LEE S. MARCUS, MD, MS, FACC, FASPC

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1 Curriculum Vitae 307 E 63 rd Street (646) New York, NY drmarcus@pcny.nyc PROFESSIONAL EXPERIENCE President Preventive Cardiology of NY 07/2015-Present New York, New York Chief Medical Officer/ Arterial Health International 04/2016-Present Chair- MAB Atlanta, Georgia Medical Director/ Optimal Executive/Optimal Wellness Group 04/ /2015 Chief Science Officer New York, New York Editor in Chief Empowered Doctor 04/ /2015 New York, New York Director/Analyst Global Markets Intelligence-Healthcare 11/ /2014 IPREO, LLC New York, New York Medical Director CareCore Cardiology 09/ /2011 Bluffton, South Carolina Medical Director REVV Medical Diagnostic, PC 08/2009-Present Ronkonkoma, New York Cardiologist/ The Heart Center 07/ /2009 Board Member MEDICAL TRAINING Fellowship Yale University School of Medicine 07/ /1999 Yale-New Haven Hospital Nuclear Cardiology Fellowship Yale University School of Medicine 07/ /1998 Yale-New Haven Hospital Cardiovascular Medicine

2 C.V., Page Two Fellowship Columbia University 07/ /1996 Columbia-Presbyterian Medical Center Circulatory Physiology/ Congestive Heart Failure/ Cardiac Transplantation Chief Residency/ New York Medical College 07/ /1994 Residency Westchester Medical Center Internal Medicine EDUCATION Medical New York Medical College 06/1990 M.D. Undergraduate Muhlenberg College 06/1986 B.S. (Cum Laude) Natural Science; Philosophy Graduate Pace University- Lubin School of Business 05/2014 M.S. as Valedictorian- Finance LICENSURE AND CERTIFICATION M.D. New York State License 03/04/1992 Diplomate American Board of Internal Medicine 1998, 2008 Cardiovascular Disease- Certification and Recertification Certification Board of Nuclear 1999, 2009 Cardiology-Nuclear Cardiology Certification and Recertification American Board of Internal Medicine 1993 Internal Medicine-expired National Board of Medical Examiners 1991

3 C.V., Page Three AFFILIATIONS Fellow-American College of Cardiology Fellow-American Society for Preventive Cardiology American Medical Association Heart Failure Society of America National Lipid Association American Society of Nuclear Cardiology Trustee- CEO Trust New York State PBA State Police Surgeon LEADERSHIP POSITIONS HONORS AND AWARDS Credentials Committee- St. Francis Hospital Founder and Medical Director- Congestive Heart Failure Unit/ Congestive Heart Failure Program- Vassar Brothers Medical Center Director- Congestive Heart Failure Program- St. Francis Hospital Director- Nuclear Cardiology/ Radiation Safety Officer The Heart Center - Board President- Dutchess/ Ulster County Chapter- American Heart Association- Board Member- The Heart Center Beta Gamma Sigma Business Honor Society 2014 Listed in Castle Connolly America s Top Doctors New York State Patient's Choice Award (voted on by patients) 2008, 2009 Listed in Hudson Valley Magazine as One of the Top Physicians in the Hudson Valley Key Volunteer Service Award- Dutchess-Ulster Division American Heart Association Most Outstanding Resident Teaching Award 1991, 1992, 1993 New York Medical College

4 C.V., Page Four CURRENT CONSULTING POSITIONS Scientific Advisory Board Xablecath, Inc. Medical Advisory Board Cognate Nutritionals Medical Director NFL Alumni Association Wellness Challenge 07/2015- Present 06/2015- Present 07/2014- Present CONSULTANT AND LECTURER Gerson Lehrman Group St. Jude Medical Glaxo-Smithkline Astra-Zeneca Scios- Johnson & Johnson AtCor Medical BIBLIOGRAPHY/ORIGINAL PAPERS Marcus, LS: Hart, D; Packer, M; Katz, SD, et al: Hemodynamic and Renal Excretory effects of Human Brain Natriuretic Peptide Infusion in Patients with Congestive Heart Failure: A Double-Blind, Placebo- Controlled, Randomized Cross-Over Trial Circulation: 1996, 94: Sun, BC; Catanese, KA; Spanier, TB; Flannery, MR; Gardocki, MT; Marcus, LS; Levin, HR; Rose, EA; Oz, MC: 100 Long-Term Implantable Left Ventricular Assist Devices: The Columbia-Presbyterian Experience Annals of Thoracic Surgery, 1999;68: ABSTRACTS Marcus, LS; Pollack, BD; Corbisiero, R.; Blake, JW; Do Recovery ST-segment Changes Following Exercise Treadmill Testing Enhance Sensitivity and Predictive Value? Clinical Research; Oct. 1993;41:609 Marcus, LS; Yushak, M.; Medina, N; Katz, SD: Assessment of Pulmonary Vascular Reactivity with Human Brain Natriuretic Peptide: Comparison with Nitroprusside Journal of Heart and Lung Transplantation. 1996; 15:1pt2 S84 Goldstein, D; Choudri, A; Garfein, ES; Flannery, M.; Marcus, LS; Rose, EA; Oz, MC: Experience with Long Term LVAD Support: Implications for Permanent Use Journal of Heart and Lung Transplantation 1998; 17 (1):63 Russell, RR; Marcus, LS; Rife, F; Tamborlane, WV; Wackers, FJTh; Young, LH; Diminished Cardiac Response to Insulin Induced Hypoglycemia in Patients with Type I Diabetes: Diabetes

5 C.V., Page Five ADDITIONAL CLINICAL RESEARCH (Partial List) Effects of Insulin Induced Hypoglycemia on Left Ventricular Function and Autonomic Balance in Diabetic and Non-Diabetic Patients. (Yale University) Randomized Evaluation of Mechanical Assist Therapy in Congestive Heart Failure (REMATCH Trial) (Columbia University College of Physicians and Surgeons) Phase II Randomized Multicenter Trial of Twice Daily Deltaparin (Fragmin) versus Intravenous Heparin with Accelerated Infusion of rt-alteplase (Activase) in Acute Myocardial Infarction (ASSENT PLUS Study) Sub-investigator; Phase III, Randomized, Open Label Trial Evaluating the Efficacy and Safety of Reopro (Abciximab) in Combination with Reduced Dose Reteplase for Treatment of Acute Myocardial Infarction ( GUSTO IV MI Study) Sub-investigator; Multicenter, Double Blind Study Comparing the Efficacy and Safety of Long Term Treatment with Valsartan, Captopril and Their Combination in High Risk Patients after Myocardial Infarction (VALIANT Study) Sub-investigator; Candesartan Cilexitil in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM Study). Principal Investigator; Viagra in Congestive Heart Failure and CAD: A double blind, randomized, placebo controlled, parallel group, multicenter, flexible dose study to evaluate the efficacy and safety of Viagra, in males with erectile dysfunction. Principal Investigator; SYNERGY: A Prospective, Randomized, Open Label, Multicenter Study In Patients Presenting With Acute Coronary Syndromes (ACS) Protocol ENO.GMA.301. Sub-Investigator; ADVANCE MI: Protocol No : Addressing the Value of Primary Angioplasty After Combination Therapy or Eptifibatide Monotherapy In Acute Myocardial Infarction. Sub-Investigator; IMPACT STUDY: The IMPACT of Medical Subspecialty on Patient Compliance to Treatment with ADVICOR. Principle Investigator; 2002 STAMINA-HFP: Registry study of Anemia in a Heart Failure Population. Principle Investigator; 2003 ACUITY: A randomized comparison of Angiomax (bivalirudin) versus lovenox/clexane (enoxaparin) in patients undergoing early invasive management for acute coronary syndromes without ST- segment elevation. Sub-Investigator; EARLY-ACS: Early Glycoprotein IIa/IIIb inhibition in Non-ST segment Elevation Acute Coronary Syndrome: A randomized Trial Evaluating the Clinical Benefits of Early Front-Loaded Eptifbatide in the Treatment of Patients with Non-ST segment Elevation Acute Coronary Syndrome. Sub-Investigator;

6 C.V., Page Six JUPITER: Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin: A Randomized, Double Blind, Multicenter, Phase III Study of Rosuvastatin (Crestor) 20 mg in the Primary Prevention of cardiovascular Events Among Subjects with Low Levels of LDL- Cholesterol and Elevated Levels of C-Reactive Protein. Sub- Investigator; FUSION II: Follow-up Serial Infusions of Natrecor (nesiritide) for the Management of Patients with Heart Failure. Principle Investigator; TRIAL TO ASSESS CHELATION THERAPY (TACT): grant # 1 UO1 ATOO Study Sponsors: National Institutes of Health (NCCAM and NHLBI) Sub- Investigator; USE-BNP STUDY: Utilizing, Studying, Evaluating BNP for monitoring in subjects with heart failure. Sponsor: Siemens Medical Solutions Diagnostics. Principle Investigator; ASCEND-HF TRIAL: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure. Principle Investigator;

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