Human Gene Editing for Reproduction:
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1 Human Gene Editing for Reproduction: What s at Stake? Where Should We Draw the Lines? BioLaw and Health Policy Society Center for Law and the Biosciences Stanford University, 23 February 2017 Marcy Darnovsky, Center for Genetics and Society
2 geneticsandsociety
3 3-person IVF Ancestry Tests Animal Models Assisted Reproduction BioBanks Bioethics Biological Determinism Biotech & Big Pharma Biopolitics Cheap White Eggs Clinical Trials Cloning CRISPR Disability Rights DNA Forensics Egg Retrieval Embryo Selection Environmentalism Eugenics Forced Sterilization Gamete Donors Gay Gene Genetic Discrimination Human Germline Gene Editing Human Rights Inheritable Genetic Modification LGBTQI Direct-to-Consumer Genetics Prenatal Screening Precision Medicine PGD Public Interest Race Religion Reproductive Justice Sequencing & Genomics Sex Selection Stem Cell Research Social Justice Surrogacy Synthetic Biology Transhumanism "Warrior Gene Viking Sperm
4 Earlier this month
5 Today s talk Key distinctions in the debate about human germline modification Summary of argument against Some 20 th -century history: US eugenics Some turn-of-the century history: An early chapter in the debate The current conversation
6 Somatic vs germline Somatic genetic modification Affects tissues and cells in existing patients Not inheritable Germline genetic modification Changes genes in eggs, sperm, embryos Inheritable and irreversible
7 Therapy vs. enhancement A clear distinction? Or inherently blurry and subjective? A feasible distinction in policy or legal terms? Or impossible to implement or enforce?
8 Profound risks to future children & generations... Not safe
9 Not needed Safer ways to have health children
10 New forms of inequalty?
11 20 th -century eugenics
12 Healthy seed & fitter families
13 Early 2000s: Human clones? GM babies?
14 GenRich & Naturals Eventually the GenRich class and the Natural class will become entirely separate species with no ability to cross-breed. Lee Silver, Princeton biologist
15 Engineering the Human Germline Goal: To make inheritable genetic modification acceptable to the public. Conclusion: The question is not if, but when and how.
16 Fertility clinic of the future? You must act before you get pregnant. Don't be sorry after she's born. This really is a once-ina-lifetime opportunity for your child-to-be.
17 The not-too-distant future
18 Widespread international agreement
19 Convention on Biomedicine and Human Rights
20 Gene editing
21 Engineering the Perfect Baby Scientists are developing ways to edit the DNA of tomorrow s children. Should they stop before it s too late?
22 The return of eugenics Researchers don t like the word but they're running ahead with the idea, and Britain is at the forefront.
23 What the CRISPR experiments mean for humanity You can imagine rogue IVF clinics offering services guaranteeing offspring will have this or that trait.
24 Genome editing: The age of the red pen It is now easy to edit the genomes of plants, animals and humans.
25 Don t edit the human germ line Nature, March 2015 Serious risks the therapeutic benefits are tenuous a path towards genetic enhancement.
26 A prudent path forward Science, April 2015 A prudent path forward for genomic engineering and germline gene modification
27 Obama administration
28 CRISPR developers
29 National Academies
30 A racehorse theory of human development You know I m proud to have that German blood. There s no question about it. Great stuff.
31 Transhumanist Trump supporter - Silicon Valley billionaire - Transhumanism s most generous supporter - More than $4M for work toward immortality
32 Rider in omnibus budget bill prohibits FDA from using funds to consider research that involves modifying human embryos On the other hand
33 What next?
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