Zambroza. Each serving of Zambroza contains:

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1 Zambroza A remarkable health product for all ages. Zambroza is an antioxidant-rich juice blend formulated with 10 highly nutritious fruit and herbal extracts. Used as a daily dietary supplement, Zambroza provides a continuous supply of powerful antioxidants and other health-promoting nutrients known to protect the body s tissues against oxidative stress and associated diseases such as cancer, coronary heart disease and inflammation. The ingredients in Zambroza have been carefully selected and combined to ensure a high ORAC value oxygen radical absorbance capacity (ORAC) is a standard measurement of antioxidant activity used in the nutraceutical, pharmaceutical and food industries. Plus, Zambroza contains no preservatives or artificial colors, sweeteners or flavors.1,2 Each serving of Zambroza contains: Mangosteen, a tropical fruit native to Malaysia and Indonesia, is known for its sweet flavor, which is similar to a mixture of grape and apple. Mangosteen fruit has been used for many years as a medicinal treatment for diarrhea, skin infection and wounds in Southeast Asia. In recent years, scientists have discovered that mangosteen contains a class of naturally occurring polyphenolic compounds known as xanthones, which have been shown to provide beneficial effects on cardiovascular diseases, including ischemic heart disease (caused by decreased blood flow to the heart), atherosclerosis (narrowing and hardening of the arteries), hypertension (high blood pressure) and thrombosis (formation of blood clots). The protective effects of xanthones in the cardiovascular system are likely due to their antioxidant, antiinflammatory, antithrombotic, and/or vasorelaxant (blood vessel relaxing) activities. In addition, laboratory research has shown that various mangosteen xanthones and xanthone derivatives inhibit the growth of human cancer cells, including breast, leukemia, liver, lung and stomach cancer cell lines. These substances have also exhibited strong antibacterial and inhibitory effects against Mycobacterium tuberculosis the Gram-positive bacterium that causes tuberculosis and methicillin-resistant Staphylococcus aureus an antibiotic-resistant superbug that can cause skin infections, bone infections, pneumonia or severe life-threatening bloodstream infections, particularly in those with weakened immune systems.3-14 Concord grape concentrate contains anthocyanins, a class of flavonoids that give intense color to many fruits and vegetables. Epidemiological studies have indicated that the moderate consumption of anthocyanin-containing products is associated with a lower risk of cardiovascular disease and improvement of visual functions. In addition, concord grapes contain resveratrol, an antioxidant found in grapes and grape products, which demonstrates anti-inflammatory and anticancer properties.15-17

2 Red grape concentrate - Red grapes contain resveratrol, a powerful antioxidant that exhibits anticancer and anti-inflammatory properties. In addition, red grapes contain anthocyanins, which offer an array of health-promoting benefits such as antioxidant protection and cardioprotective effects. Red grapes have also been shown to inhibit the proliferation (growth) of human liver cancer cells in vitro Blueberry concentrate - Blueberries have high ORAC activity and are a rich source of antioxidant compounds, including anthocyanins and vitamin C, as well as resveratrol and piceatannol, both of which are strong antioxidants and demonstrate cancer chemopreventive (cancer-preventing) activities. Blueberries have been shown to significantly inhibit mutation of breast and cervical cancer cells in vitro. In addition, blueberries have been shown to reverse age-related neurological deficits in animals Red raspberry concentrate - Red raspberries have high ORAC activity and are a rich source of anthocyanins, vitamin C and various phenolic compounds, which protect the body's tissues against oxidative stress and associated pathologies (diseases) such as cancer, coronary heart disease and inflammation. For example, raspberries have been found to significantly inhibit both the mutation of breast and cervical cancer cells in vitro, as well as the proliferation of human liver cancer cells.1,26,28,29 Red grape skin extract is a rich source of polyphenols, antioxidant substances that protect the body's tissues against oxidative stress (free radical damage). One such polyphenol, resveratrol, helps reduce capillary permeability to prevent easy bruising and may also increase high-density lipoprotein (HDL) cholesterol, thereby protecting against heart disease. Resveratrol is regarded as a powerful antioxidant that exhibits anti-inflammatory, neuroprotective and antiviral properties. In addition, preliminary studies indicate that resveratrol acts as an estrogen receptor antagonist in the presence of estrogen, thus inhibiting the growth of human breast cancer cells. Furthermore, red grape skin extract has been shown to inhibit platelet aggregation a risk factor for coronary artery disease because it can lead to the formation of blood clots. Plus, research indicates that combining grape skin extract and grape seed extract provides greater antiplatelet effects than either substance alone.1,30-32 Wolfberry (Lycium) is a commonly used Chinese herb considered to have a tonic effect on various organs. According to Traditional Chinese medicine, wolfberry nourishes and tonifies the liver and kidneys and improves eyesight. Chinese physicians also use wolfberry for treatment of infertility. In fact, in vitro results have shown a protective effect against testicular degeneration, thus providing a scientific basis for the traditional use of this plant. Pharmacological and clinical research also indicate that wolfberry imparts a protective effect on the liver, and raises serum levels and macular density of zeaxanthin, which may decrease the risk for age-related macular degeneration wolfberry is a good dietary source of zeaxanthin. Recent in vitro and animal studies show that wolfberry polysaccharides demonstrate antioxidative and immunomodulation activity, and have been shown to inhibit the growth of and induce apoptosis (cell death) in human leukemia cells. In addition, wolfberry polysaccharide given to mice provided a significant adaptability to exercise load, improved resistance and accelerated elimination of fatigue following strenuous exercise Red grape seed extract is known as a powerful antioxidant that protects the body from premature aging, disease and decay. Grape seeds contain a class of naturally occurring compounds known as proanthocyanidins, which have been shown in scientific studies to have antioxidant power that is 20 times greater than vitamin E and 50 times greater than vitamin C. Many epidemiological studies indicate that consumption of dietary polyphenolic compounds is beneficial in the prevention of cardiovascular diseases. Other studies have shown that grape seed proanthocyanidins help protect the body from sun damage; enhance vision; improve flexibility in joints, arteries and body tissues such as the heart; and improve blood circulation by strengthening capillaries, veins and arteries. In addition, grape seed extract has been shown to inhibit platelet aggregation a risk factor for coronary artery disease because it can lead to the formation of blood clots. Plus, research indicates that combining grape seed extract and grape skin extract provides greater antiplatelet effects than either substance alone. Furthermore, recent animal research has shown that grape seed extract inhibits human prostate tumor growth in mice.6,30,48,49

3 Green tea contains many polyphenolic antioxidants whose role in cancer prevention has been supported by numerous epidemiological studies. Research shows that the polyphenol EGCG (epigallocatechin-3- gallate) is among the most effective chemopreventive and apoptosis-inducing (capable of causing cell death) agents present in green tea. Recently published results of an 11-year population-based prospective study conducted by the National Cancer Center in Tokyo, Japan found an inverse association between green tea consumption and distal gastric cancer among women those in the highest category of green tea consumption had the lowest relative risk of cancer. Another recent Japanese study found that green tea consumption was associated with a lower incidence of coronary artery disease the more green tea patients consumed, the less likely they were to have coronary artery disease, which is the most common type of heart disease and the leading cause of death in the United States in both men and women Apple extract - Compared to many other commonly consumed fruits in the United States, apples have the second highest level of antioxidant activity. Apples contain a variety of phytochemicals, including quercetin, rutin and catechin, all of which are potent antioxidants. Laboratory research has shown that apples inhibit cancer cell proliferation, decrease lipid (fat) oxidation, and lower cholesterol. Epidemiological studies have linked apple consumption with reduced risk of some cancers such as lung cancer, as well as asthma, cardiovascular disease and diabetes. For example, a reduced risk of cardiovascular disease has been associated with apple consumption the Women's Health Study surveyed nearly 40,000 women with a 6.9-year follow-up and found that women ingesting apples had a 13 22% decrease in cardiovascular disease risk. Plus, apple consumption has been positively associated with general pulmonary (lung) health, including increased lung function, as well as increased weight-loss. Based on these epidemiological studies, it appears that apples may play a large role in reducing the risk of a wide variety of chronic disease and maintaining a healthy lifestyle in general References: 1Tapiero, H., et. al. Polyphenols: do they play a role in the prevention of human pathologies? Biomedicine & Pharmacotherapy; 2002, 56(4): Huang, D., et. al. High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. Journal of Agricultural and Food Chemistry; 2002, 50(16): Mangosteen in The Columbia Encyclopedia, Sixth Edition. Columbia University Press, < Accessed July Parkinson, R. Mangoes, Lychees and Mangosteen. Chinese Cuisine. < Accessed July Nakatani, K., et. al. gamma-mangostin Inhibits IkappaB Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells. Molecular Pharmacology; June 24, Jiang, D.J., et. al. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovascular Drug Reviews; 2004, 22(2): Mahabusarakam, W., et. al. Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Radical Research; 2000, 33(5): Moongkarndi, P., et. al. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia; 2004, 75(3-4): , et. al. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. Journal of Ethnopharmacology; 2004, 90(1): Matsumoto, K., et. al. Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. Journal of Natural Products; 2003, 66(8): Ho, C.K., et. al. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Medica; 2002, 68(11): Suksamrarn, S., et. al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chemical & Pharmaceutical Bulletin (Tokyo); 2003, 51(7): Iinuma, M., et. al. Antibacterial activity of xanthones from guttiferaeous plants against methicillinresistant Staphylococcus aureus. The Journal of Pharmacy and Pharmacology; 1996, 48(8):

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