Selective Activation of the K ATP Channel Is a Mechanism by Which Sudden Death Is Produced by Low-Energy Chest-Wall Impact (Commotio Cordis)
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1 Selective Activation of the K ATP Channel Is a Mechanism by Which Sudden Death Is Produced by Low-Energy Chest-Wall Impact (Commotio Cordis) Mark S. Link, MD; Paul J. Wang, MD; Brian A. VanderBrink, BA; Erick Avelar, MD; Natesa G. Pandian, MD; Barry J. Maron, MD; N.A. Mark Estes III, MD Background Sudden death due to relatively innocent chest-wall impact has been described in young individuals (commotio cordis). In our previously reported swine model of commotio cordis, ventricular fibrillation (with T-wave strikes) and ST-segment elevation (with QRS strikes) were produced by 30-mph baseball impacts to the precordium. Because activation of the K ATP channel has been implicated in the pathogenesis of ST elevation and ventricular fibrillation in myocardial ischemia, we hypothesized that this channel could be responsible for the electrophysiologic findings in our experimental model and in victims of commotio cordis. Methods and Results In the initial experiment, 6 juvenile swine were given 0.5 mg/kg IV glibenclamide, a selective inhibitor of the K ATP channel, and chest impact was given on the QRS. The results of these strikes were compared with animals in which no glibenclamide was given. In the second phase, 20 swine were randomized to receive glibenclamide or a control vehicle (in a double-blind fashion), with chest impact delivered just before the T-wave peak. With QRS impacts, the maximal ST elevation was significantly less in those animals given glibenclamide ( mv) than in controls ( mv; P 0.004). With T-wave impacts, the animals that received glibenclamide had significantly fewer occurrences of ventricular fibrillation (1 episode in 27 impacts; 4%) than controls (6 episodes in 18 impacts; 33%; P 0.01). Conclusions In this experimental model of commotio cordis, blockade of the K ATP channel reduced the incidence of ventricular fibrillation and the magnitude of ST-segment elevation. Therefore, selective K ATP channel activation may be a pivotal mechanism in sudden death resulting from low-energy chest-wall trauma in young people during sporting activities. (Circulation. 1999;100: ) Key Words: ventricular fibrillation death, sudden chest trauma sports Sudden death may occur in young sports participants when a baseball or other projectile strikes the victim over the precordium, even in the absence of structural damage to the chest wall and heart. This phenomenon is termed commotio cordis, and it predominantly affects individuals aged 5 to 18 years without preexisting heart disease. 1,2 A 1996 United States Consumer Product Safety Commission report found 38 deaths from baseball blows to the chest between 1973 and In addition, commotio cordis has been reported in ice hockey, lacrosse, and softball and as the consequence of fistfights 1,4 7 ; indeed, it may be more common than initially believed. 8 Currently, the Commotio Cordis Registry (Minneapolis, Minn) has recorded 70 victims of commotio cordis. 2 In our previously described model of commotio cordis, 9 we observed ventricular fibrillation with 30-mph impacts occurring 15 to 30 ms before the peak of the T-wave. In addition, ST-segment elevation was produced by impacts on the QRS and ST segments. However, the cellular mechanisms responsible for these striking electrophysiological consequences of blunt chest impact are unknown. Because many of the profound electrophysiological consequences observed in our experimental model of commotio cordis are similar to those of myocardial ischemia, we hypothesized that the cellular mechanisms for ST-segment elevation and ventricular fibrillation in these 2 circumstances may also be comparable. The cardiac K ATP channel is normally inactive, 10 as it is inhibited by physiological concentrations of ATP. The opening of the channel is associated with a reduction in the cellular ATP/ADP ratio, such as occurs in myocardial ischemia. 11,12 It is thought that activation of this channel is responsible for the ST-segment elevation observed in myocardial ischemia Furthermore, activation of this channel increases the likelihood of ventricular fibrillation occurring during myocardial ischemia. 13,16 19 Glibenclamide is a sulfonylurea that primar- Received December 16, 1998; revision received March 15, 1999; accepted March 31, From the Cardiac Arrhythmia Service, New England Medical Center, Tufts University School of Medicine, Boston, Mass (M.S.L., P.J.W., B.A.V., E.A., N.G.P., N.A.M.E.), and the Cardiovascular Research Division, Minneapolis Heart Institute Foundation, Minneapolis, Minn (B.J.M.). Correspondence and Reprint Requests to Mark S. Link, MD, NEMC Box #197, New England Medical Center, 750 Washington Street, Boston, MA Mark.Link@es.NEMC.org 1999 American Heart Association, Inc. Circulation is available at 413
2 414 Circulation July 27, 1999 Figure 1. Laboratory and study design for swine commotio cordis model. Animal is positioned prone in sling and impact object (150 g, size and weight of regulation baseball), affixed to aluminum shaft 55 cm in length, was directed toward base of left ventricle (with echocardiographic guidance) over distance of 1 m at 30 mph. Gating to cardiac cycle was achieved with electrophysiologic stimulator triggered from surface electrocardiographic input. Velocity of impact object was measured by chronograph (Oehler Research) modified for low velocity. ily acts by blocking the K ATP channel Preventing K ATP channel activation with glibenclamide decreases the magnitude of ST-segment elevation 14,15 and the incidence of ventricular fibrillation in myocardial ischemia. 13,16 19 To test the hypothesis that abrupt mechanical activation of the K ATP channel may be a mechanism by which virtually instantaneous sudden death results from chest-wall impact, glibenclamide (a selective blocker of the K ATP channel) was administered to animals subsequently subjected to lowenergy chest-wall impact. Methods Juvenile domesticated swine, 4 to 8 weeks old and weighing 8 to 12 kg, were used in this study. The research protocol was approved by the Animal Research Committee of the New England Medical Center in conformity with the regulations of the Association for Assessment and Accreditation of Laboratory Animal Care. Animals were anesthetized with ketamine and isoflurane and intubated; intravenous catheters were placed; and an infusion of 5% dextrose was begun. A 5% solution of glibenclamide was constituted by dissolving 5 mg of glibenclamide in 1 ml of 1 mol/l NaOH, 1 ml of 70% ethanol, and 0.7 ml of dimethyl sulfoxide in 100 ml of normal saline. 17 After infusing the active agent, animals were placed prone in a sling to approximate physiological blood flow and cardiac hemodynamics (Figure 1). Chest-wall impact was produced by a spherical wooden object (150 g), identical in size and weight to a baseball, propelled at 30 mph. The impact object was directed, using echocardiographic guidance, to strike the animal perpendicular to the chest wall directly overlying the heart. In the first series of experiments, 0.5 mg/kg glibenclamide was administered intravenously to 6 animals, after which 1 to 3 chest impacts on the QRS segment of the cardiac cycle were delivered. The results of these experiments were compared with those previously performed without the prior administration of glibenclamide, in which 10 impacts were delivered to the QRS in 9 animals. 9 The maximum ST-segment elevation in both experimental groups was measured in the first 2 beats after chest impact (0.08 s after the J-point). In the second phase of the study, either the active agent (glibenclamide) or the control vehicle was administered to a total of 20 animals. Each animal received 1 to 3 chest impacts timed from 10 ms to 40 ms before the peak of the T-wave, a period vulnerable to the induction of ventricular fibrillation. 9 The peak of the T-wave was determined from a monophasic T-wave on either lead 1 or 2 on surface ECG. If ventricular fibrillation occurred, no further impacts were given. All laboratory personnel were blinded to the identity of the infused solution (active or control) except the laboratory technician responsible for administering it. Differences between groups of animals were analyzed with the unpaired Student s t test for continuous variables (ie, magnitude of ST elevation) and Fisher s Exact Test for nominal variables (eg, incidence of ventricular fibrillation). P 0.05 was considered significant. Results QRS Impacts The 6 glibenclamide-treated animals were subjected to 14 QRS impacts. At baseline (before each impact), ST segments were isoelectric (Figure 2). The mean post-impact STsegment elevation was mv (Table 1). In the 9 previously studied animals that were not given glibenclamide and received 10 QRS impacts, ST segment elevation was mv, more than 2-fold greater than the animals who were given glibenclamide (P 0.004). In both groups of animals, the maximum ST-segment elevation was present on the first beat after impact and decreased to baseline over the following 30 to 60 s, without development of Q-waves or T-wave abnormalities (Figure 2). In animals subjected to QRS impact, there were no differences between glibenclamide-treated and control animals with regard to the occurrence of transient heart block (3 of 14 [21%] versus 4 of 10 [40%]) or left bundle branch pattern (14 of 14 versus 9 of 10). Ventricular fibrillation did not occur with QRS impacts (Table 1). T-Wave Impact Ten animals received 0.5 mg/kg glibenclamide, and a total of 27 chest-wall blows were delivered on the upslope of the T-wave; ventricular fibrillation occurred with only 1 of the 27 impacts (4%; ie, in 10% of the animals) (Table 2 and Figure 3). Ventricular tachycardia or transient polymorphic ventricular tachycardia did not occur, and premature ventricular contractions were induced by the chest blow in all animals. In contrast, in the 10 animals who received the control solution, 18 chest blows delivered at the upslope of the T-wave produced 6 episodes of ventricular fibrillation (33%; ie, in 60% of the animals; P 0.01) and 2 episodes of nonsustained polymorphic ventricular tachycardia. In those impacts that did not result in ventricular fibrillation, no significant differences existed between glibenclamide-treated and control animals with respect to ST-segment elevation ( versus mv), bundle branch blocks (4 of 26 [15%] versus 3 of 12 [25%]), transient complete heart block (3 of 26 [12%] versus 2 of 12 [17%]), or isolated premature ventricular beats (26 of 26 [100%] versus 10 of 10 [100%]). Infusion of glibenclamide did not increase the QT interval (QTc was ms preglibenclamide versus ms postglibenclamide; P 0.26). The ST-segment elevation observed with T-wave impacts was not significantly different from that observed in our previously reported study ( mv). 9 Discussion Our swine model of chest impact related sudden death shares many similarities with the human phenomenon of commotio
3 Link et al K ATP Channel Activation With Chest Trauma 415 Figure 2. Six-lead ECG showing consequences of chest-wall impact (timed to QRS segment) with 150-g spherical object that was the size and weight of regulation baseball delivered at 30 mph. Top, In control animal, marked ST-segment elevation occurs instantaneously on first beat after chest impact. Bottom, Animal administered 0.5 mg/kg glibenclamide shows markedly attenuated ST-segment elevations. cordis, including the importance of impact location and velocity, difficulty with resuscitation, and absence of significant thoracic or cardiac injury. 9,23 In the present and previous studies, we showed that the initiation of ventricular fibrillation (and, thus, sudden death) with low-energy chest-wall blows is critically TABLE 1. Electrophysiological Consequences of Low-Energy Chest Impact During the QRS Segment, With and Without the Prior Administration of Glibenclamide dependent on the timing of the blow to a vulnerable portion of the cardiac cycle. 9 Ventricular fibrillation occurred instantaneously with 30-mph impacts just before the T-wave peak, and it was not preceded by intervening ventricular tachycardia, conduction abnormalities, or ischemic ST changes. Our obser- Electrophysiological Result Control* Group (9 animals; 10 impacts) Glibenclamide Group (6 animals; 14 impacts) P Ventricular fibrillation or polymorphic ventricular tachycardia ST-segment elevation, mv Left bundle branch block 9 (90%) 14 (100%) 0.41 Complete heart block 4 (40%) 3 (21%) 0.39 *Control animals were from a prior and previously reported experiment. 9
4 416 Circulation July 27, 1999 TABLE 2. Electrophysiological Consequences of Low-Energy Chest Impact During the Upslope of the T-Wave, With and Without the Prior Administration of Glibenclamide Electrophysiological Result Control Group (10 animals; 18 impacts) Glibenclamide Group (10 animals; 27 impacts) P Ventricular fibrillation 6 (33%) 1 (4%) 0.01 Polymorphic ventricular tachycardia 2 (11%) ST-segment elevation, mv * Bundle branch blocks 3 (25%)* 4 (15%) 0.66 Complete heart block 2 (17%)* 3 (12%) 0.64 *Data based on 12 chest impacts. Data based on 26 chest impacts. vations imply that the ventricular fibrillation produced by lowenergy chest blows is not secondary to coronary spasm, myocardial ischemia, hemorrhage, heart block, or ventricular tachycardia, but rather is a primarily electrical phenomenon. Nevertheless, the cellular mechanisms responsible for this electrical event are unknown. In experimental models of myocardial ischemia, STsegment elevation and ventricular arrhythmias are due, in Figure 3. Six-lead ECG showing consequences of chest impact timed to upstroke of T-wave peak with 150-g spherical object (size and weight of regulation baseball) delivered at 30 mph. Top, Control animal demonstrating ventricular fibrillation initiated instantaneously with impact. Bottom, Animal given 0.5 mg/kg glibenclamide demonstrates only initiation of premature ventricular contraction, but no ventricular fibrillation.
5 Link et al K ATP Channel Activation With Chest Trauma 417 part, to selective activation of the K ATP channel Blocking this channel with glibenclamide reduces these electrophysiologic effects of ischemia ,24,25 Because the STsegment elevation and ventricular fibrillation seen in our experimental model of commotio cordis are similar to those reported in myocardial ischemia, we hypothesized that these entities may share the same or similar cellular mechanisms. Therefore, to test the hypothesis that activation of the K ATP channel was involved in the profound electrophysiological consequences of modest chest-wall blows (including sudden cardiac death), we designed a double-blind study in which a selective blocker of the K ATP channel (glibenclamide) or a placebo was administered to swine before delivering a chest blow. Glibenclamide was chosen because its ability to block the K ATP channel has been well established. 20,21 Indeed, in our present experiment with low-energy chest-wall blows, the incidence of ventricular fibrillation was significantly reduced from 33% of impacts (60% of animals) in controls to only 4% of impacts (10% of animals) in glibenclamide-treated animals. These results suggest that it is the immediate mechanical activation of the K ATP channel by low-energy chest-wall impact that is, in part, responsible for the ventricular fibrillation seen in our experimental model and, by inference, in sudden death on the playing field in young athletes. Prominent ST-segment elevation was also produced in our model of commotio cordis, 9 and it has also been reported in a few survivors of commotio cordis. 5,26,27 We found that ST-segment elevation was most pronounced with QRS impacts, but it was observed with chest impacts throughout the cardiac cycle. 9 ST-segment elevations were most marked on the beat following the impact; then, they decayed and normalized over the next 30 to 60 s. In the present study, glibenclamide attenuated the ST-segment elevation observed with QRS impacts, substantiating our hypothesis that the K ATP channel is activated by mechanical trauma to the chest wall in commotio cordis. It is presently unresolved as to why ST-segment elevation was more pronounced with QRS strikes compared with T-wave strikes. 9 The present experiment provides convincing evidence that chest-wall impacts occurring on both T-wave and QRS segments result in activation of the K ATP channel (Figure 4). Whether this activation leads to ventricular fibrillation or to ST-segment elevation depends on the timing of the impact. As seen in our previous experiment, 9 only impacts that occurred during the vulnerable time period of repolarization caused ventricular fibrillation. That a vulnerable period for the initiation of ventricular fibrillation exists suggests that a second trigger or condition is necessary (in addition to K ATP channel activation) for ventricular fibrillation to result from a mechanical force such as a low-energy chest-wall blow. At the current time, this additional trigger or condition is unknown, but it is likely related to the dispersion of repolarization that is present during the vulnerable period of the cardiac cycle. We previously observed marked hemorrhage in the AV bundle and bundle branches in 1 of 2 animals with transient heart block induced by chest-wall impact, suggesting that direct trauma to the conduction system caused the manifestations of heart block. 9 In support of this theory, in the present Figure 4. Magnitude of ST-segment elevation and incidence of ventricular fibrillation induced by 30-mph chest-wall impacts by spherical object (size and weight of regulation baseball) in our experimental model of commotio cordis. Significant differences between control and glibenclamide-treated animals were observed in magnitude of ST-segment elevation with QRS strikes and in incidence of ventricular fibrillation with T-wave strikes. study, we found no difference in the incidence of heart block or left bundle branch block in the glibenclamide-treated or control animals. Thus, these observations, taken together, suggest that the left bundle branch block and transient heart block that was observed in our experiments is primarily a consequence of direct mechanical trauma rather than activation of the K ATP channel. In conclusion, in this experimental model of commotio cordis, glibenclamide significantly decreased the incidence of ventricular fibrillation and the magnitude of ST segment elevation. Therefore, direct mechanical activation of the K ATP channel seems to be an important cellular mechanism by which ventricular fibrillation occurs in commotio cordis. Acknowledgments Supported by a grant from The National Operating Committee on Standards for Athletic Equipment, Overland Park, Kansas. The opinions expressed herein are those of the authors and do not necessarily reflect the opinions of the committee. We are indebted to Darisse A. Paquette, CMI, for her assistance with the figures. References 1. Maron BJ, Poliac LC, Kaplan JA, Mueller FO. Blunt impact to the chest leading to sudden death from cardiac arrest during sports activities. N Engl J Med. 1995;333: Maron BJ, Link MS, Wang PJ, Estes NAM. Clinical profile of commotio cordis: an under-appreciated cause of sudden death in the young during sports and other activities. J Cardiovasc Electrophysiol. 1999;10: Adler P, Monticone RCJ. Injuries and deaths related to baseball. In: Kyle SB, ed. Youth Baseball Protective Equipment Project Final Report. Washington, DC: United States Consumer Product Safety Commission; 1996: Kaplan JA, Karofsky PS, Volturo GA. Commotio cordis in two amateur ice hockey players despite the use of commercial chest protectors: case reports. J Trauma. 1993;34: Abrunzo TJ. Commotio cordis, the single most common cause of traumatic death in youth baseball. Am J Dis Child. 1991;145: Dickman GL, Hassan A, Luckstead EF. Ventricular fibrillation following baseball injury. Phys Sport Med. 1978;6: Maron BJ, Strasburger JF, Kugler JD, Bell BM, Brodkey FD, Poliac LC. Survival following blunt chest impact induced cardiac arrest during sports activities in young athletes. Am J Cardiol. 1997;79: Curfman GD. Fatal impact-concussion of the heart. N Engl J Med. 1998;338:
6 418 Circulation July 27, Link MS, Wang PJ, Pandian NG, Udelson JE, Lee M-Y, Vecchiotti MA, Vanderbrink B, Mirra G, Bharati S, Maron BJ, Estes NAM. An experimental model of sudden death due to low energy chest wall impact (commotio cordis). N Engl J Med. 1998;338: Noma A. ATP-regulated K channels in cardiac muscle. Nature. 1983; 305: Hiraoka M. Pathophysiological functions of ATP-sensitive K channels in myocardial ischemia. Jpn Heart J. 1997;38: Isomoto S, Kurachi Y. Function, regulation, pharmacology, and molecular structure of ATP-sensitive K channels in the cardiovascular system. J Cardiovasc Electrophysiol. 1997;8: Bekheit S-S, Restivo M, Boutjdir M, Henkin R, Gooyandeh K, Assadi M, Khatib S, Gough WB, El-Sherif N. Effects of glyburide on ischemiainduced changes in extracellular potassium and local myocardial activation: a potential new approach to the management of ischemia-induced malignant ventricular arrhythmias. Am Heart J. 1990;119: Kubota I, Yamaki M, Shibata T, Ikeno E, Hosoya Y, Tomoike H. Role of ATP-sensitive K channel on ECG ST segment elevation during a bout of myocardial ischemia. Circulation. 1993;88: Kondo T, Kubota I, Tachibana H, Yamaki M, Tomoike H. Glibenclamide attenuates peaked T wave in early phase of myocardial ischemia. Cardiovasc Res. 1996;31: Kantor PF, Coetzee WA, Carmeliet EE, Dennis SC, Opie LH. Reduction of ischemic K loss and arrhythmias in rat hearts; effect of glibenclamide, a sulfonylurea. Circ Res. 1990;66: Lepran I, Baczko I, Varro A, Papp JG. ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats. J Pharmacol Exp Ther. 1996;277: Billman GE, Avendano CE, Halliwill JR, Burroughs JM. The effects of the ATP-dependent potassium channel antagonist, glyburide, on coronary blood flow and susceptibility to ventricular fibrillation in unanesthetized dogs. J Cardiovasc Pharmacol. 1993;21: Billman GE. Role of ATP sensitive potassium channel in extracellular potassium accumulation and cardiac arrhythmias during myocardial ischemia. Cardiovasc Res. 1994;28: Fosset M, De Weille JR, Green RD, Schid-Antomarchi H, Lazdunski M. Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K channels. J Biol Chem. 1988;263: Findlay I. Inhibition of ATP-sensitive K channels in cardiac muscle by the sulfonylurea drug glibenclamide. J Pharmacol Exp Ther. 1992;261: Babenko AP, Aguilar-Bryan L, Bryan J. A view of SUR/K IR 6.X, K ATP channels. Annu Rev Physiol. 1998; 60: Link MS, Wang PJ, Pandian NG, Lee M-Y, VanderBrink B, Avelar E, Maron BJ, Estes NAM. Resuscitation in a biological model of commotio cordis, sudden death from low energy chest wall impact. J Am Coll Cardiol. 1998;31:403A. Abstract. 24. Rees SA, Curtis MJ. Pharmacological analysis in rat of the role of the ATP-sensitive potassium channel as a potential target for antifibrillatory intervention in acute myocardial ischemia. J Cardiovasc Pharmacol. 1995;26: Baczko I, Lepran I, Papp JG. KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. Eur J Pharmacol. 1997;324: Morikawa M, Hirose K, Mori T, Kusukawa J, Tomioka N, Watanabe Y. Myocardial contusion caused by a baseball. Clin Cardiol. 1996;19: Link MS, Ginsburg SH, Wang PJ, Kirchhoffer JB, Estes NAM, Parris YM. Commotio cordis: cardiovascular manifestations of a rare survivor. Chest. 1998;114:
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