Using Resting-State Functional Connectivity of the Basal Ganglia as a Biomarker for Symptoms of Parkinson's Disease
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1 Illinois Math and Science Academy Student Publications & Research Student Works Using Resting-State Functional Connectivity of the Basal Ganglia as a Biomarker for Symptoms of Parkinson's Disease Neal Modi '16 Illinois Mathematics and Science Academy, nealmodi3@gmail.com Lucy Yuan '16 Illinois Mathematics and Science Academy Todd B. Parrish Northwestern University, toddp@northwestern.edu Follow this and additional works at: Part of the Education Commons Recommended Citation Modi, N., Yuan, L., & Parrish, T. B. (2015). Using resting-state functional connectivity of the basal ganglia as a biomarker for symptoms of Parkinson's disease [PowerPoint slides]. Retrieved from This Conference Paper/Presentation is brought to you for free and open access by the Student Works at DigitalCommons@IMSA. It has been accepted for inclusion in Student Publications & Research by an authorized administrator of DigitalCommons@IMSA. For more information, please contact pgarrett@imsa.edu, jean@imsa.edu.
2 Using Resting- State Functional Connectivity Within the Basal Ganglia as a Biomarker for Symptoms of Parkinson s Disease Neal Modi and Lucy Yuan Illinois Mathematics and Science Academy Aurora, Illinois Presentation No.: O- 81
3 Disclosure Nothing to Disclose
4 Purpose To investigate the use of functional connectivity as a biomarker for PD
5 Parkinson s Disease Source: neurophysiology.wikispaces.com/rhett+syndrome Affects Nigrostriatal Dopaminergic Neurons Motor Impairments Tremors Muscular Rigidity Lessened Balance and Coordination Bradykinesia Cognitive Impairments Hallucinations Impaired Speech Delayed Memory/Memory Loss
6 Unified Parkinson s Disease Rating Scale - III UPDRS- III Score a. Posture b. Postural/Kinetic Tremor c. Resting Tremor d. Movement e. Rigidity Unified Parkinson s Disease Rating Scale Section III For assessment of Motor Symptoms Rigidity Scores: 0 to 12
7 Functional Connectivity BOLD Signals from MRI Connection between Brain Regions Signals sensitive to oxygen Synchronization of BOLD Signals = High Functional Connectivity
8 Brain Images from Parkinson s Progression Markers Initiative Database RS- fmri data from 70 PD patients obtained Aged 38-79; 21 females Data from 8 sites LP RP LC 4 ROIs Identified from AAL Left and Right Caudate Left and Right Putamen RC LP RP LC RC Analysis conducted in MATLAB Source:
9 Connectivity Correlation with Behavioral Scores Functional Connectivity correlated with PD Symptoms Connectivity between Left and Right Caudate correlated to the UPDRS- III Rigidity score Significant, P< Variables of No Interest - Scan Date - Scan Site - Age - Sex - PD Medication - Cognitive Assessment Scores
10 Functional Connectivity Maps for Left Caudate Less Severe Rigidity More warm color = More Functional Connectivity A Severe Rigidity B
11 Amount of Connectivity between Left and Right Caudate Caudate Nuclei to UPDRS- III Rigidity Severity of Rigidity in Parkinson s (UPDRS- III rigidity sub scores) R = P = 6.76E-6
12 Conclusion As functional connectivity levels in the Caudate decrease, Parkinson s Disease patients suffer worse symptoms of Rigidity Suggests use of functional connectivity as a biomarker for Parkinsonian Symptoms
13 Future Studies Further subdividing basal ganglia regions Investigate cognitive effects Correlating with subcomponents of MoCA Assess the destruction of Nigrostriatal Dopaminergic Neurons on Cognitive Function
14 Acknowledgements Dr. Todd Parrish Dr. Xue Wang Dr. Darren Gitelman Dr. Judith Scheppler Parkinson s Progression Markers Initiative Database
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