Product Support for Female Reproductive Conditions. FxMed Booklet. Based on the Treatment Strategies provided by Dr Felice Gersh, MD

Transcription

1 Product Support for Female Reproductive Conditions FxMed Booklet Based on the Treatment Strategies provided by Dr Felice Gersh, MD Unique Female Reproductive Conditions Seminar 2017 Functional & Integrative Medicine Ltd, 77 Austin St, PO Box 19033, Onekawa, Napier 4146 NZ Ph Fax

2 CHART Conditions Adenomyosis Endometriosis PCOS Uterine Fibroids (Leiomyomata) Product Brand Step 1 Modified 4 Week Detox Lower Inflammation & Toxins, Improve Gut/Metabolic Health Step 1 Modified 4 Week Detox Reduce Localized Inflammation & Stablise Mast Cells Reduce Systemic & Localised Inflammation Step 1 Modified 4 Week Detox Support Glucose Metabolism & Insulin Function, Weight Management & Detoxification Step 1 Modified 4 Week Detox Lower Inflammation & Toxins, Improve Gut/Metabolic Health A.I. Enzymes Pure Encapsulations X X X Alpha Lipoic Acid 200 mg Pure Encapsulations X BioActive B-Complex Research Nutrition X Buffered Ascorbic Acid Powder Pure Encapsulations X CurcumaSorb Pure Encapsulations X X X X Detox Pure Pack Pure Encapsulations X X X X DIM Detox Pure Encapsulations X X X X G.I. Fortify Capsules Pure Encapsulations X X X X X X G.I. Fortify Powder Pure Encapsulations X X X X X X Green Tea Extract (decaffeinated) Pure Encapsulations X X X HM Complex Pure Encapsulations X X X Inositol (Powder) Pure Encapsulations X Metabolic Xtra Pure Encapsulations X NAC 900mg Pure Encapsulations X X X X Probiotic-5 Pure Encapsulations X X X X ProOmega Capsules Nordic Naturals X X X X PureLean Pure Pack Pure Encapsulations X Quercetin Pure Encapsulations X X X Resveratrol Pure Encapsulations X X X Systemic Enzyme Complex Pure Encapsulations X X X Vitamin A + Carotenoids Pure Encapsulations X X X Vitamin D3 1,000 I.U. Capsules Pure Encapsulations X X X X Vitamin D3 1,000 I.U. Liquid Pure Encapsulations X X X X Women's Nutrients Pure Encapsulations X

3 CONTENTS Product Adenomyosis Step 1 Modified Detox Page Detox Pure Pack 3 DIM Detox 3 G.I. Fortify (Capsules/Powder) 4 HM Complex 5 Probiotic-5 6 Lower Inflammation & Toxins, Improve Gut/ Metabolic Health A.I. Enzymes 1 CurcumaSorb 2 G.I. Fortify (Capsules/Powder) 4 Green Tea Extract (decaffeinated) 4 ProOmega 6 Quercetin 7 Resveratrol 8 Systemic Enzyme Complex 8 Vitamin A + Carotenoids 8 Vitamin D3 1,000 i.u. (Capsules/Powder) 9 Uterine Fibroids (Leiomyomata) Step 1 Modified Detox Detox Pure Pack 3 DIM Detox 3 G.I. Fortify (Capsules/Powder) 4 HM Complex 5 Probiotic-5 6 Lower Inflammation & Toxins, Improve Gut/ Metabolic Health A.I. Enzymes 1 CurcumaSorb 2 G.I. Fortify (Capsules/Powder) 4 Green Tea Extract (decaffeinated) 4 ProOmega 6 Quercetin 7 Resveratrol 8 Systemic Enzyme Complex 8 Vitamin A + Caretanoids 8 Vitamin D3 1,000 i.u. (Capsules/Powder) 9 Functional Testing DUTCH Complete 10 DUTCH Cycle Mapping 11 Product Endometriosis Step 1 Modified Detox Detox Pure Pack 3 DIM Detox 3 G.I. Fortify (Capsules/Powder) 4 HM Complex 5 NAC 900mg 6 Probiotic-5 6 ProOmega 6 Reduce Localized Inflammation & Stabilize Mast Cells A.I. Enzymes 1 Alpha Lipoic Acid 200mg 1 CurcumaSorb 2 Green Tea Extract (decaffeinated) 4 Quercetin 7 Resveratrol 8 Systemic Enzyme Complex 8 Reduce Systemic & Localized Inflammation PCOS BioActive B-Complex 1 Buffered Ascorbic Acid Powder 2 CurcumaSorb 2 NAC 900mg 6 Vitamin A + Carotenoids 8 Vitamin D3 1,000 i.u. (Capsules/Powder) 9 Women s Nutrients 9 Step 1 Modified Detox Detox Pure Pack 3 DIM Detox 3 G.I. Fortify (Capsules/Powder) 4 NAC 900mg 6 Probiotic-5 6 ProOmega 6 Support Glucose Metabolism & Insulin Function, Detoxification & Weight Management Page Inositol (powder) 5 Metabolic Xtra 5 NAC 900mg 6 PureLean Pure Pack 7 Vitamin D3 1,000 i.u. (Capsules/Powder) 9

4 A.I. Enzymes Balanced plant enzyme formula. When taken with meals, this plant enzyme blend promotes the breakdown of protein, carbohydrates and fat for optimal digestion. The plant enzymes help replace naturally-occurring enzymes that are destroyed in highly processed and cooked foods. Dual support for digestion (when taken with food), also maintains healthy muscles and joints (when taken away from food). Enzymes that are stable in a wide ph range. Made with ingredients derived from pineapple and papaya that have been clinically proven to support digestion when taken with food Enhanced levels of protease, amylase and lipase. Contains rutin for protection against oxidative stress. Suggested use: 3 capsules twice daily between meals. Alpha Lipoic Acid 200mg Water and lipid soluble antioxidant; supports glucose metabolism and nerve health. Alpha Lipoic Acid (ALA) is a water and fat soluble antioxidant. ALA helps maintain healthy glucose metabolism, supports the nervous system and provides nutritional support for metabolic processes. Potent antioxidant which enhances the activity of vitamins C and E. Suggested use: 1 capsule twice daily, with meals. BioActive B-Complex Balanced, broad spectrum B vitamin support. Research Nutrition s BioActive B-Complex is a pure, balanced and hypoallergenic source of metabolically active forms of B complex vitamins, which have been demonstrated to support a range of metabolic processes, including energy production, detoxification processes, neurological health, stress response and hormone balance. The bioactive, yet unmethylated, forms are used to support optimal activity, without causing overstimulation, particularly in sensitive patients. Providing a highly versatile foundation to further supplementation (including the methylated vitamin forms). Suggested use: 1 capsule daily with a meal. 1.

5 Buffered Ascorbic Acid powder Vitamin C for sensitive individuals. Buffered Ascorbic Acid is a vitamin C dietary supplement formulated to lessen gastric irritation that may occur among sensitive individuals when consuming vitamin C. Supports gentle absorption of vitamin C. Promotes the immune and vascular system. Convenient powder form. Suggested use: 1 scoop daily. CurcumaSorb Meriva highly bioavailable curcumin phytosome. CurcumaSorb is the easily absorbed form of curcumin to help provide maximum support for musculoskeletal, digestive, liver, brain, cellular and cardiovascular health. The applications of curcumin stem from its multifocal mechanisms involving diverse intracellular signaling pathways and the regulation of hundreds of genes involved in cytokine balance, detoxification and cellular health. Meriva delivers a highly bioavailable curcumin phytosome, providing maximal support. Suggested use: 2 6 capsules per day, in divided doses, between meals. 2.

6 Detox Pure Pack Daily Packet With Metafolin L-5-MTHF. Detox Pure Pack offers gentle detoxification support for short-term or daily use in a convenient once-daily packet which promotes G.I. health and functionality. Supports phase I and phase II liver enzyme activation. Supports phase II detoxification and liver cell health. Maintains healthy intestinal integrity with L-glutamine, limiting the amount of toxins that pass in the gut. Promotes gastric, colon and liver cell function. Suggested use: Take 1 packet daily (8 capsules), with breakfast. Supplement Facts Amount Per Serving UltraNutrient three vegetarian capsules contain: vitamin A (as beta carotene) 12,500 iu vitamin D (as cholecalciferol)(d3) 400 iu vitamin E (as d-alpha tocopherol succinate) 200 iu thiamin (as thiamin HCl) (B1) 50 mg riboflavin (vitamin B2) 12.5 mg niacin (as niacinamide) 50 mg vitamin B6 (as pyridoxine HCl) 25 mg folate (as Metafolin, L-5-MTHF) 400 mcg vitamin B12 (as methylcobalamin) 500 mcg biotin 400 mcg pantothenic acid (calcium pantothenate) (B5) 200 mg calcium (as citrate/malate) 150 mg magnesium (as magnesium aspartate) 100 mg zinc (as zinc picolinate) 12.5 mg selenium (as selenomethionine) 100 mcg copper (as copper glycinate) 1 mg manganese (as manganese aspartate) 2.5 mg chromium (as chromium polynicotinate) 250 mcg molybdenum (as molybdenum aspartate) 50 mcg potassium (as potassium aspartate) 50 mg boron (as boron glycinate) 1 mg vanadium (as vanadium aspartate) 100 mcg ascorbyl palmitate (fat-soluble vitamin C) 50 mg riboflavin 5 phosphate (activated B2) 12.5 mg pyridoxal 5 phosphate (activated B6) 12.5 mg inositol hexaniacinate (no-flush niacin) 45 mg mixed carotenoids (as lutein, lycopene, zeaxanthin) 722 mcg CardioHealth Complex alpha lipoic acid (thioctic acid) 50 mg coenzyme Q10 (ubiquinone) 25 mg hawthorn (crataegus oxyacantha) extract (flower and leaf) 50 mg (standardized to contain 2% vitexins) 2 mg ginger (zingiber officinale) extract (root) 50 mg (standardized to contain 5% gingerols) 5 mg LiverEnhance Blend milk thistle (silybum marianum) extract (seed) 50 mg (standardized to contain 80% silymarin) 80 mg turmeric (curcuma longa) extract (root) 100 mg (standardized to contain 95% curcuminoids) Setria glutathione (reduced form) 25 mg other ingredients: vegetarian capsule (cellulose, water) Take 1 packet daily (8 capsules), with a meal for gentle, daily detoxification support. EPA/DHA essentials each softgel capsule contains: calories 10 calories from fat 10 total fat 1 g vitamin E (d-alpha-tocopherol) 10 iu fish oil concentrate (from anchovies, sardines) 1,000 mg providing: EPA (eicosapentaenoic acid) 300 mg DHA (docosahexaenoic acid) 200 mg other ingredients: gelatin capsule (gelatin, glycerin, water) Liver-G.I. Detox two vegetarian capsules contain: alpha lipoic acid (thioctic acid) 100 mg n-acetyl-l-cysteine (free-form) 100 mg turmeric (curcuma longa) extract (root) 100 mg (standardized to contain 95% curcuminoids) milk thistle (silybum marianum) extract (seed) 125 mg (standardized to contain 80% silymarin) 100 mg broccoli 100 mg (brassica oleracea italica) sprout concentrate (whole plant) (standardized to contain a minimum of 400 mcg sulforaphane) artichoke (cynara scolymus l.) extract (leaf) 125 mg (standardized to contain 5% cynarins) taurine (free-form) 225 mg glycine (free-form) 225 mg l-glutamine (free-form) 225 mg l-methionine (free-form) 100 mg chlorella 200 mg (chlorella pyrenoidosa) powder (cracked cell wall) ascorbyl palmitate (fat-soluble vitamin C) 20 mg other ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water) NAC (N-Acetyl-L-Cysteine) 600 mg each vegetarian capsule contains: n-acetyl-l-cysteine (free-form) 600 mg ascorbyl palmitate (fat-soluble vitamin C) 5 mg (as ascorbyl palmitate) other ingredients: vegetarian capsule (cellulose, water) Taurine 1,000 mg each vegetarian capsule contains: taurine (free-form) 1,000 mg ascorbyl palmitate (fat-soluble vitamin C) 10 mg other ingredients: vegetarian capsule (cellulose, water) DIM Detox Supports detoxification. DIM Detox promotes healthy cell cycle function and hormone metabolism to support the liver. Supports the livers natural detoxification process and cellular health. Promotes healthy estrogen metabolism. Supports Phase II detoxification. Made from broccoli and other naturally-sourced ingredients. Suggested use: 1 capsule twice a day. 3.

7 G.I. Fortify (Capsules) Supports G.I. function, motility and detoxification. G.I. Fortify (capsules) are a blend of high-impact fiber, herbs and nutrients to support overall gastrointestinal function and health. Maintains bowel regularity and movement. Supports short chain fatty acid (SCFA) production. Enhances G.I. detoxification with fiber and chlorella Suggested use: 3 capsules daily, with a meal and 8-12 oz water. Daily water intake should be increased when consuming this product. G.I. Fortify (Powder) Supports the function, microflora balance, integrity, tone, comfort, cellular health and detoxification of the gastrointestinal tract. G.I. Fortify is a blend of high-impact fiber, herbs and nutrients to support overall gastrointestinal function and health. Maintains bowel regularity and movement. Supports short chain fatty acid (SCFA) production. Soothes and enhances the mucosa lining of the G.I tract. Suggested use: Add 1 serving to 8 12 oz water. Shake, stir or blend briskly and drink immediately. Drink an additional 8 12 oz serving of water following. Daily water intake should be increased when consuming this product. Green Tea Extract (decaffeinated) Antioxidant protection. Green Tea Extract is a herbal formula that contains a high epigallocatechin gallate (EGCG) content to provide antioxidant support for all cells in the body. Green Tea Extract is caffeine free. This decaffeinated green tea extract is a herbal extract containing catechins, a class of antioxidant compounds known as polyphenols. It contains a minimum of 90% catechins, with epigallocatechin gallate, making up a minimum of 70% of the content. Research has indicated that EGCG may promote cellular health through a number of pathways, including moderating gene expression and hydroxyl radical formation. In animal studies green tea inhibits development, growth and angiogenesis of endometriosis. Suggested use: 1 capsule daily after breakfast. 4.

8 HM Complex Support for mild environmental exposure to heavy metals. Contains ingredients with natural chelating and detoxification properties for common, mild environmental exposure to heavy metals. Promotes antioxidants to help enhance immune defences. Modified citrus pectin that may help promote urinary excretion of mercury, arsenic, cadmium, lead and tin without altering excretion of minerals. Cilantro and chlorella supports the body s natural processes for eliminating heavy metals. Selenium may bind to mercury. NAC promotes excretion and supports the liver by enhancing glutathione concentration. Suggested use: 1 capsule daily in evenings. Inositol (Powder) Supports emotional wellness, behavior and mood; promotes healthy ovarian function. Inositol is a component of the B-complex family. It supports healthy central nervous system function, including emotional wellness, healthy mood and behavior. Additionally, it may promote ovarian health. Supports healthy ovulation activity, ovarian function and reproductive system. Maintains healthy LH, FSH, androgen and insulin levels. Involved in cell membrane formation and supports serotonin, norepinephrine and cholinergic receptor function. Suggested use: 1 scoop twice daily with meals. Metabolic Xtra Supports healthy insulin function and glucose homeostasis. Metabolic Xtra is a powerful combination of nutrients that helps support insulin receptor function as well as healthy glucose metabolism. Supports glucose disposal in cells by supporting AMPK signaling and insulin receptor function. Suggested use: 1 capsule three times daily with meals. 5.

9 NAC 900mg Supports antioxidant defense. NAC is a free radical scavenger that supports glutathione levels in tissues and may protect tissues from peroxidation generated by heavy metals. Supports cellular antioxidant defense system. Role in heavy metal detoxification. Made with hypoallergenic ingredients. General Suggested use: 1-2 capsules daily, between meals. Modified Detox PCOS: 1 capsule daily in evening. PCOS: 1 capsule with breakfast and 2 capsules with dinner. Endometriosis: 2-3 capsules daily, divided doses. Probiotic-5 A dairy-free blend of key probiotic bacteria to support immune and gastrointestinal health. Probiotic-5 offers 10 billion colony forming units (CFU) of beneficial bacteria to promote G.I. tract health and comfort as well as immune cell function and overall health. Helps maintain intestinal flora, supports healthy yeast balance and promotes G.I. comfort. Support gut microbial balance. Suggested use: 1 capsule daily with or between meals. ProOmega Lemon Supports joint and heart health. ProOmega offers high-intensity support for cardiovascular and neurological health. ProOmega delivers more omega-3s per serving than most other omega-3 products. Research showed a consumption of omega 3 showed a 22% decrease in endometriosis. 2 capsules contain 650mg EPA and 450mg DHA. Suggested use: Two soft gels daily, with food. For intense support, take two soft gels with food twice daily. 6.

10 PureLean Pure Pack Support for healthy glucose metabolism, lipid utilization and weight management. PureLean Pure Pack is designed to support healthy glucose metabolism and lipid utilization to help weight management. For best results, consume PureLean Pure Pack as part of a healthy lifestyle with a reduced calorie diet and regular exercise. Suggested use: Take 1 packet daily (7 capsules), with a meal. Supplement Facts Amount Per Serving PureLean Nutrients three vegetarian capsules: vitamin A (as beta carotene) 3,750 iu vitamin C (as ascorbic acid and 50% as PureWay-C ) 250 mg vitamin D (as cholecalciferol)(d3) 1,000 iu vitamin E (as d-alpha tocopherol succinate) 50 iu vitamin K (as vitamin K1) 50 mcg thiamin (as thiamin HCl) (B1) 12.5 mg riboflavin (vitamin B2) 12.5 mg niacin (as niacin and 67% niacinamide) 37.5 mg vitamin B6 (as pyridoxine HCl) 6.25 mg folate (as Metafolin, L-5-MTHF) 400 mcg vitamin B12 (as methylcobalamin) 250 mcg biotin 1.5 mg pantothenic acid (as calcium pantothenate) (B5) 25 mg calcium (as calcium citrate) 75 mg iodine (as potassium iodide) 100 mcg magnesium (as magnesium citrate) 75 mg zinc (as zinc citrate) 7.5 mg selenium (as selenomethionine) 35 mcg copper (as copper glycinate) 1 mg manganese (as manganese citrate) 1 mg chromium (as chromium polynicotinate and 50% as chromium 454 ) 200mcg potassium (as potassium citrate) 50 mg boron (as boron glycinate) 1 mg vanadium (as bis-glycinato oxo vanadium) 50 mcg riboflavin 5 phosphate (activated B2) 6.25 mg pyridoxal 5 phosphate (activated B6) 6.25 mg mixed carotenoids (as lutein, lycopene, zeaxanthin) mcg choline bitartrate 50 mg inositol 62.5 mg MacularSynergy Complex lutein 3 mg zeaxanthin 500 mcg Metabolic GlycoPlex alpha lipoic acid (thioctic acid) 150 mg cinnamon (cinnamomum cassia) extract (dried bark) 50 mg l-carnosine (beta-alanyl-l-histidine) 25 mg Metabolic LipidPlex taurine (free-form) 150 mg green tea (camellia sinensis) extract (leaf) 50 mg (providing 23% epigallocatechin gallate (EGCG)) Indian kino tree (pterocarpus marsupium) extract (heartwood) 25 mg (standardized to contain 5% pterostilbene) other ingredients: hypoallergenic plant fiber (cellulose), rice bran wax, citrus bioflavonoids, ascorbyl palmitate, vegetarian capsule (cellulose, water) EPA/DHA with lemon each softgel capsule contains: calories 10 calories from fat 10 total fat 1 g fish oil concentrate (from anchovies, sardines) 900 mg providing: EPA (eicosapentaenoic acid) 300 mg DHA (docosahexaenoic acid) 200 mg other ingredients: natural lemon flavor, proprietary antioxidant blend (rosemary extract, ascorbyl palmitate, natural tocopherols), gelatin capsule (gelatin, glycerin, water) Alpha Lipoic Acid with GlucoPhenol each vegetarian capsule contains: alpha lipoic acid (thioctic acid) 200 mg GlucoPhenol proprietary blend 138 mg providing 25 mg polyphenols from Orléans strawberry (Fragaria vesca var. Orléans) extract (fruit) and cranberry (Vaccinium macrocarpon) extract (fruit) other ingredients: rice maltodextrin, magnesium hydroxide, hypoallergenic plant fiber (cellulose), ascorbyl palmitate, vegetarian capsule (cellulose, water) Magnesium (glycinate) each vegetarian capsule contains: magnesium (as magnesium glycinate) 120 mg other ingredients: ascorbyl palmitate, vegetarian capsule (cellulose, water) Taurine 1,000 mg. each vegetarian capsule contains: taurine (free-form) 1,000 mg other ingredients: ascorbyl palmitate, vegetarian capsule (cellulose, water) Proudly supplied by Functional & Integrative Medicine Ltd, PO Box 19033, Onekawa, Napier 4146, NZ NZ Ph: NZ Fax: Aus Ph: Aus Fax: support@fxmed.co.nz Quercetin Maintains mast cell function and degranulation. Quercetin is formulated to help support cellular, cardiometabolic and immune health. Quercetin is one of the most bioactive flavonoids and helps maintain mast cell function. Considered a phytoestrogen. May work by decreasing expression of estrogen and progesterone receptors in endometrium. Animal studies have shown it inhibits growth of ectopic endometrial tissue. Supports healthy mast cell function. Antioxidant support. Suggested use: 2 capsules twice daily. 7.

11 Resveratrol Antioxidant and cardiovascular support. Resveratrol is a compound that promotes cardiovascular health through its antioxidant action. Pure Encapsulations Resveratrol is derived from one of the richest known sources, Polygonum cuspidatum, a herb utilized for centuries. Studies suggest resveratrol promotes cell health by maintaining healthy enzyme function and scavenging free radicals. Phytoalexin in polyphenols with anti-angiogenic, antioxidant and anti-inflammatory properties. Suggested use: 1 5 capsules daily, in divided doses, with or between meals. Systemic Enzyme Complex Acid resistant synergistic proteolytic enzyme formula. Systemic Enzyme Complex is formulated to support the overall health of the musculoskeletal system by maintaining healthy cell function as well as joint and cartilage health. Systemic support for musculoskeletal and tissue health Enzymes included in this formula have the potential to influence bradykinin formation, modulate the arachidonic cascade and prostaglandin E2 production, and provide fibrinolytic support. All of these actions contribute to the potential of proteolytic enzymes to maintain healthy immune mediator activity at the cellular level and overall tissue health. Suggested use: 3 capsules twice daily between meals. Vitamin A + Carotenoids Vitamin A with lutein, zeaxanthin and astaxanthin. Vitamin A + Carotenoids is designed to support healthy vision and the body s immune system. Vitamin A + Carotenoids also promotes retinal and macular health. Supports cellular, ocular and immune health. Vitamin A is essential to the healthy functioning of biological processes including vision, growth, reproductive function and the body s defense system. Suggested use: 1 capsule daily, with a meal. 8.

12 Vitamin D3 1,000 i.u. (Capsules & Liquid) Supports calcium absorption and bone health; provides potential support for breast, prostate, cardiovascular, colon and immune health. Vitamin D3 naturally supports calcium absorption and retention within bones to promote optimal bone health. Vitamin D3 also supports colon health by promoting healthy cellular function. Supports the expression of genes required for metabolism and cardiovascular health. Research has identified vitamin D receptors in uterine tissue and women with sufficient vitamin D had 32% lower odds of fibroids compared to insufficiency. Capsule Suggested use: 1-2 capsules per day, with a meal. Liquid Suggested use: 1-2 drops per day, with a meal. Women s Nutrients Now with Metafolin L-5-MTHF Multivitamin/mineral complex for women over 40. Women s Nutrients is a multivitamin and mineral complex for women over 40 designed to support breast cell health, eye integrity, urinary tract health as well as emotional health. Women s Nutrients also helps maintain healthy blood vessel function for optimal cardiovascular health. Supports breast cell health and provides support for hot flashes. Contains adaptogenic herbs to help moderate occasional stress. Suggested use: 1-2 capsules twice daily with meals. six vegetable capsules contain v 00 vitamin A (as beta carotene)... 7,500 iu vitamin C (as ascorbic acid) mg vitamin D (as cholecalciferol) (D 3 )... 1,000 iu vitamin E (as d-alpha tocopherol succinate) iu vitamin K (as vitamin K 1 ) mcg thiamin (as thiamin HCl) (B 1 ) mg riboflavin (vitamin B 2 ) mg niacin (as niacin and 67% niacinamide) mg vitamin B 6 (as pyridoxine HCl) mg folate (as Metafolin, L-5-MTHF) mcg vitamin B 12 (as methylcobalamin) mcg biotin...2 mg pantothenic acid (as calcium pantothenate) (B 5 )...50 mg calcium (as calcium citrate) mg iodine (as potassium iodide) mcg magnesium (as magnesium citrate) mg zinc (as zinc citrate) mg selenium (as selenomethionine) mcg manganese (as manganese citrate)...2 mg chromium (as chromium polynicotinate) mcg potassium (as potassium citrate) mg boron (as boron glycinate)...2 mg vanadium (as bis-glycinato oxo vanadium) mcg riboflavin 5 phosphate (activated B 2 ) mg pyridoxal 5 phosphate (activated B 6 ) mg mixed carotenoid proprietary blend mcg (as lutein, lycopene, zeaxanthin) choline bitartrate mg inositol mg alpha lipoic acid (thioctic acid) mg cranberry (Vaccinium macrocarpon) extract (fruit) mg MacularSynergy Complex lutein...6 mg zeaxanthin...1 mg BreastHealth Plus HMR lignan 7-hydroxymatairesinol mg green tea (Camellia sinensis) extract (leaf) mg (standardized to contain 65% total tea catechins and 23% epigallocatechin gallate (EGCG)) turmeric (Curcuma longa) extract (root) mg (standardized to contain 95% curcuminoids) calcium-d-glucarate...50 mg CardioPhenol Complete red wine grape (Vitis vinifera) concentrate (whole fruit) mg (standardized to contain 25% total polyphenols) grape (Vitis vinifera) extract (seed) mg (standardized to contain 92% polyphenols) pomegranate (Punica granatum l.) extract (fruit)...50 mg (standardized to contain 40% punicosides) StressCalm Blend rhodiola (Rhodiola rosea) extract (root) mg (standardized to contain 3% total rosavins and min. 1% salidroside) lemon balm (Melissa officinalis) extract (leaf)...50 mg (standardized to contain 5% rosemarinic acid) other ingredients: ascorbyl palmitate, cranberry fiber, cranberry seed oil, guar gum, sunflower lecithin, vegetarian capsule (cellulose, water) 4 6 capsules daily, in divided doses, with meals. 9.

13 Postmenopausal range (ng/mg) Cortisol Premenopausal Range your result Patient Values Age Range 52.0 (A+B+C+D) 20.0 cortisol 7.7 HOW TO READ YOUR RESULTS: number in the middle is your result Progesterone Metabolism female b-pregnanediol a-pregnanediol Low High Etiocholanolone Less Androgenic Metabolites Methylation-activity 2-Methoxy/2-OH Testosterone Low High Progesterone A weighted average of progesterone metabolites Progesterone itself is not found in urine in Androstenedione measurable levels 5a-Reductase Activity Androsterone 5α-DHT (5ß) (5α) (~3x more potent than testosterone itself). 5α-Reductase activity is assessed using the ratio of Androsterone (5α) to Etiocholanolone (5ß) :01AM :01AM :01PM :01PM 2-Methoxy-E1 Hormones are presented on this page Most potent androgen 5α-metabolism makes androgens more androgenic, most notably 5α-DHT is the most potent testosterone metabolite Precision Analytical (Raymond Grimsbo, Lab Director) Jane Doe Page 2 of Rivergate Street #301C FINAL REPORT CLIA Lic. #38D McMinnville, OR /06/2017 DutchTest.com Pregnenolone COMT methylation (protective) HOW TO READ YOUR RESULTS: Hormones are presented on this page graphically in the order the body metabolizes them. Arrows represent conversion from one hormone to another. The stars represent the low and high limits of the reference ranges ( see example, right ). The number in the middle is your result DHEA Androstenedione Low Estrone(E1) OH-E DHEAS Testosterone OH-E1 Estradiol(E2) OH-E1 Reference Range Limit (low) Progesterone Metabolism female b-pregnanediol a-pregnanediol Etiocholanolone Less Androgenic Metabolites (5ß) Low Methoxy-E1 (Protective, but not enough in urine to measure) High Methylation-activity 2-Methoxy/2-OH Testosterone Progesterone A weighted average of your result Androgen Metabolism Progesterone itself is not found in urine in Androstenedione progesterone metabolites measurable levels Estrogen Metabolism primary estrogens (E1, E2, E3) High 5a-Reductase Activity Androsterone 5α-DHT (5α) (~3x more potent than testosterone itself). 5α-Reductase 2-OH 70% 2-OH 39.9% activity is assessed using the ratio of Androsterone (5α) to Etiocholanolone (5ß). Most potent androgen 5α-metabolism makes androgens more androgenic, most notably 5α-DHT is the most potent testosterone metabolite Pregnenolone 4-OH 10% 4-OH 8% Reference Range Limit (high) Age-Dependent DHEAS Ranges Postmenopausal range Estriol(E3) Normal Estrogen Metabolism 16-OH 20% Patient Estrogen Metabolism 4-OH-E1 CYP3A4 COMT methylation (protective) 2-Methoxy-E1 Age DHEAS DHEA Premenopausal Range Androstenedione Estrone(E1) 16-OH 52.1% OH-E1 If not methylated, 4-OH-E1 can bind to and damage DNA DHEAS Testosterone Patient Values Pineal CYP3A4 Estradiol(E2) primary estrogens (E1, E2, E3) OH-E1 Reference Range Limit (low) 16-OH-E Methoxy-E1 (Protective, but not enough in urine to measure) your result Androgen Metabolism Estrogen Metabolism 2-OH 8% Reference Range Limit (high) Age-Dependent DHEAS Ranges Postmenopausal range (A+B+C+D) Estriol(E3) Normal Estrogen Metabolism 2-OH 70% 4-OH 10% 20% 16-OH Patient Estrogen Metabolism 4-OH-E1 Age DHEAS > Premenopausal Range 16-OH 52.1% If not methylated, 4-OH-E1 can bind to and damage DNA Precision Analytical (Raymond Grimsbo, Lab Director) Jane Doe Page 3 of Rivergate Street #301C FINAL REPORT CLIA Lic. #38D McMinnville, OR /06/2017 DutchTest.com Cortisol and Cortisone interconv ert (11b-HSD) and are metabolized to THF & THE for excretion 0 Patient Values Limit (low) 52.0 (A+B+C+D) Age your result Range Limit (high) FUNCTIONAL TESTING DUTCH Complete by Precision Analytical This advanced hormone testing was developed to surpass industry standards for available testing options. DUTCH testing offers the most extensive profile of sex and adrenal steroid hormones, along with their all-important metabolites. The daily (diurnal) pattern of free cortisol, along with melatonin is included. This unique combination of clinical information is not available by any other testing method. This advanced hormone testing was developed to surpass industry standards for available testing options. DUTCH testing offers the most extensive profile of sex and adrenal steroid hormones, along with their all-important metabolites. EFFECTIVE HRT MONITORING DUTCH testing was specifically made to be optimally effective for most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones. THE EASIEST COLLECTION Patients collect just four or five dried urine samples over a 24-hour period. Dried specimen samples are convenient to collect, easy to ship and stable for several weeks. CLINICAL VALIDATION All Precision Analytical testing methods go through a rigorous and ongoing validation process to verify accuracy, precision, recovery, linearity, etc. in the pursuit of the most accurate and precise techniques available for hormone testing. Ordering physician: Precision Analytical low limit high limit How to read the graphical representation of results Daily Free Cortisol Pattern High Range Limit Low Range Limit Accession # Jane Doe 123 4th St. Anytown, FL DOB: Age: 40 Gender: Female Hormone Testing Summary Sex Hormones Total Estrogen Waking (A) Morning (B) Afternoon (C) Night (D) Last Menstrual Period: Collection Times: See Pages 2 and 3 for a thorough breakdown of sex hormone metabolites Progesterone (Sum of 8 Estrogen Metabolites) (Serum Equivalent, ng/ml) Progesterone Serum Equivalent is a calculated value based on urine pregnanediol. Total DHEA Production Adrenal Hormones See pages 4 and 5 for a more complete breakdown of adrenal hormones > hr Free Cortisol Free cortisol best reflects tissue levels. Metabolized cortisol best reflects total cortisol production. Sex Hormones and Metabolites Ordering physician: Precision Analytical :01AM :01AM :01PM :01PM All units are given in ng/mg creatinine Testosterone Total DHEA Production (DHEAS + Etiocholanolone + Androsterone) metabolism Metabolized Cortisol (THF+THE) (Total Cortisol Production) Thank you for testing with us! ======================================================================================= Please be sure to always read below for any specific lab comments. More detailed comments can be found on page 7. PLEASE NOTE: We have added a new marker to the DUTCH Complete. See page 5 and provider comments for information on 8-OHdG. - Because inflammation blocks DHEA being converted to DHEAS, consider inflammation as a potential part of the overall clinical picture when DHEAS is significantly lower than the downstream metabolites of DHEA (Androsterone, Etiocholanolone) as seen in this case (see page3). ======================================================================================= Your DUTCH Complete report will include a summary (page 1), a list of all of the hormones tested and their ranges (pages 2,4) as well as a graphical representation of the results (pages 3,5). You will also see a steroid pathway for your reference (page 6) and provider notes. This report is not intended to treat, cure or diagnose any specific diseases. There is a series of videos in our video library at dutchtest.com that you may find useful in understanding the report. The following videos (which can also be found on the website under the listed names) may be particularly helpful in aiding your understanding: DUTCH Complete Overview (quick overview) Estrogen Tutorial; Androgen Tutorial; Cortisol Tutorial Precision Analytical (Raymond Grimsbo, Lab Director) Jane Doe Page 1 of Rivergate Street #301C FINAL REPORT CLIA Lic. #38D McMinnville, OR /06/2017 DutchTest.com Accession # Jane Doe 123 4th St. Anytown, FL DOB: Age: 40 Gender: Female graphically in the order the body metabolizes them. Arrows represent conversion from one hormone to another. The stars represent the low and high limits of the reference ranges ( see example, right ). The Last Menstrual Period: Collection Times: Category Test Result Units Normal Range Progesterone Metabolites b-pregnanediol Below premenopausal range ng/mg a-pregnanediol Low end of range ng/mg Androgen Metabolites DHEAS Low end of range 26.0 ng/mg Androsterone High end of range ng/mg Etiocholanolone Within range ng/mg Testosterone Within range 7.7 ng/mg a-DHT High end of range 7.5 ng/mg a-Androstanediol Above range 42.0 ng/mg b-Androstanediol Within range 32.0 ng/mg Epi-Testosterone Below range 2.0 ng/mg Estrogen Metabolites Estrone(E1) Above range 28.2 ng/mg Estradiol(E2) Above range 5.1 ng/mg Estriol(E3) Above range 22.5 ng/mg OH-E1 Below premenopausal range 3.6 ng/mg OH-E1 Within range 0.7 ng/mg OH-E1 Above range 4.7 ng/mg Methoxy-E1 Below premenopausal range 0.8 ng/mg OH-E2 Within range 0.71 ng/mg Normal Ranges Luteal Postmenopausal Follicular Ovulatory Estrone (E1) Estradiol (E2) Estriol (E3) N/A N/A 2-OH-E N/A N/A 4-OH-E N/A N/A 16-OH-E N/A N/A 2-Methoxy-E N/A N/A Oral Pg (100mg) a-pregnanediol b-pregnanediol ß 5ß 5α 5α CYP1A1 (protective pathway) Precision Analytical (Raymond Grimsbo, Lab Director) Jane Doe Page 3 of Rivergate Street #301C FINAL REPORT CLIA Lic. #38D McMinnville, OR /06/2017 DutchTest.com 28.2 CYP3A4 CYP1B1 5ß 5ß COMT α 5α 5.1 > CYP1A1 (protective pathway) CYP3A4 CYP1B1 Cortisone (ng/mg) COMT CRH ACTH S T R E S S Hypothalamus Pituitary Adrenal Gland High Range Limit Low Range Limit Stress (or inflammation) causes the brain to release ACTH, which stimulates the adrenal glands to make hormones DHEA Melatonin* (Waking) A patient s catabolic vs anabolic balance can be estimated by observing relative DHEA (anabolic) vs cortisol (catabolic) production Cortisol Waking (A) Morning (B) Afternoon (C) Night (D) Note: "Waking" samples reflect overnight production hr Free Cortisone Cortisol Metabolism Circulating Free Cortisol Daily Free Cortisone Pattern Daily Free Cortisol Pattern 39.9% 4-OH More cortisone More cortisol metabolites (THE) metabolites (THF) (ng/mg) Cortisol Total DHEA Production (DHEAS + Etiocholanolone + Androsterone) High Range Limit Low Range Limit NOTE: This 11b-HSD index measures the balance of cortisol and cortisone metabolites which best reflects the overall balance of active cortisol and inactive cortisone systemically. Reference Range hr Free Cortisol Total DHEA Production > Metabolized Cortisol (THF+THE) (Total Cortisol Production) Waking (A) Morning (B) Afternoon (C) Night (D) NOTE: The balance between free cortisol and free cortisone reflects the kidney's conversion of cortisol to cortisone. See below for the overall preference between cortisol and cortisone. Provider Notes DUTCH welcomes 8-OHdG 8-OHdG (8-hydroxy-deoxyguanosine) results can be seen on page 5 of the DUTCH Complete report. It is a marker for estimating DNA damage due to oxidative stress (ROS creation). 8-OHdG is considered pro-mutagenic as it is a biomarker for various cancer and degenerative disease initiation and promotion. It can be increased by chronic inflammation, increased cell turnover, chronic stress, hypertension, hyperglycemia/pre-diabetes/diabetes, kidney disease, IBD, chronic skin conditions (psoriasis/eczema), depression, atherosclerosis, chronic liver disease, Parkinson's (increasing levels with worsening stages), Diabetic neuropathy, COPD, bladder cancer, or insomnia. Studies have shown higher levels in women with breast and prostate cancers. When levels are elevated it may be prudent to eliminate or reduce any causes and increase the consumption of antioxidant containing foods and/or supplements. Reference Range Thank you for testing with us! If this is your first report, you are encouraged to watch our educational videos on how to read the report. There are hyperlinks to these videos on the first page of a DUTCH Complete or in these comments (below). The videos can also be seen by going to and visiting the video library. Comments in the report that are specific to the patient ARE IN ALL CAPS or may be bold. The other information is general information that we hope you will find useful in understanding the patient's results. These results are not intended to diagnose any specific conditions. Treatments based on results should be made by a qualified healthcare provider. THE PATIENT REPORTS IRREGULAR MENSTRUAL CYCLES. THE PATIENT REPORTED SYMPTOMS OF EXCESS ESTROGEN. THIS CAN BE CAUSED BY EXCESS ESTROGEN OR PROGESTERONE DEFICIENCY. RESULTS SHOULD BE CAREFULLY REVIEWED. WE DO NOT REPORT A PROGESTERONE TO ESTROGEN RATIO. HOWEVER, YOU CAN INVESTIGATE THIS ISSUE BY LOOKING AT THE RELATIVE LEVEL OF THESE TWO HORMONES ON THEIR RESPECTIVE GAUGES. THE PATIENT REPORTED SIGNIFICANT SYMPTOMS OF EXCESS ANDROGEN LEVELS. THE PATIENT REPORTED SIGNIFICANT FATIGUE IN BOTH THE AM AND PM. Progesterone Metabolism: The primary role of progesterone is to balance the strong effects of estrogen. Progesterone metabolites are measured and reflect progesterone levels well because very little progesterone is found in urine, so b- Pregnanediol is typically used a surrogate marker because it is the most abundant metabolite, but we also test the corresponding a-pregnanediol. The average of the two metabolites is reported for progesterone. If levels are in the lower part of the reference range compared to estrogen levels, symptoms of too much estrogen may occur When ordering the DUTCH Complete, you will see Progesterone Serum Equivalent on the summary page 1. The urine metabolites of progesterone have been proven to correlate strongly enough to serum progesterone to provide this value. The correlation is the strongest for values within the premenopausal luteal range. Urine metabolites can at times result in somewhat higher serum equivalent results in the postmenopausal range. For this reason the postmenopausal Serum Equivalent range is slightly higher than typical serum ranges. NOTE: If progesterone is taken orally (also with sublingual), these metabolites are elevated from gut metabolism and results do NOT accurately reflect serum levels. Androgen Metabolism: This group of hormones is typically thought of as male hormones, but they play a key role for women as well. Testosterone is made in the ovaries as well as the adrenal glands. In postmenopausal women, the adrenal glands are the primary source of testosterone. a-dht (a-dihydrotestosterone) is the most potent androgen (3X more than testosterone), but it is primarily made within the liver and target cells (it is a paracrine hormone) and not by the gonads. a- DHT is subsequently deactivated to a-androstanediol within target tissues and then excreted. Only a fraction of a-dht formed actually enters circulation as a-dht (Toscano, 1987). The corresponding beta metabolites (for example b-dht) are not androgenic. Looking at the balance of androsterone (alpha) and etiocholanolone offer the best approximation of how readily DHT will be made. Elevated androgens can cause general and sexual aggression, increased muscle mass, increased facial/body hair, reduction of fat deposition, and increased libido. Androgen deficiency can lead to decreased sexual function, vaginal dryness, fatigue, depression, and bone loss. 5a-Reductase Activity: The competing enzymes 5a and 5b-reductase act on the androgens androstenedione (creating androsterone and etiocholanolone located under the progesterone picture) and testosterone (creating a-dht and b-dht). They also metabolize progesterone, and cortisol. The alpha metabolites of androstenedione and testosterone are far more androgenic than their beta counterparts. Consequently, increased 5a-reductase activity may be accompanied by clinical signs of androgenicity (excess facial hair growth, scalp hair loss, acne, irritability, oily skin, prostate issues in men...etc). If the patient heavily favors the 5a pathway and there are concerns of excess androgenicity (or prostate cancer risk), this may be worth addressing. Estrogen Metabolism: There are two primary issues with respect to estrogens. 1) Estrogen production (is the patient deficient, sufficient, or in excess?) and 2) Estrogen metabolism (is the metabolism of estrogen favorable or unfavorable when looking at the phase 1 hydroxylation and phase 2 methylation pathways?) While estradiol (E2) is the most potent estrogen, levels of estrone (E1) and estriol (E3) should also be considered when evaluating the patient's estrogen production. It is important to compare the patient's distribution of metabolites from the pie chart (2nd pie chart) to "Normal Estrogen Metabolism" pie chart. If they are making considerably less of the protective 2-OH estrogens, consider something to improve this metabolism (DIM, I-3-C, etc). Be advised that increasing 2-OH metabolism will Precision Analytical (Raymond Grimsbo, Lab Director) Jane Doe Precision Page 5 Analytical of 9 (Raymond Grimsbo, Lab Director) Jane Doe Page 7 of Rivergate Street #301C FINAL REPORT CLIA Lic #38D Rivergate Street #301C FINAL REPORT CLIA Lic. #38D McMinnville, OR /06/2017 McMinnville, DutchTest.com OR /06/2017 DutchTest.com 10.

14 Estradiol (pg/ml) Progesterone b-pg / E2 Ratio NE Rivergate #301C, McMinnville, OR DUTCH Cycle Mapping by Precision Analytical Get the Full Picture Throughout the Entire Menstrual Cycle. Why is Cycle Mapping Beneficial? DUTCH Cycle Mapping provides a complete picture of the patient s cycle in a graph format allowing for a more accurate and comprehensive treatment program specific to the patient s situation. Helps evaluate hormones throughout a full menstrual cycle. Nine targeted estrogen and progesterone measurements provide important details on a patient s hormone levels in the follicular, ovulatory and luteal phases of the cycle. Easily collected in the comfort of your patients own home. Samples are couriered to FxMed then sent on to Precision Analytical Lab. When is Cycle Mapping recommended? Women struggling with infertility Women with cycling hormones but no menstrual bleeding Partial hysterectomy (ovaries intact, but no uterus) Ablations Mirena IUD (no actual menstrual bleeding due to IUD but still has hormonal symptoms) Women with irregular cycles PCOS If the luteal phase shifts from month-to-month Peri-menopause Women whose hormonal symptoms tend to fluctuate throughout the cycle PMS, mid-cycle spotting, migraines, etc. Measurement Day of Cycle Accession # Name: Sample Patient D.O.B. 12/30/1977 Provider: Provider Collection Dates 3/15-4/15/2015 Values given on this page are based on research in which women's serum and urine metabolites were measured. Actual serum measurements were not made for this test. Range Low/High Estradiol Serum Progesterone (ng/ml) Serum Estradiol (pg/ml) Progesterone DUTCH - Cycle Mapping Monthly Pattern of Estradiol and Progesterone - Serum Equivalent Day of Cycle Progesterone units = ng/ml Day of Cycle Normal Ranges Follicular Ovulatory Luteal Postmenopausal Progesterone 1-2ng/mg 4-12ng/mg ng/mg ng/mg ng/mg ng/mg 10-50ng/mg b-pg / E2 Ratio ng/mg < Precision Analytical, Inc. CLIA Lic #38D Dutch Cycle Mapping vs Saliva and Serum Testing Dutch Cycle Mapping Saliva Serum 25 samples of first-morning urine collections. Testing on targeted samples based on the actual length of the cycle. This allows for better characterization of both the ovulatory and luteal peaks. There is a higher level of hormone (~1000x) in urine than in saliva. This allows for the use of more accurate methodologies (GC-MS/MS instead of immunoassays). Dutch Cycle Mapping results correlate strongly enough to serum results that urine results are given along with serum-equivalent results for easy interpretation. Limited number of collections which may result in missing progesterone and especially estrogen peaks if not timed correctly. For women with irregular cycles, this is particularly problematic. A recent internal study showed the correlation between urine and serum to be much improved over saliva testing. This was true of progesterone, but even more so for estradiol. Serum Testing is reliable and well-suited for testing total and free E2, T and Pg. Does not test metabolites. Compared to DUTCH Cycle Mapping Test which provides a complete picture of the patients cycle, Serum Testing will only provide a snapshot of hormone levels within the cycle. DUTCH Cycle Mapping is an individual test or can be combined with the DUTCH complete test which also includes cortisol, cortisone, cortisol metabolites, DHEAS, melatonin and androgens. 11.

15 For additional information, please request FxMed s Functional Testing Reference Catalogue or contact FxMed s Technical Support Team to book in a skype training on any of these tests on or techsupport@fxmed.co.nz 12.

16 Please call our Technical Support Team on if you have further questions or Functional & Integrative Medicine Ltd, 77 Austin St, PO Box 19033, Onekawa, Napier 4146, NZ Ph Fax