Curriculum Vitae. CRISTINA MAGGIONI MD & PhD. Education 1974 to 1984

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1 Curriculum Vitae CRISTINA MAGGIONI MD & PhD Education 1974 to May 3 PhD* Ecole des Hauts Etudes en Sciences Sociales, Paris Social Psychology Dissertation on The Social Representation of Physical Body in Infertile Women and the Mediation Effect of Medicine - Director: Prof. S. Moscovici. Score: Excellent Interne * des Hôpitaux de Paris (Foreigner) Hôpital Beclère Clamart, Paris Obstetrics and Gynaecology Dept. Director: Prof Papiernick 1984 November 15 Obstetrics and Gynaecology Specialist degree Università Statale degli Studi - Milan Dissertation on Embryonic and Fetal Growth Delays Following In Vitro Fertilization and Embryo-transfer Score 70/70 with honours 1982 December 3 Clinical Psychology Master (Diploma) * University Paris VII, Paris Director: Prof. D. Anzieu Dissertation on Narcissism and Depression inside Institutions Score: Good 1981 June 30 D.E.A. Diplôme Etudes Approfondis en Psychologie* University Paris X, Paris 1980 October 21 Medicine and Surgery Doctor University Statale degli Studi - Milan Dissertation on Physician-Patient Relationship in a Gynaecological Oncology Department Score110/110 with honours 1974 High School License Liceo Classico Beccarla - Milan Score 60/60

2 Research Immunology Pharmacologic Research Institute M. Negri, Milan, Ovarian Cancer: macrophages activation and cell cytotoxicity on animal pattern and human cells Reproduction Endocrinology: A.Beclère Clamart Hospital (in collaboration with INSERM): Uterine Receptivity Phase for implantation in spontaneous and induced cycles. - A.Beclère Clamart Hospital, Paris Professors Frydman and J. Testard: Embryonic and fetal growth after F.I.V.E.T Gynecological Psychosomatic Medicine Obstetrics and Gynaecology Department. Ospedale Mangiagalli. University of Milan, Milano body image and self consciousness in infertile women attending an infertility clinic Chronobiology - Chronobiology Laboratories, University of Minnesota, Minneapolis, USA, in 1986 (Director, Prof. Halberg), intrauterine modulation of genetic expression, e.g. hypertension expression Chronobiology Obstetrics and Gynaecology Department. Ospedale Mangiagalli. University of Milan, Milano correlation between intrauterine fetal growth retardation and hormonal circadian pattern, especially atrial natriuretic peptide Endocrinology Service d endocrinologie, CHRU St. Etienne University, France, (Dir. Prof. Estour): Evaluation of insulin resistance with TTI in various endocrinological pathologies. Role of Growth Factors in Polycystic ovarian syndrome Chronobiology Institute of Clinical Medicine IV, Interuniversity Centre of Chronobiology, University of Florence blood pressure profiles in pregnancy in relation to intrauterine growth retardation risk and hypertension 8. Chronobiology - Chronobiology Laboratories, University of Minnesota, Minneapolis, USA, circadian and circannual values of melatonin in collaboration with NASA Chronobiology Obstetrics and Gynaecology Department. Ospedale Mangiagalli. University of Milan, Milano 1. intrauterine fetal growth retardation and hormonal circadian pattern,

3 2. atrial natriuretic peptide 3. circadian blood pressure rhythm and fetal growth 4. melatonin in pregnancy Gynecological Psychosomatic Obstetrics and Gynaecology Department. Ospedale Mangiagalli. University of Milan, Milano 1. body image in chronic pelvic patients 2. body image in cancer patients 3. body image in menopausal women 4. body image in anorexia and bulimia 5. body image in Rokitanski surgically-corrected young women maternal choice for elective C section endocrinology Obstetrics and Gynaecology Department. Ospedale Buzzi. University of Milan, Milano 1. placental CRH in term and post term pregnancy 2. Dheas, delivery time and depression obstetrics psychosomatic Obstetrics and Gynaecology Department. Ospedale Buzzi. University of Milan, Milano 1. PTSD, Post traumatic stress disorder, following childbirth, risk factors Clinica del lavoro, University of Milan, Milano 2. epigenetic changes in clock genes and cancer risk 3. epigenetic changes in clock genes and placental programming A Synthesis of Cristina Maggioni s Research My research in France was based on In vitro fertilization at the University Hospital Beclère, Paris under Professors Frydman and J. Testard. In this centre for In vitro fertilization I was concerned with embryo implantation after FIV and embryo transfer. There I could ascertain, using electronic microscopy by D. Martel, the uterine implantation period, i.e. the 24-hour susceptibility phase of endometrium, a phase which comes later than embryo replacement in embryo-transfer. Due to this fact, embryo implantation failure might be caused. Further developments in my findings were impossible after my return to Italy, as no FIV Centres existed there. As to the obstetrical-gynaecological field in France, I could also work with the University Hospital of Saint Etienne, specifically in its Endocrinology and Diabetes Studies Division. There, my research was based on testing insulin tolerance as to different

4 endocrinological pathologies, to osteocalcins and insulin resistance, and to ovarian polycystic disease. My knowledge about chronobiology allowed for new endocrinological interpretations. Thanks to a scholarship obtained by CNR NATO, I could work within the Chronobiology Laboratories, University of Minnesota, Minneapolis, USA, in 1986 (Director, Prof. Halberg), a laboratory with which I am still collaborating. My research there consisted in observing pressure data in pregnancy as related to gestosis risk and to intrauterine growth retardation. Moreover, I found that a correlation existed between growth retardation and some hormones, such as atrial natriuretic peptide. During my last stay at the Chronobiology Laboratories and my studies there with Professor Halberg, we analysed the circadian and circannual values of melatonin in collaboration with NASA data, which allowed us to determine that this hormone connects human fetal growth and the earth s geomagnetic fields. The main findings concerned intrauterine life, in that it can modulate genetic expression, and drug consumption by the mother, which can modify the fetal genetic expression, e.g. hypertension expression. I actually work on clock genes expression and cancer risk and clock genes methylation and prenatal programming I also took part in a research project, BIOCOS, directed by Prof. Halberg, Halberg Chronobiology Center, University of Minnesota, supported by U.S. Public Health Service (GM-13981); National Heart, Lung, and Blood Institute, National Institutes of Health (HL-40650), University of Minnesota, Earl Bakken Fund and Dr. Betty Sullivan Fund. My PhD dissertation in 1986 dealt with the changes in body pattern of infertile women. I worked on this project for five years and obtained the maximum score on my final dissertation. It is a borderline field of research in which I can still work, thanks to my collaboration with Paris VII University. Here, I have been teaching gynaecologists since 1993, both in their Specialty Course of Gynaecological Psychosomatic Medicine, and all the correlated educational activities, such as theoretical and practical lessons, ateliers, case discussion, and final dissertations. My original contribution concerns the notion of body pattern as the fundamental basis of the ego, and the psychosomatic pathologies, as changes of the body pattern. A notion I could fully express in books on the subject, that is, Il bambino inconcepibile (The Inconceivable Baby), edited by Franco Angeli, Milan, 1998, translated into French as Femmes infertiles in 2006 by In Press Edition, Paris; Il trattato di ginecologia psicosomatica (Treatise of Gynaecological Psychosomatic Medicine), in collaboration with S. Mimoun Flammarion, Paris, edited by Franco Angeli, Milan, 2003; and Il nodo della psicosomatica (The Puzzle of Psychosomatic Medicine) by Franco Angeli Edition, Milan, under publication. My last research deals with PTSD, post traumatic stress disorder following childbirth, in collaboration with Università Cattolica of Milan.

5 Methodologies for the analysis of sexual abuse among children This research allowed me to practise my competence as an expert to the public prosecutor in many Italian court cases and as a teacher and instructor to Italian gynaecologists and paediatricians. Herbal use and plants treatment on scientific bases for obstetrics and gynecology fellowships CNR - NATO (Chronobiology, at Chronobiology Laboratories, University of Minnesota, Minneapolis, USA; from to ). "Griffini- Miglierina" (Chronobiology and Pregnancy, at Chronobiology Laboratories, University of Minnesota, Minneapolis 1986). AISTMAR (Study of Obstetrical Pathology, at 1 st Obstetrical-Gynaecological Clinic, University of Milan, from to ). MD Practitioner activity Hospital Traineeship, to , at 1 st Obstetrical-Gynaecological Clinic, University of Milan. Final assessment: excellent. Obstetrical-Gynaecologist Hospital Assistant, to , at Ca' Grande Hospital, Milan. Full-time assistant. Hopitaux de Paris Assistant, to , at Hôpital Beclère Clamart, CHU Paris. Obstetrical-Gynaecologist Hospital Assistant, to , at Tradate Hospital, Varese. Substitute and then fixed-term contract Doctor Obstetrical-Gynaecologist Hospital Assistant, to at St. Anna Hospital, Maternity Unit,Como. Obstetrical-Gynaecologist Hospital Assistant, to , at Rho Hospital, Maternity Unit, Milan. University Assistant

6 to , at the Endocrinology and Diabetes Department, CHRU St. Etienne University, France University Assistant to , at the Institute of Clinical Medicine IV, Interuniversity Centre of Chronobiology, University of Florence University Assistant to , at the Institute of Clinical Medicine IV, Interuniversity Centre of Chronobiology, University of Florence University Assistant and Assistant from June 1995 to 2002, at 1 st Obstetrical-Gynaecological Clinic, University of Milan. Confirmed Researcher, Present, at 1 nd Obstetrical-Gynaecological Clinic, University of Milan, in the function of Assistant. Teaching Experience Professor of Gynaecological Psychosomatic Medicine to present for courses finalized to the Diplôme Universitaire d'initiation à la gynécologie psychosomatique, Paris VII University, Paris. It is a four-year post graduate course for gynaecologists and obstetrics. My teaching hours are 40 per year, for all levels, including clinic case discussions. I am also involved in dissertation projects for third-year students. Professor of Clinic Psychology to for the University Diploma of Obstetrics at Scuola Autonoma di Ostetricia "C. Poma " in Mantua, Italy. It is a 20-hour course or 30-hour course ( ). Professor of Gynaecologic-Obstetric at Medical School, 5 th and 6 th years, University of Milan, Italy and at the Specialization training in Obstetrics and Gynaecology A 30-hour course for Introduction to psychosomatic Obstetric and Gynaecology A 30-hour course for Introduction to Sexuality, A 30-hour course for Psychoneuro-Endocrinology, Courses and classes are to be found on the list Conferences and Seminars. - Foreign Representative of Société Française de Gynécologie Psychosomatique

7 (French Society for Gynaecologic Psychosomatic Medicine) - General Secretary of Società Italiana di Psicosomatica Obstetrica Gynecologica (Italian Society for Gynaecologic-Obstetric Psychosomatic Medicine) from 1998 to Member of the International Society of Chronobiology - Member of Executive in the function of Treasurer of the International Society of Psychosomatic in Obstetric and Gynaecology ISPOG from 2002 to Member of the Editorial Board of the Journal of Psychosomatic Obstetrics and Gynaecology Languages First languages French and Italian Second language English Interests fine arts painting,, oil and aquarelle music, piano player spirituality, Hebrew and Tora Dichiarazione veridicità Consapevole delle sanzioni penali nel caso di dichiarazioni non veritiere, di formazione o uso di atti falsi, richiamate dal art.76 del DPR n. 445/2000, dichiaro che le informazioni contenute nel presente Curriculum Vitae sono veritiere. Data Firma Dati personali Autorizzo il trattamento dei miei dati personali ai sensi del Decreto Legislativo 30 giugno 2003, n. 196 "Codice in materia di protezione dei dati personali. Data Firma