Hollowed. Bone. 1. Definition of Term. Normal Bone. Osteoporosis 골다공증

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1 As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of becoming a world-top company and seeks after healthy life of human beings through continued technology innovation and challenges. 1

2 1. Definition of Term Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone. In Latin, Osteoporosis means hollowed bone symptom, and it is same for many modern languages. Osteo porosis Normal Bone Ostéo porose Остеопороз Hollowed 骨粗鬆症 Bone 骨多孔症 Osteoporosis 골다공증 骨质疏 松症 Images from L. Mosekilde, Technology and Health Care

3 2. Why Osteoporosis Happens? Human bone repeats a cycle of creation and destruction. Osteoporosis is due to slow bone production and fast bone loss. When the balance between resorption(osteoclast) and formation(osteoblast)is broken Images from 3

4 Bone Density 2. Why Osteoporosis Happens? Women bone is aging faster especially after menopause. This leads to great danger of fracture, and collapse your body and life Menopause Fracture Threshold Age 4

5 3. Why Osteoporosis is Dangerous? Osteoporosis itself has no symptoms, but its main consequence is the increased risk of fractures. Lack of bone density leads to collapse of whole body structure. BONE Osteoporosis is fatal disease. It is like a mine planted in your body, and when there is some shock... 5

6 3. Why Osteoporosis is Dangerous? Osteoporotic fractures can be happened anywhere, anytime. It happens more often than heart attack or stroke. 6

7 3. Why Osteoporosis is Dangerous? Chronic pain caused by osteoporosis in the elderly is often attributed to fractures and can lead to further disability and early mortality. Consequences of Hip Fracture Most frequent osteoporotic fracture 100% 80% 60% 80% 40% 20% 0% 20% 30% 40% Image Source: National Osteoporosis Foundation, Washington, DC <Osteoporosis: What is it?> 2004 Mar 1 Data Source: Cooper. Am J Med 1997; 103(2A): 12s-19s 7

8 3. Why Osteoporosis is Dangerous? Osteopenia & Osteoporosis Prevalence Rate (Women) Age over 50 Osteoporosis + Osteopenia Osteopenia & Osteoporosis Prevalence Rate (Men) Age over 50 Osteoporosis + Osteopenia 8 out of 10 women suffer from osteopenia or osteoporosis. 5 out of 10 men suffer from osteopenia or osteoporosis. Normal Osteopenia Osteoporosis Normal Osteopenia Osteoporosis Source: National Health Stastics th Korea National Health and Nutrition Examination Survey

9 Incidences (per 10,000 capita) Why Osteoporosis is Dangerous? Osteoporosis Awareness and Cure Rate people could be cured on time Prevalence Rate of Fraction 8 out of 10 female osteoporosis patient were not diagnosed well, and 9 out of 10 could not be cured. Furthermore, 9 out of 10 male patient could not be diagnosed nor cured. Female Male Awareness rate Cure rate Age of 60; Vertebra Age of 70; Femur Vertebra Clavicle Humerus Carpal Tarsus Femur Source: National Health Stastics th Korea National Health and Nutrition Examination Survey 2008 Source: A Study on the Medical Utilization and Prescription Pattern of Osteoporosis The Health Insurance Review and Assessment Service, Korea Age Group

10 1 year mortality (2007, %) 3. Why Osteoporosis is Dangerous? 1 Year Mortality after Femur Fraction Population of Femur Fraction Patient (est. 2050) Total mil mil 35% of male femur fraction patient over 70 years old pass away within a year Male Female Estimation of worldwide osteoporotic femur fraction (thousand people) Age Group Source: A Study on the Medical Utilization and Prescription Pattern of Osteoporosis The Health Insurance Review and Assessment Service, Korea 2009 Asia mil mil 10

11 Bone Density 4. How Can We Prevent Osteoporosis? Lifestyle prevention of osteoporosis is the inverse of the modifiable risk factors. But also timely diagnosis is really important factor, because 90% of people could not be diagnosed nor cured Menopause Good lifestyle and timely diagnosis can prevent serious osteoporosis. Age 11

12 5. How to Diagnose Osteoporosis? Bone mineral density (BMD) has to be measured by more specialized techniques, and that is what Osteosys is researching. 12

13 6. T-Score & Z-Score The T-Score is a comparison of a patient's BMD to that of a healthy 30-year-old. The Z-score is the comparison to the age-matched normal and is usually used in cases of severe osteoporosis. Z-Score Age of 50 or menopause T-Score Non -Osteoporotic (normal) osteoporosis osteopenia severe // osteoporosis T-Score -1 SD T-Score -2.5 SD 13

14 7. Osteosys against Osteoporosis We provide the most efficient BMD solution, and more. The company name itself explains what we are looking for. We want to get rid of pore from your bone. Osteoporosis Better product for better life 9F, JnK Digital Tower, 111 Digital-ro 26, Guro Seoul Korea T: F: E: info@osteosys.com 14

15 As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of becoming a world-top company and seeks after healthy life of human beings through continued technology innovation and challenges. 15

16 1. Importance of Scanning Evidence suggests that many people who sustain a fragility fracture are not appropriately diagnosed and treated for probable osteoporosis. people could be cured on time WE ARE UNDERESTIMATING THE DANGER OF OSTEOPOROSIS!!! 16

17 1. Importance of Scanning Once it is diagnosed, there are several way to take care of osteoporosis. So timely diagnosis is the most important factor to prevent osteoporotic fracture. BUT HOW? Then should we wait until the bone is broken? Normal X-ray image can see through body, but cannot see through the bone. We have the solution. 17

18 2. DXA (Dual-energy X-ray Absorptiometry) DXA is a low radiation X-ray capable of detecting quite small percentages of bone loss. It is used to measure spine and hip bone density, or the whole skeleton. DEXXUM T Pencil beam Central BMD Compact size Low cost EXCELLUS Fan beam Central Body Composition Compact size High speed scan Middle cost PRIMUS Fan beam Whole body Composition High speed scan High resolution High cost DEXXUM T EXCELLUS PRIMUS Scanning Time 85~187 sec 20~35 sec 25~30 sec Size Compact Compact Wide 18

19 2. DXA (Dual-energy X-ray Absorptiometry) Osteosys DXA devices give you accurate diagnosis, and more. All of this progress is done really quickly. 19

20 3. pdxa (Peripheral Dual-energy X-ray Absorptiometry) pdxa is a kind of DXA but measures only peripheral (forearm, calcaneus) areas. It has moderate accuracy and price compared to DXA and QUS. EXA-3000 Forearm/Calcaneus Lifter (Optional) Compact size CCD EXA-PRESTO Forearm only 3D image analysis Compact size CMOS EXA-3000 EXA-PRESTO Scanning Time 5 sec 5 sec Weight 34.5 kg 18.6 kg 20

21 3. pdxa (Peripheral Dual-energy X-ray Absorptiometry) pdxa is a kind of DXA but measures only peripheral (forearm, calcaneus) areas. It has moderate accuracy and price compared to DXA and QUS. 21

22 4. QUS (Quantitative Ultrasound System) QUS bone densitometer can be used anywhere, anytime without limitation. It is highly cost-effective and convenient. SONOST-2000 Water balloon coupling External PC/printer required Compact size Low cost Data managing program SONOST-3000 Automatic positioning probe Waterless probe Temperature compensation Embedded PC interface with touchscreen Thermal printer BEETLE Automatic positioning probe Waterless probe Portable (Built-in Battery and supplement available) Connectable with Smartphone (Bluetooth, NFC, GPS) SONOST-2000 SONOST-3000 BEETLE Scanning Time 15 sec 15 sec 5 sec Weight 7.8kg 12.6kg 3.8kg 22

23 4. QUS (Quantitative Ultrasound System) Osteosys QUS devices are market-leading product since the launching. You will know why when you use it. Report 23

24 5. DXA / QUS Comparison DXA is gold standard device and the most recommendable device. If there is limitation of cost or space, QUS is recommended. High accuracy High precision Prescreening Cost-effective DXA QUS Body Composition Microstructure information Radiation-free Easy to use & carry DXA (Dual X-ray Absorptiometry) pdxa (Peripheral Dual-energy X-ray Absorptiometry) QUS (Quantitative Ultrasound System) 24

25 6. Scanning Methods Traditional X-rays cannot measure bone density. A number of different types of BMD tests are available, but the gold standard is DXA. WHO Gold standard 1) DXA (Dual-energy X-ray Absorptiometry) measures the spine, hip or total body 2) SXA (single-energy X-ray absorptiometry) measures the heel or wrist 3) DPA (dual photon absorptiometry) measures the spine, hip or total body 4) SPA (single photon absorptiometry) measures the wrist 5) QCT (Quantitative Computed Tomography) measures the spine or hip 6) PQCT (peripheral QCT) measures the forearm 7) QUS (Quantitative Ultrasound) uses sound waves to measure the heel or finger Cost-effective prescreening method 25

26 As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of becoming a world-top company and seeks after healthy life of human beings through continued technology innovation and challenges. 26

27 1. CORE VALUE "Better product for better life" Passion Passion Passion is the driving force and one of the prerequisites for achieving our goal. We try to reach our goal through an efficient cooperation with talented employees who have the passion and responsibility for their mission. Innovation Innovation In order to meet our customer 's satisfaction, we produce more effective and differentiated product through the innovation which is impetus of the foundation of company growth. Trust Trust We operate the company by honest and transparent management which is based on the trust. As employees, customers, and the company strive for creation of win-win corporate culture. 27

28 2. COMPANY HISTORY; ENTHUSIASTIC RESEARCHER An enthusiastic young professor wanted to make a better product for better life for the people who were suffered by osteoporosis. To realize his dream, our strong R&D center launches a new product every 2 years Studied BMD Technology at small Lab. In KonKuk University Established Osteosys with 1 st Gen. QUS Launched 1 st Gen. pdxa (Peripheral Cone Beam DXA) Launched 2 nd Gen. QUS (Waterless probe) Launched 1 st Central DXA (First pencil beam table type DXA DXA) Launched 2 nd Gen. Pencil beam (compact design & fold wing bed Down) Launched 2 nd Gen. pdxa Launched 1 st Gen. Whole body DXA (with Body composition & Assessment) Launched 1 st Gen Central smart Fan beam DXA Launched 3 rd Gen QUS (Mobile accessibility) 28

29 3. BMD-HOLIC, and More Osteosys is specialized in BMD. What Osteosys interested in is BMD. And now we are expanding our area into body composition. SONOST 2000 SONOST 3000 BeeTLe EXA 3000 EXA Presto DEXXUM T EXCELLUS PRIMUS QUS Peripheral Central Whole Body Cone Beam Pencil Beam Fan Beam DXA 29

30 4. COMPETITIVE FUNCTION & MODERN DESIGN Osteosys BMD line-up has competitive quality and price. We are making a new product with considering our end user s need. Body composition & Detailed analysis Swing arm User-friendly Interface PRIMUS EXCELLUS Foldable table Mobile accessibility DEXXUM-T 30

31 5. CLEAR IMAGE & DETAILED ANALYSIS Osteosys DXA BMD not only provides you clear image and bone density but also many additional information such as body composition and angle analysis. Vertebrae / Femur Image & Angle Analysis Whole body composition & Small Area Analysis 31

32 6. SORRY TO COMPARE, BUT WE SHOULD Seeing is believing, these are on sale in the market in They are on our price range, and are not second-handed product. 32

33 7. FAST GROWING; BMD Market Share (2016) With the good quality and cost-effective BMD devices, Osteosys is dominant in the domestic market, and main player in Chinese market. China : Approx. 60% (QUS) Korea market : 80% Color distribution in Korea > > > > > > > 33

34 8. SHARE IT WORLDWIDE We would like to share our BMD with the people around the world. 98 countries 135 worldwide sales networks 6,000 DXA 10,000 QUS installation reference 34

35 9. RESPONSIBILTY; Global Service We do not just make BMD, but also take care of it. This is not only for our reputation, but also for public health. Hub network service center Middle East and Africa 35

36 10. REAL-TIME MANAGEMENT To maximize our R&D ability, and to achieve 0% defect rate, we Osteosys has own management system. Powerful R&D Center Is composed of more than 30% of all employees in the company To research and development to meet the world market demands Zero Defect manufacturing Built and realized production line based on the ISO standard Retains highly skilled manpower Customer satisfaction Business activities to maximize custo mer satisfaction as a priority based on the Customer-oriented thinking and habits Perfect quality control 0% defect rate control as Best quality QA activity is aggressively implemented to meet the need of the customer and enforcing Total Quality Management 36

37 11. WHAT THE COMPANY NAME MEANS If you get rid of pore from osteoporosis, it will be our name. We want to prevent the poro s in your bone. Without it, you may enjoy your life much better. Osteoporosis Better product for better life 9F, JnK Digital Tower, 111 Digital-ro 26, Guro Seoul Korea T: F: E: info@osteosys.com 37