MOBC NIAAA UPDATE Brett Hagman, Ph.D. Robert Huebner, Ph.D. Division of Treatment and Recovery Research, NIAAA

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1 MOBC NIAAA UPDATE Brett Hagman, Ph.D. Robert Huebner, Ph.D. Division of Treatment and Recovery Research, NIAAA 12 th Annual RSA Satellite Session on Mechanisms of Behavior Change: New Orleans, Louisiana June 25th, 2016

2 Topics Accomplishments DTRR MOBC portfolio update MOBC funding opportunities

3 Accomplishments Inclusion of MOBC in NIAAA Strategic Plan RFA R21 (2007) Established Mechanisms of Behavior Change Interdisciplinary Research Consortium (MIRC) Sponsored special issue of ACER Supported trans-nih initiatives Co-sponsored RSA Satellite funded by U13 conference grant Built and nurtured a research portfolio at NIAAA PAR R01, R21, R03 (2014)

4 DTRR MOBC Portfolio (FY06-15) Applications Received Projects Funded Total Fiscal Year

5 Division of Treatment and Recovery Research MOBC Portfolio (Current) Total Costs (in thousands)= 17,882 (N=48) [CATEGORY NAME] (N = 4) [CATEGORY NAME] [CATEGORY (N = 1) NAME] [CATEGORY (N = 1) NAME] (N = 1) [CATEGORY NAME] (N = 1) [CATEGORY NAME] (N = 1) [CATEGORY NAME] (N = 8) [CATEGORY NAME] (N = 30) [CATEGORY NAME] (N = 1)

6 Funding Opportunities.

7 FOA: MOBC PAR Title: Mechanisms of Behavior Change in the Treatment of Alcohol Use Disorders Three Possible Mechanisms: R01 (PAR ) R21 (PAR ) R03 (PAR ) Must Submit Letter of Intent Three Submission Dates March 17, 2016 (last one) We are working on ways to renew the PAR

8 MOBC PAR Rationale for PAR Provides a special review committee comprised of MOBC researchers Encourages INNOVATIVE & TRANS-DISCIPLINARY applications across multiple domains (e.g., neuroscience) R03 mechanism encourages junior investigators (e.g., post-docs) to submit and permits secondary data analyses Encourages applications that examine MOBC inside and outside the context of treatments (e.g., non-treatment seekers; self-change process) Encourages applications with a strong methodological focus (e.g., dynamic systems approach)

9 MOBC PAR SUBMISSION CHARACTERISTICS All three submissions and grants review have already occurred June 18 th, 2014 (First PAR Review) June 2 nd and 8th, 2015 (Second PAR Review) June 22nd, 2016 (Third PAR Review) Applications 2014 Initial Apps 2015 Revised Apps 2015 Initial Apps 2016 Revised Apps 2016 R R R Total Overall success rate 13/34 = 38.3%

10 MOBC PAR MOBC Funded Grants (N=11) Examples of Funded PAR Studies Optimizing e-interventions for Alcohol Use: Do Common Factors Apply (R21) Perceived alcohol reward value and risk: Neural Correlates and Treatment Effects (R21) Dismantling MBRP: Identifying Critical Neuroimmune Mechanisms of Action (R01) MOBC Underlying Alcohol Treatment Assessment Reactivity (R01) Technical, Relational and Conditional Process Models of MI Efficacy: Meta-Analysis (R21)

11 Other Program Announcements Alcohol Use Disorders: Treatment, Services, and Recovery Research R01: PA R21: PA R03: PA Research Domain #2: Behavioral Therapies and Mechanisms of Behavioral Change Conduct longitudinal studies of the natural history of behavioral change in drinking behavior. Transdisciplinary research including genetic, electrophysiological, and imaging techniques is encouraged. Innovative measures of real-time cognitive and affective change also should be developed. Reanalyze existing studies (secondary analyses) with new models looking at potential mechanisms of change prior to treatment, and within, outside, and after treatment. Conduct experiments to elucidate the causal relationship between proposed mechanisms of behavioral change and treatment outcomes.

12 NIH Initiative Science of Behavior Change (SOBC) Goal: Identify common mechanisms that drive initiation and maintenance of behavior change across disorders Encouraged multi-disciplinary approaches: social psychology, behavioral economics, and cognitive and affective neuroscience RFA - 10 R01s (2010); 7 admin supplements (2013) Stage 1 of SOBC ( ) identified of three broad classes of intervention targets that are highly relevant to understanding the mechanisms of behavior change: self-regulation, stress reactivity and stress resilience, and interpersonal and social processes Stage 2 of SOBC (2015 current) developed the SOBC Research Network, (1) support research to identify key targets of behavioral interventions, develop robust methods to measure them, and validate them in multiple contexts; (2) develop and build an SOBC registry of studies and trials to include mediators, moderators, mechanisms, measures, and effect sizes

13 NIH Initiative Science of Behavior Change (SOBC) I) 4 RFAs (UH mechanisms; approved and funded 10 projects) Identify the most promising intervention targets Develop appropriate measures and approaches to engage targets Validate putative targets against disease outcomes II) Developed a SOBC research network and held their first kickoff meeting at NIH December 3 4 III) Present key findings at scientific conferences IV) PA : Science of Behavior Change: Use-inspired Basic Research to Optimize Behavior Change Interventions and Outcomes (Admin Supp) Goal to test how and why behavior change interventions produce and sustain desired outcomes when implemented in experimental, clinical, community, or population-level settings To study putative targets/mechanisms of action that are critical to the efficacy and effectiveness of behavioral and social interventions to produce and, as feasible, sustain desired change(s) in health behavior(s)

14 Recap NIAAA remains committed to MOBC research Take advantage of the PAR and other FOAs keep those applications coming! Focus on INNOVATION & IMPACT Funding support available from both NIAAA and NIH

15 Thank You For more information, please contact: Brett Hagman, Ph.D. NIAAA

NIAAA UPDATE. Daniel Falk, Ph.D. Brett Hagman, Ph.D. Robert Huebner, Ph.D. Division of Treatment and Recovery Research, NIAAA

NIAAA UPDATE. Daniel Falk, Ph.D. Brett Hagman, Ph.D. Robert Huebner, Ph.D. Division of Treatment and Recovery Research, NIAAA NIAAA UPDATE Daniel Falk, Ph.D. Brett Hagman, Ph.D. Robert Huebner, Ph.D. Division of Treatment and Recovery Research, NIAAA 11 th Annual RSA Satellite Session on Mechanisms of Behavior Change: San Antonio,