The State of Cancer Care: Reflections from the 2017 ASCO Annual Meeting
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1 The State of Cancer Care: Reflections from the 2017 ASCO Annual Meeting Margaret Tempero, M.D. Director, Pancreas Center, University of California, San Francisco Editor-in-Chief, Journal of the National Comprehensive Cancer Network & Wes Kidder, M.D., M.P.H. Clinical Fellow, University of California, San Francisco Overview Opening remarks by Dr. Margaret Tempero Highlights from the 2017 ASCO Annual Meeting Selected Plenary Sessions OlympiAD Study Dr. Mark Robson LATITUDE Study Dr. Karim Fazazi Patient reported outcomes for symptom monitoring Dr. Ethan Basch Selected Late Breaking Abstracts STREAM Study Dr. Viviane Hess CALM Study Dr. Gary Rodin BCMA CAR-T cells in patients with relapse refractory MM Dr. Wanhong Zhao Conclusions and Final Thoughts Questions/Comments 1
2 OlympiAD: Phase III trial of olaparib monotherapy versus chemotherapy for patients with HER2-negative metastatic breast cancer and a germline BRCA mutation Presented By Mark Robson at 2017 ASCO Annual Meeting Phase II studies of olaparib in breast cancer Presented By Mark Robson at 2017 ASCO Annual Meeting 2
3 OlympiAD study design Presented By Mark Robson at 2017 ASCO Annual Meeting Primary endpoint: progression-free survival by BICR Presented By Mark Robson at 2017 ASCO Annual Meeting 3
4 Time to second progression or death (PFS2) <br />by investigator assessment Presented By Mark Robson at 2017 ASCO Annual Meeting Overall survival (interim analysis; 46% data maturity) Presented By Mark Robson at 2017 ASCO Annual Meeting 4
5 Adverse events (any grade) in 15% of patients Presented By Mark Robson at 2017 ASCO Annual Meeting Grade 3 adverse events in 2% patients in either arm Presented By Mark Robson at 2017 ASCO Annual Meeting 5
6 Conclusions Presented By Mark Robson at 2017 ASCO Annual Meeting LATITUDE: A phase 3, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos <br />in newly diagnosed high-risk metastatic hormone-naïve prostate cancer patients Presented By Karim Fizazi at 2017 ASCO Annual Meeting 6
7 ADT + docetaxel: a new standard of care for men with mcnpc and high metastatic burden (2015) Presented By Karim Fizazi at 2017 ASCO Annual Meeting Objective Presented By Karim Fizazi at 2017 ASCO Annual Meeting 7
8 Overall study design of LATITUDE Presented By Karim Fizazi at 2017 ASCO Annual Meeting Statistically significant 38% risk reduction of death Presented By Karim Fizazi at 2017 ASCO Annual Meeting 8
9 OS benefit consistently favorable across subgroups Presented By Karim Fizazi at 2017 ASCO Annual Meeting Statistically significant 53% risk reduction of radiographic progression or death Presented By Karim Fizazi at 2017 ASCO Annual Meeting 9
10 Statistically significant improvement in all secondary end points Presented By Karim Fizazi at 2017 ASCO Annual Meeting Statistically significant 70% risk reduction of time to PSA progression Presented By Karim Fizazi at 2017 ASCO Annual Meeting 10
11 Statistically significant 30% risk reduction of time to pain progression Presented By Karim Fizazi at 2017 ASCO Annual Meeting Statistically significant 58% risk reduction of time to subsequent <br />PC therapy Presented By Karim Fizazi at 2017 ASCO Annual Meeting 11
12 Adverse events of special interest Presented By Karim Fizazi at 2017 ASCO Annual Meeting Conclusions Presented By Karim Fizazi at 2017 ASCO Annual Meeting 12
13 Overall survival results of a randomized trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment (NCT ) Presented By Ethan Basch at 2017 ASCO Annual Meeting Standard Approach to Symptom Monitoring Presented By Ethan Basch at 2017 ASCO Annual Meeting 13
14 Alternative: Systematic Symptom Monitoring Presented By Ethan Basch at 2017 ASCO Annual Meeting Study Design Presented By Ethan Basch at 2017 ASCO Annual Meeting 14
15 Patient Self-Reporting Interface Presented By Ethan Basch at 2017 ASCO Annual Meeting Statistics Presented By Ethan Basch at 2017 ASCO Annual Meeting 15
16 Patient Participation Presented By Ethan Basch at 2017 ASCO Annual Meeting Quality of Life Presented By Ethan Basch at 2017 ASCO Annual Meeting 16
17 Slide 17 Presented By Ethan Basch at 2017 ASCO Annual Meeting Slide 18 Presented By Ethan Basch at 2017 ASCO Annual Meeting 17
18 Conclusions Presented By Ethan Basch at 2017 ASCO Annual Meeting Web-based stress management for newly diagnosed cancer patients (STREAM): <br />A randomized, wait-list controlled intervention study. Presented By Viviane Hess at 2017 ASCO Annual Meeting 18
19 Slide 5 Presented By Viviane Hess at 2017 ASCO Annual Meeting Slide 7 Presented By Viviane Hess at 2017 ASCO Annual Meeting 19
20 Slide 8 Presented By Viviane Hess at 2017 ASCO Annual Meeting Slide 9 Presented By Viviane Hess at 2017 ASCO Annual Meeting 20
21 Slide 10 Presented By Viviane Hess at 2017 ASCO Annual Meeting Slide 11 Presented By Viviane Hess at 2017 ASCO Annual Meeting 21
22 Presented By Viviane Hess at 2017 ASCO Annual Meeting Slide 15 Presented By Viviane Hess at 2017 ASCO Annual Meeting 22
23 Presented By Viviane Hess at 2017 ASCO Annual Meeting Slide 17 Presented By Viviane Hess at 2017 ASCO Annual Meeting 23
24 Managing Cancer And Living Meaningfully (CALM): <br />A Randomized Controlled Trial of a<br /> Psychological Intervention for Patients with Advanced Cancer<br /> Presented By Gary Rodin at 2017 ASCO Annual Meeting Managing Cancer And Living Meaningfully (CALM) Presented By Gary Rodin at 2017 ASCO Annual Meeting 24
25 Rationale for CALM Presented By Gary Rodin at 2017 ASCO Annual Meeting Methods Presented By Gary Rodin at 2017 ASCO Annual Meeting 25
26 Outcomes Presented By Gary Rodin at 2017 ASCO Annual Meeting Primary Outcome Presented By Gary Rodin at 2017 ASCO Annual Meeting 26
27 Clinical Importance Presented By Gary Rodin at 2017 ASCO Annual Meeting Secondary Outcomes Presented By Gary Rodin at 2017 ASCO Annual Meeting 27
28 Conclusions Presented By Gary Rodin at 2017 ASCO Annual Meeting Durable remissions with BCMA specific chimeric antigen receptor (CAR)-modified T cells in patients with refractory/relapsed multiple myeloma Presented By Wanhong Zhao at 2017 ASCO Annual Meeting 28
29 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting Slide 10 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting 29
30 Slide 11 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting Slide 12 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting 30
31 Slide 13 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting Slide 15 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting 31
32 Slide 16 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting Slide 18 Presented By Wanhong Zhao at 2017 ASCO Annual Meeting 32
33 Conclusions Presented By Wanhong Zhao at 2017 ASCO Annual Meeting Questions? 33
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