Age-related reference ranges

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1 Authoriser: Peter Beresford Page 1 of 6 Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Both less than 14 days Both 14 days <1 year Both 1 9 years Both years M years M years M years M 19 + years F years F years F years F 19 + years Aspartate aminotransferase (AST) IU/L Both less than 6 weeks Both 6 weeks <1 year Both 1 2 years Both 3 5 years Both 6 11 years Both years Both 17+ years 10 35

2 Authoriser: Peter Beresford Page 2 of 6 Amino Acids (Plasma, umol/l) Gender Age <4 months Low High Both Taurine Both Aspartic Acid Both Threonine Both Serine Both Glutamic acid Both Glutamine Both Proline Both Glycine Both Alanine Both Cystine Both Valine Both Methionine Both Iso-Leucine Both Leucine Both Tyrosine Both Phenylalanine Both Ornithine Both Lysine Both Histidine Both Arginine Both Citrulline 5 63 Gender Age Child(>4m)/Adult Low High Both Taurine Both Aspartic Acid Both Threonine Both Serine Both Glutamic acid Both Glutamine Both Proline Both Glycine Both Alanine Both Cystine Both Valine Both Methionine 5 80 Both Iso-Leucine Both Leucine Both Tyrosine Both Phenylalanine

3 Authoriser: Peter Beresford Page 3 of 6 Both Ornithine Gender Age Child(>4m)/Adult Low High Both Lysine Both Histidine Both Arginine Both Citrulline Caeruloplasmin g/l F Less than 4m F 4-6m F 6-18m F 18m - 3y F 3-9y F 9-12y F 12-19y F 19+ years M Less than 4m M 4-6m M 6-18m M 18m - 3y M 3-9y M 9-12y M 12-19y M 19+ years Creatinine (serum) umol/l Both less than 2 weeks Both 2 weeks - <1 year Both 1-2 years Both 3-4 years Both 5-6 years Both 7-8 years Both 9-10 years Both 11 years Both 12 years 36 67

4 Authoriser: Peter Beresford Page 4 of 6 M 13 years M 14 years M 15 years M 16 years M 17+ years F 13 years F 14 years F 15 years F 16 years F 17+ years Free T3 pmol/l Both less than 6 days Both 6 13 days Both 14 days 16 years Both 16+ years Free T4 pmol/l Both less than 6 days Both 6 13 days Both 14 days 16 years Both 16+ years Galactitol umol/mmol creatinine Both less than 3 months 3 80 Both 3-12 months Both 1 year 6 22 Both 2-5 years 3 17 Both 6-14 years 2 10 Both 15+ years 2 4

5 Authoriser: Peter Beresford Page 5 of 6 Methylmalonic acid (Urine MMA) umol/mmol creatinine Both less than 1 year Both 1-16 years Both 16+ years Mucopolysaccharide screen: Urine Glycosaminoglycans (mg GAG/mmol creatinine) Gender Age Upper limit of normal B 0-6 months <30 B 6-12 months <26 B 1 2 years <21 B 3 4 years <14 B 5 7 years <11 B 8 15 years <9 B 16 years plus <3 Phenylalanine targets in PKU patients (bloodspots) umol/l Both up to 5 years Both 5-10 years Both 10+ years F Trying to conceive F Pregnant Phosphate mmol/l Both less than 1 month Both 1 12 months Both 1-15 years Both 16+ years

6 Authoriser: Peter Beresford Page 6 of 6 Potassium mmol/l Both less than 4 weeks Both 4 weeks 1 year Both 1 15 years Both 16+ years Triglycerides mmol/l Both less than 13 weeks Both 13 weeks 13 years Both 14+ years TSH mu/l Both less than 6 days Both 6 13 days Both 14 days 16 years Both 16+ years Urea mmol/l Both less than 28 days Both 28 days 1 year Both 1 15 years Both 16+ years Urate (Uric acid) umol/l M Less than 8 years M 8 10 years M years M 16+ years F Less than 8 years F 8 10 years F years F years F 50+ years

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