The$CAJAL$Advanced$Neuroscience$Training$Programme$

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1 TheCAJALAdvancedNeuroscienceTrainingProgramme NUTRITIONANDBRAINFUNCTIONS(NBF)2016 Speakers 21/09/2016 What"the"brain"uptake"rate"of"fatty"acids"tells"us"about"their"dietary"requirements:"Implications"for"food"sources"and"the"environment RichardBAZINET(Toronto,Canada)_AlsoInstructoronanNBFschoolproject WhatDr.BazinetreceivedhisBScfromtheUniversityofWesternOntarioandcompletedhisPhDunderthesupervisionofDr.StephenCunnaneattheUniversityofTorontoin2003.Dr.Bazinetthen completedapostdoctoralfellowshipindr.stanleyrapoport sbrainphysiologyandmetabolismsectionatthenationalinstituteonaging,nationalinstitutesofhealth.dr.bazinetjoinedtheuniversityof Torontoin2006,whereheiscurrentlyanAssociateProfessorandCanadaResearchChairinBrainLipidMetabolism.Dr.Bazinetistherecipientofseveralawards,includingtheEarlyCareerAwardfromthe International Society for the Study of Fatty Acids and Lipids; the JordiTFolchTPi Memorial Award from the American Society for Neurochemistry; the Future Leaders Award from the International Life Sciences Institute and the Young Scientist Award for the American Oil Chemists Society. Dr. Bazinet sits on several editorial boards and is currently EditorTinTChief of Prostaglandins, Leukotrienes and EssentialFattyAcidsaswellasaSeniorAssociateEditorofLipids. TheoverallgoalofDr.Bazinet sresearchprogramistoidentifythemechanismsthatregulatebrainlipidmetabolism(signaling)andtoidentifytheroleofbrainlipidmetabolisminthepathogenesisof neurodegenerativediseasesandneuropsychiatricdisorders. Dr.Bazinethaspublishedover90papers,largelyinthefieldofbrainfattyacidmetabolismandiscoTauthorofthejointWHO/FAOjointexpertconsultationondietaryfatsandthecentralnervoussystem duringaginganddisease. Food"for"thoughts" OlivierMANZONI(Marseille,France)_AlsoInstructoronanNBFschoolproject OlivierManzoni:"Earlyon,mygroupdiscoveredhownaturallyreleasedendogenouscannabinoidsparticipatetolongTtermsynapticplasticity.EndocannabinoidTmediatedlongTtermdepression(eCBTLTD) hassinceproventobeoneofthemostwidelyexpressedformsofsynapticplasticityinthecns.ourworkrevealedthatecbtltdisacommonsynapticcorrelateofneuropsychiatricdiseases.thus,ecbtltd isalteredinmicemodelsofmalnutrition,fragilex,downsyndromeanddrugabuse.ourmultiplescaleapproach(fromindividualspinetobehavior)aimsatdiscoveringnewendophenotypesof neuropsychiatricdiseasesandsuggestsnewtherapeuticstrategies." TJungKM,etal.2012NatureCommun.3:1080. TPuenteNetal.2011NatureNeurosci.14(12):1542T7. TLafourcadeMetal.2011NatureNeurosci.14(3):345T50. TheCAJALAdvancedNeuroscienceTrainingProgramme

2 22/09/2016 Comparing"dietary"interventions"in"animal"models"of"neurodegenerative"diseases:"cognitive"enhancement"or"disease"modification FrédéricCALON(Québec,Canada,LavalUniversity) Comparing dietary interventions in animal models of neurodegenerative diseases: cognitive enhancement or disease modification Dr Frédéric Calon is a biochemisttpharmacist focusing his research programonthedevelopmentoftreatmentsforneurodegenerativediseases.hisphdstudiesonheneurochemicalbasisoflevodopatinduceddyskinesiaswererecognizedwiththegoldmedalfromthe GovernorGeneralofCanadain2001.SincethestartTupofhislaboratoryin2003,hisresearchteamhasgatheredsignificantsupportfromtheCanadianInstitutesofHealthResearch(CIHR),theAlzheimer Society Canada (ASC), the Parkinson Society Canada, the Natural Sciences and Engineering Research Council of Canada (NSERC) the Canadian Foundation for Innovation and other private or public organisms.drcalonhaspublishedover100papers,whichhavebeencitedmorethan4500times.heandhisteamatlavaluniversity,quebeccity,mainlycarryonpreclinicalassaysinanimalmodelsof braindiseasesorneuropathologystudiesonhumanbrainsamples. BesideshisexpertiseonAlzheimer sdiseaseandmovementdisorders,hisgrouphasdevelopedanuniqueresearchplatformtoinvestigatequantitativelyandqualitativelythecapacityofdrugstocrossthe bloodtbrain barrier. Dr Calon is mostly known for his contribution to the discovery of a neuroprotective effect of omegat3 fatty acids in animal models of Alzheimer's disease, Parkinson s disease and ischemicstroke.theultimategoalofdrcalon sworkistoacceleratethetransferofknowledgefrombasicneurosciencetoclinicalapplicationsforcnsdiseases. TNeurodegenerativediseases,Nutrition,bloodTbrainbarrier,neuropharmacology.Calon,F,Lim,GP,Yang,F,Morihara,T,Teter,B,Ubeda,O,Rostaing,P,Triller,A,Salem,NJ,Ashe,KH,Frautschy,SA,Cole, GM(2004) TDocosahexaenoicacidprotectsfromdendriticpathologyinanAlzheimer sdiseasemousemodel.neuron,43: ParisTRobidas,S,Brochu,E,Sintes,M,Emond,V,Bousquet,M,Vandal,M,Pilote,M How"does"dietary"fatty"acids"influence"brain"function" SophieLAYE(Bordeaux,France,INRA),HeadoftheLaboratoryNutriNeuro DrLayéisaneurobiologistwhohasdevelopedresearchesontheeffectofnutritiononbrainfunctions.Inparticular,herteamisinterestedinunderstandingtheroleofdietarylipids,obesityanddiabetes in mood and cognitive disorders. They identified the mechanisms underlying the protective effect of nt3 PUFAs on depression, through the identification of their interaction with endocannabinoidt dependantneuronalplasticityandneuroinflammatorypathways.inaddition,herteamdiscoveredinanimalmodelsandhumansthatinflammationisthepathophysiologicalmechanismsinvolvedinmood andcognitivedisordersassociatedtoobesity.shehasauthoredmorethan120publications,reviewarticlesandbookchaptersonthemechanismsunderlyingtheeffectofnutritiononbrainfunctionsand behaviorandhasbeeninvitedtomoreof90conferencesandcongresses.drlayéisaresearchfellowatinstitutnationaldelarechercheagronomique,andistherecipientoftheprestigiouslaurierinra ScientificBreakthroughAward,theINRAAwardforExcellenceinResearch,thefacultymentorAwardfromBordeauxUniversity. TThomazeauA,BoschTBoujuC,ManzoniO,LayéS.NutritionalnT3PUFADeficiencyAbolishesEndocannabinoidGatingofHippocampalLongTTermPotentiation.CerebCortex.2016Mar5 TDelpechJC,ThomazeauA,MadoreC,BoschTBoujuC,LarrieuT,LacabanneC,RemusTBorelJ,AubertA,JoffreC,NadjarA,LayéS.DietarynT3PUFAsDeficiencyIncreasesVulnerabilitytoInflammationT InducedSpatialMemoryImpairment.Neuropsychopharmacology.2015Nov;40(12):2774T87 TBazinetRP,LayéS.Polyunsaturatedfattyacidsandtheirmetabolitesinbrainfunctionanddisease.NatRevNeurosci.2014Dec;15(12):771T85 T Lafourcade M, Larrieu T, Mato S, Duffaud A, Sepers M, Matias I, De SmedtTPeyrusse V, Labrousse VF, Bretillon L, Matute C, RodríguezTPuertas R, Layé S, Manzoni OJ. Nutritional omegat3 deficiency abolishesendocannabinoidtmediatedneuronalfunctions.natneurosci.2011mar;14(3):345t50. TheCAJALAdvancedNeuroscienceTrainingProgramme

3 23/09/2016 The"interaction"between"nutrition"and"the"brain;"studies"in"rodents"and"men" SUSANNELAFLEUR(TheNetherlands)_AlsoInstructoronanNBFschoolproject SusannelaFleurwasapostdocwithMaryDallmanatUCSFinSanFrancisco(UAS)andpioneeredtheideatoprovideanimalswithchoicetoconsumefatandsugarseparatefrompelletedchowasanew obesogenicanimalmodelandshowedwiththistheimportanceoffrequentsnackinginobesitydevelopment1andstressreducingpropertiesofpalatableintake2.sheiscurrentlygroupleaderatthe AcademicMedicalCenterinAmsterdamstudyingtheroleofclassicneuropeptides3andnovelneuroinflammatorymarkersinthehyperphagiaoccurringwithsnacking.Duringthecourse,Susannewill instructimaging,braininfusionandbehavioralstudiesinthisnovelobesogenicdiet. IntJObes(Lond).2014May;38(5):643T9 ProgNeurobiol.2006Aug;79(5T6):247T340. BiolPsychiatry.2015Apr1;77(7):633T41 When"a"calorie"is"not"a"calorie:"Unravelling"the"signals"driving"sugar"reward DanaSMALL(USA) DeputyDirectorforResearchandFellow,TheJohnB.PierceLaboratory_ProfessorofPsychiatryatYaleSchoolofMedicine;ProfessorofPsychologyatYaleUniversity Dr.Smallisaclinicalneuropsychologistwhohasusedneuroimagingtostudytaste,flavorandfeedinginhumanssincethemid90s.Sheperformedthefirstneuroimagingstudiesoffeedingshowingthat responsesindopaminesourceandtargetregionsdecreaseasafunctionofsatietywhileresponseinlateralprefrontalregionsincrease,andwasawardedtheallanepsteinawardbythesocietyforthe Study of Ingestive Behavior for this work in More recently, her laboratory focuses on understanding the mechanisms by which the modern food environment challenges physiology to promote obesity.towardsthisaimshehasrecentlyestablishedthemoderndietandphysiologyresearchcenterandwasrecentlyappointedtothenationalacademyofsciencesboardonbehavioral,cognitive andsensorysciences(bbcss)wheresheisleadingataskforcetounderstandtheintersectionbetweendiet,metabolismandcognitivedysfunction. *2015:AllanEpsteinAwardforawardhonorsanindividualforaspecificresearchdiscoverythathasadvancedtheunderstandingofingestivebehavior,AwardedbytheSocietyfortheStudyofIngestive Behavior *2014:ElectedtotheNationalAcademyofSciencesBoardonBehavioral,CognitiveandSensorySciences(BBCSS) *2010:RuthPikeAwardforContributionstoResearchinNutrition,PennsylvaniaStateUniversity,DepartmentofNutrition * 2007: Firmenich Young Investigator Award for Research in Fragrance and Flavors, presented by Firmenich, Geneva Switzerland 2006: Invitee National Academy of Sciences Eighteenth Annual Kavli FrontiersofScienceSymposiumforYoungInvestigators2005:MoskowitzTJacobsAwardforResearchExcellenceinthePsychophysicsofTasteandSmellpresentedbytheAssociationforChemoreception Sciences *2003:AjinomotoYoungInvestigatorAwardforResearchinGustation presentedbytheassociationforchemoreceptionsciences *2002:ElectiontotheInternationalNeuropsychologySymposium TdeAraujo,T.Lin,M.Veldhuizen,D.M.Small Metabolicregulationofbrainresponsetofoodcues.CurrentBiology,2013,23:878T883.E.Stice,S.Spoor,C.Bohon,D.M.Small T RelationbetweenobesityandbluntedstriatalresponsetofoodismoderatedbyTaq1A1DRDEGene Science2008,322:449T452.D.M.Small,R.J.Zatorre,A.Dagher,AlanC.Evans,M.JonesTGotman, T Brainactivityrelatedtoeatingchocolate:Frompleasuretoaversion,Brain,2001,124(10):1720T1733. TheCAJALAdvancedNeuroscienceTrainingProgramme

4 26/09/2016 Targeting"the"gut"microbiome"to"combat"obesity?linked"diseases AndréMarette(Québec,Canada) Dr.MaretteisProfessorofMedicineattheHeartandLungInstituteandScientificDirectoroftheInstituteofNutritionandFunctionalFoodsatLavalUniversity.HealsoholdsaresearchChaironthe pathogenesisofinsulinresistanceandcardiovasculardiseases.dr.maretteisaninternationalrenownedexpertonthepathogenesisofinsulinresistanceandhisresearchhasadvancedtheunderstanding ofthecellular/molecularmechanismsofinflammation,andopenednewpossibilitiesforpreventionandtreatmentofmetabolicsyndromethroughmodulationofthegutmicrobiotabyprebiotics. Herecentlydiscoveredthatomega3TPUFATderivedprotectinDXcanprotectagainstinsulinresistanceandtype2diabetesthroughanovelmyokineTliverglucoregulatoryaxis(NatMed2014).Dr.Marette hasreceivedseveralawardsforhisworkincludingtheprestigiousyoungscientistawardofthecanadiandiabetesassociation,andthecharlesbestawardfromtheuniversityoftorontoforhisoverall contributiontotheadvancementofscientificknowledgeinthefieldofdiabetes. Dr. Marette has published over 170 papers and reviews in peertreviewed journals including four in Nature Medicine. He sis the upcoming EditorTinTChief of the American Journal of Physiology : Endocrinology&Metabolism(July2016). Glucocorticoids"and"Brain":"from"early"life"to"senescence" RondeKloet(TheNetherlands,Leiden) AcademyprofessoroftheRoyalNetherlandsAcademyofArtsandSciences,(em)professorofMedicalPharmacologyLACDR/LUMC,LeidenUniversity ForhalfacenturyIamfascinatedbythequestionhowstresshormones,thatarecriticalforlife,canchangetheiractioninthebrainfromprotectivetoharmful,whileenhancingvulnerabilitytostressT relateddisorders.wedemonstratedthatthisswitchfromaresilienttoavulnerablebraindependsonthebalancebetweenactivationandsuppressionofstressreactionswhichisundercontrolofone singlehormone:cortisol.thisdiscoveryhasprovidedleadstowardsbiomarkersandanoveltreatmentstrategyofstresstrelatedmentaldisordersaimedtopromoteamechanismofresiliencestillpresent inthediseasedbrain. Theresultshavebeenpublishedinmorethan600scientificarticles.MyresearchreceivedinternationalrecognitionbytheGeoffreyHarrisAwardoftheEuropeanFederationofEndocrineSocieties(2005), theeuropeancollegeofneuropsychopharmacologyaward(2007),andthelifetimeachievementawardoftheinternationalsocietyofpsychoneuroendocrinology(2008)andthegoldenemilkraepelin Medal(2014)fortheimpactofourbasicresearchonthediagnosisandtreatmentofdepression.August25,2010theQueenofTheNetherlandshasbeenpleasedtoappointmeKnightoftheOrderofthe DutchLion. From1990IwasprofessorofMedicalPharmacologyatLeidenUniversity/MedicalCentern,reachingrecentlytheemeritusstatus.TheDepartmentofMedicalPharmacologyattheLeidenAcademicCenter fordrugresearchwithanoutstandingresearchgroup)*skilledinexperimentsfromgenetobehaviourwithatranslationalperspectiveforapplicationindrugdevelopmentandmedicine.from2004i amappointedacademyprofessoroftheroyalnetherlandsacademyofartsandsciencesatthelacdr,leidenuniversityandthedepartmentofendocrinology&metabolism,lumc. TDeKloetER(2014)FromReceptorBalancetoRationalGlucocorticoidTherapy.Endocrinology"155:2754T2769. TDeKloetER;JoëlsM;HolsboerF(2005)Stressandthebrain:FromadaptationtodiseaseNature"Reviews"Neuroscience6:6,463T475. TDeKloetER,OitzlMS;JoëlsM(1999)Stressandcognition:arecorticosteroidsgoodorbadguys?Trends"in"Neurosciences"22:10,422T426. TheCAJALAdvancedNeuroscienceTrainingProgramme

5 27/09/2016 Hypothalamic"nutrient"sensing"in"the"regulation"of"energy"balance" DanielaCOTA(Bordeaux,France) ResearchTeamLeader,Team EnergyBalanceandObesity,INSERMU1215NeurocentreMagendie,Bordeaux,France DanielaCotaisaneuroscientistwithaclinicalendocrinologybackground,focusingonthestudyofneuronalcircuitsandintracellularsignalingcascadesthatareinvolvedintheregulationoffoodintakeand bodyweight.shealsostudiestheimpactofthesecircuitsandneuralsystemsonperipheralmetabolism. Herworkontheendocannabinoidsystem,whichstartedwithapostdocattheMaxTPlanckofPsychiatryinMunichin2001,hascriticallydeterminedtheroleofthissystemandofthecannabinoidtype1 (CB1)receptorintheregulationofenergybalanceandinobesity.Atthesametime,herstudiesonthemTOR(mechanisticTargetOfRapamycin)pathwaywerethefirsttodemonstratethatthisintracellular signalingcascadeisacriticalintegratoroftheeffectsofhormonesandnutrientsatthelevelofthehypothalamus,abrainstructurecontrollingenergybalance. *2005EthanSimsYoungInvestigatorawardoftheObesitySociety *2007INSERMAvenirgrantprize Keyfindings: DiscoveryoffunctionalCB1receptorsinperipheralorgans(adiposetissue); Discoveryofabilityofnutrients(aminoacids)tomodulatefoodintakethroughhypothalamicintracellularpathways TCotaD,MarsicanoG,TschöpM,GrüblerY,FlachskammC,SchubertM,AuerD,YassouridisA,ThöneTReinekeC,OrtmannS,TomassoniF,CervinoC,NisoliE,LinthorstAC,PasqualiR,LutzB,StallaGK, PagottoU.Theendogenouscannabinoidsystemaffectsenergybalanceviacentralorexigenicdriveandperipherallipogenesis.JClinInvest.2003Aug;112(3):423T31. TCotaD,ProulxK,SmithKA,KozmaSC,ThomasG,WoodsSC,SeeleyRJ.HypothalamicmTORsignalingregulatesfoodintake.Science.2006May12;312(5775):927T30. TBellocchioL,SoriaTGómezE,QuartaC,MetnaTLaurentM,CardinalP,BinderE,CannichA,DelamarreA,HäringM,MartínTFontechaM,VegaD,LesteTLasserreT,BartschD,MonoryK,LutzB,ChaouloffF, PagottoU,GuzmanM*,CotaD*,MarsicanoG*.ActivationofthesympatheticnervoussystemmediateshypophagicandanxietyTlikeeffectsofCB₁receptorblockade.ProcNatlAcadSciUSA.2013Mar 19;110(12):4786T91.*sharelastauthorship Of"ghost"neurons"and"ravenous"microglia:"coupling"between"apoptosis"and"microglial"phagocytosis"in"health"and"disease" AmandaSIERRA(Bilbao,Spain)_AlsoInstructoronanNBFschoolproject IkerbasqueResearchProfessor AmandaSierraleadstheGlialCellBiologyLabattheAchucarroBasqueCenterforNeuroscienceinBizkaia,Spain.SheoriginallyimplementedtheexvivoanalysisofmicroglialfunctionbasedonFACST sorting1,2discoveredthatmicrogliaareveryefficientphagocytesinthehippocampalneurogeniccascadeinphysiologicalconditions,wheretheyremovetheexcessofnewborncells3.morerecently,she hasdescribedthatneuronalhyperactivityduringseizuresexhaustsneuralstemcells4andimpairsmicroglialphagocytosis5. TSierraA,etal.,2007.Glia55(4):412T24. TSierraA,etal.2008.Glia56(6):659T674. TSierraA,etal.2010.CellStemCell7(4):483T95. TSierraA,etal.2015.CellStemCell16:488T503. TAbiegaOetal.(underreview,PLoSBiology) TheCAJALAdvancedNeuroscienceTrainingProgramme

6 28/09/2016 Neural"Control"of"Energy"Balance:"Translating"Circuits"to"Therapies LaurentGAUTRON(Houston,USA;InternalMedicineatUTSouthwesternMedicalCenter)_AlsoInstructoronanNBFschoolproject LaurentGautron(PhD)wastrainedattheUniversityofBordeaux,HarvardMedicalschool,andtheUniversityofTexasSouthwesternMedicalCenter(UTSW)performingworkrelatedtotheneuralcircuits involvedinregulatingenergybalanceandappetite.since2012,heisassistantprofessoratutswwhereislaboratoryfocusesontheroleofctfibersinmetabolism,feedingandimmunity.dr.gautronwill instructpharmacogenetictechniquesallowingthemanipulationofhypothalamicneuronsregulatingappetiteinthemouse. TGautronetal.,Cell.2015;161(1):133T45. TUditandGautron.FrontNeurosci.2013;7:134. TGautronetal.,JCompNeurol.2011;519(15):3085T101. Developmental"programming"of"appetite" SébastienBOURET(LosAngeles,USA) Associate Professor of Pediatrics, The Saban Research Institute, Developmental Neuroscience Program, University of Southern California,Research Director CNRS " Dr. Bouret has a broad background in the field of metabolic programming and the neurobiology of obesity. His research has directly led to several breakthroughs in the understanding of the complex hormonal signals and neurodevelopmental substrates responsible for appetite regulation. Most notably, he discovered that metabolic hormones (such as leptin and ghrelin) play a crucial role in hypothalamicdevelopmentandinthenutritionalprogrammingofmetabolism. Morerecently,hislabhasreportedanunanticipatedroleforprenatalleptininthedevelopmentoftheparasympathetic innervationofpancreaticislets. Hehasauthoredmorethan65articles,reviews,andbook chaptersinthefieldof developmentalprogrammingandtheneurobiologyofobesity.inaddition,dr. Bourethasservedonnumerousjournal editorialboards,organizingcommitteesand grantreviewpanels(includingthenih)andhasbeeninvitedtolectureinternationally. *BronzemedalCNRS(2014),FrenchSocietyforNeuroendocrinologyprize(2003) Keyfindings:Metabolichormonesexertadevelopmentalactiononbrainfeedingcircuits TBouretS,LevinBE,OzanneSE.GeneTenvironmentinteractionscontrollingenergyandglucosehomeostasisandthedevelopmentaloriginsofobesity.Physiological"Reviews,95(1):47T82,2015 T Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews Z, Jarosch F, Klussmann S, Bouret SG. Ghrelin programs development of hypothalamic feeding circuits. The" Journal" of" Clinical" Investigation,125(2),846T858,2015(alsoJ"Clin"Invest(commentary),490T492,2015) TBouretSG,DraperSJ,SimerlyRB.Trophicactionofleptinonhypothalamicneuronsthatregulatefeeding.Science,2004;304(5667):108T110.(News&Views,p.63T64;ScienceEditor schoice;alsonature Medicine,12(1):52T53,2006;andNIH2004StrategicPlanforNIHObesityResearch) TheCAJALAdvancedNeuroscienceTrainingProgramme

7 03/10/2016 Neuroendocrine"polypharmacy"targeting"obesity"and"diabetes MathiasTSCHÖP(Munich,Germany) ResearchDirector,HelmholtzPioneerCampus&HelmholtzDiabetesCenter,,HelmholtzZentrumMuenchen,AlexandervonHumboldtProfessor/Chair,DivisionofMetabolicDiseases, TechnischeUniversitaetMuenchen Earlyinhiscareer,Prof.Tschöpdiscoveredtheorexigenic,adipogenic,andmetaboliceffectsofghrelin,coiningit thehungerhormone.thecorrespondingfirstauthorpublicationinnaturehastodate beencitedmorethan3170times(nature,2000).thisgroundbreakingdiscoveryaddedafundamentalpathwaytothemodelofbodyweightandglucosecontrolandestablishedanovelsetofdrugtargets forthetreatmentofthemetabolicsyndrome(nature"medicine,2009;science,2010).prof.tschöpwentontodissectguttbraincommunicationpathways,basedongithormonesignalingandlessonsfrom unravelingthemolecularunderpinningsofgastricbypasssurgery.hisseriesofreportsshowingefficacyofnovelguthormonecotagonistpeptidestargetingseveralneuroendocrinereceptors,thatinturn reducebodyweightandimproveglucosetoleranceatanunprecedentedlevel,brokenewgroundandofferednovelclinicalapproachesforthetreatmentofdiabetesandobesity(nature"chemical"biology, 2009;Science"Translational"Medicine,2013,Nature"Medicine,2015).TogetherwithhislongTtermcollaborator,chemistRichardDiMarchi(IndianaUniversity),herecentlydiscoveredyetanotherclassof novel drug candidates by engineering peptide based steroid/small molecule delivery to selected cell populations (Nature" Medicine, 2012). Several of these gut hormonetbased single molecule combinatorial therapeutics, are now in clinical development for the treatment of diabetes and obesity. After reporting on a new pathophysiological process of the metabolic syndrome involving hypothalamic astrocytosis and microgliosis (PNAS, 2010, J Clin Invest 2012) Matthias Tschöp is utilizing these novel pharmaceutical tools to specifically target inflammatory processes in metabolically relevantbraincontrolcircuits. *ErwinSchrödingerPrize2014The"Erwin"Schrödinger"Prize"recognizes"outstanding"scientific"achievements"and"technological"innovations"in"medicine,"natural"sciences"and"engineering. *ElectedMember,GermanNationalAcademyofScience(Leopoldina)2013 Key Findings : Metabolic regulation and metabolic diseases research_ Development of novel clinical approaches for the treatment of diabetes and obesity_ Treatment of the metabolic syndrome_ Translationalresearchinthefieldsofdiabetes,obesityandmetabolism_Interactionsofgastrointestinalhormoneswithcentralneuronalnetworks_Roleofghrelinintheregulationoffoodintakeand bodyweight TFinan,B.,Yang,B.,Ottaway,N.,[ ],TschöpM.Arationallydesignedmonomericpeptidetriagonistcorrectsobesityanddiabetesinrodents.Nat"MedJan;21(1):27T36(2015). TFinan,B.,Yang,B.,Ottaway,N.[ ],Tschöp,M.Targetedestrogendeliveryreversesthemetabolicsyndrome.Nat"MedDec;18(12):1847T56(2012). TDay,J.W.,Ottaway,N.,Patterson,J.T.,[ ],Tschöp,M.AnewglucagonandGLPT1coTagonisteliminatesobesityinrodents.Nat"Chem"Biol"5(10):749T57(2009). TTschöp,M.,SmileyD.,HeimanM.L.Ghrelininducesadiposityinrodents."NatureOct19;407(6806):908T13(2000). Lean"on"body"neurons" AnaDOMINGOS(Lisboa,Portugal) PrincipalInvestigatorintheObesityLaboratory,InstitutoGulbenkiandeCiencia;PhDinNeurobiology,TheRockefellerUniversity AnaDomingosstudiestheneuralmechanismsactingonfatbreakdown.Recently,theresearchteamledbyAnaDomingospublishedanimportantstudyintheprestigiousjournalCell,establishingforthefirsttimethatadipose tissueisinnervated. Wedeterminedthatactivationofsympatheticneuronsamongadipocytespromotesfatbreakdown,andconcordantlossoffatmass.Thisresultrepresentsanewstrategyfortheinductionoffatlossand, ultimately,anewantitobesitytherapythatwouldcircumventthechallengesofdrugdeliverytothebrain.inthenewlyfundedproject,anadomingoswillteamupwithtwootherresearchgroups:paulcohen(rockefeller University,USA)andDanielRazansky(TheHelmholtzInstituteforBiologicalandMedicalImaging,UniversityofMunich,Germany)tobetterunderstandtheanatomyandfunctionofneuronssurroundingfattissue,combining noveltechniquesofgeneticsandoptoacousticmicroscopy.theportugueseresearcherstates:"tofindacuretoobesitywehavetobeattheforefrontofobesityresearch,whatoftenrequiresinterdisciplinaryandariskttaking stance". T2013RapidregulationofdepressionTrelatedbehavioursbycontrolofmidbraindopamineneurons;DChaudhury,JJWalsh,AKFriedman,BJuarez,SMKu,JWKoo,...,Nature493(7433),532T536 T2004Or83bencodesabroadlyexpressedodorantreceptoressentialforDrosophilaolfaction;MCLarsson,AIDomingos,WDJones,MEChiappe,HAmrein,...,Neuron43(5),703T714 TheCAJALAdvancedNeuroscienceTrainingProgramme

8 04/10/2016 The"impact"of"stress"and"anxiety"on"behavior"and"brain"metabolism" CarmenSandi(Switzerland) ProfessorandDirectoroftheBrainMindInstituteandLaboratoryofBehavioralGenetics;EPFL,Lausanne,Switzerland Research in Carmen Sandi s laboratory aims to understand how stress and personality traits affect brain function and behavior. One of their ultimate goals is the identification of neurobiological mechanismsunderlyingvulnerabilityorresiliencetopsychopathology. Herlabiscurrentlydevelopinganambitiousresearchprogramcombiningapproachesinrodentsandhumansfocusingontheeffectsofstressonthesocialbrainandtheemergenceofviolence.Aspecial emphasis is placed on the regulation of brain bioenergetics in the longtterm programming of behavior and peripheral metabolism by early life stress. Recently, they have identified a key role for mitochondrialfunctioninthenucleusaccumbensinthelinkbetweenanxietyandsocialcompetition. *PresidentoftheEuropeanBrainandBehaviorSociety(2009T2011)_BehavioralBrainResearchPrize(2014)_ValkhofChair,RadboudUniversity(2015) Keyfindings:Howthesocialbrainandcognitionareprogrammedbystress,includingakeyroleforglucocorticoidsandcelladhesionmolecules. esandic.andhallerj.(2015)stressandthesocialbrain:behavioraleffectsandneurobiologicalmechanisms.nature"reviews"neuroscience16:290t304. THollisF.,vanderKooijM.A.,ZanolettiO.,LozanoL.,CantóC.andSandiC.(2015)Mitochondrialfunctioninthebrainlinksanxietywithsocialsubordination.ProcNatlAcadSciUSA112:15486T TLuksysG.,GerstnerW.,andSandiC.(2009)Stress,genotypeandnorepinephrineinpredictionofmousebehaviorusingreinforcementlearning.Nature"Neuroscience12:1180T1186. Role"of"mitochondrial"CB1"receptor"in"energy"metabolism" GiovanniMarsicano(Bordeaux,France) U1215NeuroCentreMagendieandUniversitédeBordeaux.DR2Inserm.GroupLeader«EndocannabinoidsandNeuroadaptation» Dr.GiovanniMarsicanoisatenuredresearcheratInserm.Heleadsthegroup EndocannabinoidsandNeuroadaptation attheneurocentremagendie,aninsermanduniversityofbordeauxresearch Center devoted to neuroscience. He is a Veterinary Medicine Doctor as formation. After the Veterinary diploma, he worked on research related to Embryonic Stem Cells from farm animals and to xenotransplantation models in Italy for 4 years. In 1997, he moved to the MaxTPlanck Institute of Psychiatry in Munich for a PhD student position, where he initiated the work on the role of typet1 cannabinoidreceptors(cb1)andoftheendocannabinoidsystem(ecs)inbrainphysiology,whichsincehasbeenhismainresearchinterest.afterphdgraduationin2001,hemadetwoposttdocperiodsin GermanyandmovedtoBordeauxin2006(recruitedasseniorscientistin2007)toleadhisindependentresearchgroup. Byusingconditionalmutagenesisinmiceandbehavioral,biochemicalandelectrophysiologicaltools,hisworkcontributeddefiningtheroleofCB1inspecificcellpopulationsinlearningandmemory,food intake and energy balance, anxiety, stresstcoping and others. Through a clear bottomtup scientific approach, these studies allowed exploring some general principles of brain functioning, such as the balancebetweenexcitationandinhibition,theinteractionsbetweenthebrainandtheperiphery,theimportanceofenergymetabolisminbrainfunctionsandglialtneuroninteractions.inparticular,the implicationsoftherecentdiscoverythatcb1receptorsarefunctionallypresentonbrainmitochondriawillbethemainfocusofthepresentation. *AwardBettencourtTSchueller2006_ERCTStartingGrant2010_GrandPrixRobertDebré2013 Key findings : Cellular and subcellular specific functions of cannabinoid typet1 CB1 receptors. Role of endocannabinoid regulation of excitatory and inhibitory neurotransmission in food intake, fear, memoryandotherbehaviors.roleofcannabinoidtmodulationofneurontglialinteractionsinlearningandmemory.bioenergeticsprocessesinthebrain. TMarsicanoG*,WotjakC*,AzadSC,BisognoT,RammesG,CascioMG,HermannH,Tang,J,HofmannC,ZieglgänsbergerW,DiMarzoVandLutzB(2002)Theendogenouscannabinoidsystemcontrols extinctionofaversivememories.nature418:530t34. T Benard G, Massa F, Puente N, Lourenço L, Bellocchio L, SoriaTGómez E, Matias I, Delamarre A, MetnaTLaurent M, Cannich A, HebertTChatelain E, Mulle C, OrtegaTGutierrez S, MartínTFontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, LópezTRodríguez ML, Grandes P, Rossignol R and Marsicano G (2012) Mitochondrial CB1 receptors regulate neuronal energy metabolism. Nature"Neuroscience15(4):558T64. T Han J, Kesner P, MetnaTLaurent M, Duan T, Xu L, Georges F, Koehl M, Abrous DN, MendizabalTZubiaga J, Grandes P, Ren W, Marsicano G* and Zhang X* (2012). Astroglial CB1 Receptors Mediate CannabinoidAlterationsofSynapticPlasticityandWorkingMemory.Cell148(5):1039T50. TheCAJALAdvancedNeuroscienceTrainingProgramme

9 06/10/2016 The"Gut"Microbiome:"a"Key"Regulator"of"brain"Function"Across"the"Lifespan JohnCRYAN(Cork,Ireland) JohnF.CryanisProfessor&Chair,Dept.ofAnatomy&Neuroscience,UniversityCollegeCork(UCC).,Cork,Ireland HereceivedaB.Sc.(Hons)andPhDfromtheNationalUniversityofIreland,Galway, Ireland.HewasavisitingfellowattheDeptPsychiatry,UniversityofMelbourne,Australia,whichwasfollowedbypostdoctoralfellowships attheuniversityofpennsylvania,philadelphia,usaandthe ScrippsResearchInstitute,LaJolla,California.HespentfouryearsattheNovartisInstitutesforBioMedicalResearchinBaselSwitzerland,asaLabHead,BehaviouralPharmacologypriortojoiningUCCin 2005.CurrentlyheisalsoaPrincipalInvestigatorintheAPCMicrobiomeInstitute. Prof.CryanhasaHTindexof67havingpublishedover300peerTreviewedarticlesandbookchapters.HeisaSeniorEditorofNeuropharmacologyandofNutritional"NeuroscienceandanEditorof"British" Journal"of"Pharmacology.Heisontheeditorialboardofafurther16journals.Hehaseditedthreebooks including Microbial"Endocrinology:"The"Microbiota?Gut?Brain"Axis"in"Health"and"Disease (Springer Press,2014). Prof.Cryan'scurrentresearchinterestsincludetheneurobiologicalbasisofstressTrelatedneuropsychiatricdisordersincludingdepression,anxietyanddrugdependence.Moreover,hisgroup is also focused on understanding the interaction between brain, gut & microbiome and how it applies to stress and immunetrelated disorders, including irritable bowel syndrome and obesity and neurodevelopmentaldisorderssuchasautism. *ElsevierAward,NeurobehavioralTeratologySociety,Montreal,2015 *AlimentaryPharmabioticCentre,ScientistoftheYearAward2015 *WIREDHealthSpeakerLondon2015 *TEDMEDSpeaker,WashingtonDC2014 * ThomsonReutersHighlyCitedResearcher2014 * TheWorld'sMostInfluentialScientificMinds2014 *UniversityofUtrechtAwardforExcellenceinPharmaceuticalResearch 2013 *UniversityCollegeCorkResearcheroftheYear2012 *EuropeanCollegeofNeuropsychopharmacologyFellowshipAward,September2006 *WyethPsychopharmacologyAward,BritishAssociationofPsychopharmacology,July2006 * YoungScientistAward,FoundationoftheEuropeanBehaviouralPharmacologySociety,September2005 Keyfindings"":Prof.CryanisbestknownforhisworkonanimalmodelsofstressTrelateddisordersandtheirpharmacologicaltreatment.Morerecentlyhisteamhasbeeninstrumentalindemonstratinga roleforthegutmicrobiomeinregulatingbrainandbehaviour. Inparticularhisresearchiscurrentlyfocusedonunderstandingtheinteractionbetweenbrain,gut&microbiomeandhowitappliesto stress,psychiatricandimmunetrelateddisordersatkeytimetwindowsacrossthelifespan. TO'LearyOF,FeliceD,GalimbertiS,SavignacHM,BravoJA,CrowleyT,El YacoubiM,VaugeoisJM,GassmannM,BettlerB,DinanTG,CryanJF.GABAB(1) receptorsubunitisoformsdifferentiallyregulate stressresilience.procnatl AcadSciUSA.2014Oct21;111(42):15232T7. TBravoJA,ForsytheP,ChewMV,EscaravageE,SavignacHM,DinanTG, BienenstockJ,CryanJF.IngestionofLactobacillusstrainregulatesemotional behaviorandcentralgabareceptorexpressionina mouseviathevagusnerve. ProcNatlAcadSciUSA.2011Sep20;108(38):16050T5. TCryanJF,O'LearyOF,JinSH,FriedlandJC,OuyangM,HirschBR,PageME, DalviA,ThomasSA,LuckiI.NorepinephrineTdeficientmicelackresponsesto antidepressantdrugs,includingselectiveserotonin reuptakeinhibitors.proc NatlAcadSciUSA.2004May25;101(21):8186T91. Programming"of"brain"structure"and"function"by"early?life"stress:"a"role"for"nutrition"and"opportunities"for"interventions" AnikoKOROSI(TheNetherlands)_AlsoInstructoronanNBFschoolproject AnikoKorosiwasapostdocatUCIinthelabofdr.Baramwhereshestudiedhowenrichedearlylifeexperiencerewiresthehypothalamus.Attheendof2010shestartedherteamasAssistantprofessorat theuniversityofamsterdamwhereherresearchfocusesontheprogrammingofcognitivefunctionsbyearlytlifestressandagingandontheroleofmetabolicsignalsandnutrientsinthiscontext1.her work encompasses pretclinical using an established mouse model of chronic earlytlife stress2 and clinical work and she is interested in developing peripheral (e.g. nutritional) intervention to prevent and/orreversethelastingconsequencesofearlytlifestress. TLucassenetal.,TrendsinNeuroscience,2013,doi:pii:S0166T2236(13)00138T /j.tins TNanincketal,hippocampus,2015,25:309T28 TheCAJALAdvancedNeuroscienceTrainingProgramme

10 TheCAJALAdvancedNeuroscienceTrainingProgramme NUTRITIONANDBRAINFUNCTIONS(NBF)2016 Instructors GuillaumeFerreira,NutriNeuro,INRA In2001GuillaumeFerreiraobtainedapermanentfacultypositionattheFrenchNationalInstituteforAgriculturalResearch(INRA)andheisnowResearchDirector.Sincetheonsetofhiscareer,hismain researchinteresthasbeentheneuralbasisofcognition.hemovedtothelab Nutrition&IntegrativeNeurobiology inbordeauxin2009todevelopaprojectfocusedontheeffectofnutritionatearly developmentalstages(adolescence)onbrainplasticityandcognition.inthecourse,guillaumewillinstructbehavioralandneurobiologicalexperimentsontheeffectofobesogenicdietonlearningand memoryprocesses. TBoitardetal.(2015)The"Journal"of"Neuroscience,"35(9): " TSoriaTGomezetal.(2015),Neuron,"88(2):306T13. TBoitardetal.(2014)Brain,"Behavior"and"Immunity,"40:9T17. TSoriaTGomezetal.(2014),Nature"Neursocience,17(3):407T15. TBoitardetal.(2012)Hippocampus,22: MarianoRuizeGayo,UniversidadCEUSanPablo MarianoRuizTGayoworkedonbehaviouraleffectsofcholecystokinin(CCK)withBernardP.RoquesatUniversitéParisV.HecontinuedstudyingtherelationshipbetweenCCK,opioidsandcannabinoidsat UniversidadComplutense(Madrid,Spain).HeiscurrentlyaprofessorofPharmacologyattheUniversitySanPablo(Madrid),wherehe sworkingontheinfluenceofleptinandcckontherelationship betweenfeedingbehaviour,learningandmemoryprocesses.marianowillinstructbehaviouralandneurobiologicalexperimentsontheeffectobesogenicdietsonlearningandmemoryprocesses. TIbíasetal.(2015)EuropeanJournalofNutrition1T8. TGarcíaTPrietoetal.(2015)MolecularNutritionandFoodResearch59(3):520T32. TValladolidTAcebesetal.(2013)NeurobiologyofLearningandMemory106:18T25. TAttanéetal.(2012)Diabetes61:310T320(2012) TStucchietal.(2012)Endocrinology153(2):690T699 AgnèsNadjar,NutriNeuro,UniversitédeBordeaux Maîtredeconférence PhD;UFRSciencesdelavie;UniversitédeBordeaux AgnèsNadjarisanAssociateProfessorattheUniversityofBordeauxandmemberofthelaboratoryofNutritionandIntegratedNeurobiology(NutriNeuro,INRA,Bordeaux).SheisalsothecoTdirectorof the Neuroinflammation axis at the Neuroscience Department of Bordeaux and coordinator for bioimaging technologies at NutriNeuro. Mostof her teaching duty is devoted to the coordination of the EuropeanNeurasmusMasterprogramme(EuropeanMasterofexcellenceinNeurosciencesgathering6internationalUniversitiesandstudentsfromallovertheworld).Since2012,AgnesNadjaristhe scientificdirectorofscilight ( Her research falls within the field of psychoneuroimmunology with a particular interest in microglia neuron interactions in physiological and pathological situations. Over the first ten first years of her career,sheelucidatedsomeofthecellularandmolecularmechanismsunderlyingtheeffectsofanacuteorchronicneuroinflammationontheseinteractionsandsubsequentneuropsychiatricdisorders. SincesheintegratedtheNutriNeurolabin2011,sheisleadingresearchesontheimpactofnutritionallipidstatusonmicroglialfunctionandconsequencesonneuronalactivity.ShealsodevelopedstateT oftthetarttechniques,suchashighresolutionimaging,tounravelmicroglialfunction. DelpechJCetal.2015TheJournalofNeuroscience,35(7):3022T33 DelpechJCetal.2015Neuropsychopharmacology MadoreCetal :151T8 TheCAJALAdvancedNeuroscienceTrainingProgramme

11 JorgeValero,UniversidadAutónomadeBarcelona,Spain JorgeValerodidhispostdoctoraltrainingatthelabofDr.CarlosSaura(UniversidadAutónomadeBarcelona,Spain)andatthelabofDr.JoãoMalva(CenterforNeursocienceandCellBiology,Universityof Coimbra, Portugal). He has demonstrated that factors modulating adult neurogenesis, such as environmental stimulation and neuroinflammation, can affect spatial memory and neurogenic reserve in mousemodelsofalzheimer'sdisease1,2.jorgehasdevelopedseveraltoolsforautomaticimageanalysis2,3.heiscurrentlyanikerbasqueresearchfellowattheachucarrobasquecenterforneuroscience, Bizkaia(Spain).Hewillinstructontheanalysisofadulthippocampalneurogenesisandassociatedbehaviors. TValeroetal.,PLoSONE.6,e16832(2011). TValeroetal.,Front.Neurosci.8,83(2014). TDiezTHermano,Valeroetal,Mol.Neurodegener.10,9(2015). XavierFioramonti,CentredesSciencesduGoutetdel'Alimentation(CSGA)CNRS,INRA,DIJON,Equipe:Détectioncérébraledesnutrimentsethoméostasieénergétique Thebrainandmoreparticularlythehypothalamusplayacriticalroleinthecontrolofenergyhomeostasisincontrollingfeedingbehaviorandtheactivityofperipheralorgansthroughhumoralandnervous regulationsystems.thiscontrolreliesonneuronsthatarecapableofintegratingmetabolicsignalsincludinghormones(e.g.leptin,insulinandghrelin)andnutrients(i.e.glucose,fattyandaminoacids). Amongthem,specializedglucoseTsensingneuronsareabletoadapttheirelectricalactivityinresponsetochangesinglucoselevel.Hislaboratoryusescomplementaryapproachestostudyneuronsfrom theelectrophysiologyonbrainslices,calciumimagingonhypothalamicprimarycultures,uptothein"vivoexperimentation. TBenaniA,HryhorczukC,GouazéA,FioramontiX,BrenachotX,GuissardC,KrezymonA,DuparcT,ColomA,NédélecE,RigaultC,LemoineA,GascuelJ,GerardyTSchahnR,ValetP,KnaufC,LorsignolA, PénicaudL.FoodintakeadaptationtodietaryfatinvolvesPSATdependentrewiringofthearcuatemelanocortinsysteminmice.JNeurosci.(2012):29;32(35):11970T9. TFioramontiX,DeakA,DeshpandeS,CarneiroL,ZhouC,SayedN,OrbanB,BerlinJR,PénicaudL,LeloupC,BeuveA,RouthVH.HypothalamicSTnitrosylationcontributestothecounterTregulatoryresponse impairmentfollowingrecurrenthypoglycemia.plosone.(2013)jul19;8(7). TFioramontiX,MarsollierN,SongZ,FakiraKA,PatelRM,BrownS,DuparcT,PicaTMendezA,SandersNM,KnaufC,ValetP,McCrimmonRJ,BeuveA,MagnanC,RouthVH.Ventromedialhypothalamicnitric oxideproductionisnecessaryforhypoglycemiadetectionandcounterregulation.diabetes.(2010);59(2):519t28. TFioramontiX,ContiéS,SongZ,RouthVH,LorsignolA,PénicaudL.Characterizationofglucosensingneuronsubpopulationsinthearcuatenucleus:integrationinneuropeptideYandproTopiomelanocortin networks?diabetes.(2007);56(5):1219t27. TFioramontiX,LorsignolA,TaupignonA,PenicaudL.AnewKATPindependentmechanisminvolvedinglucoseTexcitedneuronsofmousearcuatenucleus.Diabetes2004;53:2767T75.a ClémentineBoscheBouju,NutriNeuro,UniversitédeBordeaux ClémentineBoschTBoujudidherPhDatthelabofDr.LaurentVenance(CollègedeFrance,Paris,France)andherpostdoctoraltrainingatthelabofDr.LouiseParrTBrownlie(UniversityofOtago,Dunedin,NewZealand).Sheis 1 anexpertinelectrophysiologyandoptogeneticstorecordandcontrolelectricalactivityinneuronalnetworks.shediscoveredoneofthemechanismsofactionofdeepbrainstimulation,apowerfultherapyusedtotreat 2 Parkinson sdisease.shealsodemonstratedhowtheneuronalactivityinthemotorthalamusisalteredinparkinson sdisease.sheiscurrentlypostdoctoralfellowatnutrineurolab(inra,bordeauxuniversity,france)to 3 studytheimpactofdietaryomegat3fattyacidsonbrainfunctionwithafocusonsynapticplasticityandtheendocannabinoidsystem. TBosch,C.etal.,J."Physiol.589, (2011). TBoschTBouju,C.etal.,J."Neurosci."34, (2014). TThomazeau,A.,BoschTBouju,etal.,Cereb."Cortex."20161T9(2016) TheCAJALAdvancedNeuroscienceTrainingProgramme

12 MarieePierreMoisan,NutriNeuro,INRA MarieTPierreMoisanreceivedherPhDfromEdinburghUniversityinthelabofJSeckl,thenshedidapostTdoctoraltraininginDukeUniversitywithKLParkerandfinallyshegotatenuredpositionatthe UniversityofBordeauxwheresheusedmoleculargeneticstouncovergenesinvolvedinstressresponse1,2.Sheisnowleadingagroupfocusedontheinterplaybetweennutrition,glucocorticoidhormones andmemoryprocesses.marietpierrewillinstructontheassessmentofglucocorticoidsregulationanditsneurobiologicalconsequencesduringmemorytask. TMoisanMPetal.,(1996)NatGenet.;14(4):471T3. TMoisanMP.(2013)NatRevEndocrinol.;9(2):78 SylvieVancassel,NutriNeuro,INRA SylvieVancassel(PhD)wasappointedasaResearchScientistatINRAin1999,specializedinneurobiology,withafocusonmonoaminergicneurotransmissionandnutrition.Shespentpartofhiscarrerto lead researches on the role of nutritional lipid status on neurotransmission function and consequences on behavior and CNS pathologies. She joined the NutriNeurO lab at Bordeaux in 2012 and her currentresearchesarefocusedontheroleofinflammationinmooddisorders.shedevelopedtechniquesfordetectionandquantificationofneurotransmitterrelease,usinginvivomicrodialysisinmice andratscoupledtoelectrochemicaldetection.?"omega?3"polyunsaturated"fatty"acids"and"brain"aging.denisi,potierb,heberdenc,vancassels.curropinclinnutrmetabcare.2015mar;18(2):139t46. TAbsence"of"the"gut"microbiota"enhances"anxiety?like"behavior"and"neuroendocrine"response"to"acute"stress"in"rats.CrumeyrolleTAriasM,JaglinM,BruneauA,VancasselS,CardonaA,DaugéV,NaudonL, RabotS.Psychoneuroendocrinology.2014.?"Omega?3"fatty"acids"deficiency"aggravates"glutamatergic"synapse"and"astroglial"aging"in"the"rat"hippocampal"CA1."LatourA,GrintalB,ChampeilTPotokarG,HennebelleM,LavialleM,DutarP,PotierB, BillardJM,VancasselS,DenisI.AgingCell.2013Feb;12(1):76T84. MurielDarnaudéry,NutriNeuro,UniversitédeBordeaux Muriel Darnaudéry did her PhD in the Lab of Michel Le Moal in Bordeaux and was posttdoc of Luis Miguel GarciaTSegura in the Cajal Institute of Madrid. She was appointed assistant professor in the StefaniaMaccarilabwhereshestartedworkingonearlylifestressmodelsandneuropsychiatricvulnerability.SheisnowfullprofessorintheNutrineuroLabattheUniversityofBordeauxstudyingearlylife adverseeventsandneurobiologicalbasesunderlyingtherelationshipbetweenstress,moodandnutrition.duringthecoursemurielwillinstructanimalmodelsformooddisorders:interestandlimitations. TBarbozaSolísCetal.,(2015)ProcNatlAcadSciUSA.112(7):E738T46 TLépinayALetal.,(2015)Psychoneuroendocrinology.53:82T93. TLalouxC,etal.,(2012)Psychoneuroendocrinology.37(10):1646T58. TheCAJALAdvancedNeuroscienceTrainingProgramme

13 PierreTrifilieff,NutriNeuro,INRA PierreTrifilieffwasapostdocinEricKandel slabatcolumbiauniversity(newyork),wherehestudiedtheimplicationoflocalproteinsynthesisinlongttermplasticityandmemoryconsolidation.in2010he becamearesearchscientistatthenewyorkstatepsychiatricinstituteandfocusedontheimplicationofmesolimbicdopaminetransmissioninrewardprocessingandmotivation.hisworkunraveleda central role of the striatal dopamine D2 receptor in the pathophysiology of motivation. In 2013 he obtained a faculty position in Bordeaux where he works on the implication of membrane lipid composition T and dietary polyunsaturated fatty acids in particular T on the modulation of dopaminergic transmission and associated behaviors. Pierre Trifilieff will instruct on the behavioral and neurobiologicalbasesoffoodmotivationwithafocusonmesolimbicdopaminetransmission. TFrederickAL.*etal.(2015)MolecularPsychiatry,PMID: TTrifilieffP.&MartinezD(2013)Neuropharmacology,PMID: TTrifilieff,Petal.(2013)MolecularPsychiatry,PMID: CyrilHerry,INSERM,Headoftheteam «Circuitsneuronauxdesapprentissagesassociatifs» CyrilHerry:"DuringmyPhD,Ishowedforthefirsttimeelectrophysiologicalevidenceofaspecificroleofprefrontalplasticityintheinhibitionoffearresponsesduringconsolidationofextinction.Ithen switchedmyresearchduringmypostdoctoraltraininginthelaboratoryofpr.andreasluthïtostudytheroleoftheamygdalaintheacquisitionofextinction.there,isuccessfullyimplantedanddeveloped thetechniqueoflonglastingsingleunitrecordingsinbehavinganimalsandwasabletoidentifydistinctamygdalaneuronalpopulationsselectivelyimplicatedinthebehavioraltransitionbetweenhighand lowfearstates.in2011iwasawardedaprestigiousercstartinggrantthatallowedmetosetupmylaboratoryintheneurocentermagendie.mylaboratorylongttermprojectinthisinstituteistoidentify andmanipulatethecircuitsunderlyingfearbehaviortoultimatelydevelopnewtherapeuticstrategiesforanxietytrelatedpathologies." THerry,C.etal.,(2008).Nature,454,600T6. TGogolla,N.,etal.,(2009).Science,325,1258T61.IF:33.6. TCourtin,J.etal.,(2014).Nature,505:92T96. EtienneCoutureau,CNRS/UniversitédeBordeaux EtienneCoutureauwasapostTdocwithPr.SimonKillcrossattheSchoolofPsychology(CardiffUniversity,UK)anddiscoveredthesubtleinteractionsofprefrontalregionsinthecoordinationofactionsand habitsinrodents.heiscurrentlyacnrsresearchdirectorattheaquitaineinstituteforcognitiveandintegrativeneurosciencewhereheisleadingaresearchgroupinvestigatingtheneuralcircuitof DecisionandAdaptation.EtiennewillinstructtheneurocognitivebasesoffoodTseekingbehavior. TKillcross&Coutureau(2003)CerebralCortex13:400T408. TNaneixetal.(2012)JournalofNeuroscience,32:16223T TAlcarazetal.(2015)JournalofNeuroscience,35: TheCAJALAdvancedNeuroscienceTrainingProgramme