QUANTIFYING OPIOIDS USING LIQUID CHROMATOGRAPHY AND GAS CHROMATOGRAPHY TANDEM MASS SPECTROMETRY
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1 QUANTIFYING OPIOIDS USING LIQUID CHROMATOGRAPHY AND GAS CHROMATOGRAPHY TANDEM MASS SPECTROMETRY Nikole Gomez, Biochemistry Major Hala Schepmann, Ph.D. Professor of Bioorganic Chemistry
2 OPIOIDS? Reduce pain Morphine, codeine, and heroin 26.4 to 36 million Americans Morphine Nutt, D. (2012). Drugs Without the Hot Air. Cambridge, England: UIT Volkow, N.D. (2014 May 14). America s addiction to opioids: Heroin and prescription drug abuse. Retrieved from
3 HEROIN Schedule I Dangers to user The metabolites Heroin U.S. Food and Drug Administration. (2009 June 11). Controlled Substance Act. Retrieved from Volkow, N.D. (2014 May 14). America s addiction to opioids: Heroin and prescription drug abuse. Retrieved from Rana, S., Garg, R. K., & Singla, A. (2014). Rapid analysis of urinary opiates using fast gas chromatography-mass spectrometry and hydrogen as a carrier gas. Egyptian Journal of Forensic Sciences, 4, Zhang, X., Chen, M., Cao, G., & Hu, G. (2013). Determination of morphine and codeine in human urine by gas chromatography-mass spectrometry. Journal of Analytical Methods in Chemistry, 2013, 1-6. doi: /2013/151934
4 LIQUID CHROMATOGRAPHY The Column Synder, L. R., Kirkland, J. J., & Dolan, J. W. (2010 January 14). Introduction to Modern Liquid Chromatography McNair, H. M. & Miller, J. M. (2008 November 19). Basic Gas Chromatography
5 GAS CHROMATOGRAPHY The Column McNair, H. M. & Miller, J. M. (2008 November 19). Basic Gas Chromatography
6 MASS SPECTROMETRY Tandem Ionized Detection Mass spectrum of morphine (Zhang et al., 2013, p. 3) McNair, H. M. & Miller, J. M. (2008 November 19). Basic Gas Chromatography Zhang, X., Chen, M., Cao, G., & Hu, G. (2013). Determination of morphine and codeine in human urine by gas chromatography-mass spectrometry. Journal of Analytical Methods in Chemistry, 2013, 1-6. doi: /2013/151934
7 HAIR SAMPLES Longest detection time frame Decontamination LC/MS Gouveia, C. A., Oliveira, A., Pinho, S., Vasconcelos, C., Carvalho, F., Moreira, R. F., & Dinis-Oliveira, R. J. (2012 July 3). Simultaneous quantification of morphine and cocaine in hair samples from drug addicts by GC-EI/MS. Biomedical Chromatography, 26(8), doi: /bmc.2775 Huang, D., Liu, C., Huang, M., & Chien, C. (2009). Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 23(7), doi: /rcm.3955 Imbert, L., Dulaurent, S., Mercerolle, M., Morichon, J., Lachatre, G., & Gaulier, J. M. (2014 January). Development and validation of a single LC MS/MS assay following SPE for simultaneous hair analysis of amphetamines, opiates, cocaine and metabolites. Forensic Science International, 234,
8 URINE SAMPLES Routine testing Heroin Morphine Codeine Huang, D., Liu, C., Huang, M., & Chien, C. (2009). Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 23(7), doi: /rcm.3955 Rana, S., Garg, R. K., & Singla, A. (2014). Rapid analysis of urinary opiates using fast gas chromatography-mass spectrometry and hydrogen as a carrier gas. Egyptian Journal of Forensic Sciences, 4, Zhang, Xiaoqian, Chen, Mengchun, Cao, Gaozhong, Hu, Guoxin. (2013). Determination of morphine and codeine in human urine by gas chromatography-mass spectrometry. Journal of Analytical Methods in Chemistry, 2013, 1-6. doi: /2013/151934
9 BLOOD SAMPLES Routine testing Stability LC/MS GC/MS Huang, D., Liu, C., Huang, M., & Chien, C. (2009). Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 23(7), doi: /rcm.3955 Tiscione, N. B., Shan, X., Alford, I. & Yeatman, D. T. (2011 March). Quantitation of opioids in whole blood by electron impact-gas chromatography-mass spectrometry. Journal of Analytical Toxicology, 35, Zhang, Xiaoqian, Chen, Mengchun, Cao, Gaozhong, Hu, Guoxin. (2013). Determination of morphine and codeine in human urine by gas chromatography-mass spectrometry. Journal of Analytical Methods in Chemistry, 2013, 1-6. doi: /2013/151934
10 ACKNOWLEDGEMENTS
11 QUESTIONS? Schlafmohnfeld (Papaver somniferum) im Erzgebirgskreis, Sachsen, Deutschland
12 Codeine THANK YOU
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