MG4010 Course Information. Syllabus

Transcription

1 MG4010 Course Information Syllabus A one- semester course designed to introduce students to the basic tenets of biochemistry. The topics that will be discussed have been chosen to comply with the guidelines for the biochemistry component of the medical college admission test (MCAT), which will be incorporated into the 2015 offering of the MCAT (see for more information). The course will be taught in three components: the first is protein structure and function, enzyme mechanisms, and enzyme kinetics. The second component is nucleic acid biochemistry, including DNA replication and repair, synthesis of RNA (transcription), synthesis of proteins (translation), regulation of gene expression, and molecular techniques. The third component includes biochemical thermodynamics and an introduction to metabolism, which includes glycolysis, gluconeogenesis, TCA cycle, oxidative phosphorylation, glycogen metabolism, and fatty acid metabolism. The course will emphasize the relationship of biochemistry to disease, and will discuss, in particular, sickle cell anemia, prion diseases, collagen disorders, thalassemias, cancer in relation to mutations in DNA repair, toxins that affect RNA and protein synthesis, diabetes (both type 1 and type 2), glycogen storage diseases, mitochondrial disorders, and abnormalities in fatty acid oxidation. Meeting Times The class will meet in the Medical Sciences Building, room 2351, on Tuesdays and Thursdays, starting at 2:00 pm. Classes will end by 3:25 pm. The first class will begin at 2:00 pm, on August 27, Each individual professor will set up their office hours, and discuss them with you when they first meet the class. Dr. Lieberman will have office hours every Tuesday and Thursday from 12:30 to 1:30 pm throughout the semester. Grading Policies and Test Information There will be three exams during the quarter, the first worth 75 points (September 26, 2013), the second worth 75 points (October 31, 2013), the third exam, which will also be a cumulative exam over the entire quarter (150 points, given December 10, 2013). For the third exam, 25 points will derive from Dr. Rosevear s lectures, 25 points from Dr. Cartwright s lectures, and 100 points from Dr. Lieberman s lecture. Students are expected to take the exams when scheduled. Any unexcused absence will result in a grade of zero for that exam, and absences must be approved in advance. If ill, a doctor's note will be required to have a valid absence from an exam, and the doctor must have been seen on the day of the exam. It is anticipated that the course will be graded on a curve, but there are certain targets that will guarantee a certain grade. A final score of 270 points or more will 1

2 guarantee an A; a final score of 240 points of more will guarantee a B; a final score of 210 points or more will guarantee a C; and a final score of 180 points or more will guarantee at least a D. Thus, even if all students score above 270 points for the year, all students will receive an A. If the exams are more difficult than anticipated, then these numbers may drop, but there is no guarantee that such an adjustment will occur. Textbook The textbook for the semester will be Marks Essentials of Medical Biochemistry, A Clinical Approach, by Lieberman, Marks and Smith (ISBN = ). It should be available either in the University Bookstore or at Dubois Bookstore. You can also purchase the book from Amazon.com - Essentials- Medical- Biochemistry/dp/ /ref=la_B002882H5S_1_4?ie=UTF8&qid= &sr=1-4. The book is not available in an electronic format. Animations A number of animations have been developed to help students learn certain aspects of biochemistry. Animations on DNA synthesis and repair, Protein synthesis, the Polymerase Chain Reaction, the TCA cycle, the Electron Transport Chain, and the Proton- translocating ATP synthase, are available from the following link: Online Tutorial on Amino Acid structures and codes A student from a previous class sent me the following link which is useful for learning the structures and single letter and three letter codes for the amino acids. The site also has quizzes through which you can test yourself. Podcasts All of the lectures of the MG4010 course will have the audio portion of the lecture available from the audio files section of the course. You have the option from that folder of subscribing to a podcast (click on the RSS button, and it will automatically subscribe you if you use itunes), or you can right- click on the audio files to download them to your computer. The podcasts are usually loaded immediately after class. There is an initial test audio file, which is from three years ago (it references Autumn 2009). If you can successfully download that file, your podcasts should be set up correctly. As with any technology, there will be times when the recording system fails. As this is the first year of this course, it will not be possible to post previous year s 2

3 classroom recordings in their place. I will let the class know as soon as possible if a recording has failed. 3

4 Fall semester 2013, MG4010 schedule, Introduction to Medical Biochemistry Date Topic Chapters Lecturer 8/27/13 Introduction, water, 2 Rosevear acids, bases, buffers 8/29/13 Structures of the major 3 Rosevear compounds 9/3/13 Amino acids and 4 Rosevear proteins 9/5/13 Structure- function 5 Rosevear relationships in proteins 9/10/13 Problem solving, in class 2-5; practice Rosevear 9/12/13 Oxygen binding to Hb None Rosevear and Mb 9/17/13 Enzymes as catalysts 6 Rosevear 9/19/13 Regulation of enzyme 7 Rosevear activity 9/24/13 Problem solving, in class 6-7; practice Rosevear 9/26/13 Exam 1 10/1/13 Structure of the nucleic 9 Cartwright acids 10/3/13 Synthesis and repair of 10 Cartwright DNA 10/8/13 NO CLASS READING DAY 10/10/13 Transcription 11 Cartwright 10/15/13 Translation 12 Cartwright 10/17/13 Regulation of gene 13 Cartwright expression 10/22/13 Finish regulation, start 13 and 14 Cartwright molecular techniques 10/24/13 Finish molecular 14 Cartwright techniques and applications 10/29/13 Problem solving, in class 9-14; practice Cartwright 10/31/13 Exam 2 11/5/13 Bioenergetics 15 Lieberman 11/7/13 TCA cycle 16 Lieberman 11/12/13 Finish TCA cycle, start 16 and 17 Lieberman 1

5 oxidative phosphorylation 11/14/13 Finish oxidative 17 Lieberman phosphorylation 11/19/13 Glycolysis 18 and 25 Lieberman 11/21/13 Finish glycolysis and 18 and 22 Lieberman start glycogen metabolism 11/26/13 Finish glycogen and start 22 and 19 Lieberman fatty acid oxidation 12/3/13 Finish fatty acid 19 and 23 Lieberman oxidation, HMP shunt 12/5/13 Problem solving, in class 15-19, 22, 23, 25 Lieberman 12/12/13 (2:00 to 4:00 pm, may be subject to change) Exam 3 (final exam) 2