University of Sulaimani School of Pharmacy Dept. of Pharmaceutics Third level - Second semester
|
|
- Lorin Cain
- 6 years ago
- Views:
Transcription
1 University of Sulaimani School of Pharmacy Dept. of Pharmaceutics Third level - Second semester 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 1
2 Outlines Why rectal or vaginal route? Suppository Types of suppository base Glyceride-type fatty bases Water-soluble bases. Manufacturing Vaginal drug delivery 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 2
3 Why rectal or vaginal route? The patient is not able to make use of the oral route (unconscious, nausea). The drug under is not well suited for oral administration (acid sensitive, first pass effect) Where localized treatment of either the rectum or vagina is required. Drawback These routes are generally disliked by patients 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 3
4 Rectal drug delivery Local action: This is desired or the local treatment of pain and itching, mostly due to the occurrence of hemorrhoids (painful, swollen veins in the lower part of the rectum and anus). Antiseptics, local anesthetics, vasoconstrictors, anti-inflammatory and laxatives. Systemic action: Anti-asthmatic, anti-inflammatory and analgesic drugs Diagnostic purpose 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 4
5 Absorption of drugs from rectum Rectum is part of the colon, forming the final cm of the GIT. The total volume of mucus is approx. 3 ml. ph is about 7.5 The lower and middle rectal (inferior and middle hemorrhoidal) veins drain into the interior vena cava the heart and general circulation. The upper rectal (superior hemorrhoidal) vein drains into the portal vein the liver the heart. Bioavailability will be low for certain drugs. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 5
6 Outlines Why rectal or vaginal route? Suppository Types of suppository base Glyceride-type fatty bases Water-soluble bases. Manufacturing Vaginal drug delivery 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 6
7 Suppositories Suppositories are the primary, dosage form used for the administration of drugs via the rectal route. They are single-dose preparations with a shape, volume and consistency appropriate for rectal administration. Others that should be inserted into body orifices like urethra is called bougies Rectal suppositories are usually about 1 4 g Cylindrical bullet shape. They contain one or more active substances dispersed or dissolved in a suit able base that may be soluble or dispersible in water or may melt at body temperature. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 7
8 Suppository cont. Depending on the character of its vehicle, a suppository will either dissolve in the rectal fluid or melt on the mucous layer. Dissolution of the complete vehicle will be difficult and requires extra water. Unpleasant sensation for the patient Absorption of drug from the rectum is primarily by passive diffusion The rate and extent of drug absorption is lower than the oral route 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 8
9 Outlines Why rectal or vaginal route? Suppository Types of suppository base Glyceride-type fatty bases Water-soluble bases. Manufacturing Vaginal drug delivery 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 9
10 Suppository base An ideal suppository vehicle or base should remain solid at room temperature and melt, dissolve or disperse at body temperature. It should be non-irritating, physically and chemically stable, and pharmacologically inert. It should be convenient to handle It should contract slightly on cooling to release itself from the mold with requiring mold lubricants Less leakage 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 10
11 Fatty base They are fully or semi-synthetic. Theobroma oil (also known as cocoa butter) a very commonly used base It melts at 30 C to 36 C It is no longer used because of its many disadvantages in practice, such: Its polymorphic behavior Insufficient contraction during cooling, Low softening point, Poor water absorptive power Expensive. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 11
12 Fatty base cont. Commercial examples include: Cotmar, Fattibase, Suppocire and Witepsol. These are mixtures of natural or synthetic vegetable oils and fatty alcohol. High hydroxyl number Less hydrophobic High hydroxyl number high melting point easier manufacturing 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 12
13 Water-soluble base Hydrophilic water-soluble (or miscible) vehicles are much less frequently used. A. Glycerinated gelatin is a mixture of glycerol, gelatin and water. The mixture forms a translucent, gelatinous mixture, dispersible in the rectum. A higher proportion of gelatin in the mixture makes it more rigid and longer acting. They are mostly used for laxative purposes They are hygroscopic and require well-closed containers 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 13
14 Water-soluble base cont. B. Polyethylene glycols (macrogol): They consist of mixtures of polyethylene glycols of different molecular weight. Their melting point is higher than body temperature e.g. PEG 8000 (60 C to 63 C). PEGs are miscible with water and release the drug by diffusion. They are hygroscopic uncomfortable sensation of the patient. Incorporation of 20% of water and moistening before insersion. Poloxamers (Pluronics) are water-soluble, copolymers with a wide range of uses 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 14
15 Drug release Suppository either dissolve or melt in the rectum. If the release from the dosage form is considered as the rate-limiting step. The tendency to remain in the base should be lowered as much as possible Solubility in Fat Low High Low water High Low Low Choice of the vehicle Fatty base Aqueous base Not determined 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 15
16 Outlines Why rectal or vaginal route? Suppository Types of suppository base Glyceride-type fatty bases Water-soluble bases. Manufacturing Vaginal drug delivery 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 16
17 Manufacturing Manufacturing the suppositories and pessaries are similar in both cases and involves: Melting of the vehicle Mixing the drug and the molten vehicle Dispensing the liquid into a shape former (molding) Cooling to solidify Packing in the final container. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 17
18 Manufacturing cont. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 18
19 Manufacturing cont. Depending on the formulation, suppository molds may require lubrication before the melt is poured to facilitate clean and easy removal of the molded suppositories Lubrication is not necessary when the base is cocoa butter or polyethylene glycol Lubrication is usually necessary with glycerinated gelatin 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 19
20 Outlines Why rectal or vaginal route? Suppository Manufacturing Vaginal drug delivery Pessaries Vaginal tablets Vaginal films Vaginal rings 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 20
21 Vaginal drug delivery Vaginal delivery is used for both local and systemic effects. Local effect Anti-infectives, like clotrimazole, miconazole, clindamycin. Contraceptive (spermicide) like nonoxynol-9 Hygiene and lubrication Drugs administered for local action in the cervico-vaginal area are not required to be absorbed. Systemic effect Drugs given by intravaginal route have a higher bioavailability compared to the oral route. E.g. oestrogens, progesterone and prostaglandin analogues 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 21
22 Vaginal drug delivery cont. Drugs designed for systemic action are absorbed by passive transport. Vaginal dosage forms include pessaries, liquids (vaginal solutions, emulsions, suspensions), semi-solids (creams, gels, ointments), solids (vaginal tablets, films, capsules and rings), spray and foams. Semi-solid formulations can serve dual purposes of providing medication as well as lubrication. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 22
23 Pessaries Pessaries are solid, single-dose preparations or vaginal insertion. Pessaries can be prepared in various shapes, usually ovoid Most often prepared with glycerol-gelatin bases Polyethylene glycols are less common, since they are said to promote irritation. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 23
24 Vaginal tablet Vaginal tablets are solid, single-dose preparations. Vaginal tablets can be prepared in various shapes, ovoid being the most popular Excipients are used to improve the disintegration of vaginal tablets, e.g. a bicarbonate together with an organic acid, which results in CO 2 release. A good filler for vaginal tablets is lactose 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 24
25 Vaginal films Vaginal films are thin layers of a polymeric material, which are designed to dissolve in the vaginal fluids and release the drug. Vaginal contraceptive film (VCF), containing nonoxynol-9 Itshould be inserted one an hour before sex Vagina should not be washed for at least 6 hour after sex. Both vaginal tablets and films can be designed to include bioadhesive polymers such as Carbopol and xanthan gum. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 25
26 Vaginal rings Vaginal rings offer the flexibility of controlled release of the drug over a prolonged period of time. An example of vaginal ring is NuvaRing, containing estrogen and progestin, used as a contraceptive. It should left in the vagina for three weeks Acts for one month. 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 26
27 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 27
Dr.N.Damodharan Professor and head Department of pharmaceutics SRM college of pharmacy
Dr.N.Damodharan Professor and head Department of pharmaceutics SRM college of pharmacy Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve
More informationSuppository Chapter Content
10 min SUPPOSITORY Suppository Chapter Content 1. Suppositories and Factors Affecting Drug Absorption 2. Ideal Suppository and Different Types of Bases 3. Methods of Suppository Manufacturing Suppository
More informationFunctional Excipients for Suppository Applications
Functional Excipients for Suppository Applications Skin Delivery Platform 2016 1 The Skin Delivery Platform Major areas of activity are in 4 pillars PLATFORM : SKIN DELIVERY Dermal Drug Delivery Mildness
More informationSuppositories. Suppositories: 08/10/2016
Suppositories Suppositories: Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. A suppositories
More informationRoutes of drug administration
Routes of drug administration Definition:- A route of administration in pharmacy is the path by which a drug is taken into the body. Classification:- The various routes of administrations are classified
More information13. SUPPOSITORY Suppository Bases. The active substance is prepared in a suitable bases. An ideal suppository bases should carry:
13. SUPPOSITORY They are solid single-dose preparations whose shapes, volumes and consistencies are suitable for rectal administration. There are also such vaginal preparations in the treatment of local
More informationPHARMACEUTICS I صيدالنيات 1 UNIT 1 INTRODUCTION
PHARMACEUTICS I صيدالنيات 1 UNIT 1 INTRODUCTION 1 PHARMACEUTICS Pharmaceutics is the science of dosage form design. The general area of study concerned with the formulation, manufacture, stability, and
More informationBiopharmaceutics Dosage form factors influencing bioavailability Lec:5
Biopharmaceutics Dosage form factors influencing bioavailability Lec:5 Ali Y Ali BSc Pharmacy MSc Industrial Pharmaceutical Sciences Dept. of Pharmaceutics School of Pharmacy University of Sulaimani 09/01/2019
More informationPurposes of suppositories
Suppositories Definition Are conical or ovoid, solid prep. For insertion into the body cavity where they melt,dissolve or disperse and exert a local or a systemic effect. Their basis is fat,a wax or glycerol-gelatin
More informationVaginal and rectal dosage forms
Vaginal and rectal dosage forms is a solid dosage form in which one or more APIs(active pharmaceutical ingredients) are dispersed in a suitable base and molded or otherwise formed into a suitable shape
More informationCompounding Options in Women s Health: Dosage Forms
Compounding Options in Women s Health: Dosage Forms Ranel A. Larsen, RPh, PharmD HRT Symposium Las Vegas, NV February 16 18, 2017 Routes of Administration Common: Topical Oral Sublingual Vaginal Other:
More informationPrincipals and dosage forms of pharmaceutics
Principals and dosage forms of pharmaceutics Part II. Semisolid dosage forms: ointments, creams, gels, pastes, suppositories, pessaries 2017 Dr. Farkas, Gyula Pharmaceutical Propedeutics Institute of Pharmaceutical
More informationIndustrial Pharmacy (3) Solutions as a dosage form. DR.Saad.M.YACOUB
Industrial Pharmacy (3) Solutions as a dosage form DR.Saad.M.YACOUB Solutions: definition A solution is a homogenous one-phase system consisting of two or more components. The solvent, or mixture of solvents,
More informationFor External Use Only. Should neither be swallowed. Nor injected
For External Use Only Should neither be swallowed Nor injected Preparations which are applied to the skin. (Topical preparations) Preparations which are applied to the mucus membranes. Local effect Systemic
More informationCHAPTER-I DRUG CHARACTERIZATION & DOSAGE FORMS
CHAPTER-I DRUG CHARACTERIZATION & DOSAGE FORMS by: j. jayasutha lecturer department of pharmacy practice Srm college of pharmacy srm university DRUG CHARACTERIZATION: Pre-formulation studies will attempt
More informationBUCCAL DRUG DELIVERY SYSTEM
BUCCAL DRUG DELIVERY SYSTEM Mr. Kambagiri Swamy M.Pharm.,(Ph.D) KRISHNA TEJA PHARMACY COLLEGE Introduction Novel drug delivery systems(ndds) are the system where the man searches for now method of entry
More informationS e c u n d u m A r t e m
VOLUME 14 NUMBER 4 S e c u n d u m A r t e m C u r rent & Practical Compounding Information for the Pharmacist. An ongoing CE Program provided by a grant from Paddock Laboratories, Inc. COMPOUNDING RECTAL
More informationPharmaceutics I صيدالنيات 1. Unit 2 Route of Drug Administration
Pharmaceutics I صيدالنيات 1 Unit 2 Route of Drug Administration 1 Routs of Drug administration The possible routes of drug entry into the body may be divided into two classes: Parenteral Rout Enteral Rout
More informationPHAR 7632 Chapter 7. Table Market and Share of Pharmaceuticals by ROA Data from Viswanathan, 2004
Student Objectives for this Chapter After completing the material in this chapter each student should:- be able to describe various routes of drug administration including the concentration versus time
More informationTYPES OF DISPENSED PREPARATIONS
TYPES OF DISPENSED PREPARATIONS Dr. Dhaivat C. Parikh Institute of Pharmacy, Nirma University DISCLAIMER This Presentation is Only for Internal Use. This Presentation is meant only for giving an overview
More informationD9G : Oro-Mucosal Dosage Forms Development Background Paper
D9G : Oro-Mucosal Dosage Forms Development Background Paper Introduction This background paper is intended to provide a basic rationale for initial formulation efforts, and define some of the terminology
More informationEnhanced delivery methods for greater efficacy
On-Line Formulation Training - Anywhere In The World - Enhanced delivery methods for greater efficacy Belinda Carli Director, Institute of Personal Care Science Image showing absorbance in the outer stratum
More informationANNEXURE -2. Excipients profiles of Compritol ATO 888, Gelucire 43/01, HPMC and PVP and have been described in the following section.
2. EXCIPIENTS PROFILES ANNEXURE -2 Excipients profiles of Compritol ATO 888, Gelucire 43/01, HPMC and PVP and have been described in the following section. 2.1. COMPRITOL 888 Non proprietary names BP:
More informationTYPES OF DOSAGE FORMS
TYPES OF DOSAGE FORMS Types of dosage forms: Definition: Dosage forms are the means by which drug molecules are delivered to sites of action within the body. The need for dosage forms: 1- Accurate dose.
More informationFORMULATION DEVELOPMENT - A QbD Approach to Develop Extended Release Softgels
Seite 1 von 8 Share this story: Issue: April 2015, Posted Date: 3/30/2015 FORMULATION DEVELOPMENT - A QbD Approach to Develop Extended Release Softgels INTRODUCTION Soft gelatin capsules (softgels) continue
More informationAssessment of Human Pharmaceutical Products Registered in Kenya by Route of Administration and Type of Dosage Form
38 East and Central African Journal of Pharmaceutical Sciences Vol. 15 (2012) 38-46 Assessment of Human Pharmaceutical Products Registered in Kenya by Route of Administration and Type of Dosage Form N.N.
More information2- Minimum toxic concentration (MTC): The drug concentration needed to just produce a toxic effect.
BIOPHARMACEUTICS Drug Product Performance Parameters: 1- Minimum effective concentration (MEC): The minimum concentration of drug needed at the receptors to produce the desired pharmacologic effect. 2-
More information6. SR, XR, CR, and TR are examples of formulations. A) oral B) modified release C) repeat action D) soft gels
1. Which is a parenteral route of administration? A) oral B) vaginal C) sublingual D) rectal 2. A local effect occurs A) at the site of administration. B) throughout the body. C) only after intravenous
More informationPediatric patients needing an oral solution sensitivity to dyes Dermatological formulations
Compounding 1 Chapter Outline Compounding Compounding Regulations Compounding Considerations Stability and Beyond-Use Dates Equipment Using a Balance Volumetric Equipment Mixing Solids and Semisolids Select
More informationUNIT 2 SOLID AND LIQUID DOSAGE FORMS
UNIT 2 SOLID AND LIQUID DOSAGE FORMS Solid and Liquid Structure 2.1 Introduction Objectives 2.2 Solid Tablets Capsules 2.3 Liquid Advantages of Liquid Disadvantages of Liquid Classification of Liquid Monophasic
More informationFORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY
FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY Mohammed Younus Ali*, Sadat Ali JJT University, Churu-Bisau Road, Jhunjhunu Rajasthan ABSTRACT: The purpose of this study was to formulate
More informationParenteral Products. By: Howida Kamal, Ph.D
Parenteral Products By: Howida Kamal, Ph.D Dosage forms Route of administration Enteral INTO Parenteral ONTO Topical Dosage forms Physical form Solid Liquid Semi-solid Powder Granules Tablets Capsules
More informationDifferent Type of Dosage Form. Pharmaceutics I
Different Type of Dosage Form 1 Pharmaceutics I Types of dosage forms: Definition: Dosage forms are the means by which drug molecules are delivered to sites of action within the body. The need for dosage
More informationPharmaceutical Preparation For Internal Use
Pharmaceutical Preparation For Internal Use 1. Solid Preparations (Tablet, Capsule, Pill) 2. Liquid Preparations (Aqua, Syrup, Elixir, Extract, Liquor, Emulsion, Mixture, Infusion, Decoction). 3. Powder
More informationFORMULATION CHOICE. How and why they are chosen. Dr Andy Fowles On behalf of ECPA Specification Expert Group
FORMULATION CHOICE How and why they are chosen Dr Andy Fowles On behalf of ECPA Specification Expert Group Topics Why formulate? How to identify formulation options Drivers Principle formulation type overview
More informationIntroduction to Compounding INTRODUCTION. L earning Objectives CHAPTER
CHAPTER 9 Introduction to Compounding L earning Objectives INTRODUCTION Webster s New World Dictionary defines the word compound as a verb meaning 1. to mix or combine, 2. to make by combining parts, and
More informationNon-Food Uses of Polysaccharides
Non-Food Uses of Polysaccharides John Mitchell John.Mitchell@biopolymersolutions.co.uk Acknowledgements Fundamentals of Hydrocolloid Technology Course (2003-2009) Rob Winwood Colin Melia Steve Harding
More informationINFORMATION TOPIC: II-5 OR DEMONSTRATION: II-5. DOSAGE, MEASUREMENTS, AND DRUG FORMS (Lesson Title) OBJECTIVES THE STUDENT WILL BE ABLE TO:
LESSON PLAN: 5 COURSE TITLE: UNIT: II MEDICATION TECHNICIAN GENERAL PRINCIPLES SCOPE OF UNIT: This unit includes medication terminology, dosage, measurements, drug forms, transcribing physician s orders,
More informationLab. No. 1 Second Semester Suspensions
Lab. No. 1 Second Semester Suspensions Suspensions Oral suspensions are oral liquids containing one or more active ingredients suspended in a suitable vehicle; suspended solids may slowly separate on standing
More informationChallenges and solutions for moisture sensitive API formulation
Challenges and solutions for moisture sensitive API formulation Introduction Today, formulators are looking for alternative processes to reformulate existing products or to formulate New Chemical Entities
More informationMETOLOSE: CONTENTS PAGE
METOLOSE: CONTENTS PAGE 2 Preface What is Metolose Substitution types Specifications 1) Available grades & viscosity 2) Nomenclature 3) Packaging Characteristics of Metolose Properties of Metolose 1) Powder
More informationREVISION OF MONOGRAPH ON TABLETS. Tablets
March 2011 REVISION OF MONOGRAPH ON TABLETS Final text for addition to The International Pharmacopoeia This monograph was adopted by the Forty-fourth WHO Expert Committee on Specifications for Pharmaceutical
More informationSUMMARY AND CONCLUSION
SUMMARY AND CONCLUSION 8 SUMMARY AND CONCLUSIONS In spite of the many challenges faced by researchers while designing an effective, reproducible and stable dosage form, oral dosage forms continued to maintain
More information100% Highly effective No cost No side effects
effective? Advantages Disadvantages How do I get Cost Abstinence For some it can mean no sexual contact. For others it is no sexual intercourse or vaginal penetration. A permanent surgical procedure available
More informationKING KHALID UNIVERSITY
KING KHALID UNIVERSITY COLLEGE OF PHARMACY DEPARTMENT OF PHARMACEUTICS COURSE SCHEDULE MALE SECTION SOLID DOSAGE FORMS FOR PHARMACEUTICAL SCIENCES/CLINICAL PHARMACY BY PROF DR MOHAMED FATHY Academic Session
More informationCONTROLLED-RELEASE & SUSTAINED-RELEASE DOSAGE FORMS. Pharmaceutical Manufacturing-4
CONTROLLED-RELEASE & SUSTAINED-RELEASE DOSAGE FORMS Pharmaceutical Manufacturing-4 The improvement in drug therapy is a consequence of not only the development of new chemical entities but also the combination
More informationEasy, fast and reliable!
Product Overview Easy, fast and reliable! Special easy-to-use preparations for film coating, sugar-coating, colouring and tabletting. Tailormade formulated. s film coating products are one-step coating
More informationEXCIPIENTS FOR PHARMACEUTICALS
EXCIPIENTS FOR PHARMACEUTICALS SCOPE OF APPLICATION IOI Oleo GmbH PHARMA Contents Regulatory background for the IOI Oleo site in Witten: Regulatory background for the IOI Oleo site in Witten... 3 Injectables
More informationEasy, fast and reliable!
Product Overview Easy, fast and reliable! Special easy-to-use preparations for film coating, sugar-coating, colouring and tabletting. s film coating products are one-step coating systems for pharmaceutical
More informationEmulsions. Purpose of emulsions and of emulsification:
Pharmacist Ghada Hamid Emulsions Emulsion is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is immiscible. The dispersed
More informationSuppositories and Enemas
Suppositories and Enemas Training Components Indication for use of suppository and enemas Prior to administering medication (8 Rs) Precautions Proper insertion technique Suppository Enema Storage Indication
More informationContraception Effective Methods of Birth Control
Contraception Effective Methods of Birth Control Abstinence Means choosing NOT to have sex It is the ONLY method that is 100% effective It is your right to be in control of your body and say NO What are
More informationINFORMATION TOPIC: II-5 OR DEMONSTRATION: II-5. DOSAGE, MEASUREMENTS, AND DRUG FORMS (Lesson Title) OBJECTIVES THE STUDENT WILL BE ABLE TO:
LESSON PLAN: 5 COURSE TITLE: UNIT: II MEDICATION TECHNICIAN GENERAL PRINCIPLES SCOPE OF UNIT: This unit includes medication terminology, dosage, measurements, drug forms, transcribing physician s orders,
More informationEuropaisches Patentamt European Patent Office Office europeen des brevets. Publication number: A2 EUROPEAN PATENT APPLICATION
Europaisches Patentamt European Patent Office Office europeen des brevets Publication number: 0 345 628 A2 EUROPEAN PATENT APPLICATION Application number: 89109891.5 391.5 Int. CI.4: A61K 9/26 Date of
More informationPh. D Synopsis. Mr. Mehul Pravinchandra Patel Page 1
1. INTRODUCTION 1.1. Sustained Drug delivey: 1-6 It is defined as any drug or dosage form modification that prolongs the therapeutic activity of the drug. The amount of drug in the body decrease slowly
More informationLipids fatty, oily, or waxy hydrophobic organic compounds.
Lipids Lipids Lipids fatty, oily, or waxy hydrophobic organic compounds. u long hydrocarbon chain u composed of CHO Diverse group u fats u oils u waxes u steroids Do not form polymers u big molecules made
More informationMedication Administration
Medication Administration What is a medication? A medication is a drug or any other agent that is used to treat or prevent disease or injury or to restore or maintain normal functioning of body cells.
More informationNew formulas for successful drug delivery Hot-melt extrusion for enhanced solubility and bioavailability
New formulas for successful drug delivery Hot-melt extrusion for enhanced solubility and bioavailability Andreas Gryczke, an enabler in excipients Pharma Ingredients & Services. Welcome to more opportunities.
More information02/09/2016. Roles of Excipients in Pharmaceuticals:
Definition: Any substance other than the active drug or prodrug that is included in the manufacturing process or is contained in a finished pharmaceutical dosage form. Excipients are not inactive and have
More informationPhysical Pharmacy. Interfacial phenomena. Khalid T Maaroof MSc. Pharmaceutical sciences School of pharmacy Pharmaceutics department
Physical Pharmacy Interfacial phenomena Khalid T Maaroof MSc. Pharmaceutical sciences School of pharmacy Pharmaceutics department 1 Introduction The boundary between two phases is generally described as
More informationThe Function of Emollients in Skin Care
The Function of Emollients in Skin Care Benjamin Schwartz Ontario SCC Education Day September 18, 2018 Lipid knowledge for the personal care industry Emollient - definition Wikipedia: complex mixtures
More informationLipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study)
Lipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study) Presented by Dr. AHMED ATEF DONIA, PH. D., Lecturer of Pharmaceutical Technology, Faculty of Pharmacy, Tanta
More informationLecithin and Phospholipids for Cosmetics Applications
Lecithin and Phospholipids for Cosmetics Applications Beauty comes from within. Lecithin is a natural constituent of all living cells with essential functions for humans, animals and plants. The term Lecithin
More informationPrincipals and Dosage Forms in the Therapy Modified Drug Release. Institute of Pharmaceutical Technology and Biopharmacy
Principals and Dosage Forms in the Therapy Modified Drug Release Institute of Pharmaceutical Technology and Biopharmacy Dosage forms Definition: Dosage forms are the means by which drug molecules are delivered
More informationFORMULATION AND EVALUATION OF NATURAL PALM OIL BASED DICLOFENAC SODIUM SUPPOSITORIES
IJPSR (2013), Vol. 4, Issue 2 (Research Article) Received on 24 October, 2012; received in revised form, 27 November, 2012; accepted, 26 January, 2013 FORMULATION AND EVALUATION OF NATURAL PALM OIL BASED
More informationVaginitis. Antibiotics Changes in hormone levels due to pregnancy, breastfeeding, or menopause Douching Spermicides Sexual intercourse Infection
WOMENCARE A Healthy Woman is a Powerful Woman (407) 898-1500 Vaginitis Vaginitis is an inflammation of a woman s vagina. It is one of the most common reasons why women see their health care providers.
More informationPERCENTAGE and RATIO STRENGTH
University of Kerbala College of Pharmacy Department of Pharmaceutics Principles of Pharmacy Practice Lecture 3 PERCENTAGE and RATIO STRENGTH Assistant lecturer Zahraa Alaa Hasan MSc. Drug Delivery 2018-2019
More informationDrug Development by Government Pharmaceutical Organization. Dr. Rachaneekorn Jevprasesphant The Government Pharmaceutical Organization (GPO) Thailand
Drug Development by Government Pharmaceutical Organization Dr. Rachaneekorn Jevprasesphant The Government Pharmaceutical Organization (GPO) Thailand 20August 2012 GPO s Profile GPO was established in 1966.
More informationTopical Preparations
Topical Preparations One of the functions of the skin is to protect the internal body components against the external environment and thus to control the passage of chemicals into and out of the body.
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS
Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar
More informationExcipients make the difference! Dr. Felicitas Guth Global Technical Service Excipients Pharma Ingredients & Services BASF SE
Excipients make the difference! Dr. Felicitas Guth Global Technical Service Excipients Pharma Ingredients & Services BASF SE Paradigm shift in pharmaceutical development Traditional medicinal products
More informationREFERENCES OVERVIEW ADVANTAGES AEROSOLS. Aerosols. and Foams
COMMONWEALTH OF AUSTRALIA Copyright Regulations 1969 WARNING This material has been reproduced and communicated to you by or on behalf of Monash University pursuant to Part VB of the Copyright Act 1968
More informationB. semisolid materials consisting of hydrophilic and hydrophobic portions
CHEM 470 Understanding Emulsions I. Definitions A. Any heterogeneous system which has at least one immiscible or barely miscible liquid dispersed in another liquid in the form of tiny droplets. A. Becher,
More informationEP A2 (19) (11) EP A2 (12) EUROPEAN PATENT APPLICATION. (43) Date of publication: Bulletin 2011/42
(19) (12) EUROPEAN PATENT APPLICATION (11) EP 2 377 14 A2 (43) Date of publication: 19..11 Bulletin 11/42 (21) Application number: 10329.0 (1) Int Cl.: A61K 9/00 (06.01) A61K 31/13 (06.01) A61K 31/167
More informationIntroduction to. Pharmacokinetics. University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D
Introduction to 1 Pharmacokinetics University of Hawai i Hilo Pre-Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D 2 Learning objectives Understand compartment models and how they effects
More informationCHAPTER-2 DRUG AND POLYMER PROFILES
57 CHAPTER-2 DRUG AND POLYMER PROFILES 58 2.1 DRUG PROFILES 2.1.1 Lamivudine (3TC) 85 US FDA approval date: November 1995 Structural formula of lamivudine Physicochemical properties of lamivudine 1. Description
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationLarge scale production
Large scale production Rotary capsule machine: This machine has two, side-by-side cylinders in each of which half-moulds are cut. These cylinders, like the rollers of a mangle, rotate in contrary direction
More informationGuidance on Pharmaceutical Excipient Suitability Studies (PESS) with Chinese Pharmacopeia (Volume 4): Basics and Examples
Guidance on Pharmaceutical Excipient Suitability Studies (PESS) with Chinese Pharmacopeia (Volume 4): Basics and Examples Professor Jiasheng Tu, Ph. D. France 2018/09 content 1 Introduction 2 PESS guidance
More informationREGULATORY PERSPECTIVE. Dr. Raghunandan H V Associate Professor JSSCP, JSSU, Mysore
1 REGULATORY PERSPECTIVE Dr. Raghunandan H V Associate Professor JSSCP, JSSU, Mysore Contents 2 1. Role of Dissolution Testing in Generic Drug Approval 2. Dissolution Testing Recommendation for Solid Oral
More informationINTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES
International Journal of Institutional Pharmacy and Life Sciences 4(2): March-April 2014 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Pharmaceutical Sciences Review Article!!! Received:
More informationMedication Administration. By: Carolyn McCune RN, BSN, MSN, CRNP
Medication Administration By: Carolyn McCune RN, BSN, MSN, CRNP Percutaneous Administration Medications application to the skin or mucus membranes Ointments, creams, powders, lotions, solutions into the
More informationDESIGN AND DEVELOPMENT OF COLON TARGETED DRUG DELIVERY SYSTEM OF 5 FLUORURACIL & METRONIDAZOLE
1. Introduction: DESIGN AND DEVELOPMENT OF COLON TARGETED DRUG DELIVERY SYSTEM OF 5 FLUORURACIL & METRONIDAZOLE Oral controlled - release formulations for the small intestine and colon have received considerable
More information1. Gastric Emptying Time Anatomically, a swallowed drug rapidly reaches the stomach. Eventually, the stomach empties its content in the small
Lecture-5 1. Gastric Emptying Time Anatomically, a swallowed drug rapidly reaches the stomach. Eventually, the stomach empties its content in the small intestine. Because the duodenum has the greatest
More informationCell Membranes, Epithelial Barriers and Drug Absorption p. 1 Introduction p. 2 The Plasma Membrane p. 2 The phospholipid bilayer p.
Cell Membranes, Epithelial Barriers and Drug Absorption p. 1 Introduction p. 2 The Plasma Membrane p. 2 The phospholipid bilayer p. 3 Dynamic behaviour of membranes p. 4 Modulation of membrane fluidity
More informationHemorrhoids. What are hemorrhoids? What is the cause? What are the symptoms?
What are hemorrhoids? Hemorrhoids Hemorrhoids are swollen veins in the lower end of your intestine (rectum) or the anus. The anus is the opening where bowel movements pass out of your body. Hemorrhoids
More informationGranulation Aggregation
Granulation Aggregation Wet granulation Solvent granulation (crust granules) Binder granulation (sticked granules) Granulation liquid Water Water + alcohol mixture Macromolecular colloidal solution i.e.:
More informationBiopharmaceutics. Lec: 4
64 Biopharmaceutics Physicochemical Properties of Drugs Affecting Bioavailability Lec: 4 1 Assist. Lecturer Ali Yaseen Ali BSc Pharmacy MSc Industrial Pharmaceutical Sciences Dept. of Pharmaceutics School
More informationCommercial Bulleting Aloe Flakes
Commercial Bulleting Aloe Flakes Be a Pioneer using Aloe Vera Flakes in food and beverage industry AMB s exclusive Aloe Flakes demonstrates superior solubility retaining the highest percentage of the benefical
More informationDow Wolff Cellulosics. Using ingenuity and savvy. TM Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow
Dow Wolff Cellulosics Pharmaceutical Excipients Using ingenuity and savvy to help design healthcare solutions TM Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow Enhancing
More informationStool softeners are medicines like (ducolox - pericolace - senokot). You want the stool to remain soft so it is easier to empty the bowel.
"Bowel Management" How the Body Works The food you eat and drink provides your body with many nutrients. These nutrients give you energy and help you stay healthy. As food moves through your body it breaks
More informationSlide 1. Slide 2. Slide 3. Drug Action and Handling. Lesson 2.1. Lesson 2.1. Drug Action and Handling. Drug Action and Handling.
Slide 1 Drug Action and Handling Chapter 2 1 Slide 2 Lesson 2.1 Drug Action and Handling 1. Differentiate dose, potency, and efficacy in the context of the actions of drugs. 2. Explain the pharmacologic
More informationAROMATIC MEDICINE Integrated Advanced Essential Oil Therapeutics for Common Clinical Conditions. 8 day in class International Advanced Diploma Course
AROMATIC MEDICINE Integrated Advanced Essential Oil Therapeutics for Common Clinical Conditions 8 day in class International Advanced Diploma Course by Mark Webb BSc, MASCC (Australia) MODULE I (Days 1
More informationEXCIPIENTS. EXCELLENCE IN OLEOCHEMICAL EXCIPIENTS AND APIs PHARMA. IOI Oleo GmbH
EXCIPIENTS EXCELLENCE IN OLEOCHEMICAL EXCIPIENTS AND APIs PHARMA IOI Oleo GmbH Contents EXCIPIENTS... 5 Liquid lipids... 6 Solid triglycerides... 8 Partial glycerides... 12 Emulsifiers... 14 Specialities...
More information<1151> Pharmaceutical Dosage Forms and <1152> Animal Drugs for Use in Animal Feeds
Pharmaceutical Dosage Forms and Animal Drugs for Use in Animal Feeds Will Brown Veterinary Drugs Stakeholder Forum February 19-20, 2014 Development of a Compendial Taxonomy and Glossary for
More informationPharmacokinetics I. Dr. M.Mothilal Assistant professor
Pharmacokinetics I Dr. M.Mothilal Assistant professor DRUG TRANSPORT For a drug to produce a therapeutic effect, it must reach to its target and it must accumulate at that site to reach to the minimum
More informationMedicinal Cannabis Dosage Forms in California
Mica Gross President Sante Botanica / COO MDBioLogics Medicinal Cannabis Dosage Forms in California An Overview of Cannabis Dosage Forms Forms of dosage are the specific vehicles by which cannabis, or
More informationA Guide to Your Burning Questions
The #1 Doctor Recommended Brand A Guide to Your Burning Questions Use products as directed. 2017 Pfizer Consumer Healthcare Put an End to Your Uncomfortable Questions We understand that talking about hemorrhoids
More informationIntroduction pharmacology and drug administration
1 Introduction to pharmacology and drug administration INTRODUCTION Pharmacology is the study of drugs or chemicals used to treat and cure disease and their interactions in the body. Within the study of
More informationTablet is a major category of solid dosage forms which are widely used worldwide. Extensive information is required to prepare tablets with good
TABLET PRODUCTİON Tablet is a major category of solid dosage forms which are widely used worldwide. Extensive information is required to prepare tablets with good quality at high standards. Based on preformulation
More information