Upper Limb Salvage With Endovascular Treatment of Acute Axillary Artery Occlusion Secondary to Proximal Humeral Fracture
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1 ASE REPORT AND REVIEW Upper Limb Salvage With Endovascular Treatment of Acute Axillary Artery Occlusion Secondary to Proximal Humeral Fracture Tsuyoshi Isawa, MD 1 ; Kenji Suzuki, MD 1 ; Hideki Abe, MD 2 From 1 Sendai Kousei Hospital, Sendai, Japan, and 2 Sanyudo Hospital, Yonezawa, Japan. ABSTRAT: Acute axillary artery occlusion associated with proximal humeral fracture is rare. Traditionally, axillary artery complications associated with humeral fractures are managed with open surgery. However, open vascular repair presents a considerable challenge to even the most skilled surgeons. Endovascular treatment (EVT) offers an alternative to surgical management. We describe the case of an 82-year-old Japanese male with acute upper limb ischemia (AULI) secondary to acute axillary artery occlusion caused by a proximal humeral fracture. He was successfully treated with EVT. Unless there is vessel transection, EVT is feasible and offers a minimally invasive and prompt therapy for AULI resulting from axillary artery occlusion. VASULAR DISEASE MANAGEMENT 2015;12(3):E36-E43 Key words: endovascular management, acute upper limb ischemia, proximal humeral fracture Acute upper limb ischemia (AULI) is much less commonly encountered and clinically recognized than acute ischemia of the lower limb. 1 According to a previous report, the early commencement of revascularization is crucial for limb salvage in patients with AULI. 2 Sudden axillosubclavian artery occlusion is one cause of AULI. However, it rarely occurs as a complication of proximal humeral fracture. 3 Although there are some reports on endovascular treatment (EVT) for the management of axillosubclavian artery injuries, such as lacerations, pseudoaneurysms, and arteriovenous fistulas, 4 there are only a few reports on its application in acute axillo-subclavian arterial occlusions. 5,6 We present a case demonstrating the value of immediate EVT in the management of AULI secondary to acute axillary artery occlusion caused by a closed humeral fracture. opyright HMP ommunications ASE PRESENTATION An 82-year-old Japanese male presented with severe pain in the left shoulder and arm, with discoloration of hand and fingers, 2 hours after falling at home. His medical history included osteoporosis and prostate cancer that were well controlled with medical treatment. On admission, his vital signs were stable. On physical examination performed approximately 2 hours after Vascular Disease Management March
2 om m un ic at io n s ASE REPORT AND REVIEW op yr ig ht H M P Figure 1. Radiograph showing proximal fracture of the left humerus before (A) and after closed reduction (B). Figure 2. Serial computed tomography images of the left axilla showing the axillary artery (large arrow), occluded near the fracture site without contrast extravasation, and a piece of fractured humerus bone (small arrow). Images are viewed in a cranial (A) to caudal (B) direction. Vascular Disease Management March
3 om m un ic at io n s ASE REPORT AND REVIEW M P Figure 3. Three-dimensional computed tomography images of the left axilla from a slight right anterior oblique angle showing axillary artery obstruction (arrow). Early phase (A). Late phase (B). op yr ig ht H the fall there were no brachial, radial, or ulnar pulses in the left arm. There were no open wounds. The hand and forearm were pale and cool, but the skin of the fingers was dark, indicating critical ischemia. In spite of mild hypoesthesia, there was no weakness in his hand and fingers. His hemoglobin was 9.6 g/dl and the estimated glomerular filtration rate was 71.9 ml/min/1.73 m2. The serum creatine kinase level was 123 IU/L. An initial radiography of the left shoulder revealed a three-part fracture of the left proximal humerus with severe medial displacement, according to Neer classification. To restore blood flow, he underwent immediate closed reduction under interscalene brachial plexus block (Figure 1). However, the distal pulses were still not palpable and the fingers remained dusky. An early phase contrasted computed tomography (T) scan showed an abrupt obstruction of the left axillary artery adjacent to the fracture site, without evidence of contrast extravasation. This finding suggested occlusion associated with an intimal tear caused by the displaced shaft of the humerus rather than arterial transection. Late-phase contrasted T images revealed a faint visualization of the brachial artery distal to the occluded axillary artery (Figures 2 and 3). His upper limb was thought to be salvageable because of the lack of weakness in his left hand and fingers. TREATMENT At first, thromboembolectomy with a Fogarty catheter or bypass surgery was considered as the primary procedure. However, there were no experienced surgeons on duty at nearby tertiary hospitals who could immediately perform such operations. Therefore, we opted for EVT for upper limb salvage. A transfemoral Vascular Disease Management March
4 ASE REPORT AND REVIEW op yr ig ht H M P Figure 4. Thrombi aspirated from the axillary artery. om m un ic at io n s artery. Following intravenous heparin (5,000 U), selective angiography was performed. The axillary artery was occluded proximally without the visualization of distal vessels. A 6 Fr JR4 Launcher guiding catheter (Medtronic) was placed in the left subclavian artery with the aid of a angled soft guidewire. Next, a 5 Fr JR4 Trail diagnostic catheter (Fukuda Denshi) was introduced using the mother-child technique. With the support of the 5 Fr diagnostic catheter antegradely advanced to a point just proximal to the occluded part of the artery, the guidewire was successfully passed through the occlusion and reached the brachial artery. The delivery of a Thrombuster II 6 Fr aspiration catheter (Kaneka Medix) from a femoral artery was not possible because of the tortuous axillosubclavian artery. Therefore, we tried to gain access through the brachial artery. The brachial artery provides a more direct, shorter, and less tortuous approach for the treatment of axillary artery lesions. Although several attempts at brachial artery puncture were unsuccessful using a antegrade guidewire as a landmark to obtain retrograde access, we achieved radial access under fluoroscopic guidance and introduced a 6 Fr long sheath. A Thruway guidewire (Boston Scientific) was passed through the lesion in retrograde fashion, advanced into the guiding catheter in the left subclavian artery, and retrieved with a Gooseneck snare (ev3) to gain sufficient backup force. Next, aspiration thrombectomy via the transradial approach was performed using an aspiration catheter, and several large thrombi were aspirated from the axillary artery (Figure 4). With distal vessel angiographic visualization following aspiration, a 6 mm 40 mm Sterling balloon catheter (Boston Scientific) was advanced over Figure 5. Stent deployment. approach under local anesthesia was used, with placement of a 6 Fr sheath into the right common femoral Vascular Disease Management March
5 ASE REPORT AND REVIEW Figure 6. Angiogram confirming abrupt axillary artery occlusion before endovascular treatment (A) and patency of the stented axillary artery after endovascular treatment (B). the guidewire. The balloon was inflated at 8 atmospheres for 60 seconds. After the balloon dilatation, the distal blood flow was only partially restored and the cyanosis of the upper limb did not resolve. We observed a flow-limiting, angiographically identifiable dissection that extended from the axillary artery to the subclavian artery. Therefore, we deployed a 6 mm 40 mm SMART ontrol self-expandable stent (ordis orporation) distally and a 6 mm 120 mm counterpart proximally, avoiding the origin of the vertebral artery. Unfortunately, there was a gap between the stents; therefore, an additional 6 mm 18 mm Palmaz Genesis balloon-expandable stent (ordis orporation) was placed between them (Figure 5). After postdilatation, the patency of the vertebral and internal thoracic arteries was protected and brisk flow was achieved in the axillary artery within 6 hours of the onset of symptoms (Figure 6). Strong brachial and radial pulses became palpable and the cyanosis of the upper limb disappeared. He suffered a right-sided cerebellar stroke, which was associated with the procedure, but symptoms including dizziness and nausea were controlled with conservative treatment. Double antiplatelet therapy was initiated with clopidogrel 75 mg/day and aspirin 100 mg/day. He underwent open reduction and an internal fixation of the proximal humeral fracture 1 month after EVT. He was discharged well after undergoing rehabilitation, and to date, he has had no symptoms of residual ischemia. opyright HMP ommunications DISUSSION The most common causes of AULI include embolism (47%) and thrombosis (28%), whereas trauma accounts for only 25% of cases. 7 In addition to direct arterial Vascular Disease Management March
6 ASE REPORT AND REVIEW trauma, remote arterial trauma can cause AULI when traction on a blood vessel causes an injury to the vessel at a site distant from the evident bony or soft tissue damage. 8 In particular, the violent overstretching of an artery under hyperabduction can precipitate acute arterial injuries, which can involve a total or partial rupture of all arterial layers or intimal damage only, causing lumen occlusion. 3,9 Although axillary artery injury sometimes occurs with shoulder dislocation and clavicle fractures, it is rarely concomitant with proximal humeral fractures. 10 Although open surgery has become the mainstay of primary treatment for acute upper limb ischemia related to trauma, the procedure is technically demanding, even for experienced operators. Furthermore, it was used to prevent critical ischemia and successfully often takes time to obtain reperfusion because of the anatomical complexity of the arteries that are adjacent rarely compromise the axillary artery. The occurrence of AULI represents an emergency indication for surgical intervention to prevent gangrene of the affected extremity. If the arm is to be successfully salvaged in patients with AULI, revascularization should be achieved within 6 hours of the onset of symptoms. 2 Therefore, an immediate access to vascular surgeons capable of accomplishing complex operations is crucial. If the restoration of blood flow is delayed, there is a risk of acute renal failure secondary to myoglobinemia. However, the immediate availability of skilled vascular surgeons may be limited, particularly in rural areas in Japan. In this setting, EVT is a viable alternative to surgery. In the present case, EVT salvage the upper limb of the patient. In general, EVT is feasible unless there is hemody- to the clavicle and brachial plexus. In contrast, thromboembolectomy with a Fogarty catheter has gained an adequate proximal vascular fixation site. 4 One manamic instability, vessel transection, or the absence of widespread acceptance as first-line treatment for the jor advantage of EVT over open surgical repair is that management of nontraumatic AULI. The rate of limb general anesthesia is not required, enabling faster revascularization and minimizing blood loss. Furthermore, salvage following thromboembolectomy has been reported as 98%. 11 EVT can be immediately performed after diagnostic EVT is seldom indicated, and consequently has been angiography, in which vascular access remote from the rarely used as the concurrent treatment of both traumatic and nontraumatic AULI. To our knowledge, of percutaneous aspiration thromboembolectomy us- local injury is obtained. Kim et al described the efficacy there are few case reports on EVT for occluded axillosubclavian arteries associated with blunt trauma, in- approach with placement of a 7 Fr sheath. 12 Successful ing a 6 Fr or 7 Fr guiding catheter via a transbrachial cluding clavicular and scapular fracture. 5,6 However, no recanalization was achieved in all 11 patients enrolled reports on EVT for an occluded axillary artery related in that study, although no cases of concomitant trauma to proximal humeral fracture have been published. such as fractures were included. In our case, although This may be because the number of cases is small. The we made several attempts under fluoroscopic guidance, humerus is more distant from the axillary artery than we were unable to obtain brachial access. Although the clavicle and scapula, and fractures of the humerus ultrasound-guided retrograde arterial access in the opyright HMP ommunications Vascular Disease Management March
7 ASE REPORT AND REVIEW brachial artery would have made the procedure faster, we were inexperienced in the procedure. Therefore, we opted for a more familiar procedure, radial access under fluoroscopic guidance. Brachial access usually allows the use of a 7 Fr sheath. Instead, we obtained radial access and selected a 6-Fr sheath because a 7-Fr one was too large to insert into his radial artery. Despite use of a 6 Fr aspiration catheter, by repeating aspiration and stent placement, a large amount of thrombus was aspirated and acceptable reperfusion was achieved within the critical period for limb salvage. Although 5- to 10-month patency has been reported in a few cases, 13 the long-term results of deploying stents in the axillary artery have not yet been well investigated. In the present case we had no alterna- the result of partial or complete arterial transection. tive because upper limb ischemia persisted even after balloon dilatation and the aspiration of the thrombus. we had to use it for covering a short gap between the two SMART ontrol stents. From our experiences, a balloon-expandable stent does not increase the likelihood of stent strut fracture if it is short. There are potential procedure-related complications associated with the use of EVT for acute axillosubclavian artery occlusion secondary to trauma. The risk of distal embolization during recanalization of an occlusion must be considered. The placement of the stent near the origin of the vertebral artery should be avoided to prevent vertebrobasilar embolization. onsideration must also be given to the possibility that traversing the occlusive lesions with a guidewire may cause bleeding because the occlusion may be Therefore, a T must be performed before the procedure to determine whether there is a hematoma Long-term follow-up is required to confirm stent around the artery or a hemothorax. Either of these patency in this patient. findings suggests the transection of the artery, in We believe that, for choosing the type of stent for which case open surgical repair is a preferred treatment option. axillary artery, the following factors are important: acceptable flexibility and sufficient radial strength. SMART ontrol stents demonstrate these factors. ONLUSION Therefore, we used these stents to cover the axillary In the management of AULI, treatment should be artery lesion. In general, the axillary artery and superficial femoral artery are similar because they have high emic symptoms. EVT offers a minimally invasive and initiated as early as possible after the onset of isch- mobility. We speculate that the clinical effectiveness prompt alternative to open surgery or thromboembolectomy with a Fogarty catheter for AULI resulting of the SMART ontrol stents for both axillary artery and superficial femoral artery lesions may be similar. from an occluded axillary artery. n The evidence of the long-term result of the SMART ontrol stent for superficial femoral artery lesions has Editor s note: Disclosure: The authors have completed been established. 14 As for a balloon-expandable stent and returned the IMJE Form for Disclosure of Potential (Palmaz Genesis), although it was not suitable for axillary artery lesions because of the lack of flexibility, to the content onflicts of Interest The authors report no disclosures related herein. opyright HMP ommunications Vascular Disease Management March
8 ASE REPORT AND REVIEW Manuscript received September 8, 2014; provisional acceptance given November 3, 2014; final manuscript accepted December 5, Address for correspondence: Tsuyoshi Isawa, MD, Sendai Kousei Hospital, ardiology, 4-15 Hirose-machi, Sendai, Miyagi, Japan. REFERENES 1. Eyers P, Earnshaw JJ. Acute non-traumatic arm ischaemia. Br J Surg. 1998;85(10): Miller HH, Welch S. Quantitative studies on the time factor in arterial injuries. Ann Surg. 1949;130: Modi S, Nnene O, Godsiff SP, Esler N. Axillary artery injury secondary to displaced proximal humeral fractures: a report of two cases. J Orthop Surg. 2008;16(2): DuBose JJ, Rajani R, Gilani R, et al. Endovascular management of axillo-subclavian arterial injury: a review of published experience. Injury. 2012;43(11): IIkay E, Rahman A, Ozdemir H, et al. Endovascular stent management of acute traumatic subclavian artery occlusion by intimal flap. Eur J Vasc Endovasc Surg Extra. 2003;6: Molloy S, Jacob S, Buckenham T, Taylor RS. Percutaneous repair of an acute traumatic subclavian artery occlusion. Eur J Vasc Endovasc Surg. 2001;21(1): Turner EJH, Loh A, Howard A. Systematic review of the operative and non-operative management of acute upper limb ischemia. J Vasc Nurs. 2012;30(3): Quraishy MS, awthorn SJ, Giddings AEB. ritical ischaemia of the upper limb. J R Soc Med. 1992;85(5): Theodorides T, de Keizer. Injuries of the axillary artery caused by fractures of the neck of the humerus. Injury. 1976;8(2): Yagubyan M, Panneton JM. Axillary artery injury from humeral neck fracture: a rare but disabling traumatic event. Vasc Endovasc Surg. 2004;38(2): Hernandez-Richter T, Angele MK, Helmberger T, et al. Acute ischemia of the upper extremity: long-term results following thrombembolectomy with the Fogarty catheter. Langenbecks Arch Surg. 2001;386(4): Kim SK, Kwak HS, hung GH, Han YM. Acute upper limb ischemia due to cardiac origin thromboembolism: the usefulness of percutaneous aspiration thromboembolectomy via a transbrachial approach. Korean J Radiol. 2011;12(5): Vijayvergiya R, Yadav M, Grover A. Percutaneous endovascular management of atherosclerotic axillary artery stenosis: report of 2 cases and review of literature. World J ardiol. 2011;3(5): Suzuki K, Iida O, Soga Y, et al. Long-term results of the S.M.A.R.T. ontroltm stent for superficial femoral artery lesions, J-SMART registry. irc J. 2011;75(4): opyright HMP ommunications Vascular Disease Management March
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