Cannabinoid Type 1 Receptors in Astrocytes. Giovanni Marsicano, PhD
|
|
|
- David Jefferson
- 5 years ago
- Views:
Transcription
1 Cannabinoid Type 1 Receptors in Astrocytes EndoCannabinoids and NeuroAdaptation INSERM U862 NeuroCentre Magendie Bordeaux, France 1 Cannabinoid type 1 receptors in astrocytes 1964 OH O 9 -Tetrahydrocannabinol O NH Anandamide OH Learning 3000 a.c. HPA axis plasticity Pain perception Food Intake Rewarding 2 Inflammation Locomotion Sleep Neurogenesis Sexual Behaviour How do 1 receptors do all these beautiful things 3 1
2 Text book: mechanisms of action of 1 THC/AEA 1 + K + ir + MAPK - Ca 2+ camp + PKA G i/o - - adenylyl cyclase P ATP K + A 4 hyperpolarization Decrease of neuronal excitability Text book: endocannabinoids Extracellular Depolarization Release EC Uptake Membrane Precursors + AA Precursor Enzyme 2 EC Ca 2+ + camp ATP PKA + Degradation Degrading Enzymes EC Intracellular 5 Text book: Es are retrograde neurotransmitters Pre-Synaptic GABA/Glu Ca 2+ Action potential Retrograde suppression of neurotransmitter release EC 6 Depolarization EC Ca 2+ Post-Synaptic 2
3 Where is 1 expressed Many different brain regions Distinct neuronal subpopulations Local, inhibitory GABAergic network CA3 CA1 DG Principal projecting circuits Entorhinal Cortex Hippocampus Amygdala Marsicano and Lutz, Are there cell-type specific functions of 1 Conditional Knock-out The Cre/loxP system loxp Cre Sequence X 8 Conditional Knock-out The Cre/loxP system Wild type loxp Gene of interest Cre recombinase modified = "wild type" or floxed allele Tissue-specific Transgenic expression of Cre recombinase 9 Tissue-specific mutant 3
4 Deletion of 1 from specific neuronal populations Cre/LoxP system 1 floxed mice crossed with NEX-Cre or Dlx 5/6-Cre mice ISH analysis of 1 mrna expression Cortical Glutamatergic Neurons (Glu-1-KO) GABAergic Neurons (GABA-1-KO) 10 Monory et al., Neuron 2006, PLoS, 2007; Bellocchio et al., Nat Neurosci 2010 Deletion of 1 from specific neuronal populations Immunohistochemical analysis of 1 protein in conditional mutants 1-KO Glu-1-KO GABA-1-KO 11 GABAergic neurons contain the large MAJORITY of 1 in the brain Cortical glutamatergic neurons contain the MINORITY of 1 in the brain 12 Differential roles of 1 in neurons Fasting-induced food intake Fasted 1-KO eat less than controls (Di Marzo et al., Nature 2001) F.I. (grams) F.I. (grams) Glu-1-KO (Deletion in cortical glutamatergic neurons) 1 2 Time (h) (Deletion in all cells of the body) Full 1-KO 1 2 Time (h) GABA-1-KO (Deletion in GABAergic neurons) F.I. (grams) Time (h) 4
5 What about astrocytes Until 2008, there was debate on the presence of 1 in astrocytes (only in culture) 2007: We start generating GFAP-1-KO mice (hgfap-creert2 from F. Kirchhoff, Hirrlinger et al., 2006) 2008: Electrophysiological and functional evidence (Navarrete & Araque, 2008) Pedro Grandes Bilbao Astrocyte 1 GFAP-1-KO neur astroglial onal 1 13 Han et al., Cell 2012 Cannabinoids induce hippocampal LTD in vivo Anaesthetized rats Xia Zhang University of Ottawa, Canada Systemically Intra CA1 14 Cannabinoids induce hippocampal LTD in vivo Anaesthetized rats 1 R dependent Systemically 1 R antagonist AM281: 10 min before HU min after HU
6 Mechanisms of in vivo -LTD Glu GABA AP-5: selective antagonist (intra-ca1) 16 Mechanisms of in vivo -LTD Glu -mediated LTD endocytosis Collingridge et al., 2010 GABA Tat-GLUR2: endocytosis blocker 17 Mechanisms of in vivo -LTD Glu GABA 1 R 18 subtype -specific deletion of in mouse GLU- -KO GABA- -KO -LTD does not depend on neuronal 1 receptors Where is the responsible 1 R 6
7 Mechanisms of in vivo -LTD Glu Astrocyte GABA 19 astrocyte GFAP- 1 R-KO mice astroglial 1 neuronal 1 neuro nal GFAP-1-KO -LTD depends on astroglial 1 Receptors 20 What is -LTD good for Working memory Transient holding and processing of new / already stored information Important for reasoning, comprehension, learning, memory updating 30 s THC 1 Carlini et al., 1973; Ranganathan and D Souza, 2006 How does THC alter working memory What is -LTD good for A Delayed non matching to sample in the T-maze Training B 30 s A Correct choice Test B 21 7
8 What is -LTD good for Delayed matching to place in the Morris water maze Vehicle THC Session 23 X1 X+1 Start Time and distance gain from Trial 1 to Trial What is -LTD good for A Delayed non matching to sample in the T-maze Training Test Ro25,6981 and ifenprodil: NR2B-preferring antagonists Tat-GluR2: inhibitor of GluR2 endocytosis B 30 s Correct choice Cannabinoid effect on WM depends on and AMPA A B 24 What is -LTD good for Delayed matching to place in the Morris water maze Start Vehicle THC Session 12 3 X X+1 subtype -specific deletion of in mouse GLU- 1 R-KO Time and distance gain from Trial 1 to Trial 4 GABA- 1 R-KO Cannabinoid effect on WM does not depend on neuronal 1 Receptors 1 R 8
9 25 What is -LTD good for Delayed matching to place in the Morris water maze Start Vehicle THC Session 12 3 X X+1 Astrocyte GFAP- 1 R-KO mice Time and distance gain from Trial 1 to Trial 4 Astrocyte GFAP-1-KO Cannabinoids impair working memory through astroglial 1 Receptor 1 R Mechanisms of cannabinoid impairment of working memory Working Memory impairments 1 receptors mediate cannabinoid-induced in vivo LTD 1 receptors mediate cannabinoid-induced impairment of working memory 26 Han*, Kesner*, Metna-Laurent* et al., Cell Thanks to ZHANG Xia, Philip KESNER (Ottawa), HAN Jing (Xi an), Franck KIRCHHOFF (Germany), Pedro GRANDES, Nagore PUENTE (Bilbao) Mathilde Love & Peace METNA Francis Grumpy CHAOULOFF Federico Sick MASSA Giovanni Little Gio BENARD Jose Mandolin CRUZ Tifany Breakfast DESPREZ Edgar El Chino SORIA Astrid Mama CANNICH Dany Blondie VERRIER Hu- Acupuncture -BO Philipp I.D. BETHGE Peggy Betty Boop VINCENT Michele Buonarroti COLAVITA Arnau Cataluña BUSQUETS Roman I am here SERRAT Laurie Russian ROBIN Carolina MUGURUZA Merryl MALEZIEUX 9
10 28 10
A Cannabinoid link between mitochondria and memory 2
A Cannabinoid link between mitochondria and memory 2 1942 1964 O OH Δ 9 -Tetrahydrocannabinol 1990 CB1 1992 O NH Anandamide OH FEAR 3000 a.c. Skin GI tract Bone HPA axis Neuronal plasticity Giovanni Pain
Bimodal control of stimulated food intake by. the endocannabinoid system
Bimodal control of stimulated food intake by the endocannabinoid system Luigi Bellocchio 1,*, Pauline Lafenêtre 1,*, Astrid Cannich 1, Daniela Cota 2, Nagore Puente 3, Pedro Grandes 3, Francis Chaouloff
Cannabinoids 101. Matthew Hill, Ph.D. Hotchkiss Brain Institute University of Calgary
Cannabinoids 101 Matthew Hill, Ph.D. Hotchkiss Brain Institute University of Calgary Disclosures Have received honoraria for Scientific Consultation: Pfizer International GW Pharmaceuticals Receive operating
Synapses and Neurotransmitters
Synapses and Neurotransmitters Communication Between Neurons Synapse: A specialized site of contact, and transmission of information between a neuron and an effector cell Anterior Motor Neuron Figure 45-5
The$CAJAL$Advanced$Neuroscience$Training$Programme$
TheCAJALAdvancedNeuroscienceTrainingProgramme NUTRITIONANDBRAINFUNCTIONS(NBF)2016 Speakers 21/09/2016 What"the"brain"uptake"rate"of"fatty"acids"tells"us"about"their"dietary"requirements:"Implications"for"food"sources"and"the"environment
BIPN140 Lecture 8: Synaptic Transmission II
BIPN140 Lecture 8: Synaptic Transmission II 1. Postsynaptic Receptors: Metabotropic & Ionotropic 2. Postsynaptic Responses (Postsynaptic Potentials, PSPs) 3. Neurotransmitters Su (FA16) Chemical Synapse:
Psychology 320: Topics in Physiological Psychology Lecture Exam 2: March 19th, 2003
Psychology 320: Topics in Physiological Psychology Lecture Exam 2: March 19th, 2003 Name: Student #: BEFORE YOU BEGIN!!! 1) Count the number of pages in your exam. The exam is 8 pages long; if you do not
Synaptic plasticity and addiction
Synaptic plasticity and addiction Julie A. Kauer* and Robert C. Malenka Abstract Addiction is caused, in part, by powerful and long-lasting memories of the drug experience. Relapse caused by exposure to
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) The hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
Bimodal Control of Fear-Coping Strategies by CB 1 Cannabinoid Receptors
The Journal of Neuroscience, May 23, 2012 32(21):7109 7118 7109 Behavioral/Systems/Cognitive Bimodal Control of Fear-Coping Strategies by CB 1 Cannabinoid Receptors Mathilde Metna-Laurent, 1,2 * Edgar
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) Hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
TITLE: Altered Astrocyte-Neuron Interactions and Epileptogenesis in Tuberous Sclerosis Complex Disorder
AWARD NUMBER: W81XWH-12-1-0196 TITLE: Altered Astrocyte-Neuron Interactions and Epileptogenesis in Tuberous Sclerosis Complex Disorder PRINCIPAL INVESTIGATOR: Dr. David Sulzer, Ph.D. CONTRACTING ORGANIZATION:
Modeling Depolarization Induced Suppression of Inhibition in Pyramidal Neurons
Modeling Depolarization Induced Suppression of Inhibition in Pyramidal Neurons Peter Osseward, Uri Magaram Department of Neuroscience University of California, San Diego La Jolla, CA 92092 possewar@ucsd.edu
BIPN140 Lecture 12: Synaptic Plasticity (II)
BIPN140 Lecture 12: Synaptic Plasticity (II) 1. Early v.s. Late LTP 2. Long-Term Depression 3. Molecular Mechanisms of Long-Term Depression: NMDA-R dependent 4. Molecular Mechanisms of Long-Term Depression:
When cells are already maximally potentiated LTP is occluded.
When cells are already maximally potentiated LTP is occluded. Stein, V et al., (2003) J Neurosci, 23:5503-6606. Also found in Rat Barrel Cortex Ehrlich & Malinow (2004) J. Neurosci. 24:916-927 Over-expression
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Hypothalamic TLR triggers sickness behavior via a microglia-neuronal axis Sungho Jin, *, Jae Geun Kim,, *, Jeong Woo Park, Marco Koch,, Tamas L. Horvath and Byung Ju Lee Department of Biological Sciences,
Shift 1, 8 July 2018, 09:30-13:00
Shift 1, 8 July 2018, 09:30-13:00 CNS patterning A001-A014 Stem cells: basic biology and postnatal neurogenesis - part I Development of neural systems: Molecular and genetic characterisationa Epigenetic
The Endocannabinoid System
The Endocannabinoid System Think of this system as the wizard behind the curtain. It underlies all the other systems, including the Autonomic Nervous System. Overall it influences well-being and the perception
Embryonic MGE Cells as a Treatment for Epilepsy December 1, 2012
Embryonic MGE Cells as a Treatment for Epilepsy December 1, 2012 Scott C. Baraban, PhD University of California, San Francisco American Epilepsy Society Annual Meeting Disclosure Name of Commercial Interest
Endocannabinoids and Lipid Mediators in Brain Functions
Endocannabinoids and Lipid Mediators in Brain Functions Miriam Melis Editor Endocannabinoids and Lipid Mediators in Brain Functions Editor Miriam Melis Dept Biomedical Sciences Division of Neuroscience
Cellular mechanisms of information transfer: neuronal and synaptic plasticity
Cellular mechanisms of information transfer: neuronal and synaptic plasticity Ivan Pavlov (UCL Institute of Neurology, UK) Anton Chizhov (Ioffe Physical Technical Institute) Pavel Zykin (St.-Petersburg
GENETIC APPROACHES TO MOLECULAR AND CELLULAR COGNITION: A Focus on LTP and Learning and Memory
Annu. Rev. Genet. 2002. 36:687 720 doi: 10.1146/annurev.genet.36.062802.091007 Copyright c 2002 by Annual Reviews. All rights reserved First published online as a Review in Advance on September 12, 2002
Glutamate Overview. How can one neurotransmitter have so many diverse functions?
tamate Overview How can one neurotransmitter have so many diverse functions? Darryle Schoepp, Ph.D. Senior Vice President and Franchise Head, Neuroscience Control of Excitability via Amino Acid Neurotransmitters
Cellular Neurobiology / BIPN 140
SECOND MIDTERM EXAMINATION Fall, 2015 GENERAL INSTRUCTIONS 1. Please write your name on ALL 6 pages. 2. Please answer each question IN THE SPACE ALLOTTED. 1) /10 pts 2) /10 pts 3) /15 pts 4) /15 pts 5)
Neuronal Plasticity, Learning and Memory. David Keays Institute of Molecular Pathology
Neuronal Plasticity, Learning and Memory David Keays Institute of Molecular Pathology http://keayslab.org Structure 1. What is learning and memory? 2. Anatomical basis 3. Cellular basis 4. Molecular
Synaptic Plasticity and Memory
Synaptic Plasticity and Memory Properties and synaptic mechanisms underlying the induction of long-term potentiation (LTP) The role of calcium/calmodulin-dependent kinase II (CamKII) in the induction,
Supplementary Figure 1) GABAergic enhancement by leptin hyperpolarizes POMC neurons A) Representative recording samples showing the membrane
Supplementary Figure 1) GABAergic enhancement by leptin hyperpolarizes POMC neurons A) Representative recording samples showing the membrane potential recorded from POMC neurons following treatment with
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. Declarative memory conscious,
Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections Ronald S. Duman, PhD
Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections Ronald S. Duman, PhD Introduction Depression is a widespread, devastating illness, affecting approximately
Abstracts and affiliations
Dopamine Discovery Day August 30, 2012 Rikshospitalet Store auditorium, Oslo, Norway Organized by Linda H. Bergersen & Vidar Gundersen Institute of Basic Medical Sciences & Centre for Molecular Biology
MOLECULAR BIOLOGY OF DRUG ADDICTION. Sylvane Desrivières, SGDP Centre
1 MOLECULAR BIOLOGY OF DRUG ADDICTION Sylvane Desrivières, SGDP Centre Reward 2 Humans, as well as other organisms engage in behaviours that are rewarding The pleasurable feelings provide positive reinforcement
Synapse. Structure & Function. Neurotransmitter Sequence. Integration. History: 10/4/12 original version
Synapse History: 10/4/12 original version Structure & Function (This content is covered in Sinjin's presentation, see link in calendar) Neurotransmitters Synaptic cleft Post-synaptic potential Excitation
Zhu et al, page 1. Supplementary Figures
Zhu et al, page 1 Supplementary Figures Supplementary Figure 1: Visual behavior and avoidance behavioral response in EPM trials. (a) Measures of visual behavior that performed the light avoidance behavior
processes in the central nervous system (CNS), affecting many of the during the course of ethanol treatment. Ethanol stimulates the release of
INTRODUCTION INTRODUCTION Neuroscience research is essential for understanding the biological basis of ethanol-related brain alterations and for identifying the molecular targets for therapeutic compounds
JNJ : selective and slowly reversible FAAH inhibitor. Central and Peripheral PK/PD
JNJ-42165279: selective and slowly reversible FAAH inhibitor Central and Peripheral PK/PD The Endocannabinoid System Research initiated by efforts to elucidate the active substance of Cannabis (THC in
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 http://neuroscience.uth.tmc.edu/s1/chapter06.html http://neuroscience.uth.tmc.edu/s1/chapter07.html Chris Cohan, Ph.D. Dept. of
ErbB4 migrazione I parte. 3- ErbB4- NRG1
ErbB4 migrazione I parte 3- ErbB4- NRG1 1 In rodent brains postnatal neuronal migration is evident in three main areas: the cerebellum (CB), the hippocampus (Hipp) and the rostral migratory stream (RMS).
Nature Neuroscience: doi: /nn Supplementary Figure 1. Visualization of AT1a-positive cells using AT1a lacz/+ mouse.
Supplementary Figure 1 Visualization of AT1a-positive cells using AT1a lacz/+ mouse. (a f) Immunohistochemical detection of β-gal in the mouse brain. Coronal sections at the respective anteroposterior
The Endocannabinoid System: Directing Eating Behavior and Macronutrient Metabolism
The Endocannabinoid System: Directing Eating Behavior and Macronutrient Metabolism Watkins and Kim 2015 Council of Hypothalamic Metabolites Agenda The Endocannabinoid System (ECS) Intro The ECS in the
mtorc2 controls actin polymerization required for consolidation of long-term memory
CORRECTION NOTICE Nat. Neurosci.; doi:1.138/nn.3351 mtorc2 controls actin polymerization required for consolidation of long-term memory Wei Huang, Ping Jun Zhu, Shixing Zhang, Hongyi Zhou, Loredana Stoica,
Basal Ganglia Anatomy, Physiology, and Function. NS201c
Basal Ganglia Anatomy, Physiology, and Function NS201c Human Basal Ganglia Anatomy Basal Ganglia Circuits: The Classical Model of Direct and Indirect Pathway Function Motor Cortex Premotor Cortex + Glutamate
serotonin in learning and plasticity
serotonin in learning and plasticity pt.1 immediate action L P H N NRX N N R X N CDH RhoA/ROCK RAC1 DAG [Ca2+] camp GIRK2 P11 Gq CASK PICK1 VELI MINT-1 CaMK Ca2+ channel AC Gi mglur7 mglur5 Glutamate NMDAR
Charlie Taylor, PhD CpTaylor Consulting Chelsea, MI, USA
Contribution of Calcium Channel α 2 δ Binding Sites to the Pharmacology of Gabapentin and Pregabalin Charlie Taylor, PhD CpTaylor Consulting Chelsea, MI, USA Disclosure Information Charlie Taylor, PhD
Antiepileptic agents
Antiepileptic agents Excessive excitability of neurons in the CNS Abnormal function of ion channels Spread through neural networks Abnormal neural activity leads to abnormal motor activity Suppression
Cell communication. Gated ion channels. Allow specific ions to pass only when gates are open
increase decrease Cell communication Gated ion channels Allow specific ions to pass only when gates are open Triggered by: potential change, chemical binding, temperature change, stretching 1 Voltage-Gated
Cell communication. Gated ion channels. Voltage-Gated Na + Channel. Allow specific ions to pass only when gates are open
increase decrease Cell communication Gated ion channels Allow specific ions to pass only when gates are open Voltage-Gated Na + Channel Activation gate ECF Triggered by: change, chemical binding, temperature
Fig. 4. The activity of Pkc -transduced neurons is required for enhanced learning. After gene transfer, rats were tested on [] vs. +.
![Fig. 4. The activity of Pkc -transduced neurons is required for enhanced learning. After gene transfer, rats were tested on [] vs. +.](/thumbs/90/102196023.jpg "Fig. 4. The activity of Pkc -transduced neurons is required for enhanced learning. After gene transfer, rats were tested on [] vs. +.")
Research Interests Advanced cognitive learning is encoded in distributed circuits that span multiple forebrain areas. Further, synaptic plasticity and neural network theories hypothesize that essential
Synaptic Transmission: Ionic and Metabotropic
Synaptic Transmission: Ionic and Metabotropic D. Purves et al. Neuroscience (Sinauer Assoc.) Chapters 5, 6, 7. C. Koch. Biophysics of Computation (Oxford) Chapter 4. J.G. Nicholls et al. From Neuron to
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 https://nba.uth.tmc.edu/neuroscience/s1/chapter06.html https://nba.uth.tmc.edu/neuroscience/s1/chapter07.html Chris Cohan, Ph.D.
Cannabis. Member of the Cannabaceae family of flowering plants (along with hops) Cannabis sativa (v. sativa, indica, afghanica, ruderalis)
Member of the Cannabaceae family of flowering plants (along with hops) sativa (v. sativa, indica, afghanica, ruderalis) Only females flowers contain high concentrations of psychoactive oils (cannabinoids)
Hippocampal protein kinase C signaling mediates the short-term memory
Hippocampal protein kinase C signaling mediates the short-term memory impairment induced by delta9-tetrahydrocannabinol Arnau usquets-garcia* 1,2, Maria Gomis-González* 1, Victòria Salgado-Mendialdúa 1,
Supporting Information
ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD- 95 multi- protein complex U.Lalo, O.Palygin, A.Verkhratsky, S.G.N. Grant and Y. Pankratov Supporting
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses
Supplementary Information Astrocyte signaling controls spike timing-dependent depression at neocortical synapses Rogier Min and Thomas Nevian Department of Physiology, University of Berne, Bern, Switzerland
TITLE: Altered Astrocyte-Neuron Interactions and Epileptogenesis in Tuberous Sclerosis Complex Disorder
AD Award Number: W81XW -12-1-0196 TITLE: Altered Astrocyte-Neuron Interactions and Epileptogenesis in Tuberous Sclerosis Complex Disorder PRINCIPAL INVESTIGATOR: Dr. David Sulzer, Ph.D CONTRACTING ORGANIZATION:
Systems Neuroscience CISC 3250
Systems Neuroscience CISC 325 Memory Types of Memory Declarative Non-declarative Episodic Semantic Professor Daniel Leeds dleeds@fordham.edu JMH 328A Hippocampus (MTL) Cerebral cortex Basal ganglia Motor
CONTEXT. LTP (long term potentiation) definition. LTP as a interesting mechanism for learning and memory
CONTEXT LTP (long term potentiation) definition LTP as a interesting mechanism for learning and memory LTP is due primarily to a pre or post- synaptic modification? (Increased Glut release or increased
Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic I h channels. Vahri Beaumont and Robert S. Zucker
Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic I h channels Vahri Beaumont and Robert S. Zucker Background I h channels discovered in 1976 (Noma A. and Irisawa H.) Voltage-gated
Memory retention the synaptic stability versus plasticity dilemma
Memory retention the synaptic stability versus plasticity dilemma Paper: Abraham, Wickliffe C., and Anthony Robins. "Memory retention the synaptic stability versus plasticity dilemma." Trends in neurosciences
Memory: Computation, Genetics, Physiology, and Behavior. James L. McClelland Stanford University
Memory: Computation, Genetics, Physiology, and Behavior James L. McClelland Stanford University A Playwright s Take on Memory What interests me a great deal is the mistiness of the past Harold Pinter,
Neurotransmitter Systems II Receptors. Reading: BCP Chapter 6
Neurotransmitter Systems II Receptors Reading: BCP Chapter 6 Neurotransmitter Systems Normal function of the human brain requires an orderly set of chemical reactions. Some of the most important chemical
Neurotransmitter Systems III Neurochemistry. Reading: BCP Chapter 6
Neurotransmitter Systems III Neurochemistry Reading: BCP Chapter 6 Neurotransmitter Systems Normal function of the human brain requires an orderly set of chemical reactions. Some of the most important
Synaptic plasticity. Mark van Rossum. Institute for Adaptive and Neural Computation University of Edinburgh
Synaptic plasticity Mark van Rossum Institute for Adaptive and Neural Computation University of Edinburgh 1 Human memory systems 2 Psychologists have split up memory in: Declarative memory * Episodic memory
Cognitive Function Test. NOR & spatial NOR task. Introduction. Novel Object Recognition (NOR) Estrogen Receptor (ER) in Brain
Cognitive Function Test Human Rodent Sutcliffe JS, Marshall KM, Neill JC. Behavioral Brain Research 177(2007) 117-125. Radial Arm maze Morris Water maze Siriporn Vongsaiyat 16 th Feb 2007 Novel Object
SUPPLEMENTARY INFORMATION
doi: 10.1038/nature05772 SUPPLEMENTARY INFORMATION Supplemental figure 1. Enrichment facilitates learning. a. Images showing a home cage and a cage used for environmental enrichment (EE). For EE up to
Notes: Synapse. Overview. PSYC Summer Professor Claffey PDF. Conversion from an signal to a signal - electrical signal is the
PSYC 170 - Summer 2013 - Professor Claffey Notes: Synapse PDF Overview Conversion from an signal to a signal - electrical signal is the - chemical signal is the Presynaptic - refers to that sends/receives
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates L. Cheng, A. Arata, R. Mizuguchi, Y. Qian, A. Karunaratne, P.A. Gray, S. Arata, S. Shirasawa, M. Bouchard,
The Neurobiology of Schizophrenia
The Neurobiology of Schizophrenia Dost Ongur, MD PhD Neither I nor my spouse/partner has a relevant financial relationship with a commercial interest to disclose. What is Psychosis? Response Language Affect
Acetylcholine again! - thought to be involved in learning and memory - thought to be involved dementia (Alzheimer's disease)
Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function Michael E. Hasselmo * and Bradley P. Wyble Acetylcholine again! - thought to
Expanding Mindfulness as a Core Treatment Skill for Men and Women With Cognitive Deficits Thomas G. Beckers BS, LADC Vinland Center
Expanding Mindfulness as a Core Treatment Skill for Men and Women With Cognitive Deficits Thomas G. Beckers BS, LADC Vinland Center What Are We Going to Cover? To gain understanding of the nature of addiction
Introduction to some interesting research questions: Molecular biology of the primary afferent nociceptor
Introduction to some interesting research questions: Molecular biology of the primary afferent nociceptor NOCICEPTORS ARE NOT IDENTICAL PEPTIDE SubP/CGRP Trk A NON-PEPTIDE IB4 P2X 3 c-ret Snider and McMahon
Synaptic Plasticity and the NMDA Receptor
Synaptic Plasticity and the NMDA Receptor Lecture 4.2 David S. Touretzky November, 2015 Long Term Synaptic Plasticity Long Term Potentiation (LTP) Reversal of LTP Long Term Depression (LTD) Reversal of
Mechanisms of Long-Term Plasticity of Hippocampal GABAergic Synapses
ISSN 0006-2979, Biochemistry (Moscow), 2017, Vol. 82, No. 3, pp. 257-263. Pleiades Publishing, Ltd., 2017. Original Russian Text A. V. Rozov, F. F. Valiullina, A. P. Bolshakov, 2017, published in Biokhimiya,
Synaptic plasticityhippocampus. Neur 8790 Topics in Neuroscience: Neuroplasticity. Outline. Synaptic plasticity hypothesis
Synaptic plasticityhippocampus Neur 8790 Topics in Neuroscience: Neuroplasticity Outline Synaptic plasticity hypothesis Long term potentiation in the hippocampus How it s measured What it looks like Mechanisms
Action Potentials and Synaptic Transmission. BIO 219 Napa Valley College Dr. Adam Ross
Action Potentials and Synaptic Transmission BIO 219 Napa Valley College Dr. Adam Ross Review of action potentials Nodes of Ranvier Nucleus Dendrites Cell body In saltatory conduction, the nerve impulses
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. Working memory short-term
The Science of Addiction Webquest
1 The Science of Addiction Webquest For this assignment you will be using the website of The University of Utah s Genetic Science Learning Library (http://learn.genetics.utah.edu/content/addiction/). For
Outline. Outline. Background Literature and Slides 10/23/2013. The Schizophrenia Research Forum online: Molecules, Neural Networks and Behavior
Background Literature and Slides Molecules, Neural Networks and Behavior Roberto Fernández Galán, PhD Assistant Professor of Neurosciences Mt. Sinai Health Care Foundation Scholar Alfred P. Sloan Research
Drugs, addiction, and the brain
Drugs, addiction, and the brain Topics to cover: What is addiction? How is addiction studied in the lab? The neuroscience of addiction. Caffeine Cocaine Marijuana (THC) What are the properties of addiction?
Study Guide Unit 3 Psych 2022, Fall 2003
Psychological Disorders: General Study Guide Unit 3 Psych 2022, Fall 2003 1. What are psychological disorders? 2. What was the main treatment for some psychological disorders prior to the 1950 s? 3. What
CELLULAR NEUROPHYSIOLOGY
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 4. SYNAPTIC TRANSMISSION II: GLUTAMATERGIC TRANSMISSION Video 4-1: Observations and glutamate receptor channels Synaptic transmission II 1 Constance Hammond Observation
The synaptic Basis for Learning and Memory: a Theoretical approach
Theoretical Neuroscience II: Learning, Perception and Cognition The synaptic Basis for Learning and Memory: a Theoretical approach Harel Shouval Phone: 713-500-5708 Email: harel.shouval@uth.tmc.edu Course
MOLECULAR AND CELLULAR NEUROSCIENCE
MOLECULAR AND CELLULAR NEUROSCIENCE BMP-218 November 4, 2014 DIVISIONS OF THE NERVOUS SYSTEM The nervous system is composed of two primary divisions: 1. CNS - Central Nervous System (Brain + Spinal Cord)
Insulin-Leptin Interactions
Insulin-Leptin Interactions Ahmed S., Al-Azzam N., Cao B. Karshaleva B., Sriram S., Vu K. If you understand a system, you can predict it. Agenda - Energy homeostasis Overview of leptin and insulin Signaling
Is Intrinsic Hyperexcitability in CA3 the Culprit for Seizures in Rett Syndrome?
Current Literature In Basic Science Is Intrinsic Hyperexcitability in CA3 the Culprit for Seizures in Rett Syndrome? Network Hyperexcitability in Hippocampal Slices From Mecp2 Mutant Mice Revealed by Voltage-Sensitive
Basics of Computational Neuroscience: Neurons and Synapses to Networks
Basics of Computational Neuroscience: Neurons and Synapses to Networks Bruce Graham Mathematics School of Natural Sciences University of Stirling Scotland, U.K. Useful Book Authors: David Sterratt, Bruce
Glycine-gated ion channels Converging mechanism and therapeutic potentials
Glycine-gated ion channels Converging mechanism and therapeutic potentials Li Zhang Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health,
IBRO CIHR & UNESCO ADVANCED BEHVIOURAL NEUROSCEINCE SCHOOL KENYA 2008
IBRO CIHR & UNESCO ADVANCED BEHVIOURAL NEUROSCEINCE SCHOOL KENYA 2008 SYNAPTIC FUNCTION & DRUG ACTION Associate Professor Laurie Kellaway Faculty of Health Sciences University of Cape Town WHAT DOES A
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior
Manuscript EMBO-2009-71034 Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior Sachiko Taniguchi, Asami Tanimura, Yuji Kiyama, Tohru Tezuka, Ayako M. Watabe, Norikazu Katayama,
Endocannabinoid System Cannabinoid Drugs
Cannabinoid Drugs STCM Conference Bern 22.1.2013 Rudolf Brenneisen University of Bern, DKF 1 www.phytopharm.dkf.unibe.ch rudolf.brenneisen@dkf.unibe.ch Milestones 1988: First cannabinoid receptor (rat
Classes of Neurotransmitters. Neurotransmitters
1 Drugs Outline 2 Neurotransmitters Agonists and Antagonists Cocaine & other dopamine agonists Alcohol & its effects / Marijuana & its effects Synthetic & Designer Drugs: Ecstasy 1 Classes of Neurotransmitters
Biological Psychology 2012 Spring 2005 Patterson
Final Exam Biological Psychology 2012 Spring 2005 Patterson There are two versions of this exam. You have version A. Before starting the exam, mark A on question 60. MULTIPLE CHOICE. Choose the one alternative
DNA and Histone Methylation in Learning and Memory
EXPERIMENTAL BIOLOGY ANNUAL MEETING April 2010 DNA and Histone Methylation in Learning and Memory J. David Sweatt Dept of Neurobiology McKnight Brain Institute UAB School of Medicine The Molecular Basis
CB2-mediated immunoregulation in Inflammatory Bowel Disease. David Ziring, MD Clinical Instructor, UCLA Div of Peds GI
CB2-mediated immunoregulation in Inflammatory Bowel Disease David Ziring, MD Clinical Instructor, UCLA Div of Peds GI Overview Why study cannabinoid signaling in intestinal immunoregulation? G_i2 -/- mice
TECHNICAL REVIEW REPORT
TECHNICAL REVIEW REPORT Grant Agreement number: FP7 202167 Project Acronym: NeuroGLIA Project title: Molecular and cellular investigation of neuron-astroglia interactions: Understanding brain function
Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents
Research Paper CCNP 3 Innovations Award Paper Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents Tingting Duan, PhD; Ning Gu,
GABA Induced Depolarization: A Tale of Opposing Forces
GABA Induced Depolarization: A Tale of Opposing Forces December 2010 Jong M. Rho, MD Alberta Children s Hospital University of Calgary, Alberta, Canada American Epilepsy Society Annual Meeting Disclosures
Stress, glucocorticoids and memory: implications for treating fear-related disorders
Stress, glucocorticoids and memory: implications for treating fear-related disorders Dominique de Quervain 1 3, Lars Schwabe 4 and Benno Roozendaal 5,6 Abstract Glucocorticoid stress hormones are crucially
Introduction to CNS 1
Introduction to CNS 1 Types of ion channels 1- voltage-gated 2-legends-gated Voltage-gated channel A voltage Sensor component of the protein controls the gating (broken arrow) of the channel. Voltage-gated
Understanding the Brain: What Drugs Can Tell Us
LIVE INTERACTIVE LEARNING @ YOUR DESKTOP Understanding the Brain: What Drugs Can Tell Us Presented by: Dr. Rochelle D. Schwartz-Bloom March 24, 2011 Understanding the Brain: What Drugs Can Tell Us Rochelle