CURRICULUM VITAE. School of Health Professions Department of Nutrition & Metabolism University of Texas Medical Branch

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1 CURRICULUM VITAE Blake B. Rasmussen, PhD School of Health Professions Department of Nutrition & Metabolism University of Texas Medical Branch February 2019 (Abbreviated) CONTACT INFORMATION BIOGRAPHICAL INFORMATION 301 University Boulevard Birthplace: Logan, Utah Galveston, TX Citizenship: U.S. Ph: (409)-1619 Home: League City, TX EDUCATION 1992 B.S. Utah State University, Logan, Utah Exercise Science 1993 M.S. Utah State University, Logan, Utah Exercise Science 1997 Ph.D. Brigham Young University, Provo, UT Zoology/Cell Biology (Will Winder Lab) 2000 Postdoc University of Texas Medical Branch Human Metabolism (Robert Wolfe Lab) PROFESSIONAL EXPERIENCE University of Texas Medical Branch 2018 present Director, Center for Recovery, Physical Activity & Nutrition 2017 present Interim Associate Dean for Research, School of Health Professions 2013 present Professor & Chair, Department of Nutrition & Metabolism Associate Director, Center for Recovery, Physical Activity & Nutrition 2009 present Professor, School of Health Professions 2005 present Senior Fellow, Sealy Center on Aging 2005 present Full Member, Graduate School of Biomedical Sciences Associate Professor, Department of Physical Therapy University of Southern California Assistant Professor, Division of Integrative & Evolutionary Biology Assistant Professor, Department of Kinesiology RESEARCH INTEREST The focus of our research is on the nutritional and contractile regulation of human skeletal muscle protein synthesis and growth. We currently have two main objectives: 1) To determine how muscle cells sense amino acids and initiate the cellular process of protein synthesis. We are currently looking at this in a transgenic animal model and in humans with a clinical trial. 2) To determine the mechanisms underlying how muscle contraction activates protein synthesis, gene expression and overall muscle growth. We use both animal models and human acute and chronic exercise models to examine mtorc1 signaling, translation initiation, mtorc1 translocation to the lysosome, and expression of

2 genes involved in muscle hypertrophy. The prevention of muscle loss during aging (Sarcopenia) is our long term goal. GRANTS EXTERNAL FUNDING Active Grants as PI or Core / Project Leader Title: University of Texas Adult Clinical Center (MoTrPAC) Role: Principal Investigator MPI: N. Musi (UTHSCSA) Source: National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIA Amount: $6,670,000 Period: Title: Effect of Whey Protein Hydrolysate on Human Muscle Protein Synthesis Role: Principal Investigator Source: Meiji Co., Ltd. Period: Title: Metabolism & Biology Resource Core, UTMB Claude Pepper OAIC Role: Core Leader (PI: Volpi) Source: National Institute on Aging, NIA Amount: $734,175 (current cycle); Total Award: $3.4 million (current cycle) Period: PEER-REVIEWED PUBLICATIONS (from > 120) 1. Winder, W.W., H.A. Wilson, D.G. Hardie, B.B. Rasmussen, C.A. Hutber, G.B. Call, R.D. Clayton, L.M. Conley, S. Yoon, and B. Zhou. Phosphorylation of rat muscle acetyl-coa carboxylase by AMP-activated protein kinase and protein kinase A. Journal of Applied Physiology 82(1): , Rasmussen, B.B. and W.W. Winder. Effect of exercise intensity on skeletal muscle malonyl-coa and acetyl-coa carboxylase. Journal of Applied Physiology 83(4): , Hutber, C.A., B.B. Rasmussen and W.W. Winder. Endurance training attenuates the decrease in skeletal muscle malonyl-coa with exercise. Journal of Applied Physiology 83(6): , Rasmussen, B.B., C.R. Hancock, and W.W. Winder. Postexercise recovery of skeletal muscle malonyl-coa, acetyl-coa carboxylase and AMP-activated protein kinase. Journal of Applied Physiology 85(5): , Merrill, G.F., E.J. Kurth, B.B. Rasmussen, and W.W. Winder. Influence of malonyl-coa and palmitate concentration on rate of palmitate oxidation in rat muscle. Journal of Applied Physiology 85(5): , Rasmussen, B.B., E. Volpi, D.C. Gore, and R.R. Wolfe. Androstenedione does not stimulate muscle protein anabolism in young healthy men. Journal of Clinical Endocrinology and Metabolism 85(1): 55-59, Rasmussen, B.B., K.D. Tipton, S.L. Miller, S.E. Wolf, and R.R.Wolfe. An oral essential amino acidcarbohydrate supplement enhances muscle protein anabolism following resistance exercise. Journal of Applied Physiology 88(2): , 2000.

3 8. Volpi, E., B. Mittendorfer, B.B. Rasmussen, and R.R. Wolfe. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. Journal of Clinical Endocrinology and Metabolism, 85(12): , Tipton, K.D., B.B. Rasmussen, S.L. Miller, S.E. Wolf, S. Owens-Stovall, B. Petrini, and R.R. Wolfe. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. American Journal of Physiology-Endocrinology and Metabolism, 282(2): E197-E206, Volpi, E., M. Sheffield-Moore, B.B. Rasmussen, and R.R. Wolfe. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA, 286 (10): , Martini, W.Z., O. Irtun, D.L. Chinkes, B.B. Rasmussen, D.L. Traber, and R.R. Wolfe. Alteration of hepatic fatty acid metabolism after burn injury in pigs. Journal of Parenteral and Enteral Nutrition, 25 (6): , Rasmussen, B.B., R.R. Wolfe, and E. Volpi. Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly. Journal of Nutrition Health and Aging. 6(6): , Rasmussen, B.B., U. Holmback, E. Volpi, B. Morio-Liondore, D. Paddon-Jones, R.R. Wolfe. Malonyl-CoA regulates functional carnitine palmitoyl-transferase I activity and fat oxidation in human skeletal muscle. Journal of Clinical Investigation, 110: , Durham, W.J., S.L. Miller, C.W. Yeckel, D.L. Chinkes, K.D. Tipton, B.B. Rasmussen, and R.R. Wolfe. Leg glucose and protein metabolism during and acute bout of resistance exercise in humans. Journal of Applied Physiology, 97: , Volpi, E., S.A. Lieberman, D.M. Ferrer, Gilkison, C.R., B.B. Rasmussen, M. Nagamani, and R.J. Urban. The relationship between testosterone, body composition, and insulin resistance: a lesson from a case of extreme hyperandrogenism. Diabetes Care, 28(2): , Bell,J.A., S. Fujita, E. Volpi, J. Cadenas, and B.B. Rasmussen. Short-term Insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreases. American Journal of Physiology: Endocrinology & Metabolism, 289: E999-E1006, Rasmussen, B.B., S. Fujita, R.R. Wolfe, B. Mittendorfer, M. Roy, V.L. Rowe, and E. Volpi. Insulin resistance of muscle protein metabolism in aging. FASEB Journal, 20(6):768-9, Bell, J.A., E. Volpi, S. Fujita, J. Cadenas, and B.B. Rasmussen. Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetes. Journal of Nutrition, 136(5): , Bell,J.A., E. Volpi, S. Fujita, J.G. Cadenas, and B.B. Rasmussen. Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-coa. Diabetologia, 49(9): , Fujita, S, B.B. Rasmussen, J.G. Cadenas, J.J. Grady, and E. Volpi. The effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. American Journal of Physiology: Endocrinology & Metabolism, 291: E , Dreyer, H.C., S. Fujita, J.G. Cadenas, D.L. Chinkes, E. Volpi, and B.B. Rasmussen. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. Journal of Physiology, 576: , Fujita, S., B.B. Rasmussen, J.A. Bell, J.G. Cadenas, and E. Volpi. Basal muscle intracellular amino acid kinetics in women and men, American Journal of Physiology: Endocrinology & Metabolism, 292(1):E77-83, Fujita, S., B.B. Rasmussen, J.G. Cadenas, M. J. Drummond, E.L. Glynn, F.R. Sattler, and E. Volpi. Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/mTOR signaling. Diabetes 56(6): , Fujita, S., H.C. Dreyer, M.J. Drummond, E.L. Glynn, J.G. Cadenas, F. Yoshizawa, E. Volpi, and B.B. Rasmussen. Nutrient signalling in the regulation of human muscle protein synthesis. Journal of Physiology 582(Pt 2):813-23, 2007.

4 25. Fujita, S., T. Abe, M.J. Drummond, J.G. Cadenas, H.C. Dreyer, Y. Sato, E. Volpi, and B.B. Rasmussen. Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. Journal of Applied Physiology 103(3):903-10, Dreyer, H.C., E.L. Glynn, H.L. Lujan, C.S Fry, S.E. DiCarlo, and B.B. Rasmussen. Chronic paraplegia-induced muscle atrophy downregulates the mtor/s6k1 signaling pathway. Journal of Applied Physiology, 104: 27-33, Glynn, E.L., H.L Lujan, V.J Kramer, M.J Drummond, S.E. DiCarlo, and B.B. Rasmussen. A chronic increase in physical activity inhibits fed-state mtor/s6k1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. Applied Physiology, Nutrition, and Metabolism 33(1):93-101, Dreyer H.C, M.J. Drummond, B. Pennings, S. Fujita, E.L. Glynn, D.L. Chinkes, S. Dhanani, E. Volpi, and B.B. Rasmussen. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mtor signaling and protein synthesis in human muscle. American Journal of Physiology: Endocrinology & Metabolism 294: E392-E400, Drummond, M.J., S. Fujita, T. Abe., H.C. Dreyer, E. Volpi, and B.B. Rasmussen. Human muscle gene expression following resistance exercise and blood flow restriction. Medicine and Science in Sports and Exercise 40(4): , Drummond, M.J., E.L. Glynn, H.L. Lujan, S.E. DiCarlo, and B.B. Rasmussen. Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle. Muscle & Nerve 37(4): Drummond, M.J., H.C. Dreyer, B. Pennings, C.S. Fry, S. Dhanani, E.L. Dillon, M. Sheffield-Moore, E. Volpi, and B.B. Rasmussen. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. Journal of Applied Physiology, 104(5):1452-6, Drummond, M.J., J.A. Bell, S. Fujita, H.C. Dreyer, E.L. Glynn, E. Volpi, and B.B. Rasmussen. Amino acids are necessary for the insulin-induced activation of mtor/s6k1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle. Clinical Nutrition, 27: , Volpi, E., D.L. Chinkes, and B.B. Rasmussen. Sequential muscle biopsies during a six-hour tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics. American Journal of Physiology: Endocrinology & Metabolism, 295(4): E959-63, Drummond M.J., J.J. McCarthy, C.S. Fry, K.A. Esser, and B.B. Rasmussen. Aging differentially affects human skeletal muscle microrna expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids. American Journal of Physiology: Endocrinology & Metabolism, 295(6): E1333-E1340, Dreyer H.C., M.J. Drummond, E.L. Glynn, S. Fujita, D.L. Chinkes, E. Volpi and B.B. Rasmussen. Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during post-exercise recovery. Journal of Applied Physiology, 105(6): , Drummond M.J., M. Miyazaki, H.C. Dreyer, B. Pennings, S. Dhanani, E. Volpi, K.A. Esser, and B.B. Rasmussen. Expression of growth-related genes in young and old human skeletal muscle following an acute stimulation of protein synthesis. Journal of Applied Physiology, 106: , Drummond M.J., C.S. Fry, E.L. Glynn, H.C. Dreyer, S. Dhanani, K.L. Timmerman, E. Volpi, and B.B. Rasmussen. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. Journal of Physiology, 587(7): , Fujita, S., H.C.Dreyer, M.J.Drummond, E.L.Glynn, E. Volpi, and B.B. Rasmussen. Essential amino acid and carbohydrate ingestion prior to resistance exercise does not enhance postexercise muscle protein synthesis. Journal of Applied Physiology, 106: , Fujita S., E.L. Glynn, K.L. Timmerman, B.B. Rasmussen, and E. Volpi. Supraphysiological hyperinsulinemia is necessary to stimulate skeletal muscle protein anabolism in older adults:

5 evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia, 52: , Drummond M.J., E.L. Glynn, C.S. Fry, S. Dhanani, E. Volpi and B.B. Rasmussen. Essential amino acids increase microrna-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mrna expression in human skeletal muscle. Journal of Nutrition, 139: , Dreyer H.C., S. Fujita, E.L. Glynn, M.J. Drummond, E. Volpi, and B.B. Rasmussen. Resistance exercise increases leg muscle protein synthesis and mtor signaling independent of sex. Acta Physiologica (Oxford), 199:71-81, Drummond M.J., E.L. Glynn, C.S. Fry, K.L. Timmerman, E. Volpi, and B.B. Rasmussen. An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. American Journal of Physiology: Endocrinology & Metabolism, 298: E1011-E1018, Fry C.S., E.L. Glynn, M.J. Drummond, K.L. Timmerman, S. Fujita, T. Abe, S. Dhanani, E. Volpi, and B.B. Rasmussen. Blood flow restriction exercise stimulates mtorc1 signaling and muscle protein synthesis in older men. Journal of Applied Physiology, 108: , Timmerman, K.L., J.L. Lee, H.C. Dreyer, S. Dhanani, E.L. Glynn, C.S. Fry, M.J. Drummond, M. Sheffield-Moore, B.B. Rasmussen, and E. Volpi. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mtorc1 signaling. Journal of Clinical Endocrinology & Metabolism 95: , Glynn, E.L., C.S. Fry, M.J. Drummond, H.C. Dreyer, S. Dhanani, E. Volpi, and B.B. Rasmussen. Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 299: R533-R540, Timmerman, K.L., J.L. Lee, S. Fujita, S. Dhanani, H.C. Dreyer, C.S. Fry, M.J. Drummond, M. Sheffield-Moore, B.B. Rasmussen, and E. Volpi. Pharmacological vasodilation improves the protein anabolic response of muscle to insulin in older adults. Diabetes 59(11): , Glynn, E.L., C.S. Fry, M.J. Drummond, K.L. Timmerman, S. Dhanani, E. Volpi, and B.B. Rasmussen. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. Journal of Nutrition 140: , Fry C.S., M.J. Drummond, E.L. Glynn, J.M. Dickinson, D.M. Gundermann, K.L. Timmerman, D.K. Walker, S. Dhanani, E. Volpi, and B.B. Rasmussen. Aging impairs contraction-induced human skeletal muscle mtorc1 signaling and protein synthesis. Skeletal Muscle 1:11, Dickinson, J.M., C.S. Fry, M.J. Drummond, D.M. Gundermann, D.K. Walker, E.L. Glynn, K.L. Timmerman, S. Dhanani, E. Volpi, and B.B. Rasmussen. Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. Journal of Nutrition 141: Drummond, M.J., J.J. McCarthy, M. Sinha, H.M. Spratt, E. Volpi, K.A. Esser, and B.B. Rasmussen. Aging and mirna expression in human skeletal muscle: a microarray and bioinformatics analysis. Physiological Genomics 43(10): , Drummond, M.J., C.S. Fry, E.L. Glynn, K.L. Timmerman, J.M. Dickinson, D.K. Walker, D.M. Gundermann, E. Volpi, and B.B. Rasmussen. Skeletal muscle transporter expression is increased in young and older adults following resistance exercise. Journal of Applied Physiology 111: , Drummond, M.J., J.M. Dickinson, C.S. Fry, D.K. Walker, D.M. Gundermann, P.T. Reidy, K.L. Timmerman, M.M. Markofski, D. Paddon-Jones, B.B. Rasmussen, and E. Volpi. Bed rest impairs skeletal muscle amino acid transporter expression, mtorc1 signaling, and protein synthesis in response to essential amino acids in older adults. American Journal of Physiology: Endocrinology & Metabolism 302(9): E1113-E1122, Gundermann, D.M., C.S. Fry, J.M. Dickinson, D.K. Walker, K.L. Timmerman, M.J. Drummond, E. Volpi, and B.B. Rasmussen. Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise. Journal of Applied Physiology 112(9): , 2012.

6 54. Timmerman, K.L., S. Dhanani, E.L. Glynn, C.S. Fry, M.J. Drummond, K. Jennings, B.B. Rasmussen, and E. Volpi. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to a mixed meal in older adults. American Journal of Clinical Nutrition 94: , Walker, D.K., C.S. Fry, M.J. Drummond, J.M. Dickinson, K.L. Timmerman, D.M. Gundermann, E. Volpi, and B.B. Rasmussen. Pax7+ satellite cells in young and older adults following resistance exercise. Muscle & Nerve 46: 51-59, Fry, C.S., M.J. Drummond, H. L. Lujan, S.E. DiCarlo, and B.B. Rasmussen. Paraplegia increases skeletal muscle autophagy. Muscle & Nerve 46: , Dickinson, J.M., M.J. Drummond, C.S. Fry, D.M. Gundermann, D.K. Walker, K.L. Timmerman, E. Volpi, and B.B. Rasmussen. Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle. Metabolism 62: , Glynn, E.L., C.S. Fry, K.L. Timmerman, M.J. Drummond, E. Volpi, and B.B. Rasmussen. Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism. Journal of Nutrition 143: , Dickinson, J.M., M.J. Drummond, J.R. Coben, E. Volpi, and B.B. Rasmussen. Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise. Clinical Nutrition. 32(2): , Reidy, P.T, D.K. Walker, J.M. Dickinson, D.M. Gundermann, M.J. Drummond, K.L. Timmerman, C.S. Fry, M.S. Borack, M.B. Cope, R. Mukherjea, K. Jennings, E. Volpi, and B.B. Rasmussen. Protein blend ingestion following resistance exercise promotes human muscle protein synthesis. Journal of Nutrition 143: , Fry, C.S., M.J. Drummond, E.L. Glynn, J.M. Dickinson, D.M. Gundermann, K.L. Timmerman, D.K. Walker, E. Volpi, and B.B. Rasmussen. Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in young and older adults. Journal of Gerontology: Medical Sciences 68(5): , Butteiger, D.N., M. Cope, P. Liu, R. Mukherjea, E. Volpi, B.B. Rasmussen, and E.S. Krul. A soy, whey and caseinate blend extends postprandial skeletal muscle protein synthesis in rats. Clinical Nutrition 32(4): , Drummond, M.J., K.L. Timmerman, M.M. Markofski, D.K. Walker, J.M. Dickinson, M. Jamaluddin, A.R. Brasier, B.B. Rasmussen, and E. Volpi. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 305(3): R , Szczesny, B., G. Olah, D.K. Walker, E. Volpi, B.B. Rasmussen, C. Szabo, and S. Mitra. Deficiency in repair of mitochondrial genome sensitizes proliferating myoblasts to oxidative damage. PLoS ONE 8(9): e75201, Walker, D.K., M.J. Drummond, J.M. Dickinson, M. Borack, K. Jennings, E. Volpi, and B.B. Rasmussen. Insulin increases mrna abundance of the amino acid transporter SLCA5/LAT1 via an mtorc1 dependent mechanism in skeletal muscle cells. Physiological Reports 2(3): e00238, Gundermann, D.M., D.K. Walker, P.T. Reidy, M.S. Borack, J.M. Dickinson, E. Volpi, and B.B. Rasmussen. Activation of mtorc1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin. American Journal of Physiology: Endocrinology & Metabolism 306: E1198-E1204, Reidy, P.T., D.K. Walker, J.M. Dickinson, D.M. Gundermann, M.J. Drummond, K.L. Timmerman, M.B. Cope, R. Mukherjea, K. Jennings, E. Volpi, and B.B. Rasmussen. Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle. Journal of Applied Physiology 116: , Porter, C., D.N., Herndon, D.N., E. Borsheim, T. Chao, P. Reidy, M. Borack, B.B. Rasmussen, M. Chondronikola, M. Saraf, and L.S. Sidossis. Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults. American Journal of Physiology: Endocrinology & Metabolism 307: E462-E467, 2014.

7 69. Dickinson, J.M., D.M. Gundermann, D.K. Walker, P.T. Reidy, M.S. Borack, M.J. Drummond, M. Arora, E. Volpi, and B.B. Rasmussen. Leucine-enriched amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men. Journal of Nutrition 144: , Timmerman, K.L., W.E. Amonette, M.M. Markofski, H.A. Ansinelli, E.A. Gleason, B.B. Rasmussen, and K.A. Mossberg. Blunted IL-6 and IL-10 response to maximal aerobic exercise in patients with traumatic brain injury. European Journal of Applied Physiology 115(1): , Markofski, M.M., J.M. Dickinson, M.J. Drummond, C.S Fry, S. Fujita, D.M. Gundermann, E.L. Glynn, K. Jennings, D. Paddon-Jones, P.T. Reidy, M. Sheffield-Moore, K.L. Timmerman, B.B. Rasmussen, and E. Volpi. Effect of age on basal muscle protein synthesis and mtorc1 signaling in a large cohort of young and older men and women. Experimental Gerontology 65: 1-7, Coble, J., R.J. Schilder, A. Berg, M.J. Drummond, B.B. Rasmussen, and S.R. Kimball. Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism 40: , Porter, C., N.M. Hurren, M. Cotter, N. Bhattarai, P.T. Reidy, L. Dillon, W.J. Durham, D. Tuvdendorj, M. Sheffield-Moore, E. Volpi, L.S. Sidossis, B.B. Rasmussen, and E. Borsheim. Mitochondrial respiratory capacity and function decline with advancing age in human skeletal muscle. American Journal of Physiology: Endocrinology & Metabolism 309: E224-E232, Porter, C., P.T. Reidy, N. Bhattarai, L.S. Sidossis, and B.B. Rasmussen. Resistance exercise training alters mitochondrial function in human skeletal muscle. Medicine & Science in Sports & Exercise 47(9): , Groen, B.B., A.M. Horstman, H.M. Hamer, M. de Haan, J. van Kranenburg, J. Bierau, M. Poeze, W.K. Wodzig, B.B. Rasmussen, and L.J. van Loon. Post-prandial protein handling: you are what you just ate. PLoS One 10(11):e , Porter, C., D.N. Herndon, E. Borsheim, N. Bhattarai, T. Chao, P.T. Reidy, B.B. Rasmussen, C.R. Anderson, O.E. Suman, and L.S. Sidossis. Long-term skeletal muscle mitochondrial dysfunction is associated with hypermetabolism in severely burned children. Journal of Burn Care & Research 37: 53-63, Porter, C., D.N. Herndon, M. Chondronikola, T. Chao, P. Annamalai, N. Bhattarai, M.N. Saraf, K. Capek, P.T. Reidy, A.C. Daquinag, M.G. Kolonin, B.B. Rasmussen, E. Borsheim, T. Toliver- Kinsky, and L.S. Sidossis. Human and mouse brown adipose tissue mitochondria have comparable UCP1 function. Cell Metabolism 24: , Ogunbileje, J.O., C. Porter, D.N. Herndon, T. Chao, D.R. Abdelrahman, A. Papadimitriou, M. Chondronikola, T.A. Zimmers, P.T. Reidy, B.B. Rasmussen, and L.S. Sidossis. Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn injury. American Journal of Physiology: Endocrinology & Metabolism 311: E436-48, Reidy, P.T., M.S. Borack, M.M. Markofski, J.M. Dickinson, R.R. Deer, S.H. Husaini, D.K. Walker, S. Igbinigie, S.M. Robertson, M.B. Cope, R. Mukerjea, J.M. Hall-Porter, K. Jennings, E. Volpi, and B.B. Rasmussen. Protein supplementation has minimal effects on muscle adaptations during resistance exercise training in young men: a double-blind randomized trial. Journal of Nutrition 146: , Fry, C.S., C. Porter, L.S. Sidossis, C. Nieten, P.T. Reidy, G. Hundeshagen, R. Mlcak, B.B. Rasmussen, J.O. Lee, O.E. Suman, D.N. Herndon, and C.C. Finerty. Satellite cell activation and apoptosis in skeletal muscle from severely burned children. Journal of Physiology 594: , Groen, B.B.L., A.M. Horstman, H.M. Hamer, M. de Haan, J. van Kranenburg, J. Bierau, M. Poeze, W.K.W.H. Wodzig, B.B. Rasmussen, and L.J.C. van Loon. Increasing insulin availability does not augment postprandial muscle protein synthesis in healthy young and older men. Journal of Clinical Endocrinology & Metabolism 101(11): , Borack, M.S., P.T. Reidy, S.H. Husaini, M.M. Markofski, R.R. Deer, A.B. Richison, B.S. Lambert, M.B. Cope, R. Mukherjea, K. Jennings, E. Volpi, and B.B. Rasmussen. Soy-dairy protein blend or

8 whey protein isolate ingestion induces similar post-exercise muscle mechanistic target of rapamycin complex 1 signaling and protein synthesis responses in older men. Journal of Nutrition 146: , Dickinson, J.M., P.T. Reidy, D.M. Gundermann, M.S. Borack, D.K. Walker, A.C. D Lugos, E. Volpi, and B.B. Rasmussen. The impact of post exercise essential amino acid ingestion on the ubituitin proteasome and autophagosomal-lysosomal systems in skeletal muscle of older men. Journal of Applied Physiology 122(3): , Reidy, P.T., C.S. Fry, S. Igbinigie, R.R. Deer, K. Jennings, M.B. Cope, R. Mukerjea, E. Volpi, and B.B. Rasmussen. Protein supplementation does not affect myogenic adaptations to resistance training. Medicine & Science in Sports & Exercise 49(6): , Reidy, P.T., M.S. Borack, M.M. Markofski, J.M. Dickinson, C.S. Fry, R.R. Deer, E. Volpi, and B.B. Rasmussen. Post-absorptive muscle protein turnover affects resistance training hypertrophy. European Journal of Applied Physiology 117(5): , Graber, T.G., M.S. Borack, P.T. Reidy, E. Volpi, and B.B. Rasmussen. Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mtorc1 regulation in human skeletal muscle. Nutrition & Metabolism 14:35, Reidy, P.T., C.S. Fry, J.M. Dickinson, M.J. Drummond, and B.B. Rasmussen. Postexercise essential amino acid supplementation amplifies skeletal muscle satellite cell proliferation in older men 24 hours postexercise. Physiological Reports 5(11): e13269, Graber, T.G., B.L. Rawls, B. Tian, W.J. Durham, C.R. Brightwell, A.R. Brasier, B.B. Rasmussen, and C.S. Fry. Repetitive TLR-3 activation in the lung induces skeletal muscle adaptations and cachexia. Experimental Gerontology 106: , Moro, T., C.R. Brightwell, R.R. Deer, T.G. Graber, E. Galvan, C.S. Fry, E. Volpi, and B.B. Rasmussen. Muscle protein anabolic resistance to essential amino acids does not occur in healthy older adults before or after resistance exercise training. Journal of Nutrition 148(6): , Markofski, M.M., K. Jennings, K.L. Timmerman, J.M. Dickinson, C.S. Fry, M.S. Borack, P.T. Reidy, R.R. Deer, A. Randolph, B.B. Rasmussen, and E. Volpi. Effect of aerobic exercise training and essential amino acid supplementation for 24 weeks on physical function and muscle metabolism in healthy, independent older adults: a randomized clinical trial. Journal of Gerontology: Medical Sciences, In Press, Graber, T.G., C.S. Fry, C.R. Brightwell, T. Moro, R. Maroto, N. Bhattari, C. Porter, M. Wakamiya, and B.B. Rasmussen. Skeletal muscle specific knockout of DEP domain-containing 5 increases mtorc1 signaling, muscle cell hypertrophy, and mitochondrial respiration. Journal of Biological Chemistry, In Press, Brightwell, C.R., M.M. Markofski, T. Moro, C.S. Fry, C. Porter, E. Volpi, and B.B. Rasmussen. Moderate Intensity Aerobic Exercise Improves Skeletal Muscle Quality in Older Adults. Translational Sports Medicine, In Press, Link to current lab publications: %20muscle%20%20 B. OTHER: Review Articles (Peer-Reviewed) 93. Rasmussen B.B. and RR Wolfe. Regulation of fatty acid oxidation in skeletal muscle. Annual Review of Nutrition 19: , Volpi E. and B.B. Rasmussen. Nutrition and muscle protein metabolism in the elderly. Diabetes, Nutrition, and Metabolism, 13: , 2000.

9 95. Rasmussen B.B., and SM Phillips. Contractile and nutritional regulation of human muscle growth. Exercise and Sport Sciences Reviews, 31(3): , Drummond M.J. and B.B. Rasmussen. Leucine-enriched nutrients and the regulation of mtor signalling and human skeletal muscle protein synthesis. Current Opinion in Clinical Nutrition and Metabolic Care 11(3):222-6, Paddon-Jones D. and B.B. Rasmussen. Dietary protein recommendations and the prevention of sarcopenia. Current Opinion in Clinical Nutrition and Metabolic Care 12:86-90, Drummond, M.J., H.C. Dreyer, C.S. Fry, E.L. Glynn, and B.B. Rasmussen. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mtorc1 signaling. Journal of Applied Physiology 106: , Dickinson, J.M. and B.B. Rasmussen. Essential Amino Acid Sensing, Signaling, and Transport in the Regulation of Human Muscle Protein Metabolism. Current Opinion in Clinical Nutrition and Metabolic Care 14: 83-88, Fry C.S. and B.B. Rasmussen. Skeletal muscle protein balance and metabolism in the elderly. Current Aging Science 4(3): , Walker, D.K., J.M. Dickinson, K.L. Timmerman, M.J. Drummond, P.T. Reidy, C.S. Fry, D.M. Gundermann, and B.B. Rasmussen. Exercise, amino acids and aging in the control of human muscle protein synthesis. Medicine & Science in Sports & Exercise 43(12): , Dickinson, J.M., E. Volpi, and B.B. Rasmussen. Targeting protein anabolic impairments in aging muscle with exercise and nutrition. Exercise and Sport Sciences Reviews 41(4): , Dickinson, J.M. and B.B. Rasmussen. Amino acid transporters in the regulation of human skeletal muscle protein metabolism. Current Opinion in Clinical Nutrition and Metabolic Care 16: , Layman, D.K., T.G. Anthony, B.B. Rasmussen, S.H. Adams, C.J. Lynch, G.D. Brinkworth, and T.A. Davis. Defining meal requirements for protein to optimize metabolic roles of amino acids. American Journal of Clinical Nutrition 101(Suppl): 1330S-1338S, Reidy P.T., and B.B. Rasmussen. Role of ingested amino acids/protein in the promotion of resistance exercise-induced muscle protein anabolism. Journal of Nutrition 146(2): , Moro, T., S.M. Ebert, C.M. Adams, and B.B. Rasmussen. Amino acid sensing in skeletal muscle. Trends in Endocrinology & Metabolism 27(11): , Rontoyanni, V.G., O.N. Lopez, G.T. Fankhauser, Z.F. Cheema, B.B. Rasmussen, and C. Porter. Mitochondrial bioenergetics in the metabolic myopathy accompanying peripheral artery disease. Frontiers in Physiology 8: 141, Lavin, K.L., B.M. Roberts, C.S. Fry, T. Moro, B.B. Rasmussen, and M.M. Bamman. The importance of resistance exercise training to combat neuromuscular aging. Physiology (Bethesda), In Press, Book or Encyclopedia Chapters 109. Rasmussen BB and E. Volpi. Aging: Muscle. In: Encyclopedia of Endocrinology and Endocrine Diseases. L. Martini, editor. Academic Press, San Diego, CA., 1: , Dreyer H.C. and B.B. Rasmussen. Rehabilitation Therapies. In: Encyclopedia of Health and Aging. K. Markides, editor. SAGE Publications, pp , Dickinson J.M. and B.B. Rasmussen. Exercise & Nutrition: Implications for Leg Muscle Growth in Humans. In: Advances in Medicine and Biology. L.V. Berhardt (Ed.), Hauppauge, NY: Nova Science Publishers, Inc. Volume 7: 63-86, Drummond M.J. and B.B. Rasmussen. Human Muscle Protein Metabolism in Relation to Exercise and Aging: Potential Therapeutic Applications. In: Muscle Aging, Inclusion-Body Myositis and Myopathies. V. Askanas & W.K. Engel (Eds.), Wiley-Blackwell, Oxford, England, pp , Dickinson, J.M. and B.B. Rasmussen. Amino Acids. In: Encyclopedia of Exercise Medicine in Health and Disease. F.C. Mooren and J.S. Skinner (Eds.), Springer, 2012.

10 114. Rasmussen, B.B. and E. Volpi. Muscle Biology and mtorc1 Signaling in Aging. In: Sarcopenia. A. Cruz and J. Morley (Eds.), Wiley-Blackwell, Oxford, England, Graber, T.G. and B.B. Rasmussen. Amino Acid Sensing and mtorc1 Signaling. In: Sarcopenia: Molecular, Cellular, and Nutritional Aspects. D. Meynial-Denis (Ed.), CRC Press, In Press, Editorials/Perspectives/Letters/Guidelines 116. Volpi E, Rasmussen BB, Sheffield-Moore M, and Wolfe RR Muscle protein synthesis in young and older men. Journal of the American Medical Association, (letter to the editor), 287(3): , Rasmussen BB, and Richter EA. The balancing act between protein synthesis and breakdown: exercise as a model to understand the molecular mechanisms regulating muscle mass. Journal of Applied Physiology 106: , Rasmussen BB. Phosphatidic Acid: a novel mechanical mechanism for how resistance exercise activates mtorc1 signalling. Journal of Physiology 587(14): , Timmerman KL, and Rasmussen BB. Does a reduction in anabolic signaling contribute to muscle wasting in chronic heart failure? Journal of Applied Physiology 110: , Rasmussen B.B. The missing Akt in the mechanical regulation of skeletal muscle mtorc1 signaling and growth. Journal of Physiology 589: 1507, Klionsky DJ,..Rasmussen BB, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3 rd edition). Autophagy 12(1): 1-222, MENTORING PhD STUDENTS Jill Bell Camille Brightwell Michael Borack Christopher Fry Erin Glynn David Gundermann Amanda Randolph Paul Reidy Emre Vardarli MENTORING POSTDOCTORAL FELLOWS Jared Dickinson Hans Dreyer Micah Drummond Satoshi Fujita Ted Graber Tatiana Moro Dillon Walker Editorial Boards Journal of Applied Physiology, Editor, Highlighted Topics Series Regulation of Protein Metabolism in Exercise and Recovery, Journal of Applied Physiology, Journal of Applied Physiology, current Journal Reviewer Acta Physiologica, AGE, American Journal of Clinical Nutrition, American Journal of Physiology: Cell Physiology, American Journal of Physiology: Endocrinology & Metabolism, American Journal of Physiology: Regulatory, Integrative & Comparative, Applied Physiology, Nutrition & Metabolism, British Journal of Nutrition, Cardiovascular Research, Clinical Nutrition, Diabetes, Diabetologia, European Journal of Applied Physiology, Exercise & Sport Sciences Reviews, Experimental Physiology, International Journal of Sports Medicine, Journal of the American Aging Association, Journal of the American College of Nutrition, Journal of Applied Physiology, Journal of Cachexia, Sarcopenia and Muscle, Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Investigation, Journal of Gerontology: Biological Sciences, Journal of Nutrition, Journal of Nutrition Health & Aging, Journal of Physiology, Medicine and Science in Sports and Exercise, Molecular

11 Nutrition and Food Science, Muscle & Nerve, Nutrition & Metabolism, Obesity, Physiological Reports, Rejuvenation Research, Scandinavian Journal of Medicine & Science in Sports, Sports Medicine RESEARCH PRODUCTIVITY FROM SCIENTIFIC INDEXING SERVICES Scopus Profile: Total publications 112 Citations 9,378 h-index 47 From: Scopus (accessed ) ResearchGate Profile: Total publications 158 Citations 10,296 h-index 49 From: ResearchGate (accessed ) INFLUUENT Profile: Total publications 109 Citations 9,349 h-index 47 From: UTMB INFLUUENT (accessed ) Google Scholar Profile: Citations 19,692 h-index 56 i10-index 97 From: Google Scholar (accessed )

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