Collaborative Research on Addiction at NIH (CRAN) (Formerly known as Functional Integration)

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Abraham Mathews
5 years ago
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Collaborative Research on Addiction at NIH (CRAN) (Formerly known as Functional Integration) National Institute on Drug Abuse Bringing the full power of science

1 Collaborative Research on Addiction at NIH (CRAN) (Formerly known as Functional Integration) National Institute on Drug Abuse Bringing the full power of science to bear on drug abuse and addiction Nora D. Volkow, M.D. Director National Institute on Drug Abuse Susan R.B. Weiss, PhD Associate Director for Scientific Affairs

Leaders at NIAAA, NIDA, and NCI have formed a CRAN Steering Committee that will guide integration efforts undertaken by the CRAN Coordination Committee (CCC), which consists of representatives from

3 Leaders at NIAAA, NIDA, and NCI have formed a CRAN Steering Committee that will guide integration efforts undertaken by the CRAN Coordination Committee (CCC), which consists of representatives from the three ICs. Members are: Susan Weiss (NIDA) Kevin Conway (NIDA) Denny Pintello (NIDA) Lorraine Gunzerath (NIAAA) Michele Bloch (NCI) Yvonne Hunt (NCI) The CCC, established in April 2013, is meeting regularly to coordinate: 1) FY 14/15 FOA proposals 2) Development of a website 3) Joint Council Meeting (Feb 5, 2014) 4) Other short- and long-term plans for the CRAN (e.g., training, evaluation)

4 Mission To provide a strong collaborative framework to enable NIAAA, NIDA, and NCI to integrate resources and expertise to advance substance use, abuse and addiction science research and public health outcomes.

5 IC CRAN Contributions NIDA 70% NIAAA 25% NCI 4% Others 1%

6 FY 14 CRAN FOAs Revision Applications to Promote Collaborative Research on Addiction at NIH (CRAN): Comorbidity-Related Research (R01) RFA-DA Issued: July 15, 2013; Open Date: August 24, 2013; App. Due Date: Sept 24, To target new and/or under-recognized opportunities and synergies addressing polysubstance use and comorbidity. Examples include: concurrent vs. sequential treatment of co-occurring SUDs; development of animal models; extension of policy research to new substances; screening tools for adolescents; trajectories of polysubstance use; secondary data analyses; services/systems research related to healthcare reform $3M Administrative Supplements to Promote Collaborative Research on Addiction at NIH (CRAN): Comorbidity-Related Research (Admin Supp) Issued: July 15, 2013; Open Date: August 24, 2013; App. Due Date September 24, 2013 To support research in cross-cutting areas of substance use, abuse, addiction and related health consequences that falls within the scope of the original project. Supplements are available for selected P, R, and U award mechanisms. $2M

7 CRAN- Related FOAs Mechanisms of Alcohol and Nicotine Co-Addiction (R21) PA (R01) PA which NIDA subsequently signed on to: (NOT-DA ); (NOT-DA ) Issued: April 20, 2013; Open Date: September 16, 2013 To accelerate research on neurobiological and behavioral mechanisms contributing to concurrent alcohol and nicotine co-addiction Health Services and Economic Research on the Prevention and Treatment of Drug, Alcohol, and Tobacco Abuse (R01) PA ; (R03) PA ; (R21) PA Issued: March 19, 2012; Open Date: May 16, 2012 E.g.: (1) clinical quality improvement; (2) organization and delivery of services; (3) implementation research; (4) economic and cost studies; or (5) research methodology Mechanisms of Alcohol and Stimulant Co-Addiction (R01) PA ; (R21) PA Issued: August 28, 2013; Open Date: Jan 5, 2014 To study the neurobiological and behavioral mechanisms that explain how alcohol and stimulants interact at genetic, epigenetic, cellular, neurocircuitry and behavioral levels to promote co-addiction

9 CRAN: Research Training Opportunities Solicit guidance from members of Council and Training Directors: Are current training programs integrated/ comprehensive for multiple substances? Are there redundancies? Are there training gaps/needs? How should we go about addressing these issues?

Ongoing Collaborations between the NIAAA and NIDA

addictions clinical research program, under the leadership

Markus Heilig) Collaborative Genetic/Genomics clinical

10 Ongoing Collaborations between the NIAAA and NIDA Intramural Research Programs An integrated NIAAA/NIDA addictions clinical research program, under the leadership of a single Clinical Director (Dr. Markus Heilig) Collaborative Genetic/Genomics clinical studies Optogenetics and Transgenic Technology Core (OTTC) Joint training and career development opportunities (e.g., NIDA/NIAAA/Johns Hopkins substance abuse clinical fellowship) Molecular Targets Discussions (3 X/ year)

11 Ultimately, CRAN will: foster more effective communication between Institute staff, and improve collaboration and knowledge exchange among diverse scientific communities through both formal and informal collaborations. The end result will be a seamless and comprehensive approach to prevention and treatment of all substance use, abuse, and addiction; and comorbidities.

NIAAA DIRECTOR S REPORT

NIAAA DIRECTOR S REPORT ON INSTITUTE ACTIVITIES TO THE 134 TH MEETING OF THE NATIONAL ADVISORY COUNCIL ON ALCOHOL ABUSE AND ALCOHOLISM Kenneth R. Warren, Ph.D. Acting Director National Institute on Alcohol