A gene expression bar code for microarray data

Transcription

1 A gene expression bar code for microarray data Michael J Zilliox & Rafael A Irizarry Supplementary figures and text: Supplementary Figure 1: Bar code heatmaps, dendrograms, and summaries. Supplementary Figure 2: Improved detection calls. Supplementary Figure 3: Demonstration of the lab effect and its removal by the bar code algorithm. Supplementary Figure 4: Example of the lab effect using clinical data. Supplementary Figure 5: Survival curves for breast cancer studies. Supplementary Table 1: CEL file name, GEO or ArrayExpress ID for file and experiment, and tissue type for the human samples. Supplementary Table 2: CEL file name, GEO or ArrayExpress ID for file and experiment, and tissue type for the mouse samples. Supplementary Table 3: Percentage accuracy comparison. Supplementary Table 4: Multivariable analysis of breast cancer prognostic factors. Supplementary Table 5: Odds ratio for metastasis within five years as a first event, according to the bar code prognosis. Supplementary Table 6: As Table 2 but using relative distance from the good bar code as a continuous covariate. Supplementary Methods Supplementary Results

2 Memory T cells Kidney HEK 721 B lymphoblast CL Adrenal Gland Atrial myocardium Amygdala Ventricular apex Appendix Atrioventriculr Node Bronchial epithelia Early Progenitor Bone marrow CD34+ Bone Marrow Caudate nucleus Stem Cells Naive CD4 cells Single + CD4 cells Cerebellum Cerebellum peduncles Ciliary ganglion Colorectal adenocar T cells Cultured adipocyte Lung DRG Fetal Brain Fetal Lung Fetal Thyroid Kidney Hippocampus EsophagealEpithelium Vastus lateralis Myometrium Bladder Testis EmbryoncSktlMyoblst HairFollicleBulge HairFollicleSubBulge OralSquamsCellEpithe Myoblasts HSC Frontal Cortex I 6 ES SSEA+ I 6 ES SSEA HSC FB +/+ HSC MB +/+ HSC FB +/ HSC CB +/ HSC CB +/+ HSC BM +/+ HSC BM +/ Fibroblast HBEC Heart HMEC HUVEC Hypothalamus bronchial epithelial Intervertebral disc Islet K562 Cell line Leukemia (K562) Leukemia (MOLT4) Leukemia (HL 60) Liver Lymph Node LymphomaBurkittsDaud LymphomaRaji Medulla Oblongata Hep 2 Colonic mucosal(ibs) Skeletal muscle Occipital Lobe Olfactory Bulb Ovary Pancreas Parietal Lobe CD4 T cell CD8 T cell Placenta Pons Prefrontal Cortex Prostate Quadriceps femoris Salivary Gland Skin Smooth Muscle Spinal Cord Subthalamic Nucleus SupCervicalGanglion Temporal Lobe Testi Germ Cell Testi Intersitial TestiSeminiferTubule Thalamus Theca cells Thymus Thyroid Tongue Tonsil IntrthymicTCelProgen Trachea Trigeminal Ganglion Uterus VentricularMyocrdium CD71 Early Erythroid Progenitor 721 B lymphoblast cell line K562 Cell line Leukemia Chronic Myelogenous (K562) T cells CD4 T cell CD8 T cell Memory T cells Bone marrow CD34+ Stem Cells (Umbilical Cord CD34+) Hematopoietic stem cells Hematopoeitic stem cell BM +/+ Hematopoeitic stem cell BM +/ Hematopoeitic stem cell FB +/ Hematopoeitic stem cell CB +/ Hematopoeitic stem cell CB +/+ Hematopoeitic stem cell FB +/+ Hematopoeitic stem cell MB +/+ Intrathymic T cell progenitors Naive CD4 cells Single positive CD4 cells Testis Testi Germ Cell Testi Intersitial Testi Seminiferous Tubule Fetal Brain Cerebellum Cerebellum peduncles Thalamus Pons Medulla Oblongata Parietal Lobe Subthalamic Nucleus Temporal Lobe Frontal Cortex Amygdala Occipital Lobe Prefrontal Cortex Hippocampus Caudate nucleus Hypothalamus Kidney Colonic mucosal (IBS) Hair follicle bulge Hair follicle sub bulge HBEC Normal Esophageal epithelium Oral squamous cell epithelium 293 cells (Kidney HEK) I 6 ES SSEA+ I 6 ES SSEA Hep 2 HUVEC Fibroblast Skeletal myoblast, embryonic Myoblasts HMEC IB3 1 bronchial epithelial cells Liver Quadriceps femoris muscle Vastus lateralis Skeletal muscle Atrial myocardium Left ventricular apex samples Ventricular myocardium Bronchial epithelia Colorectal adenocarcinoma Leukemia Lymphoblastic (MOLT4) Lymphoma Raji Leukemia Promyelocytic (HL 60) Lymphoma Burkitts Daudi Bone Marrow Thymus Lymph Node Tonsil Olfactory Bulb Spinal Cord Appendix Superior Cervical Ganglion Trigeminal Ganglion Atrioventricular Node Ciliary ganglion DRG Heart Tongue Fetal Thyroid Thyroid Islet Pancreas Skin Adrenal Gland Ovary Salivary Gland Trachea Bladder Prostate Placenta Lung Fetal Lung Intervertebral disc Smooth Muscle Theca cells Cultured adipocyte Myometrium Uterus Height 500 Supplemental Figure 1A Supplemental Figure 1B Bar code heatmaps, dendrograms, and summaries. A) Dendrogram obtained by using hierarchical clustering on the human bar code. The color bars below denote 16 clusters defined based on proximity (distance defined in the text). B) A heatmap was created for the human genes. The cluster dendrogram for the columns (samples) is shown in A). The cluster dendrogram for the genes is omitted for clarity.

3 CD4 T cells CD8 T cells B cells Aorta Motorneurons Atrium Ventricle Heart Naive B cell Plasma cell Germinal Center Memory B cell Lung Hippocampus Extraocular muscle Leg muscle Prostate Oviduct Uterus Vagina Neural Stem Cell Fat Stem Cell Dermis Stem Cell Forelimb autopod Hindlimb autopod Cingulate Cortex Somatosensory Cortex Lateral Geniculate N Amygdala Lumbar Spinal Cord Embryonic Fibroblast Cornea Fibroblast Skin Fibroblast Tendon Fibroblast Muscle Muscle derived stem Hypothalamus Liver Kidney Testis Ovary Skin Hematopoetic precurs Sorted Bone Marrow Testis B cells CD4 T cells CD8 T cells Plasma cell Germinal Center Naive B cell Memory B cell Liver Kidney Lumbar Spinal Cord Hypothalamus Lateral Geniculate Nucleus Amygdala Cingulate Cortex Somatosensory Cortex Motorneurons Hippocampus Atrium Ventricle Extraocular muscle Leg muscle Forelimb autopod Hindlimb autopod Vagina Oviduct Uterus Aorta Lung Skin Hematopoetic precursor Sorted Bone Marrow Heart Muscle Neural Stem Cell Cornea Fibroblast Skin Fibroblast Tendon Fibroblast Muscle derived stem cell Embryonic Fibroblast Fat Stem Cell Dermis Stem Cell Prostate Ovary Supplemental Figure 1C Supplemental Figure 1D C) As A) but for the mouse. D) As B) but for mouse.

4 Number of expressed genes (out of 2545) Dog Lymphoma Raji Atrioventricular Node Lymphoma Burkitts Daudi Ovary Leukemia Promyelocytic (HL 60) Leukemia Lymphoblastic (MOLT4) Leukemia Chronic Myelogenous (K562) Colorectal adenocarcinoma DRG Adrenal Gland Skin Ciliary ganglion Salivary Gland Trigeminal Ganglion Heart Superior Cervical Ganglion Fetal Thyroid prostate stromal cells:cancer Pancreas Olfactory Bulb Bone Marrow Tonsil Testi Seminiferous Tubule Cultured adipocyte Lymph Node Uterus Islet Hematopoietic stem cells IB3 1 bronchial epithelial cells HBEC Bladder Smooth Muscle Pons Thymus CD71 Early Erythroid Progenitor CD4 T cell Prostate Theca cells Spinal Cord Tongue Hematopoeitic stem cell BM +/ Appendix Cerebellum peduncles Skeletal myoblast, embryonic Testi Germ Cell Testi Intersitial I 6 ES SSEA+ Parietal Lobe 293 cells (Kidney HEK) Temporal Lobe Bronchial epithelia CD8 T cell Hematopoeitic stem cell CB +/ Hematopoeitic stem cell CB +/+ prostate stromal cells Hematopoeitic stem cell BM +/+ 721 B lymphoblast cell line Hematopoeitic stem cell FB +/ Trachea Subthalamic Nucleus Thyroid Hematopoeitic stem cell MB +/+ K562 Cell line Hematopoeitic stem cell FB +/+ Thalamus Fetal Brain HUVEC Myoblasts Liver Fetal Lung Medulla Oblongata Naive CD4 cells I 6 ES SSEA Hair follicle bulge Myometrium Occipital Lobe Quadriceps femoris muscle Intervertebral disc Bladder:sTCC Hair follicle sub bulge Oral squamous cell epithelium Stem Cells (Umbilical Cord CD34+) Prefrontal Cortex Placenta Single positive CD4 cells HMEC T cells Breast:Tumor Fibroblast Intrathymic T cell progenitors Kidney:Cancer Ventricular myocardium Amygdala Vastus lateralis Hep 2 Hippocampus:Severe Bone marrow CD34+ Skeletal muscle Bladder:mTCC Cerebellum Left ventricular apex samples Colonic mucosal (IBS) Frontal Cortex Caudate nucleus Hypothalamus Atrial myocardium Esophageal epithelium Hippocampus:Incipient Hippocampus:Moderate Kidney Lung Testis Esophageal epithelium:adenocarcinoma Hippocampus Memory T cells Esophageal epithelium:barrett s Supplemental Figure 1E Human Tissues Supplemental Figure 1F Human Number of Tissues in which gene is expressed E) For each of the tissues represented in the human data, we display the number of genes that are expressed. F) The histogram shows the number of genes that are present in exactly 1 tissues, 2 tissues, 3 tissues, etc... Number of genes

5 Embryonic Fibroblast Neural Stem Cell Sorted Bone Marrow Dermis Stem Cell Fat Stem Cell Muscle derived stem cell Hematopoetic precursor Prostate Lateral Geniculate Nucleus Muscle Tendon Fibroblast Skin Fibroblast Cornea Fibroblast Cingulate Cortex Hindlimb autopod Extraocular muscle Amygdala Forelimb autopod Somatosensory Cortex Leg muscle Skin Uterus Heart Motorneurons Oviduct Ovary Plasma cell Vagina Ventricle Lumbar Spinal Cord Aorta Hippocampus B cells Hypothalamus Naive B cell Germinal Center Memory B cell Atrium Kidney CD4 T cells CD8 T cells Liver Lung Testis Number of expressed genes (out of 5031) Supplemental Figure 1G Mouse Tissues Supplemental Figure 1H Mouse Number of Tissues in which gene is expressed G) As E) but for mouse. H) As F) but for mouse. Number of genes

6 Kidney HEK Atrial myocardium Ventricular apex Bronchial epithelia Bone marrow CD34+ Caudate nucleus Stem Cells Cerebellum T cells Lung Kidney Hippocampus EsophagealEpithelium Myometrium Testis HairFollicleBulge HairFollicleSubBulge Frontal Cortex Fibroblast Hypothalamus K562 Cell line Colonic mucosal(ibs) VentricularMyocrdium Genes Kidney HEK Atrial myocardium Ventricular apex Bronchial epithelia Bone marrow CD34+ Caudate nucleus Stem Cells Cerebellum T cells Lung Kidney Hippocampus EsophagealEpithelium Myometrium Testis HairFollicleBulge HairFollicleSubBulge Frontal Cortex Fibroblast Hypothalamus K562 Cell line Colonic mucosal(ibs) VentricularMyocrdium Genes Supplemental Figure 2A Supplemental Figure 2B Improved detection calls. A) For 100 randomly chosen human genes we show the manufacturers present, marginal and absent calls represented with blue, light blue and white respectively for tissues with five or more samples. B) As A) but for the bar code. White represents expressed and blue not expressed.

7 CD4 T cells CD8 T cells B cells Motorneurons Heart Hippocampus Prostate Cingulate Cortex Amygdala Muscle Hypothalamus Liver Kidney Testis Ovary Hematopoetic precurs Sorted Bone Marrow Genes CD4 T cells CD8 T cells B cells Motorneurons Heart Hippocampus Prostate Cingulate Cortex Amygdala Muscle Hypothalamus Liver Kidney Testis Ovary Hematopoetic precurs Sorted Bone Marrow Genes Supplemental Figure 2C Supplemental Figure 2D C) As A) but for mouse. D) As B) but for mouse.

8 Supplemental Figure 2E % agreement Affymetrix PMA Barcode % called present E) We obtained approximate expressed gene lists by analyzing protein data in mouse heart, hypothalamus, kidney, liver, and lung samples. By matching the reported proteins to Affymetrix gene IDs we ended up with 1652, 2243, 1699, 1728, and 2686 genes expected to be expressed in each tissue, respectively. We then computed the present/absent calls using various thresholds for the MAS 5.0 and bar code approaches. For each cut-off we determined the percentage of the known positives (from the protein data) called present (agreement) and the total number of genes called present. Here we plot agreement versus percentage called present.

9 Supplemental Figure 3 A) Log intensity correlations GSE1922 GSE1148 GSE3823 GSE3790 GSE3419 GSE2666 GSE994 GSE2240 E AFMX 5 B) Barcode correlations GSE1922 GSE1148 GSE3823 GSE3790 GSE3419 GSE2666 GSE994 GSE2240 E AFMX 5 E AFMX 5 GSE2240 GSE994 GSE2666 GSE3419 GSE3790 GSE3823 GSE1148 GSE Demonstration of the lab effect and its removal by the bar code algorithm. The correlation between every pair of samples from studies containing 10 or more arrays is shown in different shades of blue (negative correlation in red). For each gene the across-sample mean value was subtracted from the expression. The different studies are divided by black lines and labeled in the axes. In A) the blue high-correlation block on the bottom left demonstrates the lab effect. Most of the tissues in that study are completely different types and therefore the lab effect must be driving the high correlation. B) The same plot but using the bar code to define correlation.

10 Supplemental Figure 4A 08/15/02 08/15/02 08/15/02 08/15/02 05/28/02 05/22/02 06/04/02 05/28/02 Dyrskjot et al. find a difference between CIS+ and CIS- samples. We selected the 244 genes with p-values smaller than 10-6 when comparing these sample types using a t-test, and used these genes to perform hierarchical clustering using the expression data on the normal samples. These samples perfectly clustered by date. A) The green and orange bars under the dendrogram represent the samples hybridized on May/June 2002 and August 2002 respectively. The same clustering occurred for p-value cut-offs of 10 5, 10 4, and 10 3.

11 Figure 4B-C A B Normal 05/02 Normal 08/02 CIS+ CIS Log (base 2) Intensity Log (base 2) Intensity B) Across sample gene expression estimates distributions (as in Figure 1) for a gene (NM ) showing a highly significant difference between CIS+ and CIS-. The green and orange ticks shown above the plot represent the observed intensities for the normal samples hybridized on May/June 2002 and August 2002 respectively. The purple and green ticks on the bottom of the plot represent the intensities for the CIS+ and CIS- samples respectively. The vertical line is automatically drawn by the bar code method and distinguishes the intensity range associated with expressed and unexpressed genes. The bar code considers this gene to be unexpressed in all these samples. C) As B) for gene U80736 which does not show a significant difference between conditions of interest yet is expressed in most cancer samples and unexpressed in all normal samples.

12 A Supplemental Figure 5 B Proportion still alive Bad prognosis Good prognosis p= Proportion without recurrence Bad prognosis Good prognosis p= Years C Years Proportion still alive Bad prognosis Good prognosis p= Years Two new bar codes were created based on the breast cancer tumors more similar to normal and cancer tissues respectively (described in text). These were denoted the good prognosis and bad prognosis bar codes. Each of the 500 breast tumor samples were classified into either good or bad prognosis using the minimum distance. Notice the survival data was not used to define the bar codes nor to classify the samples. A) Survival curves for good prognosis and bad prognosis groups for the data used in the survival studies described by: Miller et al. and Pawitan et al. B) As A) but for relapse-free survival time data described by Sotiriou et al. C) As A) but only for the Miller et al. data.

13 Supplementary Table 1 CEL file name, GEO or ArrayExpress ID for file and experiment, and tissue type for the human samples. This table is provided as a tab delimited file.

14 Experiment_ID Sample_ID Tissue E-MEXP nr.1 Memory T cells E-MEXP nr.16 Memory T cells E-MEXP nr.6 Memory T cells GSE1455 GSM cells (Kidney HEK) GSE1455 GSM cells (Kidney HEK) GSE1455 GSM cells (Kidney HEK) GSE1455 GSM cells (Kidney HEK) GSE1455 GSM cells (Kidney HEK) E-AFMX-5 3AMH B lymphoblast cell line E-AFMX-5 3AMH B lymphoblast cell line E-AFMX-5 3AJZ Adrenal Gland E-AFMX-5 3AJZ Adrenal Gland GSE2240 GSM40980 Atrial myocardium GSE2240 GSM40989 Atrial myocardium GSE2240 GSM40981 Atrial myocardium GSE2240 GSM40982 Atrial myocardium GSE2240 GSM40983 Atrial myocardium GSE2240 GSM40984 Atrial myocardium GSE2240 GSM40985 Atrial myocardium GSE2240 GSM40986 Atrial myocardium GSE2240 GSM40987 Atrial myocardium GSE2240 GSM40988 Atrial myocardium GSE2240 GSM40990 Atrial myocardium GSE2240 GSM40999 Atrial myocardium GSE2240 GSM41000 Atrial myocardium GSE2240 GSM41001 Atrial myocardium GSE2240 GSM41002 Atrial myocardium GSE2240 GSM41003 Atrial myocardium GSE2240 GSM41004 Atrial myocardium GSE2240 GSM41005 Atrial myocardium GSE2240 GSM41006 Atrial myocardium GSE2240 GSM41007 Atrial myocardium GSE2240 GSM41008 Atrial myocardium GSE2240 GSM40991 Atrial myocardium GSE2240 GSM41009 Atrial myocardium GSE2240 GSM40992 Atrial myocardium GSE2240 GSM40993 Atrial myocardium GSE2240 GSM40994 Atrial myocardium GSE2240 GSM40995 Atrial myocardium GSE2240 GSM40996 Atrial myocardium GSE2240 GSM40997 Atrial myocardium GSE2240 GSM40998 Atrial myocardium E-AFMX-5 3AMH Amygdala E-AFMX-5 3AMH Amygdala GSE974 GSM14960 Left ventricular apex samples GSE974 GSM14962 Left ventricular apex samples GSE974 GSM14965 Left ventricular apex samples GSE974 GSM14967 Left ventricular apex samples GSE974 GSM14969 Left ventricular apex samples GSE974 GSM14973 Left ventricular apex samples E-AFMX-5 3AJZ a Appendix E-AFMX-5 3AJZ b Appendix E-AFMX-5 3ARS a Atrioventricular Node E-AFMX-5 3ARS b Atrioventricular Node GSE994 GSM15729 Bronchial epithelia GSE994 GSM15730 Bronchial epithelia

15 GSE994 GSM15731 Bronchial epithelia GSE994 GSM15732 Bronchial epithelia GSE994 GSM15733 Bronchial epithelia GSE994 GSM15734 Bronchial epithelia GSE994 GSM15735 Bronchial epithelia GSE994 GSM15736 Bronchial epithelia GSE994 GSM15719 Bronchial epithelia GSE994 GSM15737 Bronchial epithelia GSE994 GSM15738 Bronchial epithelia GSE994 GSM15739 Bronchial epithelia GSE994 GSM15740 Bronchial epithelia GSE994 GSM15721 Bronchial epithelia GSE994 GSM15726 Bronchial epithelia E-AFMX-5 3AMH CD71 Early Erythroid Progenitor E-AFMX-5 3AMH CD71 Early Erythroid Progenitor GSE2666 GSM51401 Bone marrow CD34+ GSE2666 GSM51403 Bone marrow CD34+ GSE2666 GSM51405 Bone marrow CD34+ GSE2666 GSM51407 Bone marrow CD34+ GSE2666 GSM51402 Bone marrow CD34+ GSE2666 GSM51404 Bone marrow CD34+ GSE2666 GSM51406 Bone marrow CD34+ GSE2666 GSM51408 Bone marrow CD34+ E-AFMX-5 3AJZ Bone Marrow E-AFMX-5 3AJZ Bone Marrow E-AFMX-5 3AJZ Caudate nucleus E-AFMX-5 3AJZ Caudate nucleus GSE2666 GSM51391 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51393 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51395 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51397 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51399 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51392 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51394 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51396 Stem Cells (Umbilical Cord CD34+) GSE2666 GSM51398 Stem Cells (Umbilical Cord CD34+) GSE1460 GSM24618 Na ve CD4 cells GSE1460 GSM24619 Na ve CD4 cells GSE1460 GSM24620 Na ve CD4 cells GSE1460 GSM24613 Single positive CD4 cells GSE1460 GSM24614 Single positive CD4 cells GSE1460 GSM24615 Single positive CD4 cells E-AFMX-5 3AJZ Cerebellum E-AFMX-5 3AJZ Cerebellum E-AFMX-5 3AJZ Cerebellum peduncles E-AFMX-5 3AJZ Cerebellum peduncles E-AFMX-5 3ARS a Ciliary ganglion E-AFMX-5 3ARS b Ciliary ganglion E-AFMX-5 3AMH Colorectal adenocarcinoma E-AFMX-5 3AMH Colorectal adenocarcinoma E-MEXP-76 CTR678~1 T cells E-MEXP-76 Ctr680 T cells E-MEXP-76 Ctr683 T cells E-MEXP-76 Ctr715 T cells E-MEXP-76 Ctr727 T cells E-MEXP-76 Ctr754 T cells E-AFMX-5 3AJZ Cultured adipocyte

16 E-AFMX-5 3AJZ Cultured adipocyte E-MEXP-231 DL15N Lung E-MEXP-231 DL4_11N Lung E-MEXP-231 DL4_17N Lung E-MEXP-231 DL4_1N Lung E-MEXP-231 DL4_7N Lung E-MEXP-231 DL50N Lung E-MEXP-231 DL67N Lung E-MEXP-231 DL79N Lung E-MEXP-231 DL86N Lung E-AFMX-5 3ARS e DRG E-AFMX-5 3ARS f DRG E-AFMX-5 3AJZ Fetal Brain E-AFMX-5 3AJZ Fetal Brain E-AFMX-5 3AJZ Fetal Lung E-AFMX-5 3AJZ Fetal Lung E-AFMX-5 3AJZ Fetal Thyroid E-AFMX-5 3AJZ Fetal Thyroid GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor

17 GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor

18 GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor

19 GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE1456 GSM Breast tumor GSE781 GSM11805 Kidney GSE781 GSM11814 Renal Clear Cell Carcinoma GSE781 GSM11823 Kidney GSE781 GSM11830 RCC GSE781 GSM12067 RCC GSE781 GSM12075 Kidney GSE781 GSM12079 RCC GSE781 GSM12098 Kidney GSE781 GSM12105 RCC GSE781 GSM12268 Kidney GSE781 GSM12270 RCC GSE781 GSM12283 Kidney GSE781 GSM12298 RCC GSE781 GSM12300 Kidney GSE781 GSM12399 RCC GSE781 GSM12444 Kidney GSE1297 GSM21203 Hippocampus GSE1297 GSM21204 Hippocampus GSE1297 GSM21205 Hippocampus GSE1297 GSM21206 Hippocampus GSE1297 GSM21207 Hippocampus GSE1297 GSM21208 Hippocampus GSE1297 GSM21209 Hippocampus GSE1297 GSM21210 Hippocampus GSE1297 GSM21212 Hippocampus GSE1297 GSM21213 Hippocampus GSE1297 GSM21214 Hippocampus GSE1297 GSM21215 Hippocampus GSE1297 GSM21216 Hippocampus GSE1297 GSM21217 Hippocampus GSE1297 GSM21218 Hippocampus GSE1297 GSM21219 Hippocampus GSE1297 GSM21220 Hippocampus GSE1297 GSM21221 Hippocampus GSE1297 GSM21222 Hippocampus GSE1297 GSM21223 Hippocampus GSE1297 GSM21224 Hippocampus GSE1297 GSM21225 Hippocampus GSE1297 GSM21226 Hippocampus GSE1297 GSM21227 Hippocampus GSE1297 GSM21228 Hippocampus GSE1297 GSM21229 Hippocampus GSE1297 GSM21230 Hippocampus GSE1297 GSM21231 Hippocampus GSE1297 GSM21232 Hippocampus GSE1297 GSM21233 Hippocampus GSE1420 GSM23385 Normal Esophageal epithelium GSE1420 GSM23386 Normal Esophageal epithelium GSE1420 GSM23387 Normal Esophageal epithelium GSE1420 GSM23388 Normal Esophageal epithelium GSE1420 GSM23389 Normal Esophageal epithelium GSE1420 GSM23390 Normal Esophageal epithelium GSE1420 GSM23391 Normal Esophageal epithelium GSE1420 GSM23392 Normal Esophageal epithelium

20 GSE1420 GSM23395 Barrett's Esophageal epithelium GSE1420 GSM23396 Barrett's Esophageal epithelium GSE1420 GSM23397 Barrett's Esophageal epithelium GSE1420 GSM23398 Barrett's Esophageal epithelium GSE1420 GSM23399 Barrett's Esophageal epithelium GSE1420 GSM23400 Barrett's Esophageal epithelium GSE1420 GSM23401 Barrett's Esophageal epithelium GSE1420 GSM23402 Barrett's Esophageal epithelium GSE1420 GSM23413 Adenocarcinoma Esophageal epithelium GSE1420 GSM23417 AdenocarcinomaEsophageal epithelium GSE1420 GSM23419 Adenocarcinoma Esophageal epithelium GSE1420 GSM23422 Adenocarcinoma Esophageal epithelium GSE1420 GSM23424 Adenocarcinoma Esophageal epithelium GSE1420 GSM23425 Adenocarcinoma Esophageal epithelium GSE1420 GSM23426 Adenocarcinoma Esophageal epithelium GSE1420 GSM23427 Adenocarcinoma Esophageal epithelium GSE1786 GSM30842 Vastus lateralis GSE1786 GSM30845 Vastus lateralis GSE1786 GSM30846 Vastus lateralis GSE1786 GSM30847 Vastus lateralis GSE2724 GSM52661 Myometrium GSE2724 GSM52662 Myometrium GSE2724 GSM52663 Myometrium GSE2724 GSM52664 Myometrium GSE2724 GSM52666 Myometrium GSE2724 GSM52667 Myometrium GSE2724 GSM52668 Myometrium GSE2724 GSM52669 Myometrium GSE2724 GSM52671 Myometrium GSE2990 GSM65340 Breast tumor GSE2990 GSM65341 Breast tumor GSE2990 GSM65342 Breast tumor GSE2990 GSM65343 Breast tumor GSE2990 GSM65344 Breast tumor GSE2990 GSM65345 Breast tumor GSE2990 GSM65346 Breast tumor GSE2990 GSM65347 Breast tumor GSE2990 GSM65348 Breast tumor GSE2990 GSM65349 Breast tumor GSE2990 GSM65350 Breast tumor GSE2990 GSM65351 Breast tumor GSE2990 GSM65352 Breast tumor GSE2990 GSM65353 Breast tumor GSE2990 GSM65354 Breast tumor GSE2990 GSM65355 Breast tumor GSE2990 GSM65356 Breast tumor GSE2990 GSM65357 Breast tumor GSE2990 GSM65358 Breast tumor GSE2990 GSM65359 Breast tumor GSE2990 GSM65360 Breast tumor GSE2990 GSM65361 Breast tumor GSE2990 GSM65362 Breast tumor GSE2990 GSM65363 Breast tumor GSE2990 GSM65364 Breast tumor GSE2990 GSM65365 Breast tumor GSE2990 GSM65366 Breast tumor GSE2990 GSM65367 Breast tumor

21 GSE2990 GSM65368 Breast tumor GSE2990 GSM65369 Breast tumor GSE2990 GSM65370 Breast tumor GSE2990 GSM65371 Breast tumor GSE2990 GSM65372 Breast tumor GSE2990 GSM65373 Breast tumor GSE2990 GSM65374 Breast tumor GSE2990 GSM65375 Breast tumor GSE2990 GSM65376 Breast tumor GSE2990 GSM65377 Breast tumor GSE2990 GSM65378 Breast tumor GSE2990 GSM65379 Breast tumor GSE2990 GSM65820 Breast tumor GSE2990 GSM65821 Breast tumor GSE2990 GSM65822 Breast tumor GSE2990 GSM65823 Breast tumor GSE2990 GSM65824 Breast tumor GSE2990 GSM65825 Breast tumor GSE2990 GSM65826 Breast tumor GSE2990 GSM65827 Breast tumor GSE2990 GSM65828 Breast tumor GSE2990 GSM65829 Breast tumor GSE2990 GSM65830 Breast tumor GSE2990 GSM65831 Breast tumor GSE2990 GSM65832 Breast tumor GSE2990 GSM65833 Breast tumor GSE2990 GSM65834 Breast tumor GSE2990 GSM65835 Breast tumor GSE2990 GSM65836 Breast tumor GSE2990 GSM65837 Breast tumor GSE2990 GSM65838 Breast tumor GSE2990 GSM65839 Breast tumor GSE2990 GSM65840 Breast tumor GSE2990 GSM65841 Breast tumor GSE2990 GSM65842 Breast tumor GSE2990 GSM65843 Breast tumor GSE2990 GSM65844 Breast tumor GSE2990 GSM65845 Breast tumor GSE2990 GSM65846 Breast tumor GSE2990 GSM65847 Breast tumor GSE2990 GSM65848 Breast tumor GSE2990 GSM65849 Breast tumor GSE2990 GSM65850 Breast tumor GSE2990 GSM65851 Breast tumor GSE2990 GSM65852 Breast tumor GSE2990 GSM65853 Breast tumor GSE2990 GSM65854 Breast tumor GSE2990 GSM65855 Breast tumor GSE2990 GSM65856 Breast tumor GSE2990 GSM65857 Breast tumor GSE2990 GSM65858 Breast tumor GSE2990 GSM65859 Breast tumor GSE2990 GSM65860 Breast tumor GSE2990 GSM65861 Breast tumor GSE2990 GSM65862 Breast tumor GSE2990 GSM65863 Breast tumor GSE2990 GSM65864 Breast tumor

22 GSE2990 GSM65865 Breast tumor GSE2990 GSM65866 Breast tumor GSE2990 GSM65867 Breast tumor GSE2990 GSM65868 Breast tumor GSE2990 GSM65869 Breast tumor GSE2990 GSM65870 Breast tumor GSE2990 GSM65871 Breast tumor GSE2990 GSM65872 Breast tumor GSE2990 GSM65873 Breast tumor GSE2990 GSM65874 Breast tumor GSE2990 GSM65875 Breast tumor GSE2990 GSM65876 Breast tumor GSE2990 GSM65877 Breast tumor GSE2990 GSM65878 Breast tumor GSE2990 GSM65879 Breast tumor GSE2990 GSM65880 Breast tumor GSE3167 GSM71019 Bladder GSE3167 GSM71020 Bladder GSE3167 GSM71021 Bladder GSE3167 GSM71022 Bladder GSE3167 GSM71023 Bladder GSE3167 GSM71024 Bladder GSE3167 GSM71025 Bladder GSE3167 GSM71026 Bladder GSE3167 GSM71028 Bladder GSE3167 GSM71029 Bladder GSE3167 GSM71030 Bladder GSE3167 GSM71031 Bladder GSE3167 GSM71032 Bladder GSE3167 GSM71033 Bladder GSE3167 GSM71034 Bladder GSE3167 GSM71035 Bladder GSE3167 GSM71036 Bladder GSE3167 GSM71037 Bladder GSE3167 GSM71038 Bladder GSE3167 GSM71039 Bladder GSE3167 GSM71040 Bladder GSE3167 GSM71041 Bladder GSE3167 GSM71042 Bladder GSE3167 GSM71043 Bladder GSE3167 GSM71044 Bladder GSE3167 GSM71045 Bladder GSE3167 GSM71046 Bladder GSE3167 GSM71047 Bladder GSE3167 GSM71048 Bladder GSE3167 GSM71049 Bladder GSE3167 GSM71050 Bladder GSE3167 GSM71051 Bladder GSE3167 GSM71052 Bladder GSE3167 GSM71053 Bladder GSE3167 GSM71054 Bladder GSE3167 GSM71055 Bladder GSE3167 GSM71056 Bladder GSE3167 GSM71058 Bladder GSE3167 GSM71059 Bladder GSE3167 GSM71060 Bladder GSE3167 GSM71061 Bladder

23 GSE3167 GSM71062 Bladder GSE3167 GSM71063 Bladder GSE3167 GSM71064 Bladder GSE3167 GSM71065 Bladder GSE3167 GSM71066 Bladder GSE3167 GSM71067 Bladder GSE3167 GSM71068 Bladder GSE3167 GSM71069 Bladder mucosa GSE3167 GSM71070 CIS GSE3167 GSM71071 Bladder mucosa GSE3167 GSM71072 CIS GSE3167 GSM71073 Bladder mucosa GSE3167 GSM71074 CIS GSE3167 GSM71075 Bladder mucosa GSE3167 GSM71076 CIS GSE3167 GSM71077 CIS GSE3218 GSM72495 Testis GSE3218 GSM72496 Testis GSE3218 GSM72497 Testis GSE3218 GSM72498 Testis GSE3218 GSM72499 Testis GSE3230 GSM72796 "Skeletal myoblast, embryonic" GSE3230 GSM72798 "Skeletal myoblast, embryonic" GSE3230 GSM72800 "Skeletal myoblast, embryonic" GSE3419 GSM77091 Hair follicle bulge GSE3419 GSM77092 Hair follicle sub-bulge GSE3419 GSM77093 Hair follicle bulge GSE3419 GSM77094 Hair follicle sub-bulge GSE3419 GSM77095 Hair follicle bulge GSE3419 GSM77096 Hair follicle sub-bulge GSE3419 GSM77097 Hair follicle bulge GSE3419 GSM77098 Hair follicle sub-bulge GSE3419 GSM77102 Hair follicle bulge GSE3419 GSM77103 Hair follicle sub-bulge GSE3494 GSM79114 Breast tumor GSE3494 GSM79115 Breast tumor GSE3494 GSM79116 Breast tumor GSE3494 GSM79117 Breast tumor GSE3494 GSM79118 Breast tumor GSE3494 GSM79119 Breast tumor GSE3494 GSM79120 Breast tumor GSE3494 GSM79121 Breast tumor GSE3494 GSM79122 Breast tumor GSE3494 GSM79123 Breast tumor GSE3494 GSM79124 Breast tumor GSE3494 GSM79125 Breast tumor GSE3494 GSM79126 Breast tumor GSE3494 GSM79127 Breast tumor GSE3494 GSM79128 Breast tumor GSE3494 GSM79129 Breast tumor GSE3494 GSM79130 Breast tumor GSE3494 GSM79131 Breast tumor GSE3494 GSM79132 Breast tumor GSE3494 GSM79133 Breast tumor GSE3494 GSM79134 Breast tumor GSE3494 GSM79135 Breast tumor GSE3494 GSM79137 Breast tumor

24 GSE3494 GSM79138 Breast tumor GSE3494 GSM79139 Breast tumor GSE3494 GSM79140 Breast tumor GSE3494 GSM79141 Breast tumor GSE3494 GSM79142 Breast tumor GSE3494 GSM79143 Breast tumor GSE3494 GSM79144 Breast tumor GSE3494 GSM79145 Breast tumor GSE3494 GSM79146 Breast tumor GSE3494 GSM79147 Breast tumor GSE3494 GSM79148 Breast tumor GSE3494 GSM79149 Breast tumor GSE3494 GSM79150 Breast tumor GSE3494 GSM79151 Breast tumor GSE3494 GSM79152 Breast tumor GSE3494 GSM79153 Breast tumor GSE3494 GSM79154 Breast tumor GSE3494 GSM79155 Breast tumor GSE3494 GSM79156 Breast tumor GSE3494 GSM79157 Breast tumor GSE3494 GSM79158 Breast tumor GSE3494 GSM79159 Breast tumor GSE3494 GSM79160 Breast tumor GSE3494 GSM79161 Breast tumor GSE3494 GSM79162 Breast tumor GSE3494 GSM79163 Breast tumor GSE3494 GSM79164 Breast tumor GSE3494 GSM79165 Breast tumor GSE3494 GSM79166 Breast tumor GSE3494 GSM79167 Breast tumor GSE3494 GSM79168 Breast tumor GSE3494 GSM79169 Breast tumor GSE3494 GSM79170 Breast tumor GSE3494 GSM79171 Breast tumor GSE3494 GSM79173 Breast tumor GSE3494 GSM79174 Breast tumor GSE3494 GSM79175 Breast tumor GSE3494 GSM79176 Breast tumor GSE3494 GSM79177 Breast tumor GSE3494 GSM79178 Breast tumor GSE3494 GSM79179 Breast tumor GSE3494 GSM79180 Breast tumor GSE3494 GSM79181 Breast tumor GSE3494 GSM79182 Breast tumor GSE3494 GSM79183 Breast tumor GSE3494 GSM79184 Breast tumor GSE3494 GSM79185 Breast tumor GSE3494 GSM79186 Breast tumor GSE3494 GSM79187 Breast tumor GSE3494 GSM79188 Breast tumor GSE3494 GSM79189 Breast tumor GSE3494 GSM79190 Breast tumor GSE3494 GSM79191 Breast tumor GSE3494 GSM79192 Breast tumor GSE3494 GSM79193 Breast tumor GSE3494 GSM79195 Breast tumor GSE3494 GSM79196 Breast tumor

25 GSE3494 GSM79197 Breast tumor GSE3494 GSM79198 Breast tumor GSE3494 GSM79199 Breast tumor GSE3494 GSM79200 Breast tumor GSE3494 GSM79201 Breast tumor GSE3494 GSM79202 Breast tumor GSE3494 GSM79203 Breast tumor GSE3494 GSM79204 Breast tumor GSE3494 GSM79205 Breast tumor GSE3494 GSM79206 Breast tumor GSE3494 GSM79207 Breast tumor GSE3494 GSM79208 Breast tumor GSE3494 GSM79209 Breast tumor GSE3494 GSM79210 Breast tumor GSE3494 GSM79211 Breast tumor GSE3494 GSM79212 Breast tumor GSE3494 GSM79213 Breast tumor GSE3494 GSM79214 Breast tumor GSE3494 GSM79215 Breast tumor GSE3494 GSM79216 Breast tumor GSE3494 GSM79217 Breast tumor GSE3494 GSM79218 Breast tumor GSE3494 GSM79219 Breast tumor GSE3494 GSM79220 Breast tumor GSE3494 GSM79221 Breast tumor GSE3494 GSM79222 Breast tumor GSE3494 GSM79223 Breast tumor GSE3494 GSM79224 Breast tumor GSE3494 GSM79225 Breast tumor GSE3494 GSM79226 Breast tumor GSE3494 GSM79227 Breast tumor GSE3494 GSM79228 Breast tumor GSE3494 GSM79229 Breast tumor GSE3494 GSM79230 Breast tumor GSE3494 GSM79231 Breast tumor GSE3494 GSM79232 Breast tumor GSE3494 GSM79233 Breast tumor GSE3494 GSM79234 Breast tumor GSE3494 GSM79235 Breast tumor GSE3494 GSM79236 Breast tumor GSE3494 GSM79237 Breast tumor GSE3494 GSM79238 Breast tumor GSE3494 GSM79239 Breast tumor GSE3494 GSM79240 Breast tumor GSE3494 GSM79241 Breast tumor GSE3494 GSM79242 Breast tumor GSE3494 GSM79243 Breast tumor GSE3494 GSM79244 Breast tumor GSE3494 GSM79245 Breast tumor GSE3494 GSM79246 Breast tumor GSE3494 GSM79247 Breast tumor GSE3494 GSM79248 Breast tumor GSE3494 GSM79249 Breast tumor GSE3494 GSM79250 Breast tumor GSE3494 GSM79251 Breast tumor GSE3494 GSM79252 Breast tumor GSE3494 GSM79253 Breast tumor

26 GSE3494 GSM79254 Breast tumor GSE3494 GSM79255 Breast tumor GSE3494 GSM79256 Breast tumor GSE3494 GSM79257 Breast tumor GSE3494 GSM79258 Breast tumor GSE3494 GSM79259 Breast tumor GSE3494 GSM79260 Breast tumor GSE3494 GSM79261 Breast tumor GSE3494 GSM79262 Breast tumor GSE3494 GSM79263 Breast tumor GSE3494 GSM79264 Breast tumor GSE3494 GSM79265 Breast tumor GSE3494 GSM79266 Breast tumor GSE3494 GSM79267 Breast tumor GSE3494 GSM79268 Breast tumor GSE3494 GSM79269 Breast tumor GSE3494 GSM79270 Breast tumor GSE3494 GSM79271 Breast tumor GSE3494 GSM79272 Breast tumor GSE3494 GSM79273 Breast tumor GSE3494 GSM79274 Breast tumor GSE3494 GSM79275 Breast tumor GSE3494 GSM79276 Breast tumor GSE3494 GSM79277 Breast tumor GSE3494 GSM79278 Breast tumor GSE3494 GSM79280 Breast tumor GSE3494 GSM79281 Breast tumor GSE3494 GSM79282 Breast tumor GSE3494 GSM79283 Breast tumor GSE3494 GSM79284 Breast tumor GSE3494 GSM79285 Breast tumor GSE3494 GSM79286 Breast tumor GSE3494 GSM79287 Breast tumor GSE3494 GSM79288 Breast tumor GSE3494 GSM79289 Breast tumor GSE3494 GSM79290 Breast tumor GSE3494 GSM79291 Breast tumor GSE3494 GSM79292 Breast tumor GSE3494 GSM79293 Breast tumor GSE3494 GSM79294 Breast tumor GSE3494 GSM79295 Breast tumor GSE3494 GSM79296 Breast tumor GSE3494 GSM79297 Breast tumor GSE3494 GSM79298 Breast tumor GSE3494 GSM79299 Breast tumor GSE3494 GSM79300 Breast tumor GSE3494 GSM79301 Breast tumor GSE3494 GSM79302 Breast tumor GSE3494 GSM79303 Breast tumor GSE3494 GSM79304 Breast tumor GSE3494 GSM79305 Breast tumor GSE3494 GSM79306 Breast tumor GSE3494 GSM79307 Breast tumor GSE3494 GSM79308 Breast tumor GSE3494 GSM79309 Breast tumor GSE3494 GSM79310 Breast tumor GSE3494 GSM79311 Breast tumor

27 GSE3494 GSM79312 Breast tumor GSE3494 GSM79313 Breast tumor GSE3494 GSM79315 Breast tumor GSE3494 GSM79316 Breast tumor GSE3494 GSM79317 Breast tumor GSE3494 GSM79318 Breast tumor GSE3494 GSM79319 Breast tumor GSE3494 GSM79320 Breast tumor GSE3494 GSM79321 Breast tumor GSE3494 GSM79322 Breast tumor GSE3494 GSM79323 Breast tumor GSE3494 GSM79324 Breast tumor GSE3494 GSM79325 Breast tumor GSE3494 GSM79326 Breast tumor GSE3494 GSM79327 Breast tumor GSE3494 GSM79329 Breast tumor GSE3494 GSM79330 Breast tumor GSE3494 GSM79331 Breast tumor GSE3494 GSM79332 Breast tumor GSE3494 GSM79333 Breast tumor GSE3494 GSM79335 Breast tumor GSE3494 GSM79336 Breast tumor GSE3494 GSM79337 Breast tumor GSE3494 GSM79338 Breast tumor GSE3494 GSM79339 Breast tumor GSE3494 GSM79340 Breast tumor GSE3494 GSM79341 Breast tumor GSE3494 GSM79342 Breast tumor GSE3494 GSM79343 Breast tumor GSE3494 GSM79344 Breast tumor GSE3494 GSM79345 Breast tumor GSE3494 GSM79346 Breast tumor GSE3494 GSM79347 Breast tumor GSE3494 GSM79348 Breast tumor GSE3494 GSM79349 Breast tumor GSE3494 GSM79351 Breast tumor GSE3494 GSM79352 Breast tumor GSE3494 GSM79353 Breast tumor GSE3494 GSM79354 Breast tumor GSE3494 GSM79355 Breast tumor GSE3494 GSM79356 Breast tumor GSE3494 GSM79357 Breast tumor GSE3494 GSM79358 Breast tumor GSE3494 GSM79359 Breast tumor GSE3494 GSM79360 Breast tumor GSE3494 GSM79361 Breast tumor GSE3494 GSM79362 Breast tumor GSE3494 GSM79363 Breast tumor GSE3494 GSM79364 Breast tumor GSE3524 GSM80476 Oral squamous cell epithelium GSE3524 GSM80520 Oral squamous cell epithelium GSE3524 GSM80521 Oral squamous cell epithelium GSE3780 GSM86678 Myoblasts GSE3780 GSM86680 Myoblasts GSE3780 GSM86682 Myoblasts GSE3788 GSM86779 Hematopoietic stem cells GSE3788 GSM86781 Hematopoietic stem cells

28 GSE3788 GSM86783 Hematopoietic stem cells GSE3790 GSM86787 Caudate nucleus GSE3790 GSM86789 Caudate nucleus GSE3790 GSM86791 Caudate nucleus GSE3790 GSM86793 Caudate nucleus GSE3790 GSM86795 Caudate nucleus GSE3790 GSM86796 Caudate nucleus GSE3790 GSM86799 Caudate nucleus GSE3790 GSM86801 Caudate nucleus GSE3790 GSM86802 Caudate nucleus GSE3790 GSM86803 Caudate nucleus GSE3790 GSM86808 Caudate nucleus GSE3790 GSM86812 Caudate nucleus GSE3790 GSM86814 Caudate nucleus GSE3790 GSM86816 Caudate nucleus GSE3790 GSM86817 Caudate nucleus GSE3790 GSM86818 Caudate nucleus GSE3790 GSM86819 Caudate nucleus GSE3790 GSM86820 Caudate nucleus GSE3790 GSM86821 Caudate nucleus GSE3790 GSM86822 Caudate nucleus GSE3790 GSM86823 Caudate nucleus GSE3790 GSM86824 Caudate nucleus GSE3790 GSM86825 Caudate nucleus GSE3790 GSM86826 Caudate nucleus GSE3790 GSM86827 Caudate nucleus GSE3790 GSM86828 Caudate nucleus GSE3790 GSM86829 Caudate nucleus GSE3790 GSM86830 Caudate nucleus GSE3790 GSM86831 Caudate nucleus GSE3790 GSM86832 Caudate nucleus GSE3790 GSM86833 Caudate nucleus GSE3790 GSM86929 Frontal Cortex GSE3790 GSM86931 Frontal Cortex GSE3790 GSM86933 Frontal Cortex GSE3790 GSM86937 Frontal Cortex GSE3790 GSM86938 Frontal Cortex GSE3790 GSM86939 Frontal Cortex GSE3790 GSM86940 Frontal Cortex GSE3790 GSM86942 Frontal Cortex GSE3790 GSM86943 Frontal Cortex GSE3790 GSM86947 Frontal Cortex GSE3790 GSM86948 Frontal Cortex GSE3790 GSM86951 Frontal Cortex GSE3790 GSM86957 Frontal Cortex GSE3790 GSM86958 Frontal Cortex GSE3790 GSM86959 Frontal Cortex GSE3790 GSM86960 Frontal Cortex GSE3790 GSM86961 Frontal Cortex GSE3790 GSM86962 Frontal Cortex GSE3790 GSM86963 Frontal Cortex GSE3790 GSM86964 Frontal Cortex GSE3790 GSM86965 Frontal Cortex GSE3790 GSM86966 Frontal Cortex GSE3790 GSM86967 Frontal Cortex GSE3790 GSM86968 Frontal Cortex GSE3790 GSM86969 Frontal Cortex

29 GSE3790 GSM86970 Frontal Cortex GSE3790 GSM86971 Frontal Cortex GSE3790 GSM86972 Frontal Cortex GSE3790 GSM87058 Cerebellum GSE3790 GSM87064 Cerebellum GSE3790 GSM87065 Cerebellum GSE3790 GSM87066 Cerebellum GSE3790 GSM87071 Cerebellum GSE3790 GSM87072 Cerebellum GSE3790 GSM87073 Cerebellum GSE3790 GSM87074 Cerebellum GSE3790 GSM87075 Cerebellum GSE3790 GSM87085 Cerebellum GSE3790 GSM87086 Cerebellum GSE3790 GSM87087 Cerebellum GSE3790 GSM87088 Cerebellum GSE3790 GSM87089 Cerebellum GSE3790 GSM87090 Cerebellum GSE3790 GSM87091 Cerebellum GSE3790 GSM87092 Cerebellum GSE3790 GSM87093 Cerebellum GSE3790 GSM87094 Cerebellum GSE3790 GSM87095 Cerebellum GSE3790 GSM87096 Cerebellum GSE3790 GSM87097 Cerebellum GSE3790 GSM87098 Cerebellum GSE3790 GSM87099 Cerebellum GSE3790 GSM87100 Cerebellum GSE3790 GSM87101 Cerebellum GSE3790 GSM87102 Cerebellum GSE3794 GSM87275 I-6 ES SSEA+ GSE3794 GSM87277 I-6 ES SSEA+ GSE3794 GSM87279 I-6 ES SSEA+ GSE3794 GSM87281 I-6 ES SSEA- GSE3794 GSM87283 I-6 ES SSEA- GSE3794 GSM87285 I-6 ES SSEA- GSE3823 GSM87693 Hematopoeitic stem cell- FB +/+ GSE3823 GSM87695 Hematopoeitic stem cell- FB +/+ GSE3823 GSM87697 Hematopoeitic stem cell- FB +/+ GSE3823 GSM87699 Hematopoeitic stem cell- MB +/+ GSE3823 GSM87701 Hematopoeitic stem cell- MB +/+ GSE3823 GSM87703 Hematopoeitic stem cell- MB +/+ GSE3823 GSM87705 Hematopoeitic stem cell- FB +/- GSE3823 GSM87707 Hematopoeitic stem cell- FB +/- GSE3823 GSM87709 Hematopoeitic stem cell- FB +/- GSE3823 GSM87711 Hematopoeitic stem cell- CB +/- GSE3823 GSM87713 Hematopoeitic stem cell- CB +/- GSE3823 GSM87715 Hematopoeitic stem cell- CB +/- GSE3823 GSM87717 Hematopoeitic stem cell- CB +/+ GSE3823 GSM87719 Hematopoeitic stem cell- CB +/+ GSE3823 GSM87721 Hematopoeitic stem cell- CB +/+ GSE3823 GSM87723 Hematopoeitic stem cell- BM +/+ GSE3823 GSM87725 Hematopoeitic stem cell- BM +/+ GSE3823 GSM87727 Hematopoeitic stem cell- BM +/+ GSE3823 GSM87729 Hematopoeitic stem cell- BM +/- GSE3823 GSM87731 Hematopoeitic stem cell- BM +/- GSE3823 GSM87733 Hematopoeitic stem cell- BM +/-

30 GSE3860 GSM88289 Fibroblast GSE3860 GSM88290 Fibroblast GSE3860 GSM88291 Fibroblast GSE3860 GSM88292 Fibroblast GSE3860 GSM88293 Fibroblast GSE3860 GSM88294 Fibroblast GSE3860 GSM88295 Fibroblast GSE3860 GSM88296 Fibroblast GSE3860 GSM88297 Fibroblast E-AFMX-5 3AJZ HBEC E-AFMX-5 3AJZ HBEC E-AFMX-5 3AJZ Heart E-AFMX-5 3AMH Heart GSE2638 GSM50771 HMEC GSE2638 GSM50772 HMEC GSE2638 GSM50773 HMEC GSE2639 GSM50777 HUVEC GSE2639 GSM50778 HUVEC GSE2639 GSM50779 HUVEC GSE1148 HGU133A_HYP_FEMALE_bio_1_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_1_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_1_tech_2 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_2_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_2_tech_2 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_3_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_3_tech_2 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_4_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_4_tech_2 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_5_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_5_tech_2 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio_2_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_6_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_6_tech_2 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_7_tech_1 Hypothalamus GSE1148 HGU133A_HYP_MALE_bio_7_tech_2 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio_2_tech_2 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio_3_tech_1 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio_3_tech_2 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio4_tech_1 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio4_tech_2 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio5_tech_1 Hypothalamus GSE1148 HGU133A_HYP_FEMALE_bio5_tech_2 Hypothalamus E-AFMX-5 3AJZ Hypothalamus E-AFMX-5 3AJZ Hypothalamus GSE620 GSM9514 IB3-1 bronchial epithelial cells GSE620 GSM9515 IB3-1 bronchial epithelial cells GSE620 GSM9516 IB3-1 bronchial epithelial cells GSE620 GSM9517 IB3-1 bronchial epithelial cells GSE1648 GSM27960 Intervertebral disc GSE1648 GSM27965 Intervertebral disc GSE1648 GSM27970 Intervertebral disc GSE1648 GSM27976 Intervertebral disc E-AFMX-5 3AJZ Islet E-AFMX-5 3AJZ Islet GSE1922 GSM34039 K562 Cell line GSE1922 GSM34915 K562 Cell line GSE1922 GSM34916 K562 Cell line

31 GSE1922 GSM34917 K562 Cell line GSE1922 GSM34921 K562 Cell line GSE1922 GSM34922 K562 Cell line GSE1922 GSM34923 K562 Cell line GSE1922 GSM34927 K562 Cell line GSE1922 GSM34928 K562 Cell line GSE1922 GSM34929 K562 Cell line GSE1922 GSM34933 K562 Cell line GSE1922 GSM34040 K562 Cell line GSE1922 GSM34934 K562 Cell line GSE1922 GSM34935 K562 Cell line GSE1922 GSM34939 K562 Cell line GSE1922 GSM34940 K562 Cell line GSE1922 GSM34941 K562 Cell line GSE1922 GSM34041 K562 Cell line GSE1922 GSM34134 K562 Cell line GSE1922 GSM34140 K562 Cell line GSE1922 GSM34146 K562 Cell line GSE1922 GSM34909 K562 Cell line GSE1922 GSM34910 K562 Cell line GSE1922 GSM34911 K562 Cell line E-AFMX-5 3AJZ Leukemia Chronic Myelogenous (K562) E-AFMX-5 3AJZ Leukemia Chronic Myelogenous (K562) E-AFMX-5 3AJZ Leukemia Lymphoblastic (MOLT4) E-AFMX-5 3AJZ Leukemia Lymphoblastic (MOLT4) E-AFMX-5 3AJZ Leukemia Promyelocytic (HL-60) E-AFMX-5 3AJZ Leukemia Promyelocytic (HL-60) E-AFMX-5 3AJZ Liver E-AFMX-5 3AMH Liver E-AFMX-5 3AJW Lung E-AFMX-5 3AMH Lung E-AFMX-5 3AJZ Lymph Node E-AFMX-5 3AJZ Lymph Node E-AFMX-5 3AJZ Lymphoma Burkitts Daudi E-AFMX-5 3AJZ Lymphoma Burkitts Daudi E-AFMX-5 3AMH Lymphoma Raji E-AFMX-5 3AMH Lymphoma Raji E-AFMX-5 3AJZ a Medulla Oblongata E-AFMX-5 3AJZ b Medulla Oblongata E-MEXP-271 MK2hKa_A Hep-2 E-MEXP-271 MK2hKb_A Hep-2 E-MEXP-271 MK8hKa_A Hep-2 E-MEXP-271 MK8hKb_A Hep-2 GSE2461 GSM46539 Colonic mucosal (IBS) GSE2461 GSM46541 Colonic mucosal (IBS) GSE2461 GSM46542 Colonic mucosal (IBS) GSE2461 GSM46543 Colonic mucosal (IBS) GSE2461 GSM46544 Colonic mucosal (IBS) GSE1462 GSM24652 Skeletal muscle GSE1462 GSM24653 Skeletal muscle GSE1462 GSM24654 Skeletal muscle E-AFMX-5 3AJZ Occipital Lobe E-AFMX-5 3AJZ Occipital Lobe E-AFMX-5 3AJZ Olfactory Bulb E-AFMX-5 3AJZ Olfactory Bulb E-AFMX-5 3AJZ Ovary E-AFMX-5 3AJZ Ovary

32 E-AFMX-5 3AJZ Pancreas E-AFMX-5 3AJZ Pancreas E-AFMX-5 3AJZ Parietal Lobe E-AFMX-5 3AJZ Parietal Lobe E-AFMX-5 3AMH CD4 T cell E-AFMX-5 3AMH CD4 T cell E-AFMX-5 3AMH CD8 T cell E-AFMX-5 3AMH CD8 T cell E-AFMX-5 3ARS IA Placenta E-AFMX-5 3ARS HB Placenta E-AFMX-5 3AJZ a Pons E-AFMX-5 3AJZ b Pons E-AFMX-5 3AJZ Prefrontal Cortex E-AFMX-5 3AJZ Prefrontal Cortex E-AFMX-5 3AJZ Prostate E-AFMX-5 3AMH Prostate GSE873 GSM13417 Quadriceps femoris muscle GSE873 GSM13418 Quadriceps femoris muscle GSE873 GSM13419 Quadriceps femoris muscle E-AFMX-5 3AJZ Salivary Gland E-AFMX-5 3AJZ Salivary Gland E-AFMX-5 3ARS A Skin E-AFMX-5 3ARS b Skin E-AFMX-5 3AJZ Smooth Muscle E-AFMX-5 3AJZ Smooth Muscle E-AFMX-5 3AJZ Spinal Cord E-AFMX-5 3AJZ Spinal Cord E-AFMX-5 3ARS A Subthalamic Nucleus E-AFMX-5 3ARS b Subthalamic Nucleus E-AFMX-5 3AJZ a Superior Cervical Ganglion E-AFMX-5 3AJZ b Superior Cervical Ganglion E-AFMX-5 3AJZ a Temporal Lobe E-AFMX-5 3AJZ b Temporal Lobe E-AFMX-5 3AJZ Testi Germ Cell E-AFMX-5 3AJZ Testi Germ Cell E-AFMX-5 3AJZ Testi Intersitial E-AFMX-5 3AJZ Testi Intersitial E-AFMX-5 3AJZ Testi Seminiferous Tubule E-AFMX-5 3AJZ Testi Seminiferous Tubule E-AFMX-5 3AJZ Thalamus E-AFMX-5 3AJZ Thalamus GSE1615 GSM27531 Theca cells GSE1615 GSM27532 Theca cells GSE1615 GSM27533 Theca cells GSE1615 GSM27534 Theca cells E-AFMX-5 3AJZ Thymus E-AFMX-5 3AJZ Thymus E-AFMX-5 3AMH Thyroid E-AFMX-5 3AMH Thyroid E-AFMX-5 3AJZ A Tongue E-AFMX-5 3AJZ B Tongue E-AFMX-5 3AJZ Tonsil E-AFMX-5 3AJZ Tonsil GSE1460 GSM24511 Intrathymic T cell progenitors GSE1460 GSM24609 Intrathymic T cell progenitors GSE1460 GSM24610 Intrathymic T cell progenitors E-AFMX-5 3AJZ Trachea