Effects of Short-Term Repetitive Transcranial Magnetic Stimulation on P300 Latency in an Auditory Odd-Ball Task
|
|
- Amice Short
- 5 years ago
- Views:
Transcription
1 28 INTERNATIONNAL JOURNAL OF APPLIED BIOMEDICAL ENGINEERING VOL.5, NO Effects of Short-Term Repetitive Transcranial Magnetic Stimulation on P300 Latency in an Auditory Odd-Ball Task Tetsuya Torii 1, Aya Sato 1, Yukiko Nakahara 1, Masakuni Iwahashi 2, Yuji Itoh 1, and Keiji Iramina 3, ABSTRACT The present study analyzed the effects of repetitive transcranial magnetic stimulation (rtms) on brain activity. The latency of the P300 component of the event-related potential (ERP) was used to evaluate the effects of low-frequency and short-term rtms over areas thought to be related to the generation of the P300, including the supramarginal gyrus (SMG) and dorsolateral prefrontal cortex (DLPFC). A flat figure-eight coil was used to stimulate left and right SMG and DLPFC, applying magnetic stimulation at an intensity that was 80% of the subjectś motor threshold. A total of 100 magnetic pulses were applied in rtms, with stimulation frequencies of 1.0 and 0.5 Hz. ERPs were measured while subjects completed the odd-ball task pre- and post-rtms. We found that rtms over the left SMG decreased P300 latency at 1.0 Hz rtms. Compared with the latency of pre-rtms, the latency differed by approximately 20 ms at Cz. In contrast, P300 latency increased at 0.5 Hz rtms. Compared with the latency of pre-rtms, the latency time difference was approximately 20 ms at Cz. However, 1.0 Hz rtms over left DLPFC caused an increase in P300 latency. Following rtms, latency differed by approximately 25 ms at Cz. In contrast, P300 latency was unchanged following 0.5 Hz rtms. rtms applied to the right SMG and DLPFC caused no significant differences between pre- and post-rtms, regardless of the stimulation frequency. The results demonstrated that P300 latency varied according to the frequency of rtms. These findings suggest that the effects of rtms are frequency-dependent and hemisphere-dependent. 1. INTRODUCTION Transcranial magnetic stimulation (TMS) is a neurodiagnostic tool that was first developed in 1985 [1], [2]. TMS has been used to map the function of different cortical areas [3], [4]. Repetitive transcranial magnetic stimulation (rtms) has been used in studies of the human brain [5], and to treat certain brain diseases and neurological disorders [6], [7]. Stimulating the dorsolateral prefrontal cortex (DLPFC) using TMS or rtms has been reported to provide an effective treatment for depression [8]. A brief high-current pulse produced in a wire coil (a magnetic coil) produces magnetic stimulation. In TMS or rtms, a coil placed on the scalp produces an eddy current in the brain [9], [10]. In addition, TMS and rtms are noninvasive methods for directly stimulating brain areas. Although electroconvulsive therapy (ECT) can also be used for brain stimulation, it is affected by the high impedance of the skull, skin and hair. In contrast, TMS and rtms are not affected by impedance. Magnetic fields can induce an electric current in the cortex by non-infestation. The induced electric current is required to alter neuronal activity [11]. Because of these advantages, TMS and rtms have attracted much recent research attention. Most studies of the effects of TMS and rtms have focused on the motor evoked potential (MEP) or event-related potential (ERP) [12]-[20]. The MEP has been used to evaluate the effects of TMS and rtms. While MEPs can only be used to assess the effects of magnetic stimulation to motor areas, other ERPs can be used to assess the effects of TMS and rtms to sensory areas. The P300 component of ERPs has also been used to evaluate the effects of TMS and rtms. A recent study revealed that P300 latency was delayed when TMS was applied to the left supramarginal gyrus (SMG) at 200 or 250 ms after odd-ball auditory stimulation [21]. This magnetic stimulation point (SMG) is thought to constitute the source of generation of the P300 [22]. In contrast, one study found that low-frequency rtms in the right DLPFC produced no significant change in the P300 component before and after magnetic stimulation [23]. Manuscript received on August 14, 2012 ; revised on October 17, The authors are with the Department of Medical Engineering, Gakuen University, Japan, torii@junshin-u.ac.jp 2 The author is with the Course of Information Technology, Tokai University, Japan 3 The author is with the Graduate School of Systems Life Sciences, Kyushu University, Japan However, little is known about the effects of P300 latency following low-frequency and short-term magnetic stimulation (e.g., 100 magnetic pulses at 1.0 or 0.5 Hz) using rtms. Thus, in the present study, we analyzed the effects of rtms (at 1.0 and 0.5 Hz) in the left-right SMG and DLPFC.
2 T. Torii, A. Sato, Y. Nakahara, M. Iwahashi, Y. Itoh and K. Iramina 29 pling frequency was 1,000 Hz and the synchronized sum was 20 times. Recorded data were processed using a band-pass digital filter from 0.5 Hz to 50 Hz Repetitive transcranial magnetic stimulation (rtms) Fig.1:: Auditory odd-ball task. Fig.2:: The paradigm involved the auditory odd-ball task, conducted before and shortly after repetitive magnetic stimulation (rtms). In this study, the Super Rapid Stimulator (Magstim Co. Ltd.) was used as the magnetic stimulator device, with a flat figure-eight coil (70 mm diameter). rtms was conducted with 1.0 Hz and 0.5 Hz stimulation. We used four stimulation points, including left SMG, right SMG, left DLPFC and right DLPFC. rtms was conducted using 100 magnetic pulses, each with a width of 2 ms. The strength of magnetic stimulation was set at 80% of subjects motor threshold (MT). The subjects individual MT was the point at which MEPs of more than 50 µv peakto-peak amplitude were produced in at least six of 10 successive trials. 2. MATERIALS AND METHODS 2. 1 Measurements In the current study, STIM2 (Neuro Scan Ltd.) was used to produce sound stimuli and trigger signals. The sound stimuli were used in the auditory odd-ball task, and the trigger signals were used for the initiation of electroencephalography (EEG). EEG was recorded using a personal computer. Subjects were instructed to click a computer mouse button when the target sounds in the auditory odd-ball task were presented. Reaction times (RTs) were measured using STIM Auditory odd-ball task Fig. 1 illustrates the auditory odd-ball task in this study. The auditory odd-ball task consisted of 1 khz and 2 khz sound stimuli. The standard auditory stimulus was a 1 khz sound (non-target). The deviant auditory stimulus was a 2 khz sound (target). The standard stimulus was presented in 80% of trials. The deviant stimulus was presented in 20% of trials. The auditory stimuli were randomly presented, consisting of a burst wave with a duration of 50 ms. The interval of the stimulation sounds was 2.5 seconds, and the sound pressure was 60 db. Stimulus sounds were presented to the subject through earphones Electroencephalography (EEG) EEG data were recorded in an electrically shielded room. EEG data were measured at the Fz, Cz and Pz electrodes according to the international system, and each polar contact impedance was set at less than 5 kilo ohms. Each EEG recording period lasted 1.0 second, and recording began with the standing edge of the stimulation sound. The sam- Fig.3:: Event-related potentials (ERPs) at Fz before and after 1.0 and 0.5 Hz stimulation of the left supramarginal gyrus (SMG). The black line represents the ERP before the magnetic stimulation, and the gray line represents an ERP after magnetic stimulation Experimental procedure Fig. 2 shows the experimental paradigm, divided into three phases. In this paradigm, an auditory oddball task was conducted prior to magnetic stimulation as a control condition. rtms was then applied to the left SMG, right SMG, left DLPFC or right DLPFC. The auditory odd-ball task was then conducted again immediately following rtms, to evaluate the effects of magnetic stimulation. In this study, we enrolled 13 healthy (six female and seven male) right-handed volunteers as subjects. Subjects ages ranged from years of age. Subjects were instructed to relax and remain seated during testing.
3 30 INTERNATIONNAL JOURNAL OF APPLIED BIOMEDICAL ENGINEERING Fig.4:: ERPs at the Fz before and after 1.0 and 0.5 Hz stimulation of the right SMG. The black line represents an ERP before the magnetic stimulation, and the gray line represents an ERP after the magnetic stimulation. Fig.5:: ERPs at Fz before and after 1.0 and 0.5 Hz stimulation of the left dorsolateral prefrontal cortex (DLPFC). The black line represents an ERP before the magnetic stimulation, and the gray line represents an ERP after magnetic stimulation. 3. RESULTS Fig. 3 shows ERPs at the Fz electrode before and after magnetic stimulation of the left SMG, which was found to shorten P300 latency with 1.0 Hz rtms, and delay P300 latency with 0.5 Hz rtms. Compared with the control condition, immediately following 1.0 Hz magnetic stimulation, P300 latencies were shortened by 25.6 ms at the Fz electrode, 20.6 ms at the Cz electrode and 33.6 ms at the Pz electrode. Compared with the control condition, immediately following 0.5 Hz stimulation, P300 latencies were delayed by 25.3 ms at the Fz electrode, 17.3 ms at the Cz electrode and 23.4 ms at the Pz electrode. Fig. 4 shows ERPs at the Fz electrode before and after magnetic stimulation of the right SMG, which did not affect P300 latencies with 1.0 and 0.5 Hz rtms. Compared with the control condition, immediately after 1.0 Hz magnetic stimulation, P300 la- VOL.5, NO Fig.6:: ERPs at Fz before and after 1.0 and 0.5 Hz stimulation of the right DLPFC. The black line represents an ERP before magnetic stimulation, and the gray line represents an ERP after magnetic stimulation. tencies were little altered by 0.9 ms at the Fz electrode, 4.8 ms at the Cz electrode and 6.0 ms at the Pz electrode. Compared with the control condition, immediately after 0.5 Hz, magnetic stimulation, P300 latencies were little altered by 1.7 ms at the Fz electrode, 1.2 ms at the Cz electrode and 0.1 ms at the Pz electrode. Fig. 5 shows ERPs at the Fz electrode before and after magnetic stimulation of the left DLPFC. DLPFC stimulation delayed P300 latency with 1.0 Hz rtms and did not change P300 latency with 0.5 Hz rtms. Compared with the control condition, immediately after 1.0 Hz magnetic stimulation, P300 latencies were delayed by 17.7 ms at the Fz electrode, 27.2 ms at the Cz electrode and 25.8 ms at the Pz electrode. Compared with the control condition, immediately after magnetic stimulation with 0.5 Hz, P300 latencies were little altered by 6.7 ms at the Fz electrode, 1.7 ms at the Cz electrode and 7.9 ms at the Pz electrode. Fig. 6 shows ERPs at the Fz electrode before and after magnetic stimulation of the right DLPFC, which did not change P300 latencies at 1.0 and 0.5 Hz rtms. Compared with the control condition, immediately after 1.0 Hz magnetic stimulation, P300 latencies were little altered by 4.6 ms at the Fz electrode, 3.9 ms at the Cz electrode and 0.2 ms at the Pz electrode. Compared with the control condition, immediately after 0.5 Hz magnetic stimulation, P300 latencies were little altered by 6.8 ms at the Fz electrode, 5.5 ms at the Cz electrode and 4.7 ms at the Pz electrode. Paired t-tests were used to examine significant differences in P300 latencies between before and after rtms. Fig. 7 shows P300 latencies and the ratio of P300 latency before (control condition) and after magnetic stimulation of the left SMG with (a) 1.0 and (b) 0.5 Hz rtms. With 1.0 Hz rtms, the significant difference before and after rtms was observed (Fz: p 0.001, Cz: p 0.001, Pz: p 0.001).
4 T. Torii, A. Sato, Y. Nakahara, M. Iwahashi, Y. Itoh and K. Iramina 31 (a) 1.0 Hz rtms (a) 1.0 Hz rtms (b) 0.5 Hz rtms Fig.7:: P300 latencies and difference in normalized P300 latencies to each pre-rtms over the left SMG at (a) 1.0 Hz and (b) 0.5 Hz. In the difference in normalized P300 latency, the positive bar indicates the shortened state and negative bar indicates the delayed state. (b) 0.5 Hz rtms Fig.8:: P300 latencies and difference in normalized P300 latencies difference to each pre-rtms over the right SMG at (a) 1.0 Hz and (b) 0.5 Hz. In the difference in normalized P300 latency, the positive bar indicates the shortened state and the negative bar indicates the delayed state.
5 32 INTERNATIONNAL JOURNAL OF APPLIED BIOMEDICAL ENGINEERING VOL.5, NO (a) 1.0 Hz rtms (a) 1.0 Hz rtms (b) 0.5 Hz rtms Fig.9:: P300 latencies and difference in normalized P300 latencies to each pre-rtms over the left DLPFC at (a) 1.0 Hz and (b) 0.5 Hz. In the difference in normalized P300 latency, the positive bar indicates the shortened state and the negative bar indicates the delayed state. (b) 0.5 Hz rtms Fig.10:: P300 latencies and difference in normalized P300 latencies to each pre-rtms over the right DLPFC at (a) 1.0 Hz and (b) 0.5 Hz. In the difference in normalized P300 latency, the positive bar indicates the shortened state and the negative bar indicates the delayed state.
6 T. Torii, A. Sato, Y. Nakahara, M. Iwahashi, Y. Itoh and K. Iramina 33 (a) Left SMG (a) Left DLPFC (b) Right SMG Fig.11:: Reaction time and difference in normalized reaction time difference for each pre-rtms over (a) the left SMG and (b) right SMG at target sounds. For the difference in normalized reaction time, the positive bar indicates shortened latency, and the negative bar indicates delayed latency. (b) Right DLPFC Fig.12:: Reaction time and difference in normalized reaction time to each pre-rtms over (a) the left DLPFC and (b) right DLPFC at target sounds. For the difference in normalized reaction time, the positive bar indicates shortened latency and the negative bar indicates delayed latency.
7 34 INTERNATIONNAL JOURNAL OF APPLIED BIOMEDICAL ENGINEERING VOL.5, NO The results revealed a significant difference before and after 0.5 Hz rtms (Fz: p<0.001, Cz: p<0.001, Pz: p<0.01). Fig. 8 shows P300 latencies and the ratio of P300 latency before (control condition) and after magnetic stimulation to the right SMG with (a) 1.0 and (b) 0.5 Hz. Significant differences were not observed before and after magnetic stimulation of this area. Fig. 9 shows P300 latencies and the ratio of P300 latency before (control condition) and after magnetic stimulation of the left DLPFC with (a) 1.0 and (b) 0.5 Hz. The results revealed a significant difference before and after 1.0 Hz rtms (Fz: p<0.01, Cz: p<0.01, Pz: p<0.01). With 0.5 Hz rtms, significant differences were not observed before and after left DLPFC stimulation. Fig. 10 shows P300 latencies and the ratio of P300 latency before (control condition) and after magnetic stimulation of the right DLPFC with (a) 1.0 and (b) 0.5 Hz. Significant differences were not observed before and after magnetic stimulation in this area. Fig. 11 and Fig. 12 show RTs before and after magnetic stimulation of the left SMG, right SMG, left DLPFC and right DLPFC, and the normalization of the ratio of reaction time in the control condition. Significant differences were not observed before and after magnetic stimulation. 4. DISCUSSION Previous studies have reported that low-frequency rtms decreases cortical excitability, while highfrequency rtms increases excitability [24]-[26]. As such, we predicted that low-frequency rtms would delay P300 latencies. This hypothesis was confirmed by the observed effects of 1.0 Hz rtms over the left DLPFC and 0.5 Hz rtms over the left SMG. These results indicate that 1.0 Hz rtms over the left DLPFC and 0.5 Hz rtms over the left SMG inhibit cerebral cortex activity. However, P300 latency was not delayed following 1.0 Hz rtms in the left SMG, 0.5 Hz rtms in the left DLPFC, or rtms of either frequency in the right SMG or DLPFC. P300 latency exhibited a particularly strong decrease following 1.0 Hz rtms over the left SMG. This result suggests that 1.0 Hz rtms over the left SMG excites the cerebral cortex. Previous studies have suggested that neuronal excitation can be induced by rtms [27], [28]. Thus, the current results suggest that neuronal excitation elicited by rtms increased the activity of inhibitory synapses. This indicates that excited neurons were inhibited, transitioning to a suppressed or resting state. This inhibition also resulted from low-frequency magnetic stimulation, including 1.0 Hz rtms of the left DLPFC and 0.5 Hz rtms of the left SMG. The present results thus suggest that activated neurons in the left DLPFC (0.5 Hz rtms), right SMG and DLPFC (1.0 or 0.5 Hz rtms) were inhibited by inhibitory synapses. Following this inhibition, excited neurons returned to the resting state. This may explain why P300 latencies were not affected by these types of stimulation. In other words, it is thought that the left DLPFC (0.5 Hz rtms) and right SMG and DLPFC (1.0 and 0.5 Hz rtms) were affected by magnetic stimulation even when P300 latency was unaltered. However, if neurons were exposed to high-frequency magnetic stimulation, even at inhibitory synapses, the transition from a strongly excited state to the resting or inhibited state may be difficult. In the current study, 1.0 Hz rtms over the left SMG was found to induce a sustained state of excitation. This was caused by low-frequency magnetic stimulation of 1.0 Hz. In addition, the SMG and DLPFC have been shown to be involved in generating the P300 [22]. However, the P300 latency of right SMG and DLPFC has been little altered compared with the left SMG and DLPFC. These results suggest that the left SMG was most susceptible to magnetic stimulation and most tributary to generation of P300, compared with other areas. These results are consistent with other frequency-dependent effects reported in the left but not the right DLPFC [29], indicating that low-frequency rtms applied to the right DLPFC produced no significant changes [23]. In this study, 1.0 Hz magnetic stimulation of the left SMG induced excitation, while inhibition was induced by 1.0 Hz magnetic stimulation of the left DLPFC and 0.5 Hz magnetic stimulation of the left SMG. In addition, the resting state was induced by 0.5 Hz magnetic stimulation of the left DLPPFC and 1.0 or 0.5 Hz magnetic stimulation of the right SMG and DLPFC. Taken together, the current results demonstrate that 1.0 and 0.5 Hz rtms over the left SMG and DLPFC results in different effects on P300 latencies. 5. CONCLUSION The present study analyzed the effects of rtms on regional brain activity. The P300 latency of ERPs was used to evaluate the effects of low-frequency and short-term rtms by stimulating bilateral SMG and DLPFC. The results revealed different effects on P300 latencies following 1.0 and 0.5 Hz rtms over the left SMG and DLPFC. These findings indicate that the effects of rtms over the left SMG and DLPFC were frequency-dependent. The results also demonstrated that rtms over the right SMG and DLPFC had no significant effects on P300 latencies and were therefore not frequency-dependent. There were also no differences in RTs, regardless of the stimulation frequency or the hemisphere stimulated. References [1] A. T. Barker, I. L. Freeston, R. Jalinous, P. A. Merton, and H. B. Morton, Magnetic stimulation of the human brain., J. Physiol, vol. 369, p. 3, July [2] A. T. Barker, R. Jalinous, and I. L. Freeston, Non-invasive magnetic stimulation of human motor cortex., Lancet, vol. 1, pp , May [3] T. Paus, R. Jech, C. J. Thompson, R. Comeau, T.
8 T. Torii, A. Sato, Y. Nakahara, M. Iwahashi, Y. Itoh and K. Iramina 35 Peters, and A. C.Evans, Transcranial magnetic stimulation during positron emission tomography: A new method for studying connectivity of the human cerebral cortex., J. Neuroscience, vol. 17(9), pp , May [4] A. Pascual-Leone, E. M. Wassermann, J. Grafman and M. Hallett, The role of the dorsolateral prefrontal cortex in implicit procedural learning., Exp Brain Res, vol. 107, pp , [5] A. Pascual-Leone, J. R. Gates and A. Dhuna, Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation., Neurology, vol. 41, pp , May [6] L. G. Cohen, S. Sato, D. Rose, S. Bandinelli, C. V. Kufta, Hallett M, Correlation of transcranial magnetic stimulation (TCMS), direct cortical stimulation (DCS) and somatosensory evoked potentials (SEP) for mapping of hand motor representation area (HMRA) [abstract]., Neurology, vol. 39, pp. 375, March [7] M. S. George, E. M. Wassermann, T. A. Kimbrell, J. T. Little, W. E. Williams, A. L. Danielson, B. D. Greenberg, M. Hallett, R. M. Post, Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial., Am J Psychiatry, 154(12), pp , Dec [8] E. M. Wassermann, S. H. Lisanby, Therapeutic application of repetitive transcranial magnetic stimulation: a review., Clin Neurophysiology, 112, pp , [9] M. C. Ridding and J. C. Rothwell, Is there a future for therapeutic use of transcranial magnetic stimulation., Nature 8, pp , [10] M. Hallett, Transcranial magnetic stimulation: A primer., Neuron, vol. 55, pp , [11] G. Hasey, Transcranial Magnetic Stimulation in the Treatment of Mood Disorder: A Review and Comparison with Electroconvulsive Therapy., Can J Psy chiatry, vol. 46, pp , Oct [12] A. Pascual-Leone, V. Walsh, and J. Rothwell, Transcranial magnetic stimulation in cognitive neurosciencevirtual lesion, chronometry, and functional connectivity., Current Opinions in Neurobiology, vol. 10, pp , [13] M. Hamada, R. Hanajima, Y. Terao, N. Arai, T. Furubayashi, S. Inomata-Terada, A. Yugeta, H. Matsumoto, Y. Shirota and Y. Ugawa, Quadropluse stimulation is more effective than pairedpulse stimulation for plasticity induction of the human motor cortex., Clinical neurophysiology, vol. 118, pp , [14] G. W. Thickbroom, M. L. Byrnes, D. J. Edwards and F. L. Mastaglia, Repetitive pairedpulse TMS at I-wave periodicity markedly increases corticospinal excitability: A new technique for modulating synaptic plasticity., Clinical neurophysiolog, vol. 117, pp , [15] K. Iramina, T. Maeno, Y. Kowatari and S. Ueno, Effects of Transcranial Magnetic Stimulation on EEG Activity., IEEE Trans. Magn, vol. 38, pp , [16] K. Iramina, T. Maeno, Y. Nonaka and S. Ueno, Measurement of evoked EEG induced by transcranial magnetic stimulation., J. Appl. Phys, vol. 93, pp , [17] T. Paus, P. K. Sipila and A. P. Strafella, Synchronization of neuronal activity in the human primary cortex by transcranial magnetic stimulation: an EEG study., J. Neurophysiol, vol. 86, pp , [18] G. Thut, J. R. Ives, F. Kampmann, M. A. Pastor, and A. Pascual-Leone, A new device and protocol for combining TMS and online recordings of EEG and evoked potentials., J. Neurosci. Methods, vol. 15, pp. 141, Feb [19] T. Torii, K. Nojima, A. Matsunaga, M. Iwahashi, and K. Iramina, Comparison of Influences on P300 Latency in the Case of Stimulating Supramarginal Gyrus and Dorsolateral Prefrontal Cortex by rtms., 5 th Kuala Lumpur International Conference on Biomedical Engineering IFMBE Proceedings, vol. 35, pp , [20] T. Torii, A. Sato, M. Iwahashi, and K. Iramina, Effects of low-frequency repetitive transcranial magnetic stimulation on event-related potential P300., J. Appl. Phys, vol. 111, pp. 07B , [21] M. Iwahashi, Y. Katayama, S. Ueno and K. Iramina, Effect of Transcranial magnetic stimulation on P300 event-related potential., Annual International Conference of IEEE EMBS 31 st, pp , [22] E. Halgren, K. Marinkovic, P. Chauvel, Generators of the late cognitive potentials in auditory and visual oddball tasks., Electroencephalography and Clinical Neurophysiology, vol. 106, pp , [23] N. R. Cooper, P. B. Fitzgerald, R. J. Croft, D. J. Upton, R. A. Segrave, Z. J. Daskalakis and J. Kulkarni, Effects of rtms on an auditory oddball task: a pilot study of cortical plasticity and the EEG., Clinical EEG and neurosocience, vol. 39, pp , [24] E. M. Wassermann, Risky and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the international workshop on the safety of repetitive transcranial magnetic stimulation., Electroencephalography and clinical neurophysiology, vol. 108, pp. 1 16, [25] R. Chen, J. Classen, C. Gerloff, P. Celnik, E. M. Wassermann, M. Hallett, and L. G. Cohen, Depression of motor cortex excitability by lowfrequency transcranial magnetic stimulation., NEUROLOGY, vol. 48, pp , [26] A. Berardelli, M. Inghilleri, J.C. Rothwell, S. Romeo, A. Curr, F. Gilio, N. Modugno and
9 36 INTERNATIONNAL JOURNAL OF APPLIED BIOMEDICAL ENGINEERING VOL.5, NO M. Manfredi, Facilitation of muscle evoked responses after repetitive cortical stimulation in man., Exp Brain Res, vol. 122, pp , [27] Y. Mano, Y. Morita, R. Tamura, S. Morimoto, T. Takayanagi and R. F. Mayer, The site of action of magnetic stimulation of human motor cortex in a patient with motor neuron disease., J Electromyography Kinesiology, vol. 3, pp , [28] Y. Mano, T. Nakamurro, K. Ikoma, T. Takayanagi and R. F. Mayer, A clinicophysiologic study of central and peripheral motor conduction in hereditary demyelinating motor and sensory neuropathy., Electromyogr. Clin. Neurophysiol., vol. 33, pp , [29] D. Knoch, P. Brugger and M. Regard, Suppressing versus releasing a habit: Frequencydependent effects of prefrontal transcranial magnetic stimulation., Cerebral Cortex, vol. 15, pp , Y. Nakahara received her Ph.D degree in Engineering from Kyushu University, Japan, in From 1997 to 2011, she worked at the Faculty of Engineering, Tohwa University. She has been a professor of the Faculty of Engineering in Tohwa University. In 2011, she moved to Junshin Gakuen University as an associate professor of Faculty of Health Sciences. M. Iwahashi received his Ph.D degree in Engineering from Kyushu University, Japan, in From 1980 to 2011, he worked at the Faculty of Engineering, Tohwa University. In 2011, he moved to Junshin Gakuen University, and he has been a professor of Faculty of Health Sciences in Junshin Gakuen University. In 2012, he moved to Tokai University as a project professor of School of Industrial Engineering. T. Torii completed his Ph.D program without a Ph.D. degree in the Graduate School of Life Science and Systems Engineering from Kyushu Institute of Technology, Japan, in From 1996 to 2011, he worked at the Faculty of Engineering, Tohwa University. He has been a lecturer of the Faculty of Engineering in Tohwa University. In 2011, he moved to Junshin Gakuen University as a lecturer of Faculty of Health Sciences. A. Sato received her masters degree in Engineering from Kurume Institute of Technology, Japan, in From 2004 to 2011, she worked at the Faculty of Engineering, Tohwa University. She has been a project lecturer of the Faculty of Engineering in Tohwa University. In 2011, she moved to Junshin Gakuen University as a research associate of Faculty of Health Sciences. Y. Ito received his M.D. degree in Medicine from Kurume University, Japan, in In 2011, he moved to Junshin Gakuen University as a project professor of Faculty of Health Sciences. K. Iramina received his Ph.D degree in Engineering from Kyushu University, Japan, in From 1991 to 1995, he worked at the Department of Electronics, Kyushu University. In 1996, he moved to the University of Tokyo, Japan and he has been an associate professor of Institute of Biomedical Engineering, the University of Tokyo. In 2005, he moved Kyushu University as a professor of Graduate School of Information Science an Electrical Engineering. He has been also a professor of Graduate School of Systems Life Sciences in Kyushu University.
Effects of Sub-Motor-Threshold Transcranial Magnetic Stimulation on. Event-Related Potentials and Motor-Evoked Potentials
東海大学基盤工学部紀要 5(2017 年 )1 頁 ~6 頁 Bull. School of Industrial and Welfare Engineering Tokai Univ., 5(2017), pp.1-6 Effects of Sub-Motor-Threshold Transcranial Magnetic Stimulation on Event-Related Potentials
More informationIntroduction to TMS Transcranial Magnetic Stimulation
Introduction to TMS Transcranial Magnetic Stimulation Lisa Koski, PhD, Clin Psy TMS Neurorehabilitation Lab Royal Victoria Hospital 2009-12-14 BIC Seminar, MNI Overview History, basic principles, instrumentation
More informationEffect of Transcranial Magnetic Stimulation(TMS) on Visual Search Task
INTERNATIONAL JOURNAL OF APPLIED BIOMEDICAL ENGINEERING VOL.2, NO.2 2009 1 Effect of Transcranial Magnetic Stimulation(TMS) on Visual Search Task K. Iramina, Guest member ABSTRACT Transcranial magnetic
More informationNeurophysiological Basis of TMS Workshop
Neurophysiological Basis of TMS Workshop Programme 31st March - 3rd April 2017 Sobell Department Institute of Neurology University College London 33 Queen Square London WC1N 3BG Brought to you by 31 March
More informationStatement on Repetitive Transcranial Magnetic Stimulation for Depression. Position statement CERT03/17
Statement on Repetitive Transcranial Magnetic Stimulation for Depression Position statement CERT03/17 Approved by the Royal College of Psychiatrists, Committee on ECT and Related Treatments: February 2017
More informationWater immersion modulates sensory and motor cortical excitability
Water immersion modulates sensory and motor cortical excitability Daisuke Sato, PhD Department of Health and Sports Niigata University of Health and Welfare Topics Neurophysiological changes during water
More informationLong lasting effects of rtms and associated peripheral sensory input on MEPs, SEPs and transcortical reflex excitability in humans
Journal of Physiology (2002), 540.1, pp. 367 376 DOI: 10.1113/jphysiol.2001.013504 The Physiological Society 2002 www.jphysiol.org Long lasting effects of rtms and associated peripheral sensory input on
More informationEffect of intensity increment on P300 amplitude
University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School 2004 Effect of intensity increment on P300 amplitude Tim Skinner University of South Florida Follow this and
More informationTranscranial Magnetic Stimulation
Transcranial Magnetic Stimulation Session 4 Virtual Lesion Approach I Alexandra Reichenbach MPI for Biological Cybernetics Tübingen, Germany Today s Schedule Virtual Lesion Approach : Study Design Rationale
More information( Transcranial Magnetic Stimulation, TMS) TMS, TMS TMS TMS TMS TMS TMS Q189
102 2004 35 2 3 : 1 2 2 ( 1 DK29220 ; 2 100083) ( Transcranial Magnetic Stimulation TMS) TMS TMS TMS TMS TMS TMS TMS ; ; ; Q189 Transcranial Magnetic Stimulation ( TMS) : Physiology Psychology Brain Mapping
More informationCopyright 2002 American Academy of Neurology. Volume 58(8) 23 April 2002 pp
Copyright 2002 American Academy of Neurology Volume 58(8) 23 April 2002 pp 1288-1290 Improved executive functioning following repetitive transcranial magnetic stimulation [Brief Communications] Moser,
More informationBiomedical Research 2013; 24 (3): ISSN X
Biomedical Research 2013; 24 (3): 359-364 ISSN 0970-938X http://www.biomedres.info Investigating relative strengths and positions of electrical activity in the left and right hemispheres of the human brain
More informationTranscranial Magnetic Stimulation for the Treatment of Depression
Transcranial Magnetic Stimulation for the Treatment of Depression Paul E. Holtzheimer, MD Associate Professor Departments of Psychiatry and Surgery Geisel School of Medicine at Dartmouth Dartmouth-Hitchcock
More informationWhat is Repetitive Transcranial Magnetic Stimulation?
rtms for Refractory Depression: Findings and Future Jonathan Downar, MD PhD Asst Professor, Dept of Psychiatry University of Toronto, Canada Co-Director, rtms Clinic Toronto Western Hospital University
More informationPrimary motor cortical metaplasticity induced by priming over the supplementary motor area
J Physiol 587.20 (2009) pp 4845 4862 4845 Primary motor cortical metaplasticity induced by priming over the supplementary motor area Masashi Hamada 1, Ritsuko Hanajima 1, Yasuo Terao 1,ShingoOkabe 1, Setsu
More informationNeurosoft TMS. Transcranial Magnetic Stimulator DIAGNOSTICS REHABILITATION TREATMENT STIMULATION. of motor disorders after the stroke
Neurosoft TMS Transcranial Magnetic Stimulator DIAGNOSTICS REHABILITATION TREATMENT of corticospinal pathways pathology of motor disorders after the stroke of depression and Parkinson s disease STIMULATION
More informationMaturation of corticospinal tracts assessed by electromagnetic stimulation of the motor cortex
Archives of Disease in Childhood, 1988, 63, 1347-1352 Maturation of corticospinal tracts assessed by electromagnetic stimulation of the motor cortex T H H G KOH AND J A EYRE Department of Child Health,
More informationNaoyuki Takeuchi, MD, PhD 1, Takeo Tada, MD, PhD 2, Masahiko Toshima, MD 3, Yuichiro Matsuo, MD 1 and Katsunori Ikoma, MD, PhD 1 ORIGINAL REPORT
J Rehabil Med 2009; 41: 1049 1054 ORIGINAL REPORT REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION OVER BILATERAL HEMISPHERES ENHANCES MOTOR FUNCTION AND TRAINING EFFECT OF PARETIC HAND IN PATIENTS AFTER STROKE
More informationMOTOR EVOKED POTENTIALS AND TRANSCUTANEOUS MAGNETO-ELECTRICAL NERVE STIMULATION
MOTOR EVOKED POTENTIAS AND TRANSCUTANEOUS MAGNETO-EECTRICA NERVE STIMUATION Hongguang iu, in Zhou 1 and Dazong Jiang Xian Jiaotong University, Xian, People s Republic of China 1 Shanxi Normal University,
More informationEE 4BD4 Lecture 11. The Brain and EEG
EE 4BD4 Lecture 11 The Brain and EEG 1 Brain Wave Recordings Recorded extra-cellularly from scalp (EEG) Recorded from extra-cellularly from surface of cortex (ECOG) Recorded extra-cellularly from deep
More informationTREATMENT-SPECIFIC ABNORMAL SYNAPTIC PLASTICITY IN EARLY PARKINSON S DISEASE
TREATMENT-SPECIFIC ABNORMAL SYNAPTIC PLASTICITY IN EARLY PARKINSON S DISEASE Angel Lago-Rodriguez 1, Binith Cheeran 2 and Miguel Fernández-Del-Olmo 3 1. Prism Lab, Behavioural Brain Sciences, School of
More informationTranscranial Magnetic Stimulation
Transcranial Magnetic Stimulation Scientific evidence in major depression and schizophrenia C.W. Slotema Parnassia Bavo Group The Hague, the Netherlands Faraday s law (1831) Electrical current magnetic
More informationMAGPRO. Versatility in Magnetic Stimulation. For clinical and research use
MAGPRO Versatility in Magnetic Stimulation For clinical and research use Magnetic Stimulation From A World Leader MagPro is a complete line of non-invasive magnetic stimulation systems, including both
More informationNIH Public Access Author Manuscript Conf Proc IEEE Eng Med Biol Soc. Author manuscript; available in PMC 2010 January 1.
NIH Public Access Author Manuscript Published in final edited form as: Conf Proc IEEE Eng Med Biol Soc. 2009 ; 1: 4719 4722. doi:10.1109/iembs.2009.5334195. Estimation of Brain State Changes Associated
More informationSTUDIES OF HUMAN MOTOR PHYSIOLOGY WITH TRANSCRANIAL MAGNETIC STIMULATION
ABSTRACT: Transcranial magnetic stimulation (TMS) is a safe, noninvasive, and painless way to stimulate the human motor cortex in behaving human subjects. When it is applied as a single-pulse, measurements
More informationP300 A cognitive evaluation tool in acute ischemic stroke A Narrative review
P300 A cognitive evaluation tool in acute ischemic stroke A Narrative review Siva Priya R 1*, Rashij M 2 1College of Allied Health Sciences, Gulf Medical University, Ajman, UAE 2Govt District Hospital,
More informationShort interval intracortical inhibition and facilitation during the silent period in human
J Physiol 583.3 (27) pp 971 982 971 Short interval intracortical inhibition and facilitation during the silent period in human Zhen Ni, Carolyn Gunraj and Robert Chen Division of Neurology, Krembil Neuroscience
More informationElectrophysiological Substrates of Auditory Temporal Assimilation Between Two Neighboring Time Intervals
Electrophysiological Substrates of Auditory Temporal Assimilation Between Two Neighboring Time Intervals Takako Mitsudo *1, Yoshitaka Nakajima 2, Gerard B. Remijn 3, Hiroshige Takeichi 4, Yoshinobu Goto
More informationD. Debatisse, E. Fornari, E. Pralong, P. Maeder, H Foroglou, M.H Tetreault, J.G Villemure. NCH-UNN and Neuroradiology Dpt. CHUV Lausanne Switzerland
Vegetative comatose and auditory oddball paradigm with Cognitive evoked potentials (CEPs) and fmri: Implications for the consciousness model of Damasio and Guerit D. Debatisse, E. Fornari, E. Pralong,
More informationNEURO-MS TMS. Diagnostic Monophasic Magnetic Stimulator
NEURO-MS Diagnostic Monophasic Magnetic Stimulator Diagnostics of neurological disorders Powerful monophasic stimulus Ergonomic and lightweight coils of different shapes and sizes Configurations for single
More informationNeuro-MS/D DIAGNOSTICS REHABILITATION TREATMENT STIMULATION. Transcranial Magnetic Stimulator. of motor disorders after the stroke
Neuro-MS/D Transcranial Magnetic Stimulator DIAGNOSTICS of corticospinal pathway pathology REHABILITATION of motor disorders after the stroke TREATMENT of depression and Parkinson s disease STIMULATION
More informationNon-therapeutic and investigational uses of non-invasive brain stimulation
Non-therapeutic and investigational uses of non-invasive brain stimulation Robert Chen, MA, MBBChir, MSc, FRCPC Catherine Manson Chair in Movement Disorders Professor of Medicine (Neurology), University
More informationThe Central Nervous System
The Central Nervous System Cellular Basis. Neural Communication. Major Structures. Principles & Methods. Principles of Neural Organization Big Question #1: Representation. How is the external world coded
More informationAdvAnced TMS. Research with PowerMAG Products and Application Booklet
AdvAnced TMS Research with PowerMAG Products and Application Booklet Table of ConTenTs Introduction p. 04 Legend p. 06 Applications» navigated TMS p. 08» clinical Research p. 10» Multi-Modal TMS p. 12»
More informationNeuro-MS/D Transcranial Magnetic Stimulator
Neuro-MS/D Transcranial Magnetic Stimulator 20 Hz stimulation with 100% intensity Peak magnetic field - up to 4 T High-performance cooling: up to 10 000 pulses during one session Neuro-MS.NET software
More informationThe neurolinguistic toolbox Jonathan R. Brennan. Introduction to Neurolinguistics, LSA2017 1
The neurolinguistic toolbox Jonathan R. Brennan Introduction to Neurolinguistics, LSA2017 1 Psycholinguistics / Neurolinguistics Happy Hour!!! Tuesdays 7/11, 7/18, 7/25 5:30-6:30 PM @ the Boone Center
More informationBME 701 Examples of Biomedical Instrumentation. Hubert de Bruin Ph D, P Eng
BME 701 Examples of Biomedical Instrumentation Hubert de Bruin Ph D, P Eng 1 Instrumentation in Cardiology The major cellular components of the heart are: working muscle of the atria & ventricles specialized
More informationAUTOCORRELATION AND CROSS-CORRELARION ANALYSES OF ALPHA WAVES IN RELATION TO SUBJECTIVE PREFERENCE OF A FLICKERING LIGHT
AUTOCORRELATION AND CROSS-CORRELARION ANALYSES OF ALPHA WAVES IN RELATION TO SUBJECTIVE PREFERENCE OF A FLICKERING LIGHT Y. Soeta, S. Uetani, and Y. Ando Graduate School of Science and Technology, Kobe
More informationTranscranial Magnetic Stimulation in the investigation and treatment of schizophrenia: a review
Schizophrenia Research 71 (2004) 1 16 www.elsevier.com/locate/schres Transcranial Magnetic Stimulation in the investigation and treatment of schizophrenia: a review H. Magnus Haraldsson*, Fabio Ferrarelli,
More informationThe Nervous System. Neuron 01/12/2011. The Synapse: The Processor
The Nervous System Neuron Nucleus Cell body Dendrites they are part of the cell body of a neuron that collect chemical and electrical signals from other neurons at synapses and convert them into electrical
More informationQuick Guide - eabr with Eclipse
What is eabr? Quick Guide - eabr with Eclipse An electrical Auditory Brainstem Response (eabr) is a measurement of the ABR using an electrical stimulus. Instead of a traditional acoustic stimulus the cochlear
More informationBeyond Blind Averaging: Analyzing Event-Related Brain Dynamics. Scott Makeig. sccn.ucsd.edu
Beyond Blind Averaging: Analyzing Event-Related Brain Dynamics Scott Makeig Institute for Neural Computation University of California San Diego La Jolla CA sccn.ucsd.edu Talk given at the EEG/MEG course
More informationCombining tdcs and fmri. OHMB Teaching Course, Hamburg June 8, Andrea Antal
Andrea Antal Department of Clinical Neurophysiology Georg-August University Goettingen Combining tdcs and fmri OHMB Teaching Course, Hamburg June 8, 2014 Classical Biomarkers for measuring human neuroplasticity
More informationTranscranial Magnetic Stimulation
Transcranial Magnetic Stimulation Date of Origin: 7/24/2018 Last Review Date: 7/24/2018 Effective Date: 08/01/18 Dates Reviewed: 7/24/2018 Developed By: Medical Necessity Criteria Committee I. Description
More informationCONTENTS. Foreword George H. Kraft. Henry L. Lew
EVOKED POTENTIALS Foreword George H. Kraft xi Preface Henry L. Lew xiii Overview of Artifact Reduction and Removal in Evoked Potential and Event-Related Potential Recordings 1 Martin R. Ford, Stephen Sands,
More informationORIGINAL ARTICLE. Therapeutic Efficacy of Right Prefrontal Slow Repetitive Transcranial Magnetic Stimulation in Major Depression
Therapeutic Efficacy of Right Prefrontal Slow Repetitive Transcranial Magnetic Stimulation in Major Depression A Double-blind Controlled Study ORIGINAL ARTICLE Ehud Klein, MD; Isabella Kreinin, MD; Andrei
More informationEvent-Related Potentials Recorded during Human-Computer Interaction
Proceedings of the First International Conference on Complex Medical Engineering (CME2005) May 15-18, 2005, Takamatsu, Japan (Organized Session No. 20). Paper No. 150, pp. 715-719. Event-Related Potentials
More informationThe Verification of ABR Response by Using the Chirp Stimulus in Moderate Sensorineural Hearing Loss
Med. J. Cairo Univ., Vol. 81, No. 2, September: 21-26, 2013 www.medicaljournalofcairouniversity.net The Verification of ABR Response by Using the Chirp Stimulus in Moderate Sensorineural Hearing Loss SOHA
More informationPsychoBrain. 31 st January Dr Christos Pliatsikas. Lecturer in Psycholinguistics in Bi-/Multilinguals University of Reading
PsychoBrain 31 st January 2018 Dr Christos Pliatsikas Lecturer in Psycholinguistics in Bi-/Multilinguals University of Reading By the end of today s lecture you will understand Structure and function of
More informationPremotor transcranial direct current stimulation (tdcs) affects primary motor excitability in humans
European Journal of Neuroscience, Vol. 27, pp. 1292 1300, 2008 doi:10.1111/j.1460-9568.2008.06090.x Premotor transcranial direct current stimulation (tdcs) affects primary motor excitability in humans
More informationIs There Evidence for Effectiveness of Transcranial Magnetic Stimulation in the Treatment of Psychiatric Disorders?
[EVIDENCE-BASED PHARMACOLOGY] by BIJU BASIL, MD, DPM; JAMAL MAHMUD, MD, DPM; MAJU MATHEWS, MD, MRCPsych, DIP PSYCH; CARLOS RODRIGUEZ, MD; and BABATUNDE ADETUNJI, MD, DPM Dr. Basil is a resident, Dr. Mahmud
More informationInvestigational basis of clinical neurophysiology. Edina Timea Varga MD, PhD Department of Neurology, University of Szeged 27th October 2015
Investigational basis of clinical neurophysiology Edina Timea Varga MD, PhD Department of Neurology, University of Szeged 27th October 2015 What is clinical neurophysiology? ? What is clinical neurophysiology?
More informationTMS: Full Board or Expedited?
TMS: Full Board or Expedited? Transcranial Magnetic Stimulation: - Neurostimulation or neuromodulation technique based on the principle of electro-magnetic induction of an electric field in the brain.
More informationResearch Perspectives in Clinical Neurophysiology
Research Perspectives in Clinical Neurophysiology A position paper of the EC-IFCN (European Chapter of the International Federation of Clinical Neurophysiology) representing ~ 8000 Clinical Neurophysiologists
More informationNeuromodulation Approaches to Treatment Resistant Depression
1 Alternative Treatments: Neuromodulation Approaches to Treatment Resistant Depression Audrey R. Tyrka, MD, PhD Assistant Professor Brown University Department of Psychiatry Associate Chief, Mood Disorders
More informationCorticomotor representation of the sternocleidomastoid muscle
braini0203 Corticomotor representation of the sternocleidomastoid muscle Brain (1997), 120, 245 255 M. L. Thompson, 1,2 G. W. Thickbroom 1,2 and F. L. Mastaglia 1,2,3 1 Australian Neuromuscular Research
More informationBiomarkers in Schizophrenia
Biomarkers in Schizophrenia David A. Lewis, MD Translational Neuroscience Program Department of Psychiatry NIMH Conte Center for the Neuroscience of Mental Disorders University of Pittsburgh Disease Process
More information1. Introduction. Sung-Ryoung Ma 1 and Bo-Kyoung Song 2 *
Journal of Magnetics 23(4), 617-623 (2018) ISSN (Print) 1226-1750 ISSN (Online) 2233-6656 https://doi.org/10.4283/jmag.2018.23.4.617 Effects of Hand Intrinsic Muscle Facilitation and Functional Task Training
More informationRecovery mechanisms from aphasia
Recovery mechanisms from aphasia Dr. Michal Ben-Shachar 977 Acquired language and reading impairments 1 Research questions Which brain systems can support recovery from aphasia? Which compensatory route
More informationINFLUENCE OF SI ON INTERHEMISPHERIC INHIBITION
INFLUENCE OF SI ON INTERHEMISPHERIC INHIBITION INFLUENCE OF PRIMARY SOMATOSENSORY CORTEX ON INTERHEMISPHERIC INHIBITION BY CHRISTOPHER M. ZAPALLOW, B.SC. A Thesis Submitted to the School of Graduate Studies
More informationRapid Transcranial Magnetic Stimulation (rtms) and Normalisation of the
1 Rapid Transcranial Magnetic Stimulation (rtms) and Normalisation of the Dexamethasone Suppression Test (DST). Short Title: Normalisation of DST with rtms Saxby Pridmore, M.D Department of Psychological
More informationPriming Stimulation Enhances the Depressant Effect of Low- Frequency Repetitive Transcranial Magnetic Stimulation
The Journal of Neuroscience, November 26, 2003 23(34):10867 10872 10867 Behavioral/Systems/Cognitive Priming Stimulation Enhances the Depressant Effect of Low- Frequency Repetitive Transcranial Magnetic
More informationShort-latency sensory afferent inhibition: conditioning stimulus intensity, recording site, and effects of 1 Hz repetitive TMS
UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF Aus dem Kopf- und Neurozentrum Klinik und Poliklinik für Neurologie Klinikdirektor: Prof. Dr. med. Christian Gerloff Short-latency sensory afferent inhibition: conditioning
More informationA pilot study of the use of EEG-based synchronized Transcranial Magnetic Stimulation (stms) for treatment of Major Depression
Jin and Phillips BMC Psychiatry 2014, 14:13 RESEARCH ARTICLE Open Access A pilot study of the use of EEG-based synchronized Transcranial Magnetic Stimulation (stms) for treatment of Major Depression Yi
More informationWhat is NBS? Nextstim NBS System
Nextstim NBS System What is NBS? NBS means navigated brain stimulation, and is used to precisely map the areas controlling muscle movements/activity in the brain. This procedure provides advanced patient
More informationNeural Correlates of Human Cognitive Function:
Neural Correlates of Human Cognitive Function: A Comparison of Electrophysiological and Other Neuroimaging Approaches Leun J. Otten Institute of Cognitive Neuroscience & Department of Psychology University
More informationTranscranial direct current stimulation modulates shifts in global/local attention
University of New Mexico UNM Digital Repository Psychology ETDs Electronic Theses and Dissertations 2-9-2010 Transcranial direct current stimulation modulates shifts in global/local attention David B.
More informationResistant Against De-depression: LTD-Like Plasticity in the Human Motor Cortex Induced by Spaced ctbs
Cerebral Cortex July 2015;25:1724 1734 doi:10.1093/cercor/bht353 Advance Access publication January 31, 2014 Resistant Against De-depression: LTD-Like Plasticity in the Human Motor Cortex Induced by Spaced
More informationRhythm and Rate: Perception and Physiology HST November Jennifer Melcher
Rhythm and Rate: Perception and Physiology HST 722 - November 27 Jennifer Melcher Forward suppression of unit activity in auditory cortex Brosch and Schreiner (1997) J Neurophysiol 77: 923-943. Forward
More informationABR assesses the integrity of the peripheral auditory system and auditory brainstem pathway.
By Prof Ossama Sobhy What is an ABR? The Auditory Brainstem Response is the representation of electrical activity generated by the eighth cranial nerve and brainstem in response to auditory stimulation.
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our
More informationMagnetic stimulation at acupoints relieves mental fatigue: An Event Related Potential (P300) study
Technology and Health Care 25 (2017) S157 S165 DOI 10.3233/THC-171318 IOS Press S157 Magnetic stimulation at acupoints relieves mental fatigue: An Event Related Potential (P300) study Shuo Yang a, Yanyun
More informationTMS Disruption of Time Encoding in Human Primary Visual Cortex Molly Bryan Beauchamp Lab
TMS Disruption of Time Encoding in Human Primary Visual Cortex Molly Bryan Beauchamp Lab This report details my summer research project for the REU Theoretical and Computational Neuroscience program as
More informationSeeing through the tongue: cross-modal plasticity in the congenitally blind
International Congress Series 1270 (2004) 79 84 Seeing through the tongue: cross-modal plasticity in the congenitally blind Ron Kupers a, *, Maurice Ptito b www.ics-elsevier.com a Center for Functionally
More informationMovimento volontario dell'arto superiore analisi, perturbazione, ottimizzazione
Movimento volontario dell'arto superiore analisi, perturbazione, ottimizzazione Antonio Currà UOS Neurologia Universitaria, Osp. A. Fiorini, Terracina UOC Neuroriabilitazione ICOT, Latina, Dir. Prof. F.
More informationMENTAL WORKLOAD AS A FUNCTION OF TRAFFIC DENSITY: COMPARISON OF PHYSIOLOGICAL, BEHAVIORAL, AND SUBJECTIVE INDICES
MENTAL WORKLOAD AS A FUNCTION OF TRAFFIC DENSITY: COMPARISON OF PHYSIOLOGICAL, BEHAVIORAL, AND SUBJECTIVE INDICES Carryl L. Baldwin and Joseph T. Coyne Department of Psychology Old Dominion University
More informationIntensive Course in Transcranial Magnetic Stimulation, Oct 29 Nov 2, 2012
MONDAY, OCTOBER 9, 0 8:30 AM 9:00 AM Introduction to the TMS Intensive Course ; Dylan Edwards, PhD 9:00 AM 0:30 AM TMS: Introduction, Mechanisms of Action, and Equipment, Part 0:45 AM :00 PM TMS: Introduction,
More informationModulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation
Kojima et al. BMC Neuroscience 2013, 14:43 RESEARCH ARTICLE Open Access Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation Sho Kojima 1,2*,
More informationBrain and Cognition. Cognitive Neuroscience. If the brain were simple enough to understand, we would be too stupid to understand it
Brain and Cognition Cognitive Neuroscience If the brain were simple enough to understand, we would be too stupid to understand it 1 The Chemical Synapse 2 Chemical Neurotransmission At rest, the synapse
More informationSupplemental Data. Brain Oscillatory Substrates. of Visual Short-Term Memory Capacity
Current Biology, Volume 19 Supplemental Data Brain Oscillatory Substrates of Visual Short-Term Memory Capacity Paul Sauseng, Wolfgang Klimesch, Kirstin F. Heise, Walter R. Gruber, Elisa Holz, Ahmed A.
More informationQuick review of neural excitability. Resting Membrane Potential. BRAIN POWER: non-invasive brain stimulation in neurorehabilitation
BRAIN POWER: non-invasive brain stimulation in neurorehabilitation Quick review of neural excitability Edelle [Edee] Field-Fote, PT, PhD, FAPTA Director of Spinal Cord Injury Research Shepherd Center Crawford
More informationModulation of single motor unit discharges using magnetic stimulation of the motor cortex in incomplete spinal cord injury
1 SHORT REPORT Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London W 8RF, UK H C Smith NJDavey D W Maskill P H Ellaway National Spinal
More informationIntraoperative Monitoring: Role in Epilepsy Based Tumor Surgery December 2, 2012
Intraoperative Monitoring: Role in Epilepsy Based Tumor Surgery December 2, 2012 Aatif M. Husain, M.D. Duke University and Veterans Affairs Medical Centers, Durham, NC American Epilepsy Society Annual
More informationSupplementary figure: Kantak, Sullivan, Fisher, Knowlton and Winstein
Supplementary figure: Kantak, Sullivan, Fisher, Knowlton and Winstein Supplementary figure1 : Motor task and feedback display during practice (A) Participants practiced an arm movement task aimed to match
More informationMagPro by MagVenture. Versatility in Magnetic Stimulation
MagPro by MagVenture Versatility in Magnetic Stimulation MagPro A proven Record of Innovation With 7 different magnetic stimulators and 27 different coils, the MagPro line from MagVenture provides the
More informationModifying the Classic Peak Picking Technique Using a Fuzzy Multi Agent to Have an Accurate P300-based BCI
Modifying the Classic Peak Picking Technique Using a Fuzzy Multi Agent to Have an Accurate P3-based BCI Gholamreza Salimi Khorshidi School of cognitive sciences, Institute for studies in theoretical physics
More informationNeurotherapy and Neurofeedback, as a research field and evidence-based practice in applied neurophysiology, are still unknown to Bulgarian population
[6] MathWorks, MATLAB and Simulink for Technical Computing. Available: http://www.mathworks.com (accessed March 27, 2011) [7] Meyer-Baese U., (2007), Digital Signal Processing with Field Programmable Gate
More informationMagPro by MagVenture. Versatility in Magnetic Stimulation
MagPro by MagVenture Versatility in Magnetic Stimulation MagPro A proven record of innovation With 7 different magnetic stimulators and 33 different coils, the MagPro line from MagVenture provides the
More informationOpposite Effects of High and Low Frequency rtms on Regional Brain Activity in Depressed Patients
Opposite Effects of High and Low Frequency rtms on Regional Brain Activity in Depressed Patients Andrew M. Speer, Timothy A. Kimbrell, Eric M. Wassermann, Jennifer D. Repella, Mark W. Willis, Peter Herscovitch,
More informationBOTULINUM TOXIN: RESEARCH ISSUES ARISING FROM PRACTICE
% of baseline CMAP Botulinum toxin: mechanism of action BOTULINUM TOXIN: RESEARCH ISSUES ARISING FROM PRACTICE Clinical benefits of botulinum toxin (BT) injections depend primarily on the toxin's peripheral
More informationTranscranial Magnetic Stimulaton: In-Depth Review of Methods, Efficacy and Future Applications
South Dakota State University Open PRAIRIE: Open Public Research Access Institutional Repository and Information Exchange Biology and Microbiology Graduate Students Plan B Research Projects Department
More informationPridmore S. Download of Psychiatry, Chapter 29. Last modified: September,
Pridmore S. Download of Psychiatry, Chapter 29. Last modified: September, 2017. 1 CHAPTER 29 TRANSCRANIAL MAGNETIC STIMULATION (TMS) Introduction ECT demonstrates that, for certain psychiatric disorders,
More informationBrian A. Coffman, PhD
Brian A. Coffman, PhD Research Instructor Department of Psychiatry University of Pittsburgh School of Medicine UPMC Western Psychiatric Hospital Pittsburgh, PA Dr. Brian Coffman is a Research Instructor
More informationMapping the cortical representation of the lumbar paravertebral muscles. NE O Connell MSc Centre for Research in Rehabilitation, Brunel University
Mapping the cortical representation of the lumbar paravertebral muscles NE O Connell MSc Centre for Research in Rehabilitation, Brunel University DW Maskill MPhil Centre for Research in Rehabilitation
More informationCan brain stimulation help with relearning movement after stroke?
stroke.org.uk Final report summary Can brain stimulation help with relearning movement after stroke? The effect of transcranial direct current stimulation on motor learning after stroke PROJECT CODE: TSA
More informationAn Overview of BMIs. Luca Rossini. Workshop on Brain Machine Interfaces for Space Applications
An Overview of BMIs Luca Rossini Workshop on Brain Machine Interfaces for Space Applications European Space Research and Technology Centre, European Space Agency Noordvijk, 30 th November 2009 Definition
More informationStudying the time course of sensory substitution mechanisms (CSAIL, 2014)
Studying the time course of sensory substitution mechanisms (CSAIL, 2014) Christian Graulty, Orestis Papaioannou, Phoebe Bauer, Michael Pitts & Enriqueta Canseco-Gonzalez, Reed College. Funded by the Murdoch
More informationThe Journal of Physiology Neuroscience
J Physiol 591.19 (2013) pp 4903 4920 4903 The Journal of Physiology Neuroscience Microcircuit mechanisms involved in paired associative stimulation-induced depression of corticospinal excitability David
More informationLeon Grunhaus, Pinhas N. Dannon, Shaul Schreiber, Ornah H. Dolberg, Revital Amiaz, Reuven Ziv, and Eli Lefkifker
Repetitive Transcranial Magnetic Stimulation Is as Effective as Electroconvulsive Therapy in the Treatment of Nondelusional Major Depressive Disorder: An Open Study Leon Grunhaus, Pinhas N. Dannon, Shaul
More informationLow frequency rtms effects on sensorimotor synchronization
Exp Brain Res (2005) 167: 238 245 DOI 10.1007/s00221-005-0029-7 RESEARCH ARTICLE Michail Doumas Æ Peter Praamstra Æ Alan M. Wing Low frequency rtms effects on sensorimotor synchronization Received: 12
More information