BRAIN & BEHAVIOR RESEARCH FOUNDATION

Transcription

1 BRAIN & BEHAVIOR RESEARCH FOUNDATION Scientific Council Dinner PRESENTING THE KLERMAN & FREEDMAN AWARDS FRIDAY, JULY 27, 2018 METROPOLITAN CLUB NEW YORK 1

2 Welcome to the Scientific Council Dinner where we will present the 2018 Klerman & Freedman Awards. The Scientific Council, led by its founding President, Dr. Herbert Pardes, review and select the most promising research ideas with the greatest potential to lead to further breakthroughs. We thank them for their time, expertise, and judgement to support the mission of the Foundation. Tonight we will recognize and honor the exceptional work of some of the outstanding researchers who have received awards through the Brain & Behavior Research Foundation s Young Investigator Grant program, which supports young scientists as they gather pilot data and proof of concept for their innovative clinical and basic research. The Prizes are named for Gerald L. Klerman and Daniel X. Freedman, two neuropsychiatry pioneers who played seminal roles as researchers, teachers, physicians and administrators. Their outstanding contributions continue to inspire scientists who knew them, as well as those who are just entering the field. The prizewinners are selected by committees of the Foundation s Scientific Council. Five young researchers are being recognized tonight for their work in psychosis, non-invasive brain stimulation to treat chronic back pain which can often lead to depression and anxiety, stress induced depression and autism spectrum disorders, memory disorders and adaptive decision making that goes awry in mental illness. Following dinner, Dr. Pardes will lead an engaging discussion on the state of research and psychiatry with select members of our Scientific Council. The Brain & Behavior Research Foundation continues to support the most promising ideas in brain research across disciplines, institutions and continents. We hope that as you learn about the achievements of this evening s honorees they will inspire your continued support of our work toward a future in which all people living with a psychiatric condition lead full, productive, and happy lives. 24 th ANNUAL KLERMAN PRIZE FOR EXCEPTIONAL CLINICAL RESEARCH Albert R. Powers III, M.D., Ph.D. Yale University School of Medicine HONORABLE MENTION Timothy Y. Mariano, M.D., Ph.D., MSc Harvard Medical School Brigham and Women s Hospital Butler Hospital 21 st ANNUAL FREEDMAN PRIZE FOR EXCEPTIONAL BASIC RESEARCH Byungkook Lim, Ph.D. University of California, San Diego HONORABLE MENTIONS Christina Gremel, Ph.D. University of California, San Diego Ueli Rutishauser, Ph.D. Cedars-Sinai Medical Center, Los Angeles Sincerely, Jeffrey Borenstein, M.D. President & CEO 2 3

3 KLERMAN Prizewinners KLERMAN Honorable Mentions THE KLERMAN PRIZE Dr. Rajiv Tandon Dr. Hans C. Brieter Dr. Schahram Akbarian Dr. Michael Maes Dr. Andrew L. Stoll Dr. Susan K. Schultz Dr. Cameron S. Carter Dr. Josephy R. Hibbeln Dr. Sarah H. Lisanby Dr. Perry F. Renshaw Dr. E. Sherwood Brown Dr. John W. Newcomer Dr. Ramin Mojtabai Dr. Helen Link Egger Dr. Joan L. Luby Dr. Melissa P. DelBello Dr. Hilary P. Blumberg Dr. Beng-Choon Ho Dr. Gabriel Alejandro de Erausquin Dr. Alina Suris Dr. Daniel P. Dickstein Dr. Mani N. Pavuluri Dr. Chadi Calarge Dr. Jess G. Fiedorowicz Dr. James McPartland Dr. Denis Jabaudon Dr. Alan Anticevic Dr Katie McLaughlin Dr. Jennifer C. Felger Dr. Elizabeth D. Abercrombie Dr. Kim T. Mueser Dr. Jose V. Pardo Dr. Steven E. Arnold Dr. Helen S. Mayberg Dr. Andrew J. Francis Dr. Katharine A. Phillips Dr. Cameron S. Carter Dr. Mark R. Serper Dr. Shitij Kapur Dr. Brian F. O Donnell Dr. Mark S. George Dr. Sohee Park Dr. Stephan Heckers Dr. Anissa Abi Dargham Dr. Jeffrey H. Meyer Dr. Yvette I. Sheline Dr. Catherine Monk Dr. Gerard Sanacora Dr. Anne L. Glowinski Dr. Gerard Sanacora Dr. Stephan Eliez Dr. Jordan W. Smoller Dr. Yuval Y. Neria Dr. Carolyn M. Salafia Dr. Brian M. D Onofrio Dr. Jennifer S. Silk Dr. Johanne Renaud Dr. Manpreet Kaur Singh Dr. Daniel Mueller Dr. Andrea Danese Dr. Mazen A. Kheirbek Dr. Bo Li Dr. Chadi Abdallah Dr. Carrie J. McAdams Dr. Erin C. Dunn Dr. Avram Holmes Dr. Danai Dima Dr. Carolyn Rodriguez The Klerman Prize, established in 1994 by Myrna M. Weissman, Ph.D., in memory of her late husband, Gerald L. Klerman, M.D., honors exceptional clinical research by a Young Investigator Grantee. A distinguished psychiatric researcher and mentor at the National Institute of Mental Health (NIMH) and a member of the faculties of Yale, Harvard and Cornell Universities, Dr. Klerman served from 1977 to 1980 as chief administrator at the Alcohol, Drug Abuse and Mental Health Administration. At the NIMH, Dr. Klerman became a central figure in the psychopharmacology service center s collaborative study of phenothiazine as a treatment for acute schizophrenia and in the program on the psychobiology of depression. He led planning of multi-site studies defining affective and anxiety disorders as well as the development and evaluation of treatments. While pioneering studies of psychotropic medications, he developed and tested interpersonal psychotherapy, a treatment now used throughout the world. Dr. Weissman is herself an eminent depression researcher at Columbia University and the New York State Psychiatric Institute. She has received three Distinguished Investigator Grants and the Brain & Behavior Research Foundation 1994 Outstanding Achievement Prize in Mood and Affective Disorders (renamed The Colvin Prize in 2012). In 2013, she joined the Foundation s Scientific Council. KLERMAN PRIZE SELECTION COMMITTEE Responsible for selecting the Klerman Prizewinners, the following Foundation Scientific Council Members make up the Selection Committee: CHAIR Robert M.A. Hirschfeld, M.D. Well Cornell Medical College, Cornell University MEMBERS Martin B. Keller, M.D. Brown University Rachel G. Klein, Ph.D. New York University Nina R. Schooler, Ph.D. State University of New York, Downstate Karen Dineen Wagner, M.D., Ph.D. University of Texas Medical Branch at Galveston 04 05

4 2018 KLERMAN PRIZEWINNER FOR EXCEPTIONAL CLINICAL RESEARCH Albert R. Powers III, M.D., Ph.D. Assistant Professor of Psychiatry Yale University 2015 Young Investigator Grant Albert R. Powers III, M.D., Ph.D. is an Assistant Professor at the Yale University Department of Psychiatry and Medical Director of the PRIME Psychosis Research Clinic at Yale. In addition to treating patients who suffer from the earliest symptoms of psychosis, he uses computational approaches to understand how sensory systems might go awry to produce hallucinations and other psychotic symptoms. As a graduate student, Dr. Powers studied multisensory integration, or the process by which the brain combines information from the different senses into a meaningful representation of the world around us. In particular, he focused upon the ability of this process to change with perceptual learning. He found that audiovisual integration is capable of far more flexibility than was previously thought, and that the changes in behavior accompanying that flexibility are accompanied by robust brain network changes. Together these findings carry implications for treatment approaches for disorders in which these processes may be abnormal, such as schizophrenia, autism, and dyslexia. Dr. Powers applied this background in sensory neuroscience to a study conducted with Yale researcher Philip Corlett, Ph.D. Aided by a Young Investigator grant, their work resulted in the first evidence for a computational model of hallucinations. While completing this work, Dr. Powers completed his psychiatric training, spending most of his outpatient time at the cutting-edge Specialized Treatment Early in Psychosis (STEP) Clinic, where he learned team-based care for first-episode psychosis and gained a passion for caring for this patient population. Dr. Powers received his B.A. from Yale University in 2004, and his Ph.D. and M.D. from Vanderbilt University School of Medicine in The work I have completed would simply not have been possible without my 2015 Young Investigator Award. Together we have laid the foundation for even more fundamental discoveries as our understanding of the computational underpinnings of psychosis grows. Receiving the Klerman Award is an incredible honor because of its storied history and impressive roster of past awardees, but most of all because it represents the esteem of my colleagues for the work I have been able to accomplish with the support of the BBRF

5 2018 KLERMAN PRIZE HONORABLE MENTION Timothy Mariano, M.D., Ph.D., M.Sc. is an Instructor of Psychiatry at Harvard Medical School and an Associate Psychiatrist at Brigham and Women s Hospital. Dr. Mariano s research interests and clinical work focus on neuromodulation, or the electromagnetic stimulation of brain and other nerve cells to modify their activity. Dr. Mariano studies a type of noninvasive brain stimulation called transcranial direct current stimulation (tdcs) as a potential treatment for the emotional symptoms of chronic low back pain. Timothy Y. Mariano, M.D., Ph.D., M.Sc. Instructor of Psychiatry Harvard Medical School Chronic low back pain is a disabling and costly disease, substantially burdening patients, families, and the health care system. Estimates suggest it may affect 15 percent to 45 percent of individuals. The emotional symptoms or suffering aspect of chronic low back pain underlies much of the syndrome s disability and reduced quality of life, and the can lead to associated psychiatric disorders such as anxiety, depression and even suicide. Current pain-relieving treatments do not address these emotional symptoms, and medications such as prescription opioids often provide only short-term relief while having serious side effects including addiction and overdose deaths. In Dr. Mariano s lab, researchers have carried out preliminary studies using tdcs to determine how the treatment may impact emotional symptoms of pain and to determine the technique s safety in treating chronic low back pain. The treatment passes a weak electrical current through two electrodes placed on the scalp to a region of the brain involved in emotional pain processing. Results from a 21-person study suggest that the treatment may reduce interference and disability in daily life from pain, as well as reduce symptoms of depression. If the results are confirmed in larger clinical trials, the technique would be a major advance in the treatment of chronic pain without reliance on opioid medications. My Young Investigator Grant came as I was navigating the critical transition from psychiatry trainee to junior faculty. It immediately allowed me to protect research time so critical to early career clinician-scientists trying to establish research independence and collect promising data that has already led to new research collaborations and will support future grant applications. I am excited to expand the clinical use Dr. Mariano received a B.S. in biomedical engineering from Harvard College in 2003 of noninvasive neuromodulation Brigham and Women s Hospital and an M.S. in cognitive neuroscience from to alleviate the suffering of some Butler Hospital the University of Oxford in He joined the Medical Scientist Training Program at of our most severely disabled Case Western Reserve University, receiving patients Young Investigator Grant his Ph.D. in biomedical engineering in 2009 and his M.D. degree in He completed his residency in general psychiatry at Brown 08 University in

6 FREEDMAN Prizewinners FREEDMAN Honorable Mentions THE FREEDMAN PRIZE Dr. Yukiko Goto Dr. Stewart A. Anderson Dr. Edwin G. Abel Dr. Kelsey C. Martin Dr. Jon R. Backstrom Dr. Jose A. Esteban Dr. Luca Santarelli Dr. Eric E. Turner Dr. Elizabeth Van Bockstaele Dr. Emmanuel N. Pothos Dr. Laurence H. Tecott Dr. Wayne Drevets Dr. Bernice E. Morrow Dr. Michael J. Caterina Dr. Aurelio A. Galli Dr. Michael W. Quick Dr. Fu-Ming Zhou The Freedman Prize honors the late Daniel X. Freedman, M.D., a pioneer in biological psychiatry and psychopharmacology and a founding member of the Brain & Behavior Research Foundation Scientific Council. It is awarded to a Young Investigator Grantee for exceptional basic studies. Dr. Freedman was an innovator in bringing the biological sciences to psychiatry. He was Professor of Psychiatry at Yale University, the University of Chicago and at the UCLA School of Medicine. He was Chair of the Department of Psychiatry at the University of Chicago for 17 years and Executive Vice Chair of the UCLA Department of Psychiatry and Biobehavioral Sciences for eight years Dr. Lisa M. Monteggia Dr. Michael D. Ehlers Dr. Thomas A. Blanpied Dr. Evelyn K. Lambe Dr. Kerry J. Ressler Dr. David A. Baker Dr. Alexandre Bonnin Dr. Zhiping Pang Dr. Garret Stuber Dr. Theodore D. Satterthwaite Dr. Michael M. Halassa Dr. Kay Tye Dr. Ilana Witten Dr. William A. Carlezon Dr. Gleb P. Shumyatsky Dr. Michael D. Ehlers Dr. Sheena Ann Josselyn Dr. Steven A. Thomas Dr. Fang Liu Dr. Stewart A. Anderson Dr. Gabriella D Arcangelo Dr. Karoly Mirnics Dr. Fang Liu Dr. Luca Santarelli Dr. M. Margarita Behrens Dr. Akira Sawa Dr. Jean-Martin Beaulieu Dr. Colleen Ann McClung Dr. Vincent P. Ferrera Dr. Benjamin Philpot Dr. Alberto Bacci Dr. Andrew A. Pieper Dr. Marie Carlen Dr. Genevieve Konopka Dr. Carmen Andreescu Dr. David Foster Dr. Hiroki Taniguchi Dr. Elena Ivleva Dr. Aristotle N. Voineskos Dr. Kristen J. Brennand Dr. Nandakumar Narayanan Dr. Conor Liston Dr. Margaret Cho Dr. Marcelo de Oliveiera Dietrich Dr. Elise B. Robinson While at Yale University in the 1950s, Dr. Freedman worked extensively with patients with schizophrenia and their families, and developed a particular interest in the clinical phenomena of psychosis, such as hallucinations. During this time, he spent a year at the National Institute of Mental Health (NIMH) to research the effects of LSD on neurotransmitters in the brain and discovered that it altered the functioning of serotonin. This began his professional focus on the role of serotonin in brain function. He went on to discover similar neurochemical processes in the brain during environmental stress and in childhood autism. He also studied elements of schizophrenia and Huntington s disease, brain mechanisms in allergy and the way that drugs interact with the central nervous system to alter behavior. FREEDMAN PRIZE SELECTION COMMITTEE Responsible for selecting the Freedman Prizewinners, the following Foundation Scientific Council Members make up the Selection Committee: CHAIR Ariel Y. Deutch, Ph.D. Vanderbilt University MEMBERS Joseph T. Coyle, M.D. McLean Hospital Harvard Medical School Affiliate Ronald S. Duman, Ph.D. Yale University Fritz A. Henn, M.D., Ph.D. Peter W. Kalivas, Ph.D. Medical University of South Carolina Husseini K. Manji, M.D., FRCPC Johnson & Johnson PRD Visiting Professor, Duke University Eric J. Nestler, M.D., Ph.D. Icahn School of Medicine at Mount Sinai Bryan L. Roth, M.D., Ph.D. University of North Carolina School of Medicine 10 11

7 2018 FREEDMAN PRIZEWINNER FOR EXCEPTIONAL BASIC RESEARCH Byungkook Lim, Ph.D. is an Assistant Professor of Neurobiology in the Division of Biological Sciences at the University of California, San Diego. Dr. Lim s research investigates the neural circuitry behind stressinduced depression and autism spectrum disorder (ASD). The onset of depression is often triggered by stressful or unpleasant events, and studies in animals have shown that repeated social stress can induce pervasive and long-lasting behavioral changes similar to those seen in people with major depressive disorder. However, researchers know very little about the neural changes that underlie these changes in behavior. Dr. Lim s lab closely examines the distinct neural circuits behind stress-induced behaviors in mice to better understand this phenomenon, using a variety of tools including viral tracing and manipulation of neural circuits, deep brain imaging, and optogenetics. In their work focusing on the brain s reward circuitry in depressive behaviors, they found that different depressive behaviors, such as impaired social interactions and lack of motivation, have distinct neural circuitries. This discovery could help to devise revolutionary circuit- specific diagnoses and treatments. Byungkook Lim, Ph.D. Assistant Professor of Neurobiology University of California, San Diego 2015 Young Investigator Grant Their research has also pinpointed circuitry in a part of the brain called the lateral septum as a potentially important hub involved in social dysfunction seen in several animal models of ASD. They are working to understand how the lateral The Young Investigator Award septum may be affected by early life stress funding helped me carry out that leads to social dysfunction in ASD, challenging and risky projects depression, and schizophrenia. when I was just establishing Dr. Lim graduated from Seoul National my own independent research University, Korea, with a B.S. in Molecular group. The fact that my proposal was selected by a renowned Biology and M.S. in Biochemistry in 2001, and received his Ph.D. in Neurobiology from University of California, Berkeley in selection committee gave He worked as a postdoctoral fellow with me confidence and support Robert Malenka, M.D., Ph.D. in the Stanford during a critical time as a University Department of Psychiatry and Behavioral Sciences. young scientist

8 2018 FREEDMAN PRIZE HONORABLE MENTION Christina M. Gremel, Ph.D. Assistant Professor of Psychology The Neurosciences Graduate Program University of California, San Diego 2015 Young Investigator Grant Christina M. Gremel, Ph.D. is an Assistant Professor of Psychology at the University of California, San Diego, and is affiliated with The Neurosciences Graduate Program. Dr. Gremel s lab examines the neural bases of goal-directed behavior. People with underlying psychiatric pathologies often have difficulties making causal judgments about their actions and the associated consequences. For example, addicts continue to make poor decisions and habitually use drugs even in the face of harsh consequences. This disruption to decision-making processes is observed in disorders ranging from schizophrenia to depression, suggesting there may be common underlying neural circuitry involved in the problem. To better understand this disruption, Dr. Gremel and her colleagues have studied how neural circuits in the brain s orbital frontal cortex and basal ganglia function to control the balance between goaldirected and habitual behaviors during normal and dysfunctional decision making. They identified a mechanism in the orbital frontal cortex that is disrupted in alcohol-dependent mice, making it difficult for the mice to carry out goal-directed decisions. However, the team also showed that increasing the activity in this area of the brain can restore some aspects of proper self-control The Young Investigator Grant following alcohol dependence. The findings really helped launch my could help researchers discover new targeted ways to treat psychiatric disorders research program, and gave such as addiction that are characterized by me the resources I needed to disruptions in decision making. lay a foundation for dissecting Dr. Gremel received her B.S. in neuroscience how the brain does adaptive from the University of Minnesota in 2002, decision making and how that and her Ph.D. in behavioral neuroscience goes awry in disease. This support from the Brain & Behavior from Oregon Health & Sciences University in She worked as a postdoctoral fellow at the National Institutes of Health in the Research Foundation helped me National Institute on Alcohol Abuse and obtain research funding from Alcoholism with Drs. Rui Costa and David the NIH and other foundations Lovinger before starting her own laboratory at UC San Diego. to continue this work

9 2018 FREEDMAN PRIZE HONORABLE MENTION Ueli Rutishauser, Ph.D. is an Associate Professor in Neuroscience in the Departments of Neurosurgery, Neurology and Biomedical Sciences at the Cedars-Sinai Medical Center. He holds a joint visiting appointment at the Division of Biology and Biological Engineering at the California Institute of Technology. Dr. Rutishauser s laboratory investigates the neural mechanisms of learning, memory, and decision making. Memory disorders are a critical aspect of many psychiatric disorders, including schizophrenia, post-traumatic stress disorder, bipolar disorders, and depression. The disease burden by memory disorders on patients as well as their families is immense, and is often not addressed even if the underlying disorder can successfully be treated with medication. In addition, successful treatment of a psychiatric condition often creates significant issues with memory as a side effect. Ueli Rutishauser, Ph.D. Associate Professor in Neuroscience Cedars-Sinai Medical Center, Los Angeles 2015 Young Investigator Grant To learn more about the underpinnings of memory in the brain, Dr. Rutishauser and his colleagues have made human single-neuron recordings in human patients who are undergoing neurosurgical procedures for epilepsy or Parkinson s disease, collecting these rare recordings directly in humans while they make, maintain, and recall memories. For the first time, they found persistently active neurons in a part of the brain called the hippocampus that remain active as long as a particular memory is held in mind. The ability to directly measure and manipulate these neurons is a critical step forward, because impaired short-term memory is a key impairment in many mental disorders and is thought to be the result of impaired coordination between persistently active cells that can potentially be restored by electrical stimulation or medication. Dr. Rutishauser studied computer science for his B.S. and received his Ph.D. in computation and neural systems from Caltech in After postdoctoral studies at Caltech and the Max Planck Institute for Brain Research in Frankfurt, Germany, he started his own lab in My BBRF award was instrumental in allowing me to start my own independent laboratory. It provided the critical funding needed to perform my first pilot studies, to publish my first major senior-author paper, and to demonstrate validity of my ideas to the field. As a result, I am now able to pursue an ambitious research program on deciphering the neural mechanisms of human memory by utilizing neurosurgical procedures to directly study the human nervous system. The goal of my studies is to develop treatments for the devastating memory disorders that result from mental illness

10 SCIENTIFIC COUNCIL BOARD OF DIRECTORS PRESIDENT Herbert Pardes, M.D. VICE PRESIDENT EMERITUS Floyd E. Bloom, M.D. Ted Abel, Ph.D. Anissa Abi-Dargham, M.D. Schahram Akbarian, M.D.,Ph.D. Huda Akil, Ph.D. Susan G. Amara, Ph.D. Stewart A. Anderson, M.D. Nancy C. Andreasen, M.D., Ph.D. Amy F.T. Arnsten, Ph.D. Gary S. Aston-Jones, Ph.D. Jay M. Baraban, M.D., Ph.D. Deanna Barch, Ph.D. Jack D. Barchas, M.D. Samuel H. Barondes, M.D. Carrie Bearden, Ph.D. Francine M. Benes, M.D., Ph.D. Karen F. Berman, M.D. Wade H. Berrettini, M.D., Ph.D. Randy D. Blakely, Ph.D. Pierre Blier, M.D., Ph.D. Hilary Blumberg, M.D. Antonello Bonci, M.D. Robert W. Buchanan, M.D. Peter F. Buckley, M.D. Ed Bullmore, Ph.D. William E. Bunney, Jr., M.D. Joseph D. Buxbaum, Ph.D. William Byerley, M.D. Ty Cannon, Ph.D. William Carlezon, Ph.D. Marc G. Caron, Ph.D. William T. Carpenter, Jr., M.D. Cameron S. Carter, M.D. BJ Casey, Ph.D. Bruce M. Cohen, M.D., Ph.D. Jonathan D. Cohen, M.D., Ph.D. Peter Jeffrey Conn, Ph.D. Edwin Cook, M.D. Richard Coppola, D.Sc. Rui Costa, Ph.D., HHMI Joseph T. Coyle, M.D. Jacqueline N. Crawley, Ph.D. John G. Csernansky, M.D. Z. Jeff Daskalakis, M.D., Ph.D. Karl Deisseroth, M.D., Ph.D. J. Raymond DePaulo, Jr., M.D. Ariel Y. Deutch, Ph.D. Wayne C. Drevets, M.D. Ronald S. Duman, Ph.D. Stan B. Floresco, Ph.D. Judith M. Ford, Ph.D. Alan Frazer, Ph.D. Robert R. Freedman, M.D. Fred H. Gage, Ph.D. Aurelio Galli, Ph.D. Mark S. George, M.D. Elliot S. Gershon, M.D. Mark A. Geyer, Ph.D. Jay N. Giedd, M.D. Jay A. Gingrich, M.D., Ph.D. David Goldman, M.D. Joshua A. Gordon, M.D., Ph.D. Elizabeth Gould, Ph.D. Anthony A. Grace, Ph.D. Paul Greengard, Ph.D. Raquel Gur, M.D., Ph.D. Suzanne N. Haber, Ph.D. Philip D. Harvey, Ph.D. Stephan Heckers, M.D. René Hen, Ph.D. Fritz A. Henn, M.D., Ph.D. Takao Hensch, Ph.D. Robert M.A. Hirschfeld, M.D. L. Elliot Hong, M.D. Steven E. Hyman, M.D. Robert B. Innis, M.D., Ph.D. Jonathan A. Javitch, M.D.,Ph.D. Daniel C. Javitt, M.D., Ph.D. Dilip Jeste, M.D. Ned Kalin, M.D. Peter W. Kalivas, Ph.D. Eric R. Kandel, M.D. Richard S.E. Keefe, Ph.D. Samuel J. Keith, M.D. Martin B. Keller, M.D. John R. Kelsoe, M.D. Kenneth S. Kendler, M.D. James L. Kennedy, M.D. Robert M. Kessler, M.D. Mary-Claire King, Ph.D. Rachel G. Klein, Ph.D. John H. Krystal, M.D. Amanda J. Law, Ph.D. James F. Leckman, M.D. Francis S. Lee, M.D., Ph.D. Ellen Leibenluft, M.D. Robert H. Lenox, M.D. Pat Levitt, Ph.D. David A. Lewis, M.D. Jeffrey A. Lieberman, M.D. Kelvin Lim, M.D. Irwin Lucki, Ph.D. Gary Lynch, Ph.D. Robert C. Malenka, M.D., Ph.D. Anil K. Malhotra, M.D. Husseini K. Manji, M.D., F.R.C.P.C. J. John Mann, M.D. 175 Members (7 Emeritus) 2 Nobel Prize Winners 2 Former Directors of the National Institute of Mental Health as well as the current Director 4 Recipients of the National Medal of Science 13 Members of the National Academy of Sciences 26 Chairs of Psychiatry & Neuroscience Departments at Leading Medical Institutions 52 Members of the National Academy of Medicine John S. March, M.D., M.P.H. Stephen Maren, Ph.D. Daniel Mathalon, Ph.D., M.D. Helen S. Mayberg, M.D. Bruce S. McEwen, Ph.D. Ronald McKay, Ph.D. James H. Meador-Woodruff, M.D. Herbert Y. Meltzer, M.D. Kathleen Merikangas, Ph.D. Richard J. Miller, Ph.D. Karoly Mirnics, M.D., Ph.D. Bita Moghaddam, Ph.D. Charles B. Nemeroff, M.D., Ph.D. Eric J. Nestler, M.D., Ph.D. Andrew A. Nierenberg, M.D. Patricio O Donnell, M.D., Ph.D. Dost Ongur, M.D., Ph.D. Steven M. Paul, M.D. Godfrey D. Pearlson, M.A., M.B.B.S. Mary L. Phillips, M.D. (CANTAB) Marina Picciotto, Ph.D. Daniel S. Pine, M.D. Robert M. Post, M.D. James B. Potash, M.D., M.P.H. Steven G. Potkin, M.D. Pasko Rakic, M.D., Ph.D. Judith L. Rapoport, M.D. Perry F. Renshaw, M.D., Ph.D., M.B.A. Kerry J. Ressler, M.D., Ph.D. Victoria Risbrough, Ph.D. Carolyn B. Robinowitz, M.D. Bryan L. Roth, M.D., Ph.D. Laura Rowland, Ph.D. John L.R. Rubenstein, M.D., Ph.D. Bernardo Sabatini, M.D., Ph.D. Gerard Sanacora, M.D., Ph.D. Akira Sawa, M.D., Ph.D. Alan F. Schatzberg, M.D. Nina R. Schooler, Ph.D. Robert Schwarcz, Ph.D. Philip Seeman, M.D., Ph.D. Yvette I. Sheline, M.D. Solomon H. Snyder, M.D., D.Sc., D.Phil. (Hon. Causa) Vikaas Sohal, M.D., Ph.D. Matthew State, M.D. Murray Stein, M.D., M.P.H. John S. Strauss, M.D. J. David Sweatt, Ph.D. John A. Talbott, M.D. Carol A. Tamminga, M.D. Laurence H. Tecott, M.D.,Ph.D. Ming T. Tsuang, M.D., Ph.D., D.Sc. Kay M. Tye, Ph.D. Leslie G. Ungerleider, Ph.D. Flora Vaccarino, M.D., Ph.D. Rita J. Valentino, Ph.D. Jim van Os, M.D., Ph.D., MRCPsych Jeremy Veenstra-VanderWeele, M.D. Susan Voglmaier, M.D., Ph.D. Nora D. Volkow, M.D. Mark von Zastrow, M.D., Ph.D. Karen Dineen Wagner, M.D., Ph.D. Daniel R. Weinberger, M.D. Myrna M. Weissman, Ph.D. Marina Wolf, Ph.D. Jared W. Young, Ph.D. L. Trevor Young, M.D., Ph.D. Jon-Kar Zubieta, M.D., Ph.D. PRESIDENT & CEO Jeffrey Borenstein, M.D. PRESIDENT, SCIENTIFIC COUNCIL Herbert Pardes, M.D. Officers CHAIRMAN Stephen A. Lieber VICE PRESIDENT Anne E. Abramson SECRETARY John B. Hollister TREASURER Arthur Radin, CPA Directors Carol Atkinson Donald M. Boardman J. Anthony Boeckh Susan Lasker Brody, MPH Suzanne Golden Bonnie D. Hammerschlag John Kennedy Harrison II Carole H. Mallement Milton Maltz Marc R. Rappaport Virginia M. Silver Kenneth H. Sonnenfeld, Ph.D., J.D. Barbara K. Streicker Barbara Toll Robert Weisman, Esq. MEMBERS EMERITUS George K. Aghajanian, M.D. Dennis S. Charney, M.D. Jan A. Fawcett, M.D. Frederick K. Goodwin, M.D. Lewis L. Judd, M.D. Kenneth K. Kidd, Ph.D

11 THE BRAIN & BEHAVIOR RESEARCH FOUNDATION is committed to alleviating the suffering of mental illness by awarding grants that will lead to advances and breakthroughs in scientific research. The Foundation funds the most innovative ideas in neuroscience and psychiatry to better understand the causes and develop new ways to treat brain and behavior disorders. Since 1987, the Foundation has awarded more than $365 million to fund more than 4,000 leading scientists around the world. This has led to over $3.5 billion in additional funding for these scientists. 100% of every dollar donated for research is invested in our research grants. Our operating expenses are covered by separate foundation grants bbrfoundation.org