Biliary Anatomy in Living-related Liver Transplantation

Transcription

1 The 5th IHPBA Congress - Istanbul Biliary Anatomy in Living-related Liver Transplantation biliary trees hilar plate

2 Assessment for Vascular Anatomy 1. 3DCT portal vein hepatic vein hepatic artery 2. No angio Assessment for Biliary Anatomy 1. Intraoperative cholangiography 2. DIC-CT, MRCP 3. No ERCP

3 Intra-operative Cholangiography clip for mapping

4 Encircle the left hepatic duct BD PV Hilar plate

5 Dissection of Bile Duct for Right Llobe Graft RHD RHA RPV away from bifurcation

6 Anatomy of Biliary System and Vascular System The portal vein and the bile duct run together always inside the liver. not always at the hilum.? Doc and Dog run together always in town not always in mountain

7 Biliary Anatomy Type I Type II Posterior Branch Type III Type IV

8 Normal anatomy of PV Different anatomy Type III anatomy

9 Anterior branch from left branch PV & BD Same anatomy

10 Different anatomy Normal anatomy of PV Type III anatomy 3 small anterior branches

11 Same anatomy Trifurcation of PV & Bile duct

12 Different anatomy Extrahepatic branch of post.br. Normal anatomy

13 Single portal vein Different anatomy Normal anatomy of bile duct Type I

14 Biliary Anatomy in Kyoto Type I Type II 65.0% 9.2% Type III Type IV 8.3% 15.0% Nakamura et al. Transplantation 2002;27:1896

15 Biliary System of Right Lobe Number of anastomotic holes in each type Type I Type II Type III Type IV One: 88% Two:10% Three:1% One:27% Two:73% One:10% Two:90% Two:95% Three:5% Nakamura et al. Transplantation 2002;27:1896

16 Cutting line of bile duct in type IV Right lobe graft Left lobe graft

17 Biliary Reconstruction for Single or Multiple Holes in Right Lobe Graft N = 48 N = 15 N = 10 Hisatsune, Yazumi et al. Transplantation (in press)

18 Biliary Reconstruction for Two Separate Holes using Duct-to-Duct Technique Close Distant Cystic duct

19 Stent Type for Duct-to-Duct Reconstruction A B C Ishiko et al. Ann Surg 2002;236:235 Type B & C were better than type A in 50 cases

20 Surgical Innovation for Special Anatomies

21 Type III anatomy with 3 small anterior branches cut Posterior branch from cystic duct

22 Donor operation Recipient operation stent ant cystic duct post cystic duct

23 Graft with one PV and two bile ducts. OK! Normal anatomy of PV but Type III anatomy

24 Intraoperative Findings of Complex Anatomy

25 Complex Anatomy and Strategy PV end-to-end anastomosis HA Donor Bile duct PV stent Bile duct HA Recipient: single PV single HA double BD

26 Biliary Complications in Right Lobe Donors

27 ERCP for Biliary Complications in Right Lobe Donors ENBD for Leakage (n=8) indication: failed percutaneous drainage period after surgery: days (ave. 77days) results: 100% success for leakage period for closure after endoscopic drainage: 7-18 days ERBD for Stenosis (n=4) background: 3 cases after successful treatment for leakage period after surgery or leakage: 1-6 months period of stenting: days Results: 50% success and 50% recurrence Hasegawa et al. Clinical Gastroenterology and Hepatology (in press)

28 ERCP for Biliary Complication in Right Lobe Donor Leakage (n=9) Stenosis (n=1) ERBD (n=1) healed ENBD (n=8) healed stricture (n=3) ERBD balloon & ENBD ERBD removal of stent removal of stent recurrence healed (n=2) recurrence (n=1) ERBD surgery healed Hasegawa et al. Clinical Gastroenterology and Hepatology (in press)

29 The Angles Between the Common Hepatic Duct and the Left Hepatic Duct - Cases Without Stricutre Hasegawa et al. Clinical Gastroenterology and Hepatology (in press)

30 The Angles Between the Common Hepatic Duct and the Left Hepatic Duct - Cases With Stricutre Hasegawa et al. Clinical Gastroenterology and Hepatology (in press)

31 Comparison of the Angles between the Donors with and without the Stricture Angle between CHD and left HD P < 0.05 Stricture (+) Stricture (-) median angle: 62 vs 119, p < 0.05 Hasegawa et al. Clinical Gastroenterology and Hepatology (in press)

32 Anatomical Change of the Biliary System after Right Lobectomy Hasegawa et al. Clinical Gastroenterology and Hepatology (in press)

33 Prevention of Biliary Complication in Right Lobe donor Keep enough length of the right hepatic duct for closure Do not skeltonize bifurcation Close the right hepatic duct horizontally Check leakage and stricture by cholangiography before abdominal closure

34 Prevention of Biliary Complication in Right Lobe donor Incidence of leakage Learning Curve ~ 2000: 2-3 / 10 donors 2001: 1 / donors 2002: 1 / donors C drain for the hepatic duct 2002 May ~: 0 / 50 donors

35 Biliary Complications after Right LobeTransplantation

36 Types of Cholangiogram of Biliary Stricture in Duct-to-Duct Anastomosis Single type (5%) Forked type (90%) Trident type (5%) Hisatsune, Yazumi et al. Transplantation (in press)

37 Relation between Anatomy and Stenosis N = 48 N = 15 N = 10 incidence 27% 27% 20% Single type Forked type Trident type 1 0 0

38 Biliary Complications Stent Insertion Balloon dilatation stents Hisatsune, Yazumi et al. Transplantation (in press)

39 Stents for Biliary Stenosis stenting Removal of stents after 1-year-stenting stenosis Stent dislocation & re-stenting

40 Inside-stent 7-10 Fr conventional plastic stent A stent stays above the sphinctor. A nylon thread is attached to distal side-hole (arrows) to aid removal of the stent. Hisatsune, Yazumi et al. Transplantation (in press)

41 Biliary Anastomotic Complications in Hepatico-Jejunostomy Egawa e al. World J Surg 2001;25:1300 Over all incidence of biliary complication in 400 cases: 18% Risks for leaks manner of stent usage intra-pulmonary shunt recipient gender Risks for stenosis leaks CMV diseases hepatic artery complication gender Blood type incompatible transplantation >2y.o.

42 Biliary Anastomotic Complications in Hepatico-Jejunostomy Graft type and Incidence in 500 cases (not published) using intermittent suture with/without stents Right left lateral ext. lateral APOLT (52) (89) (29) ( 35) (28) Leak 18% 17% 7 % 5 % 29 % Stenosis 6 % 8 % 6 % 0 % 30 %

43 Biliary Anastomotic Complications in Hepatico-Jejunostomy Learning curve : incidence of each 100 cases Blood type Incompatible LTx APOLT Right lobe 10%

44 Conclusions Anatomy of biliary system is often different from portal system at the hilum. We encountered special anatomies which we could not expect before operations and conquered them with surgical innovation. Secure donor safety first and cut the bile duct.