Visceral aneurysms: Technical options Coils, Plugs, Stents and liquid agents. Pierre P. GOFFETTE St-Luc University Hospital Brussels - Belgium
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1 Visceral aneurysms: Technical options Coils, Plugs, Stents and liquid agents Pierre P. GOFFETTE St-Luc University Hospital Brussels - Belgium
2 Pierre Goffette, M.D. Consultant/Advisory Board: Covidien (Neuro) and Terumo
3 Endovascular tools Coils (Plug) Framing Filling, expandable Detachable Bare stent Stent assistance Flow diversion Covered stents Liquids (NBCA-Onyx) Safer & Cheaper Onyx/NBCA FDS Balloon occlusion Adapted from Chiaradia M. Diag & Interventional Radiol 2015
4 Endovascular treatment options Saccular VAA Fusiform VAA VAA involving bifurcation Terminal Branches VAA Narrow neck Sac exclusion Large neck Stent/balloonassisted sac embo FDS Isolation Stent-graft (FDS+coils) False aneurysm Mycotic Isolation FDS Sac exclusion Free-flow embo + parent vessel embo Adapted from Vignali Claudio CIRSE 2008
5 Visceral /renal (pseudo)-aneurysms Literature from 2005 (series >15Pts) N VA (PA) Rupture Embol. Tech Prim TS % Pitton (2015) 45 (NA) 73% Coils/ NBCA/st-gft 93.3 Dohan (2014) 17 (17) 100% Coils/ gelfoam 94 Etezadi (2012) 41 (11) 32% Coils/gelf/thromb/st-gft 98 Spiliopoulos ( 12) 58 (37) 70% Coils 100 Ikeda (2010) 37 (37) ~70% Coils Isolation 89 Fankhauser ( 10) 185(119) 46% Coils/ Gelfoam/st-grt 98 Ikeda (2008) 22 (0) NA Coils (packing/isolation) 100 Tulsyan (2007) 48 (28) 37% Coils / NBCA 18% 98 Lagana (2006) 29 (7) 27% Coils/ NBCA/st-graft 100
6 Trapping technique Chronic pancreatitis - acute bleeding / shock Distal /proximal coiling: Micro Nester 2&3 mm
7 Male 44 yr old Alcoholic cirrhosis- Cx Pancreatitis Splenic pseudoaneurysm within pseudo-cyst Cobra C2 4 Fr 2 AVP IV 7 & 8mm
8 Narrow neck Packing technique 3D coils + Vortex/fiber/Azur (micro)-coils Additional glue-onyx to hasten thrombosis Contra-indicated for pseudoaneurysm Risk of compaction and recanalization?
9 JVIR 2013, 24(3): VAA Fup 37 MO Mean An size 19 cm Mean packing density 19 % Coil compaction 4%(46 Mo) Recanalisation 26%(24 Mo) Relationship packing density/coil compaction-recanalization P Minimal pack density Threshold value 24%
10 Balloon remodeling assisted coiling Compliant balloons: Scepter C & XC Eclipse Parent artery protection Wide-neck aneurysm Bi(tri)furcation aneurysm Packing density - µkt stability safety (small A.) Stent assisted coiling Jailing technique Coiling through struts Coiling techniques Sequential coiling and stenting
11 Balloon remodeling technique 3D Detachable coils Immediate Result 1 yr angio follow-up Passeo Prowler Plus µkt EV3 AXIUM coils (3X) AZUR µcoils (15x)
12 63 yr old female, Left hilum renal aneurysm Increased diameter over 6 months
13 63 yr old female, Left hilum renal aneurysm Enterprise Stent Neuro Coils Axium 3D (EV3) + Hydrocoils
14 Liquid embolic agents Advantages and Indications Single injection through small tortuous vessels Efficacy not affected by coagulopathy Rare for packing (Ratio NBCA/Ethiodol 1:1, 1:2) Additional tool after coiling Peristent aneurysmal flow through collaterals Careful use Spillage of glue NBCA (+ethiodol) Izaki K, JVIR 2011, 3: Kirby J, CVIR 2008, 31: Brox Jimenez A, Pancreas 2009, 38:
15 Acute necrotizing pancreatitis Massive upper GI bleeding and hemoperitoneum Coeliac trunc stenosis Glue embolization
16 Onyx for VAA exclusion Compatible balloon Onyx HD 34/500 Advantages over coils and glue Close conformation to the aneurysmal wall Very low rate of recanalization Accurate control of injection Indications Recurrence after primary coiling Primary embol of large an. bifucation an. Bratby CVIR 2006, Vanninen CVIR 2008, Güven CVIR 2009
17 Güven (CVIR 2009) Large SMA aneurysm completely filled with ONYX 500
18 Stent-Graft for VAA Author N (Rupt) Künzle S. (JVIR 2013) Boufi M et (J Vasc Surg 2011) Fankhauser (J Vasc Surg 2010) Pasklinsky (Vasc Endov S. 11) Rossi M. (CVIR 2008) 19(10) 10 (8) Type Jostent (coil 33%) Viabahn (2 in 2Pts) TS % 30d M F-up( Mo) Patency % 28 82% 80 20% Surg 10 (4) NR % 2 (2) 4 (1) Icast Fluency Jostent Adventa 100 0% % Pancr % % 5 & % % Aneur thromb. 92% 100% 100% 100% 100%
19 Stent-Graft for VAA Promising Overall Results (90-100%TS) Wall reconstruction (False-A, mycotic, Ehler-Danlos,..) Rare reperfusion (endoleaks) Asymptomatic delayed occlusion F-up by CTA Limitations Künzle S JVIR 2013 Landing zones, tortuous access, distal vessels Endoleaks (bi(tri)furcation) Long-term antiplatelets Künzle S et al JVIR 2013; 24: Rossi M et al. CVIR 2008;31:36-42.
20 Jostent GraftMaster 2 stainless steel stents + 1 extensible PTFE Balloon expandable PTFE expansion in one direction Monorail inch No shortening
21 FDS for Visceral aneurysm Multiple monolayer (FDS) vs Multilayer Silk (Balt) : SMA (Shlomovitz 2011) Pipeline (EV3): SAA (Abraham 2012) Cardiatis : most commonly used (Italian groups) Promising short-medium term results.. Preservation of side-branches Time to achieve complete thrombosis No strict correlation thrombosis / sac shrinkage Expensif
22 FDS for Visceral aneurysm Meyer C, CVIR 2011, 34:
23 Multilayer stent: Results Ruffino multicenter registry: Cardiatis stent - 19Pt J Endovasc Ther. 2012; 19: Primary patency 89% (1mo) Secondary patenccy 90,1% (1 yr) Side branch occlusion 0% Aneurysm thrombosis/shrinkage: 87%/75% No major adverse event Mortality rate 5.3%
24 CT (US)-guided percutaneous approach Failed/incomplete endovascular approach CT(Dyna CT) + Angio guidance (US for solid organs) 20-22G Chiba needle ( µkt) / 5frTeflon+µKt NBCA / Ethiodol (½ ¼) Onyx 34 Thrombin ( IU ) (µ)-coils Complications Parent artery embolization Rupture Chan R, CVIR 2004, 27: Ghassemi A, J Vasc Surg 2006,4 3: Nicholson JVIR 2007, 17:
25 Pancreatico-duodenal arcade aneurysm Day 3
26 Posterior percutaneous approach 22G Chiba 1.2 ml Thrombine Complete occlusion 3Day CT control
27 Take Home Messages Choice of emboli agent dictated by aneurysm origin & morphology and arterial access (Assisted)-Coiling techniques remains the most commonly used technique but limitations Stent-grafts and FDS are promising alternatives solutions in some anatomical conditions Percutaneous approach could be useful
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