Advanced Imaging Techniques MRI, PET, SPECT, ESI-MSI, DTI December 8, 2013
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1 Advanced Imaging Techniques MRI, PET, SPECT, ESI-MSI, DTI December 8, 2013 Robert C. Knowlton, MD, MSPH University of California San Francisco Seizure Disorders Surgical Program American Epilepsy Society Annual Meeting
2 Disclosure Name of Commercial Interest None Type of Financial Relationship NA American Epilepsy Society 2013 Annual Meeting
3 Learning Objectives Audience participants will be able to define stateof-the-art neuroimaging available to support epilepsy diagnosis and localization today. Audience participants will know that advanced imaging tools can be applied in their respective centers with existing and additional available resources. American Epilepsy Society 2013 Annual Meeting
4 Introduction / Roadmap MRI PET & SPECT Diagnostic Imaging Rules New Information? Image Registration and Processing Combining Imaging and Neurophysiology EEG / ESI MEG / MSI
5 Diagnostic MRI Lesional Partial Epilepsy (~56%) Primary Epilepsies Other + MRI - MRI - MRI +/- MRI Identified lesion or cause Cryptogenic
6 Diagnostic Accuracy Truth + - Test + a b - c d
7
8 Hippocampal Sclerosis (HS) Atrophy Hyperintensity Loss of internal architecture
9 MRI and TLE: Atypical HS End-folium sclerosis Isolated internal architecture disturbance
10 Hippocampal Internal Architecture Evaluating hippocampal internal architecture on MRI: Inter-rater reliability of a proposed scoring system. Ver Hoef et al. Epilepsy Research (2013) 106,
11 HIA Asymmetry and Surgical Outcome Concordant HIA Asym 0.5 Yes No Sz Free 5 7 Not Sz Free 1 6 Marginal Probability Odds Ratio: 4.2 p = : 272 Surgical Resections 148 Temporal lobe 84 HS+ MRI 44 other lesions 20 normal MRI 124 Extra-Temporal Paradoxical HIA Asym No Yes Sz Free 12 1 Not Sz Free 3 4 Marginal Probability Odds Ratio: 16 p = Predictive value of hippocampal internal architecture asymmetry in temporal lobe epilepsy. Ver Hoef et al. Epilepsy Research (2013) 106,
12 Tilt and Orientation
13 MRI and TLE: Besides HS Subtle parahippocampal abnormalities Hippocampal incomplete inversion (aka malrotation ) Temporal encephaloceles Hippocampal (choroidal fissure) cysts Temporal polar atrophy
14 The Parahippocampus
15 Hippocampal Malrotation diagnostic significance? Bajic et al. Incomplete hippocampal inversion Is there a relation to epilepsy? Eur Radiol (2009) 19:
16 Temporal Encephaloceles
17 Hippocampal Choroid Fissure Cysts
18 MRI and ExTLE: Detecting cryptic (occult) dysplasia Visual analysis Base of the sulcus abnormalities Surface visualization Curvilinear reformatting Beyond visual analysis Voxel based morphometry (VBM) Machine learning strategies White matter microabnormalities by DWI
19 Focal Cortical Dysplasia
20 Focal Cortical Dysplasia II
21 Focal Cortical Dysplasia III
22 PET Types / Ligands 2-[ 18 F]fluoro-2-deoxy-D-glucose (FDG) [ 11 C]flumazenil [ 11 C]methyl-L-tryptophan [ 18 F]FCWAY (5-HT 1a receptor ligand) R-[ 11 C]verapamil Optimal visualization / analysis Tilt and rotation correction MRI coregistration SPM analysis helpful
23 FDG-PET Neocortical FCD Detection
24 PET-MRI Coregistration Chassoux et al. FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias. Neurology (2010) 75:
25 MRI-PET Coregistration Salamon et al. FDG-PET / MRI Coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology (2008) 71:
26 PET-MRI Coregistration
27 PET-MRI Coregistration partial volume correction
28 Ictal SPECT Visualization and Difference Analysis Intensity normalization Image alignment (registration) Subtraction Coregistration to MRI SISCOM 1 versus SPM 2 techniques 1 Subtraction Ictal SPECT with Coregistration on MRI (SISCOM) 2 Statistical Parametric Mapping (SPM)
29 Ictal SPECT analysis with SPM Ictal-interictal SPECT analyzed by SPM (ISAS) Statistical ictal SPECT coregistered to MRI (STATISCOM)
30 SPM (STATISCOM) vs SISCOM 100% Sublobar Localization of TLE 90% 80% 70% 60% 50% 40% STATISCOM SISCOM 30% 20% 10% 0% Mesial Neocortical Indeterminate Total κappa Adapted from: Kazemi et al. Ictal SPECT statistical parametric mapping in temporal lobe epilepsy. Neurology (2010); 74:
31 SPM (ISAS) vs SISCOM McNally et al. Localizing value of ictal-interictal SPECT analyzed by SPM (ISAS). Epilepsia. 2005; 46: Paige et al. Comparison of Ictal SPECT Analysis Methods. AES Platform 2010
32 ISAS vs SISCOM B A SISCO M B C ISAS
33 ispect MRI + (large lesion)
34 EEG / MEG Source Localization (EEG / MEG Source Imaging) Improving pre intracranial EEG (ICEEG) hypothesis increase proportion of patients that can proceed to surgery TLE mesial versus lateral Delineate focal epileptogenic tissue amongst larger MRI abnormalities Increase detection of cryptic focal cortical dysplasia Prediction of ICEEG yield and surgery outcome
35 ESI / MSI Sublobar Localization
36 MEG Prediction of ICEEG Yield and Surgical Outcome Subdural grids and strips Minassian et al. Ann Neurol 1999, 46: n=11 ICEEG cases, 10/11 concordant ICEEG ictal onset Mamelak et al. J Neurosurg 2002, 97: n=23 ICEEG cases, 17 were localized, 11/17 (70%) had greater than 6 or more densely clustered spikes. RamachandranNair et al. Epilepsia 2007, 48: n=22 ICEEG children cases (MRI negative). MEG single clusters agree with localized ICEEG and surgical outcome.
37 MEG Prediction of ICEEG Yield and Surgical Outcome
38 MEG Prediction of ICEEG Yield and Surgical Outcome Stereo-electroencephalography (SEEG) Jung et al. Brain 2013: 136; N=21 MRI negative cases using volumetric imaging of spike source generators, unequivocal spikes in 17 (81%) MEG spike volume extent and ictal SEEG localization SEEG Localized MEG Yes No Loc 8 0 Lateralized 3 4 Non-localized 0 2 Total 11 6 Fisher's Exact p < 0.05
39 Nonlesional Epilepsy Imaging Optimal visualization is critical take control of image processing and confirm with your own visual analysis MRI scrutinize appropriate sequences for subtle, but established epileptogenic abnormalities; refrain from temptation to over-read. PET ignore all interpretation but your own. SPECT perform either ISAS or STATISCOM. ESI/MSI use your EEG expertise to interpret.
40 Impact on Clinical Care and Practice Extracting the maximum amount information from imaging tests may increase the proportion of patients that can proceed to epilepsy surgery. Many techniques for acquiring and extracting more information from established tests are available and can be implemented at most centers. Diagnostic accuracy and reliability of new tests / information should be confirmed before given much weight in clinical decision-making.
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