved Projects Ongoing 11/2009 Valent Wheat Blast Lab R&D P NA Approved PPQ 05/ /2012 Richt Higgs Highly Pathogenic Avian Influenza (HPAI) Lab R&D and in Pigs & Chickens Western Equine Encephalitis Virus Lab R&D A/E Approved Approved Domestic & Foreign Strains A/E/P NA NA 08/2012 Higgs Yellow Fever Lab R&D and in Mosquitoes A/E/P/I NA NA Projects Updated 10/02/2017: Personnel Approved to Work with Select Agents in the BRI 120

17 Unique in the World Livestock/Crops/Food BSL 3/3E/3Ag Facility 17 BIOSECURITY RESEARCH INSTITUTE Status: Start / End Date Principal Investigators Infectious Disease/ Disease Pathogen BRI R&D Area Select Agent (CDC or USDA) Registration Transfer (or Permit) Approval 09/2012 Higgs Chikungunya Virus Lab R&D and in Mice A/E/P/I NA NA 04/2013 Wilson: USDA Richt/Ma: Rift Valley Fever (NBAF Disease Project) Lab & Small Animal R&D A/E Approved Approved 06/2014 Wilson: USDA Richt: Rift Valley Fever (NBAF Disease Project) In Sheep and Cattle A/E Approved 1 st U.S. BSL-3Ag Livestock RVF R&D NA 06/ / /2015 Vanlandingham Phebus Shi Japanese Encephalitis (NBAF Disease Project) Lab R&D and in Mice Shiga Toxin-producing Escherichia coli (STEC) Food Processing Scale R&D Classical Swine Fever (NBAF Disease Project) Lab R&D and in Livestock A/P NA NA F NA Approved A/E Approved NA 06/ /2016 Rowland Rowland Classical Swine Fever (NBAF Disease Project) Lab R&D and in Livestock African Swine Fever (NBAF Disease Project) Lab R&D and in Livestock A/E A/E 1 st Non-Federal Lab Approved 11/15/ st Non-Federal Lab Approved 11/15/2013 NA Australia ASF Strains 09/30/15 03/2016 Vanlandingham Zika Virus Lab R&D and in Mice A/P NA Approved 07/2016 Richt African Swine Fever (NBAF Disease Project) Lab R&D and in Livestock A/E Approved NA 08/2016 Richt Vesicular Stomatitis Virus (NBAF Disease Project) VSV-Ebola Vaccine Trial in Pigs A/E/P NA Approved 09/2017 Higgs Usutu Virus Lab R&D P NA Approved Projects Completed 11/2008 Hesse/Rowland Porcine Reproductive and Respiratory Syndrome (PRRS) & Porcine Circovirus in Pigs A NA Approved 04/2010 Richt Pandemic H1N1 In Pigs A NA Approved 10/ /2011 Rajagopalan NanoScale Corp. Wilson: USDA Richt: Anthrax; Glanders; Vaccinia Ankara (MVA) Lab Inactivation Studies Rift Valley Fever MP12 (NBAF-Related Project) Vaccine Strain in Sheep & Cattle P Approved Approved A/E NA Approved 11/2011 Phebus 2,000 lb. Hamburger Grinds With Shiga Toxin-producing Strains of E. coli F NA Approved Projects Updated 10/02/2017: Personnel Approved to Work with Select Agents in the BRI 120

18 18 Unique in the World Livestock/Crops/Food BSL 3/3E/3Ag Facility BIOSECURITY RESEARCH INSTITUTE Status: Start / End Date Principal Investigators Infectious Disease/ Disease Pathogen BRI R&D Area Select Agent (CDC or USDA) Registration Transfer (or Permit) Approval 08/ / / /2012 Oberst Higgs McVey USDA Phebus Plague; Brucellosis; Anthrax; Tularemia Food Threat Detection Studies Barmah Forest Virus/ Ross River Virus Lab R&D Rift Valley Fever MP12 (NBAF-Related Project) Vaccine Strain in Mice P Approved Approved A/E N/A NA A/E NA Approved 2,000 lb. Hamburger Grinds With the Anthrax Sterne F NA Approved (Vaccine) Strain 10/2012 Ma/Richt Swine Influenza In Pigs A NA Approved 05/2013 Ma/Richt H7N9 Influenza Lab R&D and in Pigs A NA Approved 09/2013 Hesse Porcine Epidemic Diarrhea Virus (PEDv) In Pigs A NA NA 02/2014 Ma/Richt Swine Influenza In Mice A NA Approved 04/2014 Phebus Anthrax Sterne (Vaccine) Strain F NA Approved Food Threat Modeling Studies 04/2014 Phebus Plague; Anthrax; Tularemia Food Threat Modeling Studies F/P Approved Approved 04/2015 White Rice Bacterial Blight Long-Term Storage P Approved Approved PPQ 12/2015 Shi Chinese Porcine Reproductive & Respiratory Syndrome Virus (PRRS) Lab R&D and in Pigs A/E NA Approved 12/2015 Shi Classical Swine Fever (NBAF Disease Project) Synthetic Virus: Lab R&D & in Pigs A/E Approved 1 st Non-Federal Livestock CSF R&D NA 01/2016 Phebus Foodborne Pathogens School Lunch Safety Study with Hospitality Management F NA Approved 06/2016 Ganta Rickettsiae rickettsia Vaccine Trial in Dogs A NA NA 07/2016 Phebus Foodborne Pathogens Commercial Scale Sausage Processing Study F NA Approved 05/2017 Wilson/Drolet USDA Exotic Bluetongue Lab R&D P/E NA Approved 05/2017 Wilson/McVey: USDA Richt: Schmallenberg Virus Lab R&D and in Sheep & Cattle A/E/P NA Approved Projects Updated 10/02/2017: Personnel Approved to Work with Select Agents in the BRI 120

19 BSL 3/3E/3Ag Facility Livestock/Crops/Food 19

20 20 BSL 3/3E/3Ag Facility Livestock/Crops/Food

21 Bio/Agro Security Enterprise Federal & State Collaborators 21

22 22 Bio/Agro Security Enterprise Federal & State Collaborators

23 Bio/Agro Security Enterprise Private Sector Collaborators 23

24 24 Bio/Agro Security Enterprise Private Sector Collaborators

25 Bio/Agro Security Enterprise Growing the Opportunities 25

26 26 Bio/Agro Security Enterprise Growing the Opportunities

27 Bio/Agro Security Enterprise Growing the Opportunities 27

28 28 Bio/Agro Security Enterprise Growing the Opportunities

29 Bio/Agro Security Enterprise Growing the Opportunities 29

30 America s Silicon Valley for Biodefense Protecting the USA s food supply, economy and people Manhattan, Kansas NBAF in Kansas Hits the Mission Bull s-eye!