Material Safety Data Sheet

Transcription

1 Material Safety Data Sheet Issuing Date 25-Apr-2007 MSDS PN: REV. L 1. PRODUCT AND COMPANY IDENTIFICATION Product Name Product Code(s) Trade Name(s) Recommended Use Phenylisothiocyanate/n-Heptane , 40028N 5% PHENYLISOTHIOCYANATE IN N-HEPTANE; PITC REAGENT; PROTEIN SEQUENCER REAGENT R1 For research use only. Not for use in diagnostic procedures. Supplier Address APPLIED BIOSYSTEMS 850 LINCOLN CENTRE DRIVE FOSTER CITY CA USA TELEPHONE: (650) (USA) Emergency Telephone Number CHEMTREC: (INTERNATIONAL) (NORTH AMERICA) 2. HAZARDS IDENTIFICATION DANGER! Emergency Overview FLAMMABLE LIQUID AND VAPOR May be fatal if inhaled, absorbed through skin, or swallowed Irritating to eyes, respiratory system and skin Causes central nervous system depression May cause adverse liver effects May cause adverse kidney effects May cause adverse cardiovascular effects Appearance Colorless Physical State Liquid Odor Slight Potential Health Effects Principle Routes of Exposure Acute Toxicity Eyes Skin Inhalation Ingestion Chronic Effects Aggravated Medical Conditions Inhalation, Skin contact, Eye contact. Irritating to eyes. Irritating to skin. Irritating to respiratory system. May cause central nervous system depression with nausea, headache, dizziness, vomiting, and incoordination. Harmful if swallowed. Potential for aspiration if swallowed. Ingestion may cause irritation to mucous membranes. Repeated or prolonged skin contact may cause skin irritation and/or dermatitis and sensitization of susceptible persons. Central nervous system. Skin disorders. Allergies. Respiratory disorders. Page 1 / 8

2 Interactions with Other Chemicals Environmental Hazard Use of alcoholic beverages may enhance toxic effects. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. See Section 12 for additional Ecological information. 3. COMPOSITION/INFORMATION ON INGREDIENTS Chemical Name CAS-No Weight % Heptane (n-) Phenyl Isothiocyanate FIRST AID MEASURES General Advice Eye Contact Skin Contact Inhalation Ingestion Notes to Physician Protection of First-aiders In case of injury caused by fire: Flush with plenty of water immediately. Continue flushing during transport to hospital or medical center. Rinse thoroughly with plenty of water, also under the eyelids. Keep eye wide open while rinsing. Immediate medical attention is required. Wash off immediately with soap and plenty of water removing all contaminated clothes and shoes. If skin irritation persists, call a physician. Move to fresh air in case of accidental inhalation of vapors. If breathing is irregular or stopped, administer artificial respiration. If symptoms persist, call a physician. Immediate medical attention is required. Call a physician or Poison Control Center immediately. Rinse mouth. Drink 1 or 2 glasses of water. Never give anything by mouth to an unconscious person. Do not induce vomiting. Treat symptomatically. Remove all sources of ignition. Use personal protective equipment. 5. FIRE-FIGHTING MEASURES Flammable Properties HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Flash Point 4 C / 39 F Method Closed cup Suitable Extinguishing Media Explosion Data Sensitivity to mechanical impact Sensitivity to static discharge Water spray. Carbon dioxide (CO2). Foam. Dry chemical. Cool containers with flooding quantities of water until well after fire is out. None. Yes. Specific Hazards Arising from the Chemical Flammable. Vapors may travel to source of ignition and flash back. Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus and full protective gear. Page 2 / 8

3 NFPA Health Hazard 3 Flammability 3 Stability 0 Physical and Chemical Hazards - HMIS Health Hazard 3* Flammability 3 Stability 0 Personal Precautions - 6. ACCIDENTAL RELEASE MEASURES Personal Precautions Methods for Containment Methods for Cleaning Up Use personal protective equipment. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Prevent further leakage or spillage if safe to do so. Dam up. Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Pick up and transfer to properly labeled containers. Soak up with inert absorbent material. Other Information Refer to protective measures listed in Sections 7 and HANDLING AND STORAGE Handling Storage Wear personal protective equipment. Avoid contact with skin and eyes. Do not breathe vapors or spray mist. Keep away from open flames, hot surfaces and sources of ignition. Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapors). Use only in an area containing flame proof equipment. Keep containers tightly closed in a cool, well-ventilated place. Keep away from heat and sources of ignition. Keep in properly labeled containers. 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Exposure Guidelines Chemical Name ACGIH TLV OSHA PEL NIOSH IDLH Heptane (n-) TWA: 400 ppm STEL: 500 ppm TWA: 1600 mg/m 3 TWA: 400 ppm STEL: 2000 mg/m 3 STEL: 500 ppm TWA: 2000 mg/m 3 TWA: 500 ppm 750 ppm NIOSH IDLH: Immediately Dangerous to Life or Health Engineering Measures Personal Protective Equipment Eye/Face Protection Skin and Body Protection Respiratory Protection Hygiene Measures Showers, eyewash stations, and ventilation systems. Tightly fitting safety goggles. Face-shield. Wear fire/flame resistant/retardant clothing. Long sleeved clothing. In case of insufficient ventilation wear suitable respiratory equipment. When using, do not eat, drink or smoke. Wash hands and face before breaks and immediately after handling the product. Remove and wash contaminated clothing before re-use. Page 3 / 8

4 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Colorless. Odor Slight. Odor Threshold No information available. Physical State Liquid. ph No information available. Flash Point 4 C / 39 F Method Closed cup Autoignition Temperature Not applicable Decomposition Temperature No information available. Boiling Point/Range 98 C / 208 F Melting Point/Range No information available. Flammability Limits in Air Upper 6.7% Lower 1.05% Explosion Limits No information available. Specific Gravity 0.70 Water Solubility <1%. Solubility No information available. Evaporation Rate 4.3 (BuAc = 1) Vapor Pressure 46&25 Vapor Density 3.5 VOC Content >90% Viscosity No information available. Partition Coefficient (noctanol/water) No information available. 10. STABILITY AND REACTIVITY Stability Incompatible Products Conditions to Avoid Stable under recommended storage conditions. Strong oxidizing agents. Chlorinated compounds. Heat, flames and sparks. Excessive heat. Hazardous Decomposition Products Carbon monoxide (CO). Carbon dioxide (CO2). Sulfur oxides. Hazardous Polymerization Hazardous polymerization does not occur. 11. TOXICOLOGICAL INFORMATION Acute Toxicity Product Information Irritation. Product is harmful by inhalation. Irritating to skin. Vapors may cause drowsiness and dizziness. Chronic Toxicity Chemical Name LD50 Oral LD50 Dermal LC50 Inhalation Heptane (n-) 103 g/m 3 ( Rat ) 4 h Page 4 / 8

5 Chronic Toxicity Reproductive Toxicity Target Organ Effects Other Adverse Effects Repeated or prolonged skin contact may cause skin irritation and/or dermatitis and sensitization of susceptible persons. The product contains no substances known to be hazardous to health in concentrations which need to be taken into account. Central nervous system (CNS), Respiratory system, Skin. Aspiration risk: may cause lung damage if swallowed. 12. ECOLOGICAL INFORMATION Ecotoxicity Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Chemical Name Toxicity to Algae Toxicity to Fish Microtox Daphnia Magna (Water Flea) Heptane (n-) LC50= mg/l Cichlid fish EC50 > 10 mg/l 24 h 96 h Persistence and Degradability No product level data available. Chemical Name Log Pow Heptane (n-) DISPOSAL CONSIDERATIONS Waste Disposal Method Contaminated Packaging US EPA Waste Number This material, as supplied, is a hazardous waste according to federal regulations (40 CFR 261). Do not re-use empty containers. Dispose of in accordance with local regulations. D001 This product contains one or more substances that are listed with the State of California as a hazardous waste. Chemical Name Heptane (n-) California Hazardous Waste Status Toxic; Ignitable 14. TRANSPORT INFORMATION DOT TDG MEX Heptanes (Mixture),3,,PG HEPTANES,3,,PG,Mixture Proper Shipping Name Heptanos (Mixture) Page 5 / 8

6 14. TRANSPORT INFORMATION Heptanos,3,,Mixture ICAO IATA Heptanes,3,,PG,Mixture ERG Code 3H,Heptanes,3,PG,Mixture IMDG/IMO EmS No. F-E, S-D, Heptanes,3,PG,Mixture RID ADR Classification Code F1 Heptanes,3,,RID,Mixture ADR/RID-Labels 3 Classification Code F1 ADR/RID-Labels 3 ADN Classification Code F1 Heptanes,3, Hazard Labels 3 Limited Quantity 1 L Page 6 / 8

7 International Inventories 15. REGULATORY INFORMATION TSCA DSL EINECS/ELINCS ENCS CHINA KECL PICCS AICS Listed on inventory. For purposes of 40 CFR , this product is for Research and Development (R&D) Use Only. U.S. Federal Regulations SARA 313 Section 313 of Title I of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard Categories Acute Health Hazard Chronic Health Hazard Fire Hazard Sudden Release of Pressure Hazard Reactive Hazard Yes Yes Yes No No Clean Water Act This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR and 40 CFR ). CERCLA This material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this material. U.S. State Regulations California Proposition 65 This product does not contain any Proposition 65 chemicals. U.S. State Right-to-Know Regulations Chemical Name Massachusetts New Jersey Pennsylvania Illinois Rhode Island Heptane (n-) X X X X International Regulations Mexico - Grade Serious risk, Grade 3 Canada Chemical Name Carcinogen Status Exposure Limits Heptane (n-) Mexico: TWA= 1600 mg/m 3 Mexico: TWA= 400 ppm Mexico: STEL= 2000 mg/m 3 Mexico: STEL= 500 ppm Page 7 / 8

8 This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. WHMIS Hazard Class B2 Flammable liquid D2B Toxic materials 16. OTHER INFORMATION Issuing Date 25-Apr-2007 Revision Note No information available Disclaimer The information provided on this MSDS is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text. End of MSDS Page 8 / 8