FRAMINGHAM HEART STUDY CODING MANUAL Metabolomics (Hilic - installment 1)
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1 FRAMINGHAM HEART STUDY CODING MANUAL Metabolomics (Hilic - installment 1) COHORT: Offspring TIME INTERVAL: Exam 5 DATASET NAME: l_mtbli1_ex05_1_0610s # OBSERVATIONS: 1075 High throughput metabolite profiling was performed on plasma specimens collected from individuals in the Framingham Offspring cohort attending Examination 5. This dataset includes measurements made on blood specimens (pre-ogtt) that were collected from a subset of the Offspring Cohort participants who attended Examination 5 (and were selected for inclusion in nested case-control studies of incident diabetes and cardiovascular disease). The concentration of plasma metabolites was assessed using a liquid chromatography / mass spectrometry (LC/MS) platform and HILIC method. In the dataset, each value represents the plasma concentration of an analyte (in this case, metabolite) that was assayed. These assays were run in installments. In order to get the complete dataset, this set needs to be combined with l_mtbli2_ex05_1_0660. The value ranges, number of observations and cohorts stated in this manual are based on the original dataset. In some cases, observations may be deleted due to participant consent form restrictions or cohort participation. If observations have been deleted from this dataset, the value ranges, number of observations or cohorts may differ from those stated in this manual. Page 1 of 8
2 IDTYPE Framingham Heart Study cohort identifier 1 = Offspring Cohort ID Framingham Heart Study participant ID number NOTE for ID: ID deleted - use SHAREID SHAREID Framingham Heart Study participant SHARe ID DM_PAIR Pair ID# assigned for diabetes case-control study, where cases were matched to controls based on propensity score (to within <0.10 score) = Not paired DM_CASE Diabetes case status (cases developed CVD within 12 years of follow up) 0 = control 1 = case. = neither case, nor matched control CVD_PAIR Pair ID# assigned for CVD case-control study, where cases were matched to controls based on Framingham Risk Score (to within 1 point) = Not paired CVD_CASE CVD case status (cases developed CVD within 12 years of follow up) 0 = control 1 = case. = neither case, nor matched control Page 2 of 8
3 RANDOM Randomly selected as additional control for the incident diabetes study 0 = No 1 = Yes CKD_CASE Chronic kidney disease case status (cases developed CKD within 8 years of follow up, as part of case-cohort study) 0 = No 1 = Yes CREATINE Creatine CREATININE Creatinine XANTHOSINE Xanthosine KYNURENIC_ACID Kynurenic Acid OH_ANTHRANILIC_ACID 3-OH-anthranilic Acid ANTHRANILIC_ACID Anthranilic Acid ALLANTOIN Allantoin Page 3 of 8
4 AMINOISOBUTYRIC_ACID Aminoisobutyric Acid BETAINE Betaine CHOLINE Choline DIMETHYLGLYCINE Dimethylglycine TRIMETHYLAMINE_N_OXIDE Trimethylamine-n-oxide CITRULLINE Citrulline ORNITHINE Ornithine CARNITINE Carnitine CIS_TRANS_HYDROZYPROLINE cis/trans-hydroxyproline GABA GABA Page 4 of 8
5 NMMA NMMA ALPHA_GLYCEROPHOSPHOCHOL Alpha-glycerophosphocholine GLYCEROL Glycerol N_CARBAMOYL_B_ALANINE n-carbamoyl_b_alanine NIACINAMIDE Niacinamide TAURINE Taurine THIAMINE Thiamine THYROXINE Thyroxine TRIIODOTHYRONINE Triiodothyronine Page 5 of 8
6 SEROTONIN Serotonin HIAA 5-HIAA ADENOSYLHOMOCYSTEINE 5'-adenosylhomocysteine ADMA ADMA SDMA SDMA ARGININOSUCCINATE Argininosuccinate CARNOSINE Carnosine COTININE Cotinine Page 6 of 8
7 ADENOSINE Adenosine ALANINE Alanine ASPARTATE Aspartate GLUTAMIC_ACID Glutamic Acid PHENYLALANINE Phenylalanine GLYCINE Glycine HISTIDINE Histidine ISOLEUCINE Isoleucine LYSINE Lysine LEUCINE Leucine Page 7 of 8
8 METHIONINE Methionine ASPARAGINE Asparagine PROLINE Proline GLUTAMINE Glutamine ARGININE Arginine SERINE Serine THREONINE Threonine VALINE Valine TRYPTOPHAN Tryptophan TYROSINE Tyrosine Page 8 of 8
1.E+07 1.E+07 1.E+07 8.E+06 6.E+06 4.E+06 2.E+06
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