The Role of TAVI in high-risk and normal-risk Patients
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1 The Role of TAVI in high-risk and normal-risk Patients Joachim Schofer Hamburg University Cardiovascular Center and Department for percutaneous treatment of structural heart disease Albertinen Heart Center
2 Disclosure Speaker name: Joachim Schofer, MD, PhD I have the following potential conflicts of interest to report: X Consulting of Direct Flow Medical
3 The typical TAVI patient? Old very old Frail very frail Lots of co-morbidities Prior CABG (poor LV function) Chronic kidney disease Severe COPD Peripheral arterial disease Chronic atrial fibrillation Cancer in remission But still enjoying life!
4 Who should not undergo TAVI? Lindman B et al., JACC CV Interv 2014
5 PARTNER Trial Inoperable Cohort B Kapadia, TCT 2014
6 Are surgical risk scores the key? Makkar RR et al., N Engl J Med 2012
7 Definition of Surgical Risk No universally accepted criteria which clearly separates risk categories Low Risk Intermediate Risk High Risk Extreme Risk VARC-2 Estimated 30 day (2012) 1 mortality <4% Estimated 30 day mortality 4-10% Estimated 30 day mortality >10% Est 30 day mortality >15% (very high risk) Est >50% irreversible morbidity or mortality (extreme risk) AHA/ ACC (2014) 2 Note: All bullets represent OR -STS <4% -with no additional risk indicators -STS 4-8% -1 Frailty index -1 Major Organ System compromised -Possible Procedure impediment -STS >8% - 2Frailty indices -2 Major Organ System compromised -Possible Procedure specific impediment -Predicted risk of death or major morbidity >50% at 1 y - 3 Major Organ System compromised -Severe Procedure impediment 1 Kappetein AP et al., J Am Coll Cardiol 2012; 60: Nishimura R et al., J Thorac Cardiovasc Surg 2014;148: e1-e132
8 TAVI in lower risk patients European Experience
9 TAVI in lower risk patients It s already happened! 1 Wenaweser, et al., Eur Heart J 2013; 34: ; 2 Lange, et al., J Am Coll Cardiol 2012; 59: 280-7; 3 Piazza, et al., J Am Coll Cardiol Intv 2013; 6: ; 4 D Errigo, et al., Int J Cardiol 2013: 167: ; epub; 5 Latib, et al., Am Heart J 2012; 164: 910-7; Schymik, et al., J Interv Cardiol 2012; 25:
10 TAVI Populations in Europe ~50% have logistic EuroSCORE <20% 100% 80% % of Patients 60% 40% 20% 0% UK (n=870) FRANCE 2 (n=3152) ADVANCE (n=1013) GARY (n=2582) Belgian Registry (n=579) log EuroSCORE <10 log EuroSCORE log EuroSCORE < 20 log EuroSCORE > 20 1 Moat, et al., J Am Coll Cardiol 2011; 58: ; 2 Gilard, et al., N Engl J Med 2012; 366: ; 3 Linke, et al., Eur Heart J 2014, [E-pub ahead of print], 4 Mohr, et al., Eur J Cardiothorac Surg 2014, [E-pub ahead of print], 5 Bosmans, et al., presented at EuroPCR 2012
11 Retrospective Risk-Stratification Lower risk patients have favorable outcomes
12 Propensity Matched Study TAVI vs. SAVR Piazza et al. J Am Coll Cardiol Interv 2013; 6:443-51
13 3666 patients enrolled TAVI 782 SAVR matched patients TAVI 405 SAVR patients excluded based on propensity scores TAVI 377 SAVR patients excluded based on STS score <3% and >8% 510 matched patients (STS scores 3-8%) TAVI 255 patients analyzed (Lost to follow-up 3) SAVR 255 patients analyzed (Lost to follow-up 8) Piazza et al. J Am Coll Cardiol Interv 2013; 6:443-51
14 Matched TAVI vs. SAVR STS 3-8% 30-day All-cause mortality 1-year All-cause mortality 7% 17% Piazza et al. J Am Coll Cardiol Interv 2013; 6:443-51
15 Similar outcomes between TAVI & SAVR in matched intermediate risk... STS (%, mean) Log EuroSCORE (%, mean) TAVI (n=255 ) Piazza 1 OBSERVANT 2 Latib 3 SAVR (n=255) p TAVI (n=133) SAVR (n=133) p TAVI (n=111) SAVR (n=111) na na Day Mortality (%) Piazza, et al. J Am Coll Cardiol Intv 2013; 6: D Errigo, et al. Int J Cardiol 2013; 167: Latib, et al. Am Heart J 2012; 164:910-7 p
16 TAVI in lower risk patients US Experience
17 TAVI Populations in the US Definition of Extreme and High risk is a moving target May 2007 July 2013 May 2007 July 2013
18
19 The PARTNER IIA Trial Study Design n = 2000 Randomized Patients Yes Operable (STS 4) ASSESSMENT: Transfemoral Access Symptomatic Severe Aortic Stenosis ASSESSMENT by Heart Valve Team No 2011 patients enrolled in 22 months! Transfemoral (TF) TF TAVR SAPIEN XT 1:1 Randomization VS Surgical AVR Transapical (TA) / TransAortic (TAo) TAVR: TA / TAo SAPIEN XT 1:1 Randomization VS Surgical AVR Mean STS ~6% ~75% TF access Primary Endpoint: All-Cause Mortality + Disabling Stroke at Two Years (Non-inferiority)
20
21 Conclusions I Lower risk patients are currently being treated (Europe > US), they may have other reasons not to undergo surgery Clinical outcomes in patients with lower surgical risk scores are excellent.
22 Conclusions II Offering TAVR to intermediate surgical risk patients is justified if performed within the confines of a Heart Team Although there are good reasons to believe that in normal risk patients TAVI compares favorable to surgery, the definite answer will come from the ongoing randomized trials (which, however, are using devices that are no longer used in Europe)
23 The Role of TAVI in high-risk and normal-risk Patients Joachim Schofer Hamburg University Cardiovascular Center and Department for percutaneous treatment of structural heart disease Albertinen Heart Center
Igor Palacios, MD Director of Interventional Cardiology Massachusetts General Hospital Professor of Medicine Harvard Medical School
Aortic Stenosis: Current State of Percutaneous Therapies, Emerging Technologies and Future Directions Igor Palacios, MD Director of Interventional Cardiology Massachusetts General Hospital Professor of
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