ZIVAK TECHNOLOGIES. Multitasker-LC Walk Away UHPLC Analyzer For LC-MS/MS
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1 ZIVAK TECHNOLOGIES Multitasker-LC Walk Away UHPLC Analyzer For LC-MS/MS
2 Clinical Diagnostic Market Roche, Siemens,Midray Abbott, Beckman Currrent Clinical Diagnostic Market Immunoassay, ELISA, RIA,FIA Sciex, Agilent, Thermo Shimadzu, Waters.. Clinical Diagnosis with LC-MS/MS and HPLC Gold Standart Methods WHY?
3 2. False positive samples, when the results of the reference assay (LC-MS/MS-total-D) were less than 40 nmol/l but one or more of the immunoassays gave greater than or equal to 40 nmol/l. State-of-the-Art Vitamin D Assays: A Comparison of Automated Immunoassays with Liquid Chromatography Tandem Mass Spectrometry Methods Christopher-John L. Farrell,1,2 Steven Martin,1 Brett McWhinney,3 Isabella Straub,4 Paul Williams,5 and Markus Herrmann1,4* Clinical Chemistry 58: (2012)
4 NIST USA Traceability Report for Different Technics for Vit D2-D3 (Zivak 243A and 243B)
5 Limitations of HPLC and LC-MS/MS For Routine Clinical Use Roche, Siemens,Midray Abbott, Beckman Currrent Clinical Diagnostic Market Immunoassay, ELISA, RIA,FIA %95-97 FUTURE Ready to Use Analysis Kits Automation and Barcode Reading Walk-away HPLC and LC-MS/MS Analysers Sciex, Agilent, Thermo Shimadzu, Waters.. Clinical Diagnosis with LC-MS/MS and HPLC Gold Standart Methods %3-5
6 LC-MS/MS vs Immunoassay Advantages Disadvantages MS/MS methods High Specificity High Sensitivity Lower Kit Costs Multiplexing Measurements High Throughput Non-Automated Qualified staff required The need of rigorous kit validation Automated Barcode Reading Direct injection from Vacu tube Higher maintenance cost (20 K USD / year) Higher owner capital cost (200 K USD / device) Immunoassay Automated No need for qualified staff Validated kits Affordable prices Better traceability (barcode readers, Online LIS connection) Low Specificity Low Sensitivity Higher Kit Costs High Potential for interference
7 LC-MS/MS vs Immunoassay Advantages Disadvantages Zivak Multitasker Automated LC-MS/MS System High Specificity High Sensitivity Lower Kit Costs Multiplexing Measurements High Throughput Non-Automated Qualified staff required The need of rigorous kit validation Automated Barcode Reading Direct injection from Vacutube Online LIS connection Higher maintenance cost (20 K USD / year) Higher owner capital cost (200 K USD / device) Immunoassay Automated No need for qualified staff Validated kits Affordable prices Better traceability (barcode readers, Online LIS connection) Low Specificity Low Sensitivity Higher Kit Costs High Potential for interference
8 Turn Your LC-MS/MS Instrument into Walk Away Clinical Analyzer Roche, Siemens, Midray Abbott, Beckman Currrent Clinical Diagnostic Market Immunoassay, ELISA, RIA,FIA Sciex, Agilent, Thermo Shimadzu, Waters.. Clinical Diagnosis with LC-MS/MS and HPLC Gold Standart Methods
9 Zivak Multitasker-LC OUR VISION Each LC-MS/MS will need an automated sample prep LC Zivak Multitasker Full Automated Sample Preparation and Injection System
10 Multitasker - LC with TandemGold MS Turkey
11 Multitasker - LC with Shimadzu 8040 MS India
12 Multitasker LC with Sciex 4500 MS Italy
13 Multitasker - LC with Thermo TSQ MS South Korea
14 HB-100 New Design 2017 The New HBA1c Analyser 1,5 min analysis time for HbA1c and HbF 6,0 min analysis time for A1c, F, A0, A2, S, C, D, E Variants Real walk-away system with unique modules
15 Zivak NEW VD-200 D2-D3 Analyser UHPLC System World s only Walk-Away 25-OH Vitamin D2-D3 UHPLC-UV System April-2016
16 HPLC and LC/MS/MS Kits 16
17 Kit Test Times (sample prep. + run time) Psychoactive Drugs Urine LC-MS/MS Analysis Kit Amino Acid Biological Fluids LC-MS/MS Analysis Kit PKU Serum LC-MS/MS Analysis Kit PKU Dried Blood Spots LC-MS/MS Analysis Kit Organic Acid Urine LC-MS/MS Analysis Kit Neonatal Screening Dried Blood Spots LC-MS/MS Analysis Kit Immunosuppressant Whole Blood LC-MS/MS Analysis Kit VMA HVA 5-HIAA Urine LC-MS/MS Analysis Kit Catecholamines Urine LC-MS/MS Analysis Kit Metanephrine Urine LC-MS/MS Analysis Kit Neurotransmitters in Urine LC-MS/MS Analysis Kit 25-Hydroxyvitamin D2-D3 Serum LC-MS/MS APCIAnalysis Kit Total Homocysteine Serum LC-MS/-MS Analysis Kit Hemoglobin A1c Whole Blood HPLC Analysis Kit Hemoglobin Variant Whole Blood HPLC Analysis Kit PKU Serum HPLC Analysis Kit PKU Dried Blood Spots HPLC Analysis Kit 25-Hydroxyvitamin D2-D3 Serum HPLC Analysis Kit Vitamin A-E Serum HPLC Analysis Kit 25-Hydroxyvitamin D2-D3 Serum VD-200 UHPLC Analysis Kit 7 min 20 min 2 min 2 min 20 min 1.5 min 2 min 15 min 16 min 13 min 13 min 2 min 2.5 min 1.5 min 6.5 min 2 min 2 min 6 min 8 min 3 min
18 Matrix /IS Labeled Standarts,Controls and Calibrators. 18
19 Clinical HPLC Analysis Kits HbA1C in Whole Blood Hb Variant and ß-Thalassemia 25-OH Vitamin D2/D3 in Serum Phe, Tyr and Trp in Serum & Plasma and DBS
20
Distribuido en España por: INGENIERIA ANALITICA S.L Tel: Fax:
Distribuido en España por: INGENIERIA ANALITICA S.L Tel: +34 902.45.6677 Fax: +34 902.46.6677 www.ingenieria-analitica.com inf@ingenieria-analitica.com FUTURANAYSIS About Zivak UNIQUE SOLUTION FROM ONE
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All stocks and calibration levels were prepared in water: methanol (50:50) v/v to cover range of all steroid concentrations (refer Table 1).
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