BIOGRAPHICAL SKETCH. DEGREE (if applicable) Postdoctoral Associate 11/2015 6/2017

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1 BIOGRAPHICAL SKETCH NAME Robert Tomasz Mankowski, Ph.D. era COMMONS USER NAME mankowski CURRENT POSITION TITLE Assistant Professor EDUCATION/TRAINING INSTITUTION AND LOCATION Academy of Physical Education in Katowice, Poland Academy of Physical Education in Katowice, Poland Erasmus University Medical Center in Rotterdam, The Netherlands University of Florida, Gainesville, FL, USA DEGREE (if applicable) START DATE END DATE FIELD OF STUDY B.S. 9/2005 6/2008 Physiotherapy M.S. 9/2008 6/2010 Physiotherapy Ph.D. 9/2010 9/2015 Exercise Physiology Postdoctoral Associate 11/2015 6/2017 Biology of Aging Clinical Research A. Personal Statement I am an Assistant Professor at the Department of Aging and Geriatric Research at the University of Florida. After completing my undergraduate degree in Physiotherapy in Poland, I pursued my doctoral training at the Department of Rehabilitation Medicine in Rotterdam in The Netherlands under supervision of a sports physician, Dr. Stephan Praet and mentorship of the Department Chair, Dr. Henk Stam. During my doctoral fellowship I was interested in cardio-respiratory and microvascular responses to hypoxic and hyperoxic air conditions during exercise in young adults and type 2 diabetes patients (a,b,c). During that period of time, I gained a lot of experience in exercise physiology testing (spiro-ergometry) and non-invasive cardiovascular assessments (e.g. hemodynamic monitoring, near-infrared spectroscopy). Additionally, I supervised one medical student and one movement science master student, which resulted in successfully defended master theses. Moreover, I led three-month courses on exercise physiology for medical students (four academic years). I learned the Dutch Language (fluent) within 1 year for the communication and administrative purposes. At the end of my doctoral fellowship, I spent three months at the Institute on Aging at the University of Florida where I continued practicing my writing and analytical skills under supervision of Dr. Christiaan Leeuwenburgh and Dr. Stephen Anton. This collaboration resulted in three papers and sparked my interest in aging research. After completing my doctoral degree, I began my postdoctoral training at the University of Florida under the same mentoring team. My postdoctoral training consisted of gaining experience in basic science (highresolution respirometry, Western blots, ELISA, DNA damage assays, PCR) and cardiovascular clinical assessments (methods: speckle tracking echocardiography and flow-mediated dilation). I have developed collaborations with Departments of Pathology and Cardiology at the University of Florida to increase competitiveness of my translational cardiovascular research. As a faculty, my research is focused on antiinflammatory interventions to improve cardiovascular function in rather healthy older adults. I am also implementing my cardiovascular measures in critical care and developing my research niche that combines cardiovascular disease and outcomes after critical care (d), inflammation and aging science. Older critical care survivors demonstrate high levels of persistent inflammation and high risk of cardiovascular disease. My work is supported by the American Heart Association and NIH. a. Rozenberg R, Mankowski RT, van Loon LJ, Langendonk JG, Sijbrands EJ, van den Meiracker AH, Stam HJ, Praet SF. Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study. Eur J Med Res Jan 8; 21(1):1. b. Mankowski RT, Michael S; Rozenberg R, Stokla S, Stam HJ; Praet SF. Heart-rate variability threshold as an alternative for spiro-ergometry testing: a validation study. J Strength Cond Res May 19.

2 c. Mankowski RT, Michael S, Rozenberg R, Stokla S, Stam HJ, Praet SF. Heart-Rate Variability Threshold as an Alternative for Spiro-Ergometry Testing: A Validation Study. J Strength Cond Res Feb;31(2): d. Mankowski RT, Yende S, Angus DC. Long-term impact of sepsis on cardiovascular health. Intensive Care Med May 8. doi: /s B. Positions and Honors OCCUPATION START END SUPERVISOR/ FIELD INSTITUTION DATE DATE EMPLOYER Doctoral Erasmus University 9/2010 9/2015 Exercise Physiology Dr. Stam/Dr. Praet Student Medical Center Postdoctoral Biology of Aging Dr. Leeuwenburgh/ 11/2015 6/2017 University of Florida Associate Clinical Research Dr. Anton Assistant 7/2017 Present Clinical Research University of Florida Dr. Anton Professor Academic and Professional Honors American Heart Association Career Development Award July 2018 June 2021 Accepted to the Early Career Reviewer (ECR) Program, Center for Scientific Review, National Institute of Health February 2018 Claude D. Pepper Junior Scholar Training award April 2017 March Internal Research Grant Doctoral Trajectory Erasmus University Medical Center, Rotterdam, the Netherlands, September July 2015 Internal Travel Grant for a Scholarship at the University of Florida, Erasmus University Medical Center, Rotterdam, The Netherlands, April - July 2014 Memberships in professional societies American Physiological Society American Heart Association American College of Sports Medicine Mitochondrial Physiological Society C. Contributions to Science 1. Effect of dietary antioxidant supplementation (AS) in conjunction with exercise training on health benefits. Few recent pre-clinical and clinical reports have shown that AS in combination with endurance training may blunt the beneficial effects of exercise (e.g. mitochondrial biogenesis, insulin sensitivity, blood pressure), and therefore may impair healthy aging. I reviewed the available pre-clinical and clinical studies and concluded that the reason for inconsistent effects of AS could possibly be in different AS compositions, doses, duration time of supplementation and exercise training modalities. Our future studies are based on conclusions of this review (Mankowski et al. 2015). Findings on the effects of other nutritional compounds on tackling inflammation in aging will result in future clinical trials (Mankowski et al and Custodero et al. 2018). a. Mankowski RT, Anton SD, Buford TW, Leeuwenburgh C. Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.Med Sci Sports Exerc Sep; 47(9): b. Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabbà C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SD. Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis. Ageing Res Rev May 25;46: doi: /j.arr [Epub ahead of print] Review.

3 c. Mankowski RT, Leeuwenburgh C, Manini TM, Woods AJ, Anton SD. Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults - A Short Report of a Placebo-Controlled Clinical Trial. J Frailty Aging. 2018;7(2): Physical activity is important to prevent development of the metabolic syndrome. However, extended sitting time during a day may also increase the probability of developing the metabolic syndrome in older adults. We found in a cross-sectional analysis of the multicenter clinical trial (the LIFE Study) that higher levels of objectively measured sitting time during a day was associated with higher probability of developing the metabolic syndrome and higher probability of developing diabetes (Mankowski et al. 2015). Additionally, we found that physical activity was associated with major mobility disability incidence in the LIFE Study participants (Mankowski 2017). a. Mankowski RT, Anton SD, Axtell R, Chen SH, Fielding RA, Glynn NW, Hsu FC, King AC, Layne AS, Leeuwenburgh C, Manini TM, Marsh AP, Pahor M, Tudor-Locke C, Conroy DE, Buford TW; LIFE Research Group. Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. J Am Geriatr Soc Aug 11. b. Mankowski RT, Aubertin-Leheudre M, Beavers DP, Botoseneanu A, Buford TW, Church T, Glynn NW, King AC, Liu C, Manini TM, Marsh AP, McDermott M, Nocera JR, Pahor M, Strotmeyer ES, Anton SD; LIFE Research Group. Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations The LIFE Study. Exp Gerontol Oct; 70:32-6. D. Complete List of Published Work in MyBibliography: descending E. Conferences (5 years) American College of Sports Medicine Annual Meeting, 2014, Orlando, FL, USA. Poster Presentation. Integrative Physiology of Exercise, 2014, Miami, FL, USA. Poster Presentation. Mitochondrial Physiology Society Conference, 2015, London, United Kingdom. Advances in Skeletal Muscle Biology in Health and Disease, 2016, Gainesville, FL, USA. Poster Presentation. BioIron Conference 2017, Los Angeles, CA, USA. Annual Claude D. Pepper Meeting on Aging Research, Washington D.C., VA, USA. Poster Presentation. Annual Retreat of the University of Michigan Research Education Core, Ann Arbor, MI, USA. From Cardiac Mechanisms to Patent Care, 2018, New London, NH, USA. Poster Presentation. F. Review Service for Journals Nature Communications Aging Cell Preventive Medicine Experimental Gerontology PLOS One European Journal of Medical Research Journal of Rehabilitation Medicine Annals of Medicine Biological Research for Nursing G. Memberships

4 American Physiological Society American Heart Association Mitochondrial Physiology Society American College of Sports Medicine H. Research Grants Last 5 years The American Heart Association Career Development Award 7/1/2018-6/30/2021 Cardiac Dysfunction in Older Sepsis Survivors Total award funding: $231,000 This study aims to characterize cardiac dysfunction in sepsis survivors. Large number of patients become chronically ill and are at higher risk for cardiovascular disease after sepsis. Early detection of cardiac dysfunction may be a target for future interventions to reduce the risk of cardiovascular disease. The American Heart Association Postdoctoral Fellowship 7/1/2017-6/30/2019 The Effects of Resveratrol on Cardiovascular Function in Older Adults Total award funding: $106,532 This study aims at investigating an effect of a dietary supplement, resveratrol (RSV) (present in red wine and grapes), on improvement in cardiovascular function and cardiovascular disease risk reduction during aging. This fellowship provides full postdoctoral salary coverage, research and travel funds. The award was declined by the PI due to his transition to a faculty position. The Claude D. Pepper Older American Independence Center (IOAC) 4/1/2017-3/31/2019 Junior Scholar Career development grant in aging research. Total award funding: $120,751 This program aims to train me toward scientific independence. The program will allow me transition to a junior faculty position at the Department of Aging and Geriatric Research. The research budget will allow me conduct research on the effects of curcumin on myocardial contractility and systemic iron metabolism in older adults. Claude D. Pepper Older American Independence Center (IOAC) 9/1/2016-8/31/2018 An Effect of Resveratrol on cardiovascular Function in Older Adults Total award funding: $65,525 This study aims at investigating an effect of a dietary supplement, resveratrol (RSV) (present in red wine and grapes), on improvement in cardiovascular function and cardiovascular disease risk reduction during aging. Claude D. Pepper Older American Independence Center (IOAC) 4/1/2017-3/31/2019 Does dietary supplementation with curcumin maintain or improve physical and cognitive function in aging adults at increased risk for disability (SPICE) Total award funding: $100,000 Role: MPI This study aims at investigating an effect of a dietary supplement, curcumin, on improvement in physical and cognitive function in older adults. NIH 1 R01 AT (PI: Anton) 9/1/2013-5/31/2019 REVIVE - Resveratrol to Enhance Vitality and Vigor in Elders Total award funding: $1,565,507 Role: Co-Investigator The proposed clinical trial will test whether daily supplementation with 1000mg of resveratrol will improve mitochondrial function and physical performance in generally healthy but moderately functioning older men and women. The central hypothesis is that resveratrol treatment will improve mitochondrial function by activating

5 key genes involved in mitochondrial biogenesis and metabolism, and that these biological/cellular changes can enhance physical performance among both low to moderately functioning older adults. NIH 1R21AG A1 (Buford) 4/1/2016-3/31/2018 Total award funding: $412,500 Role: Co-Investigator Resveratrol and exercise to treat functional limitations in late life This study will be the first to evaluate the potential of two doses of resveratrol for improving the efficacy of physical exercise in treating age-related functional limitations. As such, the study has important implications for advancing the NIA mission of developing interventions to improve the health and quality of life older adults.