AS BETTER medical care allows. Splenorenal Shunt. An Ideal Procedure in the Pacific. See Invited Critique at end of article ORIGINAL ARTICLE
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1 Splenorenal Shunt ORIGINAL ARTICLE An Ideal Procedure in the Pacific Linda L. Wong, MD; Cedric Lorenzo, MD; Whitney M. Limm, MD; Livingston M. Wong, MD Hypothesis: Splenorenal shunt, an accepted treatment to prevent recurrent variceal bleeding, is an ideal procedure for patients with psychosocial issues or limited access to tertiary medical centers. Methods: We retrospectively reviewed the medical records of 34 patients (32 distal splenorenal shunts and 2 central splenorenal shunts) treated from January 1, 1995, through December 31, 2001, for demographic data, substance abuse status, psychosocial factors, previous treatments, Child class, length of hospital stay, operative transfusions, complications, and outcome. Results: Of the 34 patients, 17 were from surrounding Pacific islands (as many as 3800 miles away from Honolulu, Hawaii). Sixteen patients were Child class A, and 18 were Child class B. Twenty-four patients were either homeless, actively involved in substance abuse, or being treated for psychiatric problems, and 20 patients were either uninsured or insured by third-party payers that did not cover liver transplantation. Four patients underwent distal splenorenal shunt for a failed transjugular intrahepatic portosystemic shunt. Patients received a mean of 1.3 U of packed red blood cells (range, 0-5 U), and 15 received no blood transfusions. Mean length of hospital stay was 12.7 days (9 days postoperatively). Perioperative mortality was 8.8%. Three patients rebled postoperatively, 2 because of gastric ulcers and 1 because of an inadequate shunt. The 1-year survival rate was 95% in the 20 patients for whom data were available. Conclusions: Splenorenal shunt is an important treatment for noncompliant patients or patients living in remote areas where access to specialized treatments, such as endoscopy, transjugular intrahepatic portosystemic shunt, ultrasonography, and liver transplantation, is limited. We can achieve acceptable morbidity and mortality in this group of patients, although follow-up can be difficult. Arch Surg. 2002;137: From the Department of Surgery, St Francis Medical Center, University of Hawaii School of Medicine, Honolulu. AS BETTER medical care allows patients to live longer with complications of cirrhosis, variceal bleeding will become more prevalent. Liver transplantation is the ultimate option for complications of liver disease, but the harsh reality is that there are simply not enough livers for all patients with end-stage liver disease. Despite splitliver techniques, adult-sized live-donor liver transplants, and donors with expanded criteria, many patients will still die as a result of end-stage liver disease. Thus, it is important for liver surgeons and hepatologists to determine which patients are truly viable candidates for transplantation and which should be treated in a more palliative way. Surgical shunts, the distal splenorenal shunt in particular, are an excellent choice for control of recurrent variceal bleeding. Rebleeding and encephalopathy rates are low, and shunt patency is excellent. 1-6 Patients undergo a minimum of follow-up diagnostic studies, and this also appears to be cost-effective. 7 Surgical shunts have been used to treat patients with variceal bleeding, as a definitive treatment and as a bridge to liver transplantation in patients with reasonable hepatic synthetic function. 4,7,8 See Invited Critique at end of article Transjugular intrahepatic portosystemic shunts (TIPSs) have also been 1125
2 Sociodemographic and Disease Characteristics of 34 Patients With Splenorenal Shunts No. of Characteristic Patients of residence Oahu, Hawaii 18 Maui, Hawaii 8 Guam 4 Hawaii (Big ), Hawaii 2 American Samoa 1 Truk 1 Cause of liver disease Hepatitis C and alcoholic liver disease 15 Alcoholic liver disease 5 Hepatitis B 3 Cryptogenic cirrhosis 3 Hepatitis C 2 Hepatitis B and C and alcoholic liver disease 2 Autoimmune disease/primary biliary cirrhosis 2 Noncirrhotic portal hypertension 2 Psychosocial factor Alcohol, active use 13 Alcohol, past abuse 9 Intravenous drug abuse 10 Other illicit drug use 7 Smoking 22 Currently unemployed 19 Homeless 5 Documented history of psychiatric disorder 4 Incarcerated 1 Insurance status Insured 14 Insured, but liver transplantation not covered 18 Uninsured 2 Liver transplantation status Had subsequent liver transplantation 1 Placed on waiting list but removed for noncompliance 2 Awaiting a transplant and on list 2 Not a candidate for transplantation 29 used to treat variceal bleeding. This interventional radiologic procedure, in which a communication is created between the portal vein and a hepatic vein, nearly revolutionized treatment for variceal bleeding in the early 1990s because of its minimally invasive approach. After several years of mainstream use, however, enthusiasm has waned because of problems with shunt stenosis or occlusion. Ultrasonography studies and venograms are necessary for close follow-up, and reinterventions to maintain or salvage the shunt are frequently required In Hawaii, we have a unique population of patients who frequently come from distant Pacific s for treatment of complicated medical problems. Medical care in these remote areas is often limited to primary care and basic general surgical procedures in good-risk patients. If more complex problems are present or patients are a poor risk, such as those with variceal bleeding, referral to the tertiary care centers in Honolulu, Hawaii, on the island of Oahu, is generally required. Once the problem is addressed and the patient returns home, follow-up care and compliance are often minimal. Many areas do not have access to blood banks, endoscopy, abdominal ultrasonography, or interventional radiology. Several tertiary care centers on Oahu have the ability to perform TIPS, and about 60 such procedures were performed at our medical center from January 1, 1995, through December 31, It is often impossible to reevaluate the TIPS with ultrasonograms in patients who have no access to ultrasonography or who cannot return to Honolulu because of financial constraints. Because of problems with compliance and follow-up, we have increasingly recommended splenorenal shunts. In this article, we review our experience with this procedure. SUBJECTS AND METHODS We retrospectively reviewed the medical records of all patients who underwent splenorenal shunt during the 6-year period from January 1, 1995, through December 31, Demographic data, including age, sex, race, and island of residence, were noted. We also recorded the cause of the liver disease, the number of variceal bleeding episodes, and previous treatments. Psychosocial issues, including history of smoking, use of alcohol or other drugs, documented psychiatric history, living arrangements, and insurance status, were noted. Finally, information on encephalopathy, ascites, bilirubin, prothrombin time, and albumin were reviewed to calculate a Child-Pugh score. Patients were then classified as follows: Child A indicates a Child-Pugh score of less than 7; Child B, Child-Pugh score of 7 to 9; and Child C, Child-Pugh score of 10 or higher. In terms of the treatment, we noted the type of splenorenal shunt, the number of blood transfusions required during surgical treatment, the length of the hospital stay, and whether the procedure was elective or semiurgent. Those patients undergoing elective splenorenal shunt were not bleeding at the time of admission but had bled recently on previous admissions. Semiurgent splenorenal shunt implied that the patient was bleeding on hospital admission but was stabilized for at least 3 days before surgical treatment and was not actively bleeding at the time of the operation. We also reviewed the medical records for postoperative complications and rebleeding. Follow-up visits were recorded for patients who lived on Oahu. Patients on the neighboring Hawaiian s and other Pacific s were monitored by their local primary care physician, and follow-up by our group was made via telephone calls or clinic notes. For those patients who were supposedly lost to follow-up, we called all physicians involved, attempted to contact patients at their last known addresses and telephone numbers, and searched all published obituaries in both major newspapers in Hawaii from the time of the operation until the present. RESULTS During the 6-year period from January 1, 1995, to December 31, 2001, 34 splenorenal shunts were performed by our group of surgeons. The mean patient age was 50.4 years, and there were 24 men and 10 women. Nineteen patients were white, 10 were Asian (Japanese, 2; Chinese, 2; Korean, 2; Filipino, 2; and Vietnamese, 1) and 5 were Pacific ers (Chamorran, 3; Samoan, 1; and Marshallese, 1). A little more than half the patients were from Oahu, the island on which these splenorenal shunts were performed at 3 tertiary medical centers (Table). 1126
3 Northern Marianas Wake Midway Hawaii Palau Guam Marshall s Johnston Palmyra To Asia Micronesia Papau New Guinea Nauru Solomon s Tuvalu Howland/Baker Kiribati Tokalau Jarvis Australia Coral Sea Vanuatu New Caledonia Wallis Fiji Norfolk Western Samoa Tonga American Samoa Cook Niue French Polynesia Pitcairn New Zealand Patients in the Pacific s travel long distances to Honolulu, Hawaii, for treatment of variceal bleeding. The arrows indicate flight paths taken to reach tertiary medical centers in Honolulu. Eight patients were from Maui, a Hawaiian island (approximately 90 miles from Oahu), 4 patients were from Guam (3800 miles away), 2 patients were from the Big of Hawaii (210 miles away), 1 patient was from American Samoa (2598 miles away), and 1 patient was from Truk, a Northern Marianas island (approximately 3500 miles away) (Figure). All patients from islands other than Oahu were brought in by air ambulance. Endoscopy was not available in Samoa and Truk. At the time of these transfers, Doppler ultrasonography and interventional radiology were not available on any of these islands except Oahu. Twenty-four of 34 patients undergoing splenorenal shunt had hepatitis C, alcoholic liver disease, or a combination of these diseases. Three patients had cryptogenic cirrhosis, and 2 patients had autoimmune disease or primary biliary cirrhosis. Two patients had noncirrhotic portal hypertension, including 1 with lymphoma and leukemia and another with schistosomiasis (Table). With regard to psychosocial issues, 22 patients were either actively using alcohol or had abused alcohol in the past; 22 patients also had a history of smoking, with 14 currently smoking. Ten patients had a history of intravenous drug abuse, and 7 patients used other illicit drugs (cocaine, heroin, and methamphetamine). Eleven patients were currently employed, and 19 were currently unemployed, not including patients who were retired or disabled. Four patients had documented psychiatric problems for which they were being treated. Five patients were homeless, and 1 patient was imprisoned at the time of surgical treatment (Table). Of the 34 patients who underwent splenorenal shunt, 14 patients had insurance that would also cover liver transplantation, if necessary. Eighteen patients had either state government or Pacific subsidized medical insurance that either did not cover liver transplantation or might cover it in a transplant center outside Hawaii, provided that certain criteria were met. Two patients were uninsured (Table). Three patients underwent central splenorenal shunt because of massive splenomegaly and ascites in addition to bleeding, and the remaining 31 patients underwent distal splenorenal shunt with splenopancreatic-gastric disconnection. Fifteen operations were performed on an elective basis. The remaining 19 patients were admitted urgently for a variceal bleeding episode and stabilized for 3 to 8 days prior to undergoing surgical treatment. No patient was actively bleeding at the time of the operation. In patients for whom the information was available, 31 had a mean of 3 bleeding episodes before surgical treatment. Nine patients had operations following their first bleeding episode because of severe esophageal and gastric varices, and 4 patients underwent distal splenorenal shunt for a failed TIPS. Sixteen patients were Child class A, and 18 patients were Child class B on the day of the operation. Blood transfusions at the time of surgical treatment were from 0 to 5 U of packed red blood cells. The mean transfusion was 1.3 U, and 15 patients did not receive any transfusion. The mean length of hospital stay was 12.7 days total or 9 days postoperatively. Two patients had early bleeding postoperatively that was related to gastric ulcers, but no interventions other 1127
4 than transfusions and endoscopy were necessary. Rebleeding occurred in 1 patient who had an incomplete splenopancreatic-gastric disconnection and an extremely large left coronary vein. He underwent placement of a transjugular, intrahepatic, portosystemic shunt, which was complicated by portal vein thrombosis 4 months postoperatively. He then required a modified Sugiura procedure (gastric devascularization and esophageal transection) for recurrent bleeding because he was not a candidate for transplantation. No patient died intraoperatively or in the 7 days following surgical treatment. Three patients died in the 30- day period after splenorenal shunt. One patient died of massive liver failure on postoperative day 17. Another patient died on postoperative day 9 because of respiratory failure and a fungal infection probably related to steroid use for her autoimmune disease. The third patient died of complications related to acute pancreatitis on postoperative day 26. Of the 31 patients who survived the perioperative period, 3 patients are known to have died of unrelated causes at 8 months, 3 years, and 4 years following the operation. Of the remaining patients, 24 are known to be alive, and 5 have been lost to follow-up; 3 patients who have been lost to follow-up have not appeared on any published obituary list since their operation. Two patients live in Guam and have not been seen by physicians there. Of the 20 patients for whom data are available and who survived the perioperative period, the 1-year survival rate was 95%. COMMENT Multiple studies have confirmed the efficacy of splenorenal shunts. In series with 32 to 296 patients, perioperative mortality has ranged from 0% to 14%. 1,3,4,6,12-14 Shunt patency rates have been 92% to 94%, 1,3,5,13 and the likelihood of rebleeding has been 3.8% to 14%. 1,3,4,6,12-14 The rate of portosystemic encephalopathy has been reported to be 5% to 19%. 1,3-5,12-14 Maintenance of portal circulation by splenopancreatic disconnection plays a role in the development of encephalopathy. Spina et al 15 demonstrated in 27 of 131 patients that those who underwent distal splenorenal shunt with splenopancreatic disconnection were much less likely to develop chronic encephalopathy (0% vs 17% in patients with no splenopancreatic disconnection). Those 18 patients (14%) who developed chronic encephalopathy tended to have abolished portal perfusion. Jin and Rikkers 16 also confirmed that early portal vein thrombosis following distal splenorenal shunt contributed significantly to the development of both encephalopathy and severe ascites. Nonsurgical TIPS is used to control variceal bleeding and treat refractory ascites. This is a minimally invasive procedure performed by interventional radiologists with high technical success rates (greater than 90%) and excellent initial control of bleeding in most series. 9,10,17 Unfortunately, TIPS stenosis occurs in 50% to 70% of patients and accounts for a rebleeding rate of 15% to 30%. Encephalopathy also occurs in about 15% to 30% of patients, and TIPS can be used as a bridge to liver transplantation in patients with recurrent variceal bleeding. Early reports even suggested that TIPS could decrease blood loss at transplantation because of decreased portal hypertension. 20,21 Later studies, however, demonstrated that blood loss, operative time, and length of hospital stay were not affected by the presence of a TIPS before liver transplantation A number of groups have directly compared outcome in patients undergoing distal splenorenal shunt vs TIPS. Two retrospective studies on Child class A and B patients demonstrated that patients who underwent TIPS had significantly higher rebleeding rates because of shunt stenosis and required more interventions. 12,13 Helton et al 25 conducted a prospective, randomized trial of 40 patients with Child class A or B scores and variceal bleeding; 20 underwent distal splenorenal shunt, and 20 underwent TIPS. The 30-day mortality was higher in patients who underwent TIPS (20% vs 0% in patients who underwent distal splenorenal shunt). The patients who underwent TIPS also had significantly more rebleeding episodes, diagnostic studies, shunt revisions, and rehospitalizations. Total charges for a patient who underwent TIPS were $ vs $ for a patient who underwent distal splenorenal shunt. Finally, a decision analysis model by Zacks et al 7 of Child class A patients with cirrhosis and variceal bleeding demonstrated that a patient who underwent TIPS survived a mean of 1.96 years and required 1.7 procedures at a cost of $41685 compared with a patient who underwent distal splenorenal shunt, survived 1.86 years, and required 1.0 procedures at a cost of $ They concluded that distal splenorenal shunt was more cost-effective. Most will agree that distal splenorenal shunt is the procedure of choice for a Child class A patient with variceal bleeding. For patients who are Child class B or C, the possibility of a liver transplant looms in the future and often plays a role in deciding between TIPS or distal splenorenal shunt. Menegaux et al 26 studied 38 patients who underwent liver transplantation; 25 had TIPS, and 32 had splenorenal shunt prior to transplantation. Patients who had a pretransplantation TIPS required fewer blood transfusions at the time of the operation and had shorter operative times and shorter hospital and intensive care unit stays. Abouljoud et al 27 reviewed 35 patients with liver transplants, 18 with previous TIPS, and 17 with previous distal splenorenal shunt. No difference in the intraoperative transfusion requirement was noted, although the operative time was longer in the distal splenorenal shunt group. There were 3 deaths in the distal splenorenal shunt group compared with no deaths in the TIPS group. Intraoperative hemodynamics were better in the TIPS group because portal vein pressures were significantly higher. Both studies suggested that TIPS was perhaps a more favorable choice as a bridge to transplantation. In general, it is difficult to study this group of patients in large, randomized, controlled prospective trials. These patients are frequently unreliable and noncompliant, with diseases that are often self-induced and ongoing. One study even reported that 19% of patients were lost to follow-up. 5 Unfortunately, we have often been unable to document many of these psychosocial factors 1128
5 at the time the patient is admitted to the hospital with acute variceal bleeding. Four such patients in our series underwent distal splenorenal shunt after their TIPS had occluded, and we had determined these patients to be noncompliant or unsuitable candidates for transplantation. This approach has been described by Selim et al 28 who performed conversion of failed TIPS to distal splenorenal shunts in 4 patients with Child class A or B cirrhosis; however, these conversions were done for primarily technical reasons. For the noncompliant patient and the patient who is not a candidate for a transplant, distal splenorenal shunt is the ideal procedure. Studies have consistently shown its efficacy and cost-effectiveness and the lack of need for future interventions. We have been able to perform distal splenorenal shunt with acceptable morbidity and mortality in patients who are frequently at a great distance from tertiary medical centers or who have significant psychosocial issues. Following a TIPS closely with ultrasonograms or venograms is simply not possible in such situations because these tests are either not available or the patients are lost to follow-up and will only seek treatment with acute rebleeding. Thus, we propose that the 2 most important factors in deciding whether to use TIPS or distal splenorenal shunt are Child status and patient compliance or psychosocial factors. We have shown data here that most centers would be reluctant to report, but they reflect the reality of the nature of these patients. The presence of factors such as active substance abuse, homelessness, lack of social or financial support, and distance from tertiary medical centers that can treat endstage liver disease must be noted prior to any decision. These factors are generally discussed in determining appropriateness for liver transplantation and should be discussed before deciding between TIPS and distal splenorenal shunt as well. Although we would ideally like to study this issue in a controlled, prospective fashion, the nature of these patients will probably never allow for such a study. This study was presented as a poster at the 73rd Annual Meeting of the Pacific Coast Surgical Association, Las Vegas, Nev, February 17, 2002, and published after peer review and revision. Corresponding author: Linda L. Wong, MD, 2226 Liliha St, Suite 402, Honolulu, HI ( REFERENCES 1. Nagsue N, Kohno H, Ogawa Y, et al. Appraisal of distal splenorenal shunt in the treatment of esophageal varices: an analysis of prophylactic, emergency, and elective shunts. World J Surg. 1989;13: Henderson MJ. Role of distal splenorenal shunt for long-term management of variceal bleeding. World J Surg. 1994;18: Orozco H, Mercado MA, Garcia JG, et al. Selective shunts for portal hypertension: current role of a 21-year experience. Liver Transpl Surg. 1997;3: Jenkins RL, Gedaly R, Pomposelli JJ, et al. Distal splenorenal shunt: role, indications, and utility in the era of liver transplantation. Arch Surg. 1999;134: Knechtle SJ, Alessandro AM, Armbrust MJ, et al. Surgical portosystemic shunts for treatment of portal hypertensive bleeding: outcome and effect on liver function. Surgery. 1999;126: Henderson MJ, Warren WD, Millikan WJ, et al. Distal splenorenal shunt with splenopancreatic disconnection: a 4-year assessment. Ann Surg. 1989;10: Zacks SL, Sandler RS, Biddle AK, et al. Decision analysis of transjugular intrahepatic portosystemic shunt versus distal splenorenal shunt for portal hypertension. Hepatology. 1999;29: Rikkers LF, Jin G, Lagnas AN, et al. Shunt surgery during the era of liver transplantation. Ann Surg. 1997;226: LaBerge JM, Somberg KA, Lake JR, et al. Two-year outcome following transjugular intrahepatic portosystemic shunt for variceal bleeding: results in 90 patients. Gastroenterology. 1995;108: Caldwell DM, Ring EJ, Rees CR, et al. Multicenter investigation of the role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension. Radiology. 1995;196: Haskal ZJ, Pentecost MJ, Soulen MC, et al. Transjugular intrahepatic portosystemic shunt stenosis and revision: early and midterm results. AJR Am J Roentgenol. 1994;163: Henderson JM, Nagel A, Curtas S, et al. Surgical shunts and tips for variceal decompression in the 1990s. Surgery. 2000;128: Khaitiyar JS, Luthra SK, Prasad N, et al. Transjugular intrahepatic portosystemic shunt versus distal splenorenal shunt: a comparative study. Hepatogastroenterology. 2000;47: Orozco H, Mercado MA. The evolution of portal hypertension surgery: lessons from 1000 operations and 50 years experience. Arch Surg. 2000;135: Spina GP, Santambrogio R, Opocher E, et al. Factors predicting chronic hepatic encephalopathy after distal splenorenal shunt: a multivariate analysis of clinical and hemodynamic variables. Surgery. 1993;114: Jin G, Rikkers L. The significance of portal vein thrombosis after distal splenorenal shunt. Arch Surg. 1991;126: Rossle M, Haag K, Ochs A. The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med. 1994;330: Sanyal AJ, Freeman A, Shiffman ML, et al. Portosystemic encephalopathy after transjugular intrahepatic portosystemic shunt: results of a prospective, controlled study. Hepatology. 1994;20: Somberg KA, Riegler JL, LaBerge JM, et al. Hepatic encephalopathy after transjugular intrahepatic portosystemic shunts: incidence and risk factors. Am J Gastroenterol. 1995;90: Woodle ES, Darcy M, White HM, et al. Intrahepatic portosystemic vascular stents: a bridge to hepatic transplantation. Surgery. 1993;113: Menegaux F, Baker E, Keeffe EB, et al. Impact of transjugular intrahepatic portosystemic shunt on orthotopic liver transplantation. World J Surg. 1994;18: Millis M, Imagawa D, Olthoff K, et al. TIPS: impact on liver transplantation. Transplant Proc. 1995;27: Somberg KA, Lombardero MS, Lawlor SM, et al. Impact of transjugular intrahepatic portosystemic shunts on liver transplantation: a controlled analysis. Transplant Proc. 1995;27: Somberg KA, Lombardero MS, Lawlor SM, et al. A controlled analysis of the transjugular intrahepatic portosystemic shunt in liver transplant recipients. Transplantation. 1997;63: Helton WS, Maves R, Wicks K, et al. Transjugular intrahepatic portasystemic shunt vs surgical shunt in good-risk cirrhotic patients: a case-control comparison. Arch Surg. 2001;136: Menegaux F, Keeffe EB, Baker E, et al. Comparison of transjugular and surgical portosystemic shunts on the outcome of liver transplantation. Arch Surg. 1994; 129: Abouljoud MS, Levy MF, Rees CR, et al. A comparison of treatment of transjugular intrahepatic portosystemic shunt or distal splenorenal shunt in the management of variceal bleeding prior to liver transplantation. Transplantation. 1995; 59: Selim N, Fendley MJ, Boyer TD, et al. Conversion of failed transjugular intrahepatic portosystemic shunt to distal splenorenal shunt in patients with Child A or B cirrhosis. Ann Surg. 1998;227:
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