Multiscale Model of Oxygen transport in Diabetes
|
|
- Letitia Reed
- 6 years ago
- Views:
Transcription
1 BENG 221: Poblem Solving Poject Multiscale Model of Oxygen tanspot in Diabetes Decembe 1, 2016 Austin Budick Nafeesa Khan Sihita Rudaaju
2 Motivation Diabetes emains a significant health condition today, and affects not only key egulatoy systems within the body, but cetain bodily tissues as well. This disease is pehaps best associated with a distubance in the pocessing of suga consumed though food, due to eithe a lack of insulin o to a deceased efficiency of this homone within an affected peson [1]. Howeve, it is equally impotant to note that diabetes has demonstated effects within the composition of the micovasculatue, shown by thickening of the basement membane in human capillaies [2]. This alteation of the vessel stuctue can be linked to a deficiency in the amount of oxygen that is ultimately tanspoted to the suounding body tissue [3]. By modelling the physiological effects of diabetes on the capillaies, the effects of this disease can be bette undestood in ode to potentially mitigate its accompanying health isks. The scope of diabetes within the United States alone has been well established. The Centes fo Disease Contol and Pevention (CDC) have estimated that 29.1 million, o 9.3%, of the population have developed some fom of diabetes, with appoximately 8 million of this numbe emaining undiagnosed [4]. This condition has been elated to othe health isks as well, as death ates fom cadiovascula disease have been shown to be almost twice as high in affected individuals ove eighteen yeas old. Additionally, hospitalization ates fo instances of both heat attack and stoke ae almost twice as high in affected individuals ove twenty yeas old. The effects of diabetes also include significant medical costs, with $176 billion, ove two times the costs fo those without this disease, estimated fo aveage expenditues [4]. Poblem Statement Basement membane thickening is a significant change affected by the development of diabetes in both type I and type II vaieties. Because it is composed of poteins that ae closely elated to collagen, this membane expeiences an incease in potein synthesis when subjected to vaious types of damage caused by diabetes and its elated health conditions [2]. This state of the vessel bounday, as pictued in Figue 1, has been linked to seveal conditions esulting fom diabetes, such as neuopathy [3]. Additionally, 1
3 eseach [5] has yielded distibutions of membane thickness fo both diabetic patients as well as unaffected individuals. The esults, shown in Figue 2, display a significant incease in membane width that is enhanced with age 5. Futhe studies have implied that this incease in thickness is due to a lage tunove accompanied by a significant decease in the eventual degadation of the membane [2]. Figue 1: Images of capillaies with both nomal and inceased thickness (left) along with distibutions of membane aea in nomal and diabetic patients. [3] Figue 2: Effects of diabetes and aging on membane thickness compaed to unaffected individuals. [5] The effects of diabetes on the capillay basement membane width esult in multiple disuptions in the final steps of oxygen delivey. Afte passing the vessel wall following elease, diffusion is the pimay diving foce of oxygen to each the suounding tissue. Howeve, the distance that can be coveed by this pocess is extemely limited, equiing 2
4 Figue 3: Oxygen tanspot unde nomal and diabetic conditions. Distance between the individual capillaies is inceased, educing the effects of nomal diffusion. [7] close aangement of the capillay aay. In patients with diabetes, the space between individual capillaies is geatly inceased, while the limited ange of diffusion ceates egions in the tissue whee ischemia can develop (Figue 3). In this case, theapies might be necessay in ode to incease the patial pessue of oxygen within the vessels, estoing delivey [6]. Pio to diffusion outside the vessels, oxygen deficiency may also occu due to an incease in blood velocity due to diabetes. It has been epoted that duing an incease in membane width, a shunt may occu within the vessel netwok, petubing flow within the capillaies and peventing delivey to the suounding tissue due to less time fo oxygen extaction [3]. While this pompts an incease in blood flow to meet the needs of the tissue, hypoxia can aise in the adjacent cells [3]. This incease in fluid velocity has also been obseved in othe studies of diabetes, listing an intequatile ange fom 15.9 x 10 3 cm/s to 89.0 x 10 3 cm/s in those unaffected by diabetes, and a ange fom 68.4 x 10 3 cm/s to 21.8 x 10 2 cm/s in those with the condition [7]. Both the incease in distance between capillaies and the distubed flow within the vasculatue povide the basis fo a model that can epesent the extent of diabetes with espect to oxygen delivey. In each case, the final tansfe of oxygen to the body is inhibited, due to inceases in the flow of the blood itself as well as to inceased distances coveed by the basement membane. By taking the paametes found unde each of these conditions into account, oxygen movement within the capillaies can be chaacteized at each step. This is modelled fom the elease of molecules fom hemoglobin into an individual vessel, followed by passage though the suounding wall and basement membane, and finally though the tissue itself. In this way, the extent of change 3
5 to this pocess unde diabetic conditions can be bette undestood by way of a compehensive model. Model The model deived is based on oxygen tanspot at multiple stages within a vessel and its suounding tissues. In this instance, movement though the vessel itself, the vessel wall, and a potion of tissue beyond the wall has been accounted fo. The blood vessel is modeled as a single capillay whee hemoglobin eleases oxygen, which exits the cell as it entes into the plasma. Fom hee, oxygen tavels to the vessel wall, nomally expeiencing both convection and diffusion while moving towads a laye of endothelial cells, and subsequently diffusing futhe into the absobing tissue (Figue 4). Figue 4: Model of oxygen tanspot within a single capillay. This pathway depicted indicates oxygen elease fom hemoglobin and exit fom the cell, followed by flow down the vessel and diffusion to the vessel wall and suounding tissue. Within the developed model, cetain assumptions ae made to poduce a mathematical analysis of oxygen tanspot. The intestitial space between the vessel wall and the tissue has been disegaded. Assumptions ae detemined fo each stage of tanspot, and ae made based on easonable estimates as well as a focus on diffusion in a single dimension within the model. The following sections explain each stage in futhe detail. Blood vessel The assumptions consideed fo the blood vessel ae listed below. 1) Homogenous solution of hemoglobin 2) No diffusion in the axial diection 4
6 Figue 5: Model of oxygen tanspot within a blood capillay. 3) No flow in the adial diection 4) Hb, HbO 2 and O 2 ae in equilibium 5) Constant velocity of oxygen along the axial (z) diection 6) Constant diffusion coefficient D c Convection cuents ae not impotant fo ou model and tanspot of oxygen occus pimaily in the adial diection. Consideing these simplifications, the blood vessel is modeled as a small capillay [10]. Diffusion occus exclusively in the adial diection at a constant diffusivity D c and axial diffusion is ignoed. Deoxygenated hemoglobin and oxygen ae assumed to be in equilibium with oxygenated hemoglobin, and the concentation of hemoglobin [Hb] is held constant. Finally, the velocity of oxygen tanspoted is only consideed in the z-diection at a constant ate v. Fom these paametes, the following balance equations ae utilized fo hemoglobin and oxygen. +v. [O 2 ] = D O2 2 [O 2 ] R O2 (1) [HbO 2 ] +v. [HbO 2 ] = D HbO2 2 [HbO 2 ] R O2 (2) These equations ae simplified fo the case of steady state flow and oxygen tanspot in a cylindical conduit. Consideing neglected diffusion in axial (z), o flow diection and no flow in the adial diection (), the equations ae tanslated to as below. v [O 2] z = D O2 ( 2 [O 2 ] ) k [Hb][O 2 ]+k[hbo 2 ] (3) 5
7 v [HbO 2] z = D HbO2 ( 2 [HbO 2 ] [HbO 2 ] )+k [Hb][O 2 ] k[hbo 2 ] (4) In ode to obtain the analytical solution, the poblem is futhe simplified. Fluid velocity is only consideed in the adial diection, oxyhemoglobin and oxygen ae in local chemical equilibium (o the ate of eaction is zeo), and diffusion only in the adial diection. No net oxygen exchange was assumed acoss the bounday. Thus, zeo flux bounday conditions ae consideed at both boundaies of capillay. The initial concentation of oxygen in the capillay is modeled on the basis of fluid velocity inside a tube. Consequently, the concentation is highest at the cente of the capillay C 0 and is zeo at the bounday, vaying adially in a linea fashion. The above assumptions lead to the following equation. = D c ) (5) Bounday conditions: (0,t) = 0 ( cw,t) = 0 (6) Initial condition: [O 2 ](,0) = C 0 (1 cw ) (7) Vessel wall Figue 6: Model of oxygen tanspot within the vessel wall. The assumptions fo this stage ae as follows: 6
8 - Diffusion only occus in the adial diection - Unifom consumption of oxygen by mitochondia in endothelial cells - Constant diffusivity D w Simila assumptions as the capillay ae made fo the vessel wall. Additionally, a constant consumption tem of oxygen by mitochondia is consideed. This consumption tem is epesented as M w. A simple way of connecting the thee stages of oxygen tanspot is devised. The steady state value of oxygen concentation is used as a bounday condition fo the consequent stage. Thus, steady state oxygen concentation deived fom the capillay stage is used as a bounday condition hee. Zeo flux condition is consideed at the othe bounday. It is also assumed that thee is no oxygen pesent in the vessel wall initially. These assumptions lead to the following equations. = D w ) M w (8) Bounday conditions: [O 2 ]( cw,t) = C ( wt,t) = 0 (9) Initial condition: [O 2 ](,0) = 0 (10) Tissue Figue 7: Model of oxygen tanspot within the suounding tissue. The assumptions consideed fo the suounding tissue ae as given: - Diffusion only occus in the adial diection - Unifom consumption of oxygen by mitochondia in endothelial cells 7
9 - Constant diffusivity D t Assumptions fo the suounding tissue ae simila to those consideed in the vessel wall. Steady state oxygen concentation in the vessel wall is used as a bounday condition hee. It is assumed that thee is no oxygen pesent in the tissue initially. The equations ae as follows. = D t ) M t (11) Bounday conditions: [O 2 ]( wt,t) = M w 4D w 2 wt +C ( t,t) = 0 (12) Initial condition: [O 2 ](,0) = 0 (13) Analytical Solution Blood vessel = D c ) (14) Bounday conditions: (0,t) = 0 ( cw,t) = 0 (15) Initial condition: [O 2 ](,0) = C 0 (1 cw ) (16) This simplified model esembles a homogenous patial diffusion equation in the cylindical coodinates. It can be solved using sepaation of vaiables. u(,t) = X()T(t) (17) Substituting this new definition into the homogenous PDE and eaanging esults in one time-dependent equation and one space-dependent equation. Bessel functions ae 8
10 used fo the solution. T(t) = Ce Dλ2 t (18) 2 2 X 2 + X +2 λ 2 x = 0 (19) X() = AJ 0 (λ) (20) Applying the bounday conditions and using local extemes of Bessel function J n (0) = 0 J n (0) = 0 (21) X = λ n0 (22) Using the pinciple of supeposition, the final solution to the homogenous equation is the weighted sum of all possible solutions: u(,t) = A n J 0 (λ n )e Dλ2 t n=1 (23) To solve fo the constant A n, the initial condition is applied to the above solution. The esult is integated ove the adius of the capillay. u(,0) = u 0 () = A n J 0 (λ n ) (24) n=1 cw 0 u 0 ()J 0 (λ m )d = cw A n J 0 (λ n )J 0 (λ m )d (25) n=1 0 cw 0 u 0 ()J 0 (λ m )d = A m 2 cw 2 J 1(λ m cw ) 2 (26) A m = 2C cw 0 (1 0 cw )J 0 (λ m )d (27) cwj 2 1 (λ m cw ) 2 Solving fo integals of the above Bessel functions becomes complicated. Hence, the 9
11 same setup is solved in Catesian coodinates. The solution is as follows. O 2 (,t) = (C 0 0.5)+ n=1 2C 0 (nπ) 2(1 cos(nπ))cos(nπ cw )e Dc( 2 nπcw)t (28) Figue 8: Analytical and numeical solution fo blood vessel modeled as capillay in Catesian coodinates. Vessel wall Bounday conditions: = D w ) M w (29) [O 2 ](0,t) = C (L w,t) = 0 (30) Initial condition: [O 2 ](,0) = 0 (31) Fo the paticula solution, a steady state condition was assumed to aive at the solution. 0 = D w ) M w (32) 10
12 u p (,t) = M w 4D w 2 +C (33) The homogenous patial diffusion equation in cylindical coodinates can be solved using sepaation of vaiables. u h (,t) = X()T(t) (34) Substituting this new definition into the homogenous PDE and eaanging esults in one time-dependent equation and one space-dependent equation. Bessel functions ae used fo the solution. T(t) = Ce Dλ2 t (35) 2 2 X 2 + X +2 λ 2 x = 0 (36) X() = AJ 0 (λ) (37) Applying the bounday conditions and using local extemes of Bessel function J n (0) = 0 J n (0) = 0 (38) X = λ n0 (39) Using the pinciple of supeposition, the final solution to the homogenous equation is the weighted sum of all possible solutions: u h (,t) = A n J 0 (λ n )e Dλ2 t n=1 (40) To solve fo the constant A n, the initial condition is applied to the sum of paticula and homogenous solution. The esult is integated ove the width of vessel wall. u(,0) = u 0 () = A n J 0 (λ n ) (41) 11 n=1
13 Lw u 0 ()J 0 (λ m )d = 0 Lw A n J 0 (λ n )J 0 (λ m )d (42) n=1 0 Lw cw 2 u 0 ()J 0 (λ m )d = A m 0 2 J 1(λ m L w ) 2 (43) u(,t) = n=1 2 ( J 2(λ m L w J 3 (λ m L w )) 1 +(C L )L w w λ m J 1 (λ m L w ) λj 1 (λ m L w ) )J 0(λ m L w )e Dwλmt (44) Tissue Bounday conditions: = D t ) M t (45) [O 2 ](0,t) = M w 4D w 2 cw +C (L t,t) = 0 (46) Initial condition: [O 2 ](,0) = 0 (47) Fo the paticula solution, a steady state condition was assumed to aive at the solution. 0 = D t ) M t (48) The solution is simila to that of vessel wall. u(,t) = n=1 2 L 2 t u p (,t) = M t 4D t 2 +C (49) ( J 2(λ m L t J 3 (λ m L t )) +( M w 2 1 λ m J 1 (λ m L t ) 4D wt+c 0 0.5)L t w λj 1 (λ m L t ) )J 0(λ m L t )e Dtλmt (50) 12
14 Table 1: Values of Paametes Constant Desciption V alue v O 2 velocity in capillay 0.1 cm/s [10] v d O 2 velocity in capillay in diabetes 0.12 cm/s [7] C o Initial O 2 concentation in capillay 1.62 x 10 4 g/ml [10] [Hb] Deoxyhemoglobin Concentation in capillay 0.55 g/ml [10] [HbO 2 ] Hemoglobin Concentation in capillay 0.34 g/ml [10] k p Oxygen and Hemoglobin association ate 30 x 10 6 /Ms [11] k Oxygen dissociation ate 20 x 10 6 /Ms [11] D c Diffusivity of O 2 in capillay 1.62 x 10 5 cm 2 /s [10] D w Diffusivity of O 2 in vessel wall 8.73 x 10 6 cm 2 /s [10] D t Diffusivity of O 2 in tissue 2.41 x 10 5 cm 2 /s [10] cw Inne adius of vessel wall 4.0 x 10 4 cm [10] wt Oute adius of vessel wall 6.0 x 10 4 cm [8] wt,d Oute adius of vessel wall in diabetes 9.0 x 10 4 cm [8] t Oute adius of tissue 15.0 x 10 4 cm (abitay) M w O 2 consumption in vessel wall 5.0 x 10 3 mlo 2 /ml/s [12] M t O 2 consumption in tissue 1.58 x 10 4 mlo 2 /ml/s [12] Numeical Model The numeical validation is computed using MATLAB and its built-in PDE solve. Additional factos not included in the analytical solution ae accounted fo including: velocity of blood flow in the z-diection, dissociation ates of hemoglobin and oxygen, and coupling of bounday conditions between the diffeent sections of the model. The equations used fo the numeical validation ae as follows and paametes ae those listed in the table. Bounday and initial conditions mentioned in the model desciption have been used. Blood vessel: v [O 2] z = D c ( 2 [O 2 ] )+R O 2 (51) R O2 = k[hbo 2 ] k p [Hb][O 2 ] (52) Vessel wall: = D w ) M w (53) 13
15 Suounding tissue: = D t ) M t (54) In diabetic patients, the width of the vessel wall is lage compaed to healthy condition. The following gaphs illustate the levels of oxygen concentation in diabetic condition in compaison to nomal vessel wall width. In ode to bette visualize the oxygen concentation diffeences between diseased and healthy conditions, 2D gaphs wee plotted epesenting oxygen levels in each stage. Figue 9: Plots of oxygen tanspot within healthy and diabetic capillaies. Figue 10: Plots of oxygen tanspot though the vessel wall unde nomal and diabetic conditions. Figue 11: Plots of oxygen tanspot though the suounding tissue unde nomal and diabetic conditions. 14
16 Figue 12: Oxygen tanspot cutoff within healthy and diabetic tissue at 0.4 seconds. Figue 13: Oxygen tanspot within the capillay. Plots indicate the tanspot ove time. 15
17 Conclusion and Futue Wok We constucted a multi-scale model of oxygen diffusion fom a capillay into suounding tissue to show the effects of diabetes on oxygen availability. In the analytical model we simplified the both geomety and diffeent stages involved in the pocess in addition to utilizing steady state solutions as bounday conditions fo the following step in the tanspot of oxygen to the suounding tissue. The effect of velocity incease in the diabetic condition on oxygen availability can be seen in the capillay plots of figue one. Inceased velocity (by appoximately 120%) in diabetes does not decease the amount of oxygen available at the ed blood cell (RBC) site (Z= 0 cm) (seen in figue 13 and plot 3 of figue 9) but does decease the amount of oxygen futhe away (in ou case Z= 0.5cm, figue 9 plot 3). This diffeence in oxygen is caied though to the vessel wall and tissue (figues 10 and 11). The steady state value of the pevious stage was taken as the left bounday condition in these calculations. As can be seen, the oiginal diffeence in oxygen caused by velocity incease in diabetes caies though to the tissue. Howeve, it is notable that the shape of the oxygen availability cuve at the inteface of the vessel wall and tissue (the thid plot of figue 10), changes due to a thicke membane. Figue 12 shows the compounded effect of capillay membane thickening and inceased velocity, whee a cutoff time is set at.04 seconds of diffusion in the vessel wall and is used as the left bounday condition in the tissue stage. This eflects that oxygen elease by RBCs would come in pulses and diffusion would not go to steady state. In that case, the thicke membane in addition to inceased capillay velocity deceases the amount of oxygen available to tissue. Finally, figue 13 shows the isolated effect of wall thickening on oxygen availability. Plots one though thee demonstate that even with velocity being highe in the diabetic condition, oxygen concentation is still the same at Z=0 (site of the RBC. Howeve, even if the same amount of oxygen is available to the vessel wall between the healthy and diabetic case, the inceased thickness still educes oxygen availability (seen by the gap between the ed and blue line in the fouth plot. In the numeical model, we wee able to account fo moe factos involved in the oxygen tanspot pocess and showed a decease in the oxygen available to tissues duing 16
18 diabetes by using liteatue-based changes in blood velocity and wall thickness. Consequently, less oxygen is available in the second step duing tanspot though the capillay wall, whee anothe confounding facto in diabetes, basement membane thickening, futhe educes the amount of oxygen that eaches the tissue. The diffeence in oxygen available to tissue at intefaces of the stages and at the end can be seen in figues one though thee. Effectively, in the diabetic condition, oxygen is moving too quickly in the capillay to popely diffuse to the est of the body, which is futhe hindeed by a geate distance within the vessel wall that must be passed befoe eaching the tissue. Chonic eduction in oxygen supply could be eithe coelative o causative with diabetes symptoms and complications. A pimay agument fo this would be a change in cell metabolism in esponse to deceased oxygen. Ostegaad et al. obseved an incease in neuopathy in diabetic patients due to these changes in blood flow, which limited not only oxygen availability to tissue but glucose as well3. While we applied this model to the case of diabetes, it could also be used to analyze othe disease states, such as anemia o sickle cell disease. In addition, modifications could be made to model tanspot of othe nutients o molecules, such as glucose, CO 2 o CO. Multiple complex chemical, geometic and anatomical aspects of oxygen tanspot wee eithe not included o wee simplified fo this model. These included assumptions egading the natue of blood flow, simplifications in oxygen and hemoglobin dissociation kinetics, and simplified anatomy of the capillay (the intestitial space was not included). In ode to build a moe ealistic model we would want to account fo these aspects as well as the discete natue of oxygen diffusion fom individual ed blood cells, instead of a continuum. Ou model shows the decease in oxygen made available to tissue in the diabetic case compaed to the healthy model. This is due to the obseved incease in blood velocity though capillaies in diabetes as well as basement membane thickening. Theefoe oxygen has less time to diffuse though a given section of the capillay wall, and must also tavel a geate distance befoe eaching the tissue. We believe that by taking this step to undestanding the mechanisms of this disease, we povide a basis fo continued eseach into moe effective theapeutics fo those affected. We hope to continue this study to gain futhe insight into inceasingly complex scenaios povided by diabetes. 17
19 Refeences [1] Kelly, Jane. Diabetes. Centes fo Disease Contol and Pevention, Accessed 24, Oct [2] Williamson, J.R., and C. Kilo. Capillay Basement Membane in Diabetes. Diabetes vol. 32, no. 2, 1983, pp Accessed 26, Oct [3] Ostegaad, Leif et al. The effects of capillay dysfunction on oxygen and glucose extaction in diabetic neuopathy. Diabetologia, 2014, pp Accessed 26, Oct [4] National Diabetes Repot, Centes fo Disease Contol and Pevention, Accessed 27, Oct [5] Kilo, Chales, Nancy Vogle, and Joseph R. Williamson. Muscle Capillay Basement Membane Changes Related to Aging and to Diabetes Mellitus. Depatments of Medicine and Pathology, Washington Univesity School of Medicine, 1972, pp Accessed 25, Oct [6] Boulton, Andew J. The Diabetic Foot, an Issue of Medical Clinics. Medical Clinics of Noth Ameica, vol. 97, no. 5, 2013, pp Accessed 24, Oct [7] Flynn, M.D., M.E. Edmonds, J.E. Tooke, and P.J. Watkins. Diect measuement of capillay blood flow in the diabetic neuopathic foot Diabetologia, Accessed 27, Oct [8] Hellums, J. David, et al. Simulation of intaluminal gas tanspot pocesses in the micociculation. Annals of biomedical engineeing 24.1 (1995): [9] Vadapalli, Ajun, Roland N. Pittman, and Aleksande S. Popel. Estimating oxygen tanspot esistance of the micovascula wall. Ameican Jounal of Physiology-Heat and Ciculatoy Physiology (2000): H657-H671. [10] Vadapalli, Ajun, Daniel Goldman, and Aleksande S. Popel. Calculations of oxygen tanspot by ed blood cells and hemoglobin solutions in capillaies. Atificial Cells, Blood Substitutes, and Biotechnology 30.3 (2002): [11] Vandegiff, K. D., et al. Detemination of the ate and equilibium constants fo oxygen and cabon monoxide binding to R-state human hemoglobin coss-linked between the alpha subunits at lysine 99. Jounal of Biological Chemisty (1991):
INDIVIDUALIZATION FEATURE OF HEAD-RELATED TRANSFER FUNCTIONS BASED ON SUBJECTIVE EVALUATION. Satoshi Yairi, Yukio Iwaya and Yôiti Suzuki
INDIVIDUALIZATION FEATURE OF HEAD-RELATED TRANSFER FUNCTIONS BASED ON SUBJECTIVE EVALUATION Satoshi Yaii, Yukio Iwaya and Yôiti Suzuki Reseach Institute of Electical Communication / Gaduate School of Infomation
More informationStochastic Extension of the Attention-Selection System for the icub
Stochastic Extension of the Attention-Selection System fo the icub Technical Repot (in pepaation) H. Matinez, M. Lungaella, and R. Pfeife Atificial Intelligence Laboatoy Depatment of Infomatics Univesity
More informationAnalytical and Numerical Investigation of FGM Pressure Vessel Reinforced by Laminated Composite Materials
Jounal of Solid Mechanics Vol. 6, No. 1 (2014) pp. 43-53 Analytical and Numeical Investigation of FGM Pessue Vessel Reinfoced by Laminated Composite Mateials A.R Ghasemi *, A. Kazemian, M. Moadi Depatment
More informationOPTIMUM AUTOFRETTAGE PRESSURE IN THICK CYLINDERS
Junal Meanial Decembe 007, No. 4, - 4 OTIMUM AUTOFRETTAGE RESSURE IN THICK CLINDERS Aman Ayob *, M. Kabashi Elbashee Depatment of Applied Mechanics, Faculty of Mechanical Engineeing, Univesiti Tenologi
More informationShunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development
Shunting Inhibition Contols the Gain Modulation Mediated by Asynchonous Neuotansmitte Release in Ealy Development Vladislav Volman 1,2,3 *, Hebet Levine 1, Teence J. Sejnowski 1,2,3,4 1 Cente fo Theoetical
More informationHTGR simulations in PSI using MELCOR 2.2
WIR SCHAFFEN WISSEN HEUTE FÜR MORGEN Jamo Kalilainen :: Paul Schee Institut HTGR simulations in PSI using MELCOR 2.2 10 th Meeting of the Euopean MELCOR Use Goup (EMUG), 25 27 Apil, Zage, Coatia Intoduction
More informationThe Probability of Disease. William J. Long. Cambridge, MA hospital admitting door (or doctors oce, or appropriate
Repinted fom Poceedings of the Fifteenth Annual Symposium on Compute Applications in Medical Cae, pp 619-623, 1991 The Pobability of Disease William J. Long MIT Laboatoy fo Compute Science Cambidge, MA
More informationA Mathematical Model of The Effect of Immuno-Stimulants On The Immune Response To HIV Infection
Intenational Jounal of Latest Engineeing Reseach and Applications (IJLERA) ISSN: 455-7137 A Mathematical Model of The Effect of Immuno-Stimulants On The Immune Response To HIV Infection *iwa P. 1, Rotich
More informationInterpreting Effect Sizes in Contrast Analysis
UNDERSTANDING STATISTICS, 3(1), 1 5 Copyight 004, Lawence Elbaum Associates, Inc. TEACHING ARTICLES Intepeting Effect Sizes in Contast Analysis R. Michael Fu Depatment of Psychology Appalachian State Univesity
More informationTwo universal runoff yield models: SCS vs. LCM
J. Geog. Sci. 2015, 25(3): 311-318 DOI: 10.1007/s11442-015-1170-2 2015 Science Pess Spinge-Velag Two univesal unoff yield models: SCS vs. LCM LI Jun, * LIU Changming, WANG Zhonggen, LIANG Kang Key Laboatoy
More informationMETHODS FOR DETERMINING THE TAKE-OFF SPEED OF LAUNCHERS FOR UNMANNED AERIAL VEHICLES
Jounal of KONES Powetain and Tanspot, Vol. 25, No. 1 2018 METHODS FOR DETERMINING THE TAKE-OFF SPEED OF LAUNCHERS FOR UNMANNED AERIAL VEHICLES Gzegoz Jastzębski, Leszek Ułanowicz Ai Foce Institute of Technology
More informationTechnical and Economic Analyses of Poultry Production in the UAE: Utilizing an Evaluation of Poultry Industry Feeds and a Cross-Section Survey
Available online at www.sciencediect.com ScienceDiect APCBEE Pocedia 8 (2014 ) 266 271 2013 4th Intenational Confeence on Agicultue and Animal Science (CAAS 2013) 2013 3d Intenational Confeence on Asia
More informationThe Egyptian Journal of Hospital Medicine (January 2018) Vol. 70, Page
The Egyptian Jounal of Hospital Medicine (Januay 2018) Vol. 70, age 109-113 Coelation between Cental Coneal Thickness and Degee of Myopia Mostafa A, Mohamed M, Mohamed M. Al Hussein Univesity Hospital
More informationCould changes in national tuberculosis vaccination policies be ill-informed?
Math. Model. Nat. Phenom. Vol. 7, No. 3, 2012, pp. 78 98 DOI: 10.1051/mmnp/20127307 Could changes in national tubeculosis vaccination policies be ill-infomed? D. J. Gebey 1, F. A. Milne 2 1 Depatment of
More informationApplication Of Fuzzy Logic Controller For Intensive Insulin Therapy In Tpye 1 Diabetic Mellitus Patient
COMPUTERS and SMULATON in MOERN SCENCE, Volume Application Of Fuzzy Logic Contolle Fo ntensive nsulin Theapy n Tpye iabetic Mellitus Patient LALEH KARAR *, AL FALLAH, Shahia Ghaibzadeh, Fatollah Moztazadeh
More informationInfluencing Factors on Fertility Intention of Women University Students: Based on the Theory of Planned Behavior
Vol.32 (Healthcae and Nusing 206), pp.37-42 http://dx.doi.og/0.4257/astl.206. Influencing Factos on Fetility Intention of Women Univesity Students: Based on the Theoy of Planned Behavio Myeong-Jeong Chae,
More informationQUEEN CONCH STOCK RESTORATION
QUEEN CONCH STOCK RESTORATION Robet Glaze Associate Reseach Scientist Floida Maine Reseach Institute South Floida Regional Laboatoy Maathon, Floida INTRODUCTION Queen conch ae found in pedominantly south
More informationlsokinetic Measurements of Trunk Extension and Flexion Performance Collected with the Biodex Clinical Data Station
lsokinetic Measuements of Tunk Extension and Flexion Pefomance Collected with the Biodex Clinical Data Station MARK D. GRABINER, PhD,' JOHN J. JEZIOROWSKI, MS, PT,' ARUNA D. DIVEKAR, MS, PT' Jounal of
More informationSystolic and Pipelined. Processors
Gaduate Institute of Electonics Engineeing, NTU Systolic and Pipelined Why Systolic Pocessos Achitectue? Souces: VLSI Signal Pocessing ÜÜ Ande Hon, Jason Handube, Michelle Gunning, Beman, J. Kim, Heiko
More informationThe Regional Economics Applications Laboratory (REAL) of the University of Illinois focuses on the development and use of analytical models for urban
The Regional Economics Applications Laboatoy (REAL) of the Univesity of Illinois focuses on the development and use of analytical models fo uban and egional economic development. The pupose of the Discussion
More informationDietary Assessment in Epidemiology: Comparison of a Food Frequency and a Diet History Questionnaire with a 7-Day Food Record
Ameican Jounal of Epidemiology Copyight O 996 by The Johns Hopkins Univesity School of Hygiene and Public Health All ights eseved Vol. 4, No. 9 Pinted In U.SJU. Dietay Assessment in Epidemiology: Compaison
More informationSimulation of the Human Glucose Metabolism Using Fuzzy Arithmetic
Simulation of the uman Glucose Metabolism Using uy Aithmetic Michael anss live Nehls Institute A of Mechanics Univesity of Stuttgat Pfaffenwalding 9 755 Stuttgat Gemany ManssNehls @mechaunistuttgatde Abstact
More informationFUNCTIONAL MAGNETIC RESONANCE IMAGING OF LANGUAGE PROCESSING AND ITS PHARMACOLOGICAL MODULATION DISSERTATION
FUNCTIONAL MAGNETIC RESONANCE IMAGING OF LANGUAGE ROCESSING AND ITS HARMACOLOGICAL MODULATION DISSERTATION esented in atial Fulfillment of the Requiements fo the Degee Docto of hilosophy in the Gaduate
More informationCHAPTER 1 BACKGROUND ON THE EPIDEMIOLOGY AND MODELING OF BIV/AIDS
CHAPTER 1 BACKGROUD O THE EPDEMOLOGY AD MODELG OF BV/ADS Befoe modeling any disease it is cucial to undestand the epidemiological featues of the disease. The fist fou sections of this chapte pesent epidemiological
More informationCOHESION OF COMPACTED UNSATURATED SANDY SOILS AND AN EQUATION FOR PREDICTING COHESION WITH RESPECT TO INITIAL DEGREE OF SATURATION
COHESION OF COMPACTED UNSATURATED SANDY SOILS AND AN EQUATION FOR PREDICTING COHESION WITH RESPECT TO INITIAL DEGREE OF SATURATION Md. Abdul Alim 1 and Makoto Nishigaki 2 1 Assistant Pofesso, Depatment
More informationAPPLICATION OF THE WALSH TRANSFORM IN AN INTEGRATED ALGORITHM FO R THE DETECTION OF INTERICTAL SPIKES
APPLICATIO OF THE WALSH TRASFORM I A ITEGRATED ALGORITHM FO R THE DETECTIO OF ITERICTAL SPIKES D. Sanchez, M. Adjouadi, A. Baeto, P. Jayaka, I. Yaylali Electical & Compute Engineeing, Floida Intenational
More informationNUMERICAL INVESTIGATION OF BVI MODELING EFFECTS ON HELICOPTER ROTOR FREE WAKE SIMULATIONS
4 TH INTERNATIONAL CONGRESS OF THE AERONAUTICAL SCIENCES NUMERICAL INVESTIGATION OF BVI MODELING EFFECTS ON HELICOPTER ROTOR FREE WAKE SIMULATIONS X. K. Zioutis, A. I. Spyopoulos, D. P. Magais, D. G. Papanikas
More informationAnalysis on Retrospective Cardiac Disorder Using Statistical Analysis and Data Mining Techniques
Intenational Jounal of Applied Engineeing Reseach ISSN 0973-456 Volume 1, Numbe 17 (017) pp. 6778-6787 Analysis on Retospective Cadiac Disode Using Statistical Analysis and Data Mining Techniques Jyotismita
More informationMeasurement uncertainty of ester number, acid number and patchouli alcohol of patchouli oil produced in Yogyakarta
Measuement uncetainty of este numbe, acid numbe and patchouli alcohol of patchouli oil poduced in Yogyakata Reni Banowati Istiningum, Azis Saepuloh, Widatul Jannah, and Didit Waskito Aji Citation: AIP
More informationEffect of Hydroxymethylated Experiment on Complexing Capacity of Sodium Lignosulfonate Ting Zhou
3d Intenational Confeence on Mateial, Mechanical and Manufactuing Engineeing (IC3ME 15) Effect of Hydoxymethylated Expeiment on Complexing Capacity of Sodium Lignosulfonate Ting Zhou School of Nuclea Technology
More informationA Brain-Machine Interface Enables Bimanual Arm Movements in Monkeys
BRIN-MHINE INTERFES Bain-Machine Inteface Enables Bimanual m Movements in Monkeys Pete J. Ifft, 1,2 Solaiman Shoku, 2,3 Zheng Li, 2,4 Mikhail. Lebedev, 2,4 Miguel. L. Nicolelis 1,2,4,5,6 * Bain-machine
More informationCausal Beliefs Influence the Perception of Temporal Order
ausal eliefs Influence the Peception of Tempoal Ode Philip M. Fenbach (philip_fenbach@bown.edu) Peston LinsonGenty (peston_linsongenty@bown.edu) Steven. Sloman (steven_sloman@bown.edu) own Univesity, Depatment
More informationWhy do we remember some things and not others? Consider
Attention pomotes episodic encoding by stabilizing hippocampal epesentations Maiam Aly a,1 and Nicholas B. Tuk-Bowne a,b a Pinceton Neuoscience Institute, Pinceton Univesity, Pinceton, NJ 08544; and b
More informationF1 generation: The first set of offspring from the original parents being crossed. F2 generation: The second generation of offspring.
Padon the Punnett By: Nancy Volk The Punnett Squae This module stems fom the wok of the Austian Monk, Gego Mendel, the fathe of genetics. In the mid-1800s Mendel studied the pattens of inheitance of physical
More informationTest Retest and Between-Site Reliability in a Multicenter fmri Study
Human Bain Mapping 29:958 972 (2008) Test Retest and Between-Site Reliability in a Multicente fmri Study Lee Fiedman, 1 * Hal Sten, 2 Gegoy G. Bown, 3 Daniel H. Mathalon, 4 Jessica Tune, 1 Gay H. Glove,
More informationCH 11: Mendel / The Gene. Concept 11.1: Mendel used the scientific approach to identify two laws of inheritance
CH 11: Mendel / The Gene What genetic pinciples account fo the passing of taits fom paents to offsping? The blending hypothesis is the idea that genetic mateial fom the two paents blends togethe (the way
More informationPrevalence and Correlates of Diabetes Mellitus Among Adult Obese Saudis in Al-Jouf Region
Wold Jounal of Public Health 2017; 2(2): 81-88 http://www.sciencepublishinggoup.com/j/wjph doi: 10.11648/j.wjph.20170202.14 Pevalence and Coelates of Diabetes Mellitus Among Adult Obese Saudis in Al-Jouf
More informationChasing the AIDS Virus
doi:10.1145/1666420.1666440 With no HI vaccine in sight, viologists need to know how the vius will eact to a given combination dug theapy. by Thomas Lengaue, Andé Altmann, Alexande Thielen, and Rolf Kaise
More informationJournal of Applied Science and Agriculture
Jounal of Applied Science and Agicultue, 9(1) Januay 2014, Pages: 171-176 AENSI Jounals Jounal of Applied Science and Agicultue ISSN 1816-9112 Jounal home page: www.aensiweb.com/jasa/index.html The Relationship
More informationBEFORE PRACTICE BE PROACTIVE
EMERGENCY ACTION PLAN BEFORE PRACTICE BE PROACTIVE Equipment Field Conditions Roste Weathe Conditions Fist Aid Kit fo Supplies Athletes (if applicable) that they have thei inhale o EpiPen Emegency Action
More informationNumerical Investigations of Open-water Performance of Contra-Rotating Propellers
Poceedings of the Twenty-seventh (2017) Intenational Ocean and Pola Engineeing Confeence San Fancisco, CA, USA, June 25-30, 2017 Copyight 2017 by the Intenational Society of Offshoe and Pola Enginees (ISOPE)
More informationNadine Gaab, 1,2 * John D.E. Gabrieli, 1 and Gary H. Glover 2 INTRODUCTION. Human Brain Mapping 28: (2007) r
Human Bain Mapping 28:703 720 (2007) Assessing the Influence of Scanne Backgound Noise on Auditoy Pocessing. I. An fmri Study Compaing Thee Expeimental Designs with Vaying Degees of Scanne Noise Nadine
More informationStructural Safety. Copula-based approaches for evaluating slope reliability under incomplete probability information
Stuctual Safety 52 (2015) 90 99 Contents lists available at ScienceDiect Stuctual Safety jounal homepage: www.elsevie.com/locate/stusafe Copula-based appoaches fo evaluating slope eliability unde incomplete
More informationBy: Charlene K. Baker, Fran H. Norris, Eric C. Jones and Arthur D. Murphy
Childhood Tauma and Adulthood Physical Health in Mexico. By: Chalene K. Bake, Fan H. Nois, Eic C. Jones and Athu D. Muphy C.K. Bake, F.H. Nois, E.C. Jones and A.D. Muphy. Childhood Tauma and Adulthood
More informationAdvanced Placement Psychology Grades 11 or 12
Office of Cuiculum & Instuction Advanced Placement Psychology Gades 11 o 12 ABSTRACT The pupose of AP Psychology is to intoduce students to the systematic and scientific study of the behavio and mental
More informationJoint Iterative Equalization and Decoding for 2-D ISI Channels
Joint Iteative Equalization and Decoding fo 2-D ISI Channels Joseph A. O Sullivan, Naveen Singla, Yunxiang Wu, Ronald S. Indec Electonic Systems and Signals Reseach Laboatoy (ESSRL) Magnetics and Infomation
More informationIn addition to the threat of high morbidity
HEALTH SEVICES Hospital capacity and management pepaedness fo pandemic influenza in Victoia Ben Dewa, 1 Ian Ba, 2 Piscilla obinson 1 In addition to the theat of high mobidity and motality, influenza pandemics
More informationpneumonia from the Pediatric Clinic of the University of Padua. Serological Methods
THE YALE JOURNAL OF BIOLOGY AND MEDICINE 56 (1983), 517-521 Seodiagnosis of M. pneumoniae Infections by Enzyme- Linked Immunosobent Assay (ELISA) FRANCO BUSOLO, M.D., AND GIOVANNI ANTONIO MELONI, M.D.
More informationProtecting Location Privacy: Optimal Strategy against Localization Attacks
Potecting Location Pivacy: Optimal Stategy against Localization Attacks Reza Shoki, Geoge Theodoakopoulos, Camela Toncoso, Jean-Piee Hubaux, and Jean-Yves Le Boudec LCA, EPFL, Lausanne, Switzeland, ESAT/COSIC,
More informationChapter 16. Simple patterns of inheritance
Chapte 16 Simple pattens of inheitance 1 Genotpe and phenotpe 1) Allele A vaiant fom of a gene (e.g., Height of pea plant : tall, shot) 2) Genotpe -Genetic composition of individual -Homozgous (an individual
More informationElectronic Supplementary Information
Electonic upplementay Mateial (EI) fo Geen Chemisty. This jounal is The Royal ociety of Chemisty Electonic upplementay Infomation Cack healing and eclaiming of vulcanized ubbe by tiggeing eaangement of
More informationAdaptive and Context-Aware Privacy Preservation Schemes Exploiting User Interactions in Pervasive Environments
Adaptive and Context-Awae Pivacy Pesevation Schemes Exploiting Use Inteactions in Pevasive Envionments Gautham Pallapa*, Maio Di Fancesco t *, and Sajal K. Das* *Cente fo Reseach in Wieless Mobility and
More informationCHAPTER 6 TRACE ELEMENTAL ANALYSIS IN EPILEPTIC CHILDREN
CHAPTE 6 TACE ELEMENTAL ANALYSIS IN EPILEPTIC CHILDEN 6.1 Intoduction 6.2 eview of the Liteatue 6.3 Mateials and Method 6.4 esults 6.5 Discussion 6.6 Conclusion 119 6.1 Intoduction The object of the pesent
More informationCoupling of Substructures for Dynamic Analyses
Coupling of Substuctues fo Dynamic Analyses Roy Caig, Mevyn Bampton To cite this vesion: Roy Caig, Mevyn Bampton. Coupling of Substuctues fo Dynamic Analyses. AAA Jounal, Ameican nstitute of Aeonautics
More informationM.S.C.E., E.I.T, Staff geotechnical engineer at URS Corp.
TWO DIMENSIONAL MODEL STUDY ON INFILTRATION CONTROL AT A LATERAL PIPE JOINT USING ACRYLAMIDE GROUT H. Gukan Ozguel 1, H. A. González 2 and C. Vipulanandan 3, Membe, ASCE ABSTRACT One of te callenges faced
More informationAcademic Flow and Cyberloafing. Listyo Yuwanto. Universitas Surabaya (UBAYA), East Java, Indonesia
Psychology Reseach, Ail 2018, Vol. 8, No. 4, 173-177 doi:10.17265/2159-5542/2018.04.006 D DAVID PUBLISHING Academic Flow and Cybeloafing Listyo Yuwanto Univesitas Suabaya (UBAYA), East Java, Indonesia
More informationReliability and Validity of the Korean Version of the Cancer Stigma Scale
ORIGINAL ARTICLE ISSN (Pint) 2005-3673 ISSN (Online) 2093-758X J Koean Acad Nus Vol.47 No.1, 121 Reliability and Validity of the Koean Vesion of the Cance Stigma Scale So, Hyang Sook 1 Chae, Myeong Jeong
More informationIndependent secretion of different digestive enzymes by the pancreas
HCl AMERICAN JOURNAL OF PHYSIOLOGY Vol. 231, No. 6, Decembe 1976. Pinted in U.S.A. Independent secetion of diffeent digestive enzymes by the panceas S. S. ROTHMAN Depatment of Physiology, Univesity of
More informationThe Neural Signature of Phosphene Perception
Human Bain Mapping 31:1408 1417 (2010) The Neual Signatue of Phosphene Peception Paul C.J. Taylo, 1,2 * Vincent Walsh, 2,3 and Matin Eime 1 1 School of Psychology, Bikbeck College, London WC1E 7HX, United
More informationThe number and width of CT detector rows determine the
Iodinated Contast Opacification s in Nomal Coonay Ateies Imaged With Pospectively ECG-Gated Single Heat Beat 320-Detecto Row Computed Tomogaphy Michael L. Steigne, MD; Dimitios Mitsouas, PhD; Amanda G.
More informationVIII. FOOD AND llutrielfl' COMPOSITION OF SBP MEALS
VIII. FOOD AND llutrielfl' COMPOSITION OF SBP MEALS This chapte pesents esults of the analysis of data gatheed in the on-site meal obsevations. The analysis examines the food and nutient composition of
More informationPEKKA KANNUS, MD* Downloaded from at on April 8, For personal use only. No other uses without permission.
0196-6011/88/1003-0097$02.00/0 THE OURNAL OF ORTHOPAEDIC AND SPORTS PHYSICAL THERAPY Copyight 0 1988 by The Othopaedic and Spots Physical Theapy Sections of the Ameican Physical Theapy Association Peak
More informationInternally-headed relative clauses in sign languages
a jounal of Glossa geneal linguistics Wilbu, Ronnie. 2017. Intenally-headed elative clauses in sign languages. Glossa: a jounal of geneal linguistics 2(1): 25. 1 34, DOI: https://doi.og/10.5334/gjgl.183
More informationDistress is an unpleasant experience of an emotional,
Featue Aticle Distess Assessment: Pactice Change Though Guideline Implementation Cayl D. Fulche, MSN, APRN, BC, and Tacy K. Gosselin-Acomb, RN, MSN, AOCN Most nuses agee that incopoating evidence into
More informationThe Effects of Rear-Wheel Camber on Maximal Effort Mobility Performance in Wheelchair Athletes
Taining & Testing 199 The Effects of Rea-Wheel Cambe on Maximal Effot Mobility Pefomance in Wheelchai Athletes Authos B. Mason 1, L. van de Woude 2, K. Tolfey 1, V. Goosey-Tolfey 1 Affiliations 1 Loughboough
More informationLifespan Psychology. Chapter 3 Biology of Development. Outline. Infertility. Infertility/Reproductive technologies. Heredity/DNA/Genes
Lifespan Psychology Chapte 3 Biology of Development 1 Outline Infetility/Repoductive technologies Pobabilities Fetility ypoblems and teatments Legal and ethical issues Adoption Heedity/DNA/Genes 2 Infetility
More informationRenal Tubular and Vascular Urea Transporters: Influence of Antidiuretic Hormone on Messenger RNA Expression in Brattleboro Rats
J Am Soc Nephol 9: 1359-1366. 1998 Renal Tubula and Vascula Uea Tanspotes: Influence of Antidiuetic Homone on Messenge RNA Expession in Battleboo Rats DOMINIQUE PROMENEUR, USE BANKIR, MING-CHANG HU, and
More informationThe Impact of College Experience on Future Job Seekers Diversity Readiness
Intenational Jounal of Humanities and Social Science Vol. 3 No. 3; Febuay 2013 The Impact of College Expeience on Futue Job Seekes Divesity Readiness FELICE A. WILLIAS Louisiana State Univesity - Shevepot
More informationRelationship of Mammographic Parenchymal Patterns with Breast Cancer Risk Factors and Risk of Breast Cancer in a Prospective Study
Intenational Jounal of Epidemiology Intenational Epidemiological Association 1990 Vol. 19, No. 2 Pinted in Geat Bitain Relationship of Mammogaphic Paenchymal Pattens with Beast Cance Risk Factos and Risk
More informationAbstract. Background and objectives
Poceedings - 7th Intenational Wokshop on Biological Effects of EMF - Octobe 01 (Malta) ISBN: 978-99957-0-361-5 MORPHOLOGICAL TRANSFORMATIONS OF HUMAN CANCER CELLS AND MICROTUBULES CAUSED BY FREQUENCY SPECIFIC
More informationGLOBAL PARTNERSHIP FOR YOUTH EMPLOYMENT. Testing What Works. Evaluating Kenya s Ninaweza Program
GLOBAL PARTNERSHIP FOR YOUTH EMPLOYMENT Testing What Woks in Youth Employment: Evaluating Kenya s Ninaweza Pogam VOLUME 2: Appendices APRIL 2013 acknowledgements This epot was pepaed fo IYF by Thomaz Alvaes
More informationLow-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study
Jounal of Athletic Taining 24;39(3):223 229 by the National Athletic Taines Association, Inc www.jounalofathletictaining.og ow-evel Theapy Facilitates Supeficial Healing in Humans: A Tiple-Blind, -Contolled
More informationThe Engagement of Mid-Ventrolateral Prefrontal Cortex and Posterior Brain Regions in Intentional Cognitive Activity
Human Bain Mapping 29:107 119 (2008) The Engagement of Mid-Ventolateal Pefontal Cotex and Posteio Bain Regions in Intentional Cognitive Activity Anja Dove, 1 Tom Manly, 1 Russell Epstein, 2 and Adian M.
More informationPredictors of Maternal Identity of Korean Primiparas
J Koean Acad Nus Vol.4 No.6, 733-74 http://dx.doi.og/0.4040/jkan.20.4.6.733 Pedictos of Matenal Identity of Koean Pimipaas Chae, Hyun-Ju Song, Ju-Eun 2 Kim, Sue 3 Pat-time Lectue, College of Nusing, Sungshin
More informationCoach on Call. Thank you for your interest in When the Scale Does Not Budge. I hope you find this tip sheet helpful.
Coach on Call It was geat to talk with you. Thank you fo you inteest in. I hope you find this tip sheet helpful. Please give me a call if you have moe questions about this o othe topics. As you UPMC Health
More informationRadiation Protection Dosimetry, Volume II: Technical and Management System Requirements for Dosimetry Services. REGDOC-2.7.
Radiation Potection Dosimety, Volume II: Technical and Management System Requiements fo Dosimety Sevices REGDOC-2.7.2, Volume II Apil 2018 Dosimety, Volume II: Regulatoy document REGDOC-2.7.2, Volume II
More informationADAPTATION OF THE MODIFIED BARTHEL INDEX FOR USE IN PHYSICAL MEDICINE AND REHABILITATION IN TURKEY
Scand J Rehab Med 2000; 32: 87 92 ADAPTATION OF THE MODIFIED BARTHEL INDEX FOR USE IN PHYSICAL MEDICINE AND REHABILITATION IN TURKEY Ayse A. Küçükdeveci, 1 Günes Yavuze, 1 Alan Tennant, 2 Nuben Süldü,
More informationThe association between obesity and cardiac output (CO)
Relations of Stoke Volume and Cadiac Output to Body Composition The Stong Heat Study Taquin Collis, MD; Richad B. Deveeux, MD; May J. Roman, MD; Giovanni de Simone, MD; Jeun-Liang Yeh, PhD; Babaa V. Howad,
More informationSexual arousal and the quality of semen produced by masturbation
Human Repoduction vol.11 no.l pp.147-151, 1996 Sexual aousal and the quality of semen poduced by mastubation J.H.van Roijen 14 ' 5, A.K.Slob 4, W.L.Gianotten 2, G.R.Dohle 1 ' 3, A.T.M.van de Zon 2, J.T.M.Veebug
More informationCommissioning for Value Where to Look pack
Commissioning fo Value Whee to Look pack Suffolk and Noth East Essex - STP aea Decembe 2016 Neuological Apil 2016 Contents Intoduction to you Whee to Look pack Suppoting the STP pocess NHS RightCae and
More informationP states that is often characterized by an acute blood and
In Vivo Administation of Antibody to Inteleukin-5 Inhibits Inceased Geneation of Eosinophils and Thei Pogenitos in Bone Maow of Paasitized Mice By Donna M. Rennick, LuAnn Thompson-Snipes, Robet L. Coffman,
More informationEvaluation of the accuracy of Lachman and Anterior Drawer Tests with KT1000 ın the follow-up of anterior cruciate ligament surgery
Oiginal Aticle Jounal of Execise Rehabilitation 2016;12(4):363-367 Evaluation of the accuacy of Lachman and Anteio Dawe Tests with KT1000 ın the follow-up of anteio cuciate ligament sugey Beki Eay Kilinc
More informationS[NCE the publication of The Authoritarian
AUTHORITARIAN ATTITUDES AND PERSONALITY MALADJUSTMENT ARTHUR R. JENSEN 1 Institute of Psychiaty (Maudstey Hospital], Univesity of London S[NCE the publication of The Authoitaian Pesonality (2), the elationship
More informationCollaborative Evaluation of a Fluorometric Method for Measuring Alkaline Phosphatase Activity in Cow s, Sheep s, and Goat s Milk
Jounal of Food Potection, Vol., No., 00, Pages Copyight, Intenational Association fo Food Potection Collaboative Evaluation of a Fluoometic Method fo Measuing Alkaline Phosphatase Activity in Cow s, Sheep
More informationProbing feature selectivity of neurons in primary visual cortex with natural stimuli.
Pobing featue selectiity of neuons in pimay isual cotex with natual stimuli. T. Shapee -3, H. Sugihaa,3, A.V. Kugansky,3, S. Rebik,3, M. P. Styke -3 and K. D. Mille -3. Sloan-Swatz Cente fo Theoetical
More informationReal-Time fmri Using Brain-State Classification
Human Bain Mapping 28:1033 1044 (2007) Real-Time fmri Using Bain-State Classification Stephen M. LaConte,* Scott J. Peltie, and Xiaoping P. Hu Depatment of Biomedical Engineeing, Geogia Institute of Technology,
More informationFAST KINETIC MODELS FOR SIMULATING AMPA, NMDA, Zachary F. Mainen and Terrence J. Sejnowski*
2 FAST KINETIC MODELS FOR SIMULATING AMPA, NMDA, GABA A AND GABA B RECEPTORS Alain Destexhe, Zachay F. Mainen and Teence J. Sejnowski* The Salk Institute fo Biological Studies and The Howad Hughes Medical
More informationMicromethod for the Methyl Red Test
101 COWN, S. T. (1953). J. ga. M~CTOMO~. 9, 101-109. Micomethod fo the Methyl Red Test BY S. T. COWN National Collection of Type Cultues, Colindule venue, London, N.W. 9 SUMMRY: micomethod fo the methyl
More informationStacy R. Tomas, David Scott and John L. Crompton. Department of Recreation, Park and Tourism Sciences, Texas A&M University, USA
Managing Leisue 7, 239 250 (2002) An investigation of the elationships between quality of sevice pefomance, benefits sought, satisfaction and futue intention to visit among visitos to a zoo Stacy R. Tomas,
More informationABSTRACT I. INTRODUCTION. Perspective of the Study
26 IJSRSE Volume 2 Issue Pint ISSN : 5 Online ISSN : 44 hemed Sec: Engineeing and echnology Compaative Analysis of Clubfoot and Nomal Calf Muscle Activity Using Electomyogaphy A Case Study Humayun Mushtaq*,
More informationAppendix 1. Post - Chernobyl Thyroid Cancer in Ukraine
Appendix 1 Post - Chenobyl Thyoid Cance in Ukaine POST- CHERNOBYL THYROID CANCER IN UKRAINE. REPORT 1: Estimation of thyoid doses. 1 I. Likhtaov, 1 L. Kovgan, 1 S. Vavilov, 1 M. Chepuny, 2 A. Bouville,
More informationAntibodies to Saccharomyces cerevisiae in patients
Gut 1992; 33:171-175 Gastoenteology Unit, M H Giaffe C D Holdswoth and Univesity of Sheffield Medical School, Depatment of Clinical and Expeimental Micobiology, Royal Hallamshie Hospital, Sheffield A Clak
More informationPHARMACOKINETICS OF NEOSTIGMINE AND PYRIDOSTIGMINE IN MAN
PHARMACKINETICS F NESTIGMINE AND PYRIDSTIGMINE IN MAN Thesis submitted in accodance with the equiements of the Council fo National Academic Awads fo the Degee of Docto of Philosophy by Akba Dehghan, D.
More informationThe mystery of membrane organization: composition, regulation and roles of lipid rafts
The mystey of membane oganization: composition, egulation and oles of lipid afts Edinc Sezgin 1, Ilya Levental 2, Satyajit Mayo 3 and Chistian Eggeling 1 Abstact Cellula plasma membanes ae lateally heteogeneous,
More informationAlternative Methods of Insulin Sensitivity Assessment in Obese Children and Adolescents
Diabetes Cae Publish Ahead of Pint, published online Januay 17, 2008 Altenative Methods of Insulin Sensitivity Assessment in Obese Childen and Adolescents Sophia M Rössne, MD, (1); Matin Neovius, PhD,
More informationDrug Resistants Impact on Tuberculosis Transmission
Dug Resistants Impact on Tubeculosis Tansmission SILVIA MARTORANO RAIMUNDO Univesidade de S ao Paulo Faculdade de Medicina Rua Teodoo Sampaio 115, S ao Paulo, SP BRASIL silviam@dim.fm.usp.b EZIO VENTURINO
More informationObjective Find the Coefficient of Determination and be able to interpret it. Be able to read and use computer printouts to do regression.
Section 3.C Objective Find the Coefficient of Detemination and be able to intepet it. Be able to ead and use compute pintouts to do egession. Relevance To be able to find a model to best epesent quantitative
More informationBSc in Public Health, Health Education and Health Promotion health center of Chenaran, Mashhad University of Medical Sciences, Mashhad, IR Iran
J Health Sci Technol. 2017 July;1(2):75-79. Published online 2017 July 28. Reseach Aticle Application of the Theoy of Planned Behavio to pedict lownutient junk food consumption among male students Elham
More informationRIGHT VENTRICULAR INFARCTION - CLINICAL, HAEMODYNAMIC, ECHOCARDIOGRAPHIC AND THERAPEUTIC CONSIDERATIONS
RIGHT VENTRICULAR INFARCTION - CLINICAL, HAEMODYNAMIC, ECHOCARDIOGRAPHIC AND THERAPEUTIC CONSIDERATIONS A T H Tan B L Chia B K H Ee M Choo SYNOPSIS Right venticula infaction complicating infaction of the
More information