Criteria for the diagnosis of nevus

Transcription

1 Index Criteria for the diagnosis of nevus Criteria for the diagnosis of nevus ABCD, 1, 301, 329, 451, 501, 502 Aberrant mongolian spot, 82, 114, 120 Abtropfung, 29, 157 Achromic melanoma in situ, 422 Achromic melanoma, 598, 634, 638, 664, 676 Ackerman A.B. 29, 31, 32, 52, 75f, 119, 126, 160, 163, 273, 275, 278f, 284f, 377, 459, 468, 481, 502, 503, 535, 537, 549 Acquired dermal melanocytosis, 114 Acquired early onset nevus, 79, 81, 445 Acquired nevi with congenital features, 47, 79 Acral lentiginous melanoma, see Melanoma on acral skin Acral melanotic macula, 18 Acral nevoid melanoma, 636, 642f-647f Acral nevus, see Nevus on acral skin Acrochordon, 34, 589 Actinic keratosis, 33, 424, 439, 592 Actinic melanocytic hyperplasia, 5, 6, 9f, 10f, 15, 438 Adipocytic metaplasia, 49, 64f Adipose substitution, 49 Adnexal epithelium, involvement in acral melanoma, 635 in congenital nevus 78, 85f in lentigo maligna, 438, 440f, 442f Adolescence, 47, 114, 120, 122, 304, 355, 451, 501, 505, 678 Agminated blue nevus, 120 Agminated Spitz nevus, 156, 190 AJCC staging of melanoma, 699, 741, 742, 744f Alopecia, 45f, 48 Amelanotic melanoma, see Achromic melanoma Amyloid, 48, 157 Ancient blue nevus, 139 Ancient nevus, 51, 70f, 71f, 99, 143f, 188 Angiomatoid melanoma, 593 Angiomatoid Spitz nevus, 186, 196f, 703 Angiotropism, 141, 723 Animal-type melanoma, 88f, 122, 257, 259, 540f, 558f, 559,, 560, 562f-568f, 574, 667, 677, 702, 724 differential diagnosis with melanocytoma 270f, 547, 548, 555f, 557f blue nevus like melanoma, 535, 536 Apoptotic melanocytes, 700, 708f, 711f Areola, 15, 19, 315, 344f Artifact, 8, 52, 72f, 162, 209f, 344, 424, 425, 444, 571, 591, 594, 599 Asymmetry, 3, 415 Atypical blue nevus, 136f, 139, 140, 536, 559, 571 Atypical fibroxanthoma, 452, 458, 518f, 590, 593, 594, 598, 610f, 721, 724 Atypical junctional proliferation, 2, 7, 8, 92, 94f-96f, 401, 527, 623f Atypical melanocytic hyperplasia, 5, 635, 636, 666 Atypical nevi on genital skin, 315, 318f-328f Atypical Reed nevus, 220, 230f Atypical Spitz nevus, 189, 190, 215f, 216f, Atypical Spitz tumor, 160, 164, 186, 189, 215f, 216f in childhood, 503 in combined nevus, 288 Auricular pavilion, see ear Axillary area, 61f, 348f, 399 Balloon cell blue nevus, 122, 134f Balloon cell melanoma, 52, 189, 446, 589, 593 Balloon cell metastatic melanoma, 724 Balloon cell nevus, 52, 92, 76f, 122, 355, 357, 369f, 593, 613 Balloon cell Spitz nevus, 189, 213f BAP-1 mutation, 105f, 166, 206f, 293f, 597 Basal cell carcinoma, 35, 48, 51, 375, 385, 421 Basomelanocytic tumor, 592, 608f Bednar tumor, 138, 459, 515 Benign melanocytoma, 257, 260f-272f, 548, 554, 687f differential diagnosis with melanocytoma, 257, 547 Bizarre nevus, 51, 72f, 73f, 418 BLITZ nevus, 549 Blue nevus (common), 119, 124f-136f atypical, 123, 136f balloon cell, 122, 134f Carney complex and, 257, 258 cellular, see cellular blue nevus combined, 122, 135f compound, 122, 130f congenital 120 desmoplastic 122, 128f epithelioid, 122, 131f-133f hypopigmented, 121, 127f nail apparatus and, 121 on conjunctiva, 121, 362f Blue-nevus-like melanoma, see Melanoma resembling blue nevus Blue nevus-like-metastatic melanoma, 724, 736f, 738f Bowen disease, 418, 421, 422, 437, 703, 714 BRAF mutation, 47, 77, 166, 317, 445, 447, 451, 503, 511 Breast carcinoma, 447, 598, 723, 725 Breslow thickness, 590, 741, 744 Bulbar conjunctiva, 355, 358, 362f, 437, 675 Bullous disease, 53, 400 C-kit mutation, 303, 317, 654 Carney complex, 54, 81, 121, 257, 258, 260f-263f, 367, 550f, 554, CD34, 167, 459, 512, 515, 529, 599 CD68, 599 CD99, 483, 596 CD117, 303, 317, 483 Cellular blue nevus, 137, 143f-149f achromic, 139, 150f atypical, 140, 154f desmoplasia in, 139, 151f evolution into malignant melanoma in, 569 HMB45 in, 138 infiltrative, 141 melanoma arising in, 169, 170, 578f-580f meninges, involvement on, 141 myxoid, 139, 152f on oral cavity, 330 tumoral melanosis in, 149f Cellular neurothekeoma, 584 Cellulated common nevus, 50, 67f Cerebriform congenital nevus, 81 Childhood melanoma, 501 Chondroid differentiation, 187, 597, 617f, 724 Chronic melanoma of the leg, 721 Civatte bodies, 386, 389f, 439, 700, 708f Clark levels, 743 Clark nevus, 3, 29, 79, 186, 273, 279f-288f, 316, 339, 469, 512, 628 G. Massi and P.E. LeBoit, Histological Diagnosis of Nevi and Melanoma, 747 DOI / , Springer-Verlag Berlin Heidelberg 2014

2 748 Index differential diagnosis with Reed nevus, 220, 276 regressing melanoma, 703 melanoma 276 variants 277 Clear cell, 52, 137, 139, 146f, 239f, 334f, 418, 424, 548, 591, 594, 614f Clear cell renal carcinoma metastatic to the skin, 52 Clear cell sarcoma, 52, 139, 148, 458, 501, 591 Clitoris, 315, 653 Clonal nevus, 287 Collision melanoma, 593, 608 Combined blue nevus, 80, 122, 135f, 286, 536 Combined nevus, 34, 120, 123, 164, 235, 285, 289f-300f, 535, 548, 593, 678 differential diagnosis with melanocytoma, 264f, 265f, 272f Combined Spitz nevus, 188, 205f, 288 Common blue nevus, see Blue nevus Common blue nevus like metastatic melanoma, 724, 736f-738f Common nevus with desmoplasia, 49, 65f, 66f Comparative genomic hybridization, 51, 79, 100, 141, 166, 188, 205, 206, 237, 278, 288, 303, 317, 423, 481, 501, 510, 549, 581, 635, 723 Compound blue nevus, 122, 130f, 186 Compound lentiginous nevus, 31, 33, 277, 431f Compound nevus, definition, 29, 33 Concentric eosinophilic fibrosis, 276, 280f, 284f Congenital and acquired nevi in the first years of life, 79, 91 Congenital blue nevus, 80, 570 Congenital melanocytic hyperplasia 8 Congenital nevus, 77 blue nevus in, 80 Carney complex in, 81 cellular blue nevus in, 80 eccrine glands, involvement in, 78, 82 halo nevus and, 80 sebaceous glands, involvement of, 78 Congenital nevus with atypical junctional proliferation, 80 Congenital nevus with neurofibromatosis-like feature, 79 Congenital Spitz nevus, 80, 190 Conjunctiva, 355, 675 Contact dermatitis, 375, 376, 380f, 653 Crista profunda intermedia, 301, 312f, 634, 635 Crista profunda lateralis, 301, 321f, 634, 635 Criteria for the diagnosis of melanoma, 415 Criteria for the diagnosis of nevus, 1 Cryotherapy, 440, 690 Cupping, 157, 165 Cutaneous folds, 315 Cutaneous lichen sclerosus et atrophicus, 17, 376 Cutis-verticis-gyrata, 81 Cyst, 356, 358 Cystic cellular blue nevus, 139, 152f De novo desmoplastic melanoma, 512, 522f, 527 De novo intraepidermal epithelioid melanocytic dysplasia, 275, 424, 428f Deep penetrating nevus, 235, 239f-256f atypical, 237, 255f combined, 286 differential diagnosis with melanoma, 535, 549, 581, 583f- 588f, 724, 727f, 739f Deep penetrating nevus-like melanoma, 581, 583f-588f Deep plexiform melanoma, 581 Dermal melanocytic hamartoma, 114 Dermal melanocytosis, 82,113, 117f,118f, 121, 359, 569 Dermal melanoma, 73f, 100, 591, 592 Dermatofibroma, 5, 19, 28f, 120, 127, 185, 375, 511, 599, 724 Dermatofibrosarcoma protuberans, 138, 458, 512, 515, 522f, 598 Dermatoglyphics, 301, 306f, 634 Desmin, 459, 495 Desmoplastic common nevus, 19f, 20f, 49, 514 Desmoplastic hairless hypopigmented nevus, 81, 89f Desmoplastic melanoma, 1, 8, 50, 457, 511, 514, 516f-526f, 527, 597, 598 differential diagnosis with nevi, 121, 138, 151f, 185, 192f on acral skin, 636 on genitalia, 655 on the oral cavity, 664 recurrent 689, 744 regressing, 712f Desmoplastic (sclerotic) cellular blue nevus, 122, 128f, 139, 151 Desmoplastic Spitz nevus, 185, 190f-192f, 511 differential diagnosis with melanoma, 513, 514 Desmoplastic trichoepithelioma, 48, 60f Disseminated Spitz nevus, 156 Drug reaction, 17 Dyshesive (discohesive) pattern, 275, 316, 319f, 323f, 324f, 340 Dysplastic (Clark) nevus, 29, 273, 279f-284f, 340, 376, 400 achromic, 275 combined, 186, 200f differential diagnosis with melanoma, 422, 432f, 439, 447, 457, 458 Ear, 113, 291, 339, 510f, 721 Early onset nevi, 81, 83f, 445 Eccrine centered congenital nevus, 82 Eczema, 80, 375 Edema, 48, 58f, 143f, 380f, 446 Elastosis, see Elastotic material Elastotic material, 6, 9f, 30, 35, 219, 276, 340, 418, 419, 441f, 447, 469, 513, 529, 701 Eosinophilic globule, see Kamino bodies Epidermal hyperplasia, 3, 130f, 157, 164, 165, 217, 416, 458, 482, 503, 548, 551, 557f, 582, 590, 602f, 654 in melanoma, 590 in Spitz nevus, 187 Epidermolysis bullosa, 375, 378 Epidermolytic hyperkeratosis, 50 Epidermotropic metastatic melanoma, 122, 166, 447, 723, 739f Epithelioid blue nevus, 53, 88f, 122, 131f, 132f, 563f, 702 differential diagnosis with melanocytoma 257, 286, 546, 560 Epithelioid histiocytoma, 167 Epithelioid melanocytic dysplasia, 275, 423, 427f Epithelioid sarcoma, 167 Equine melanocytic disease, 559 Erysipeloid melanoma, 722 Erythema multiforme, 348f, 375, 378, 385 Exoserosis, 376 Expansive nodules, 237, 456f, 574f, 678 Extramammary Paget disease, 52, 447, 654, 655, 678 Extraskeletal myxoid chondrosarcoma, 598 Eyelid, 5, 82, 113, 114, 359, 419, 424, 437, 675 Fibroelastosis, see Elastotic material Fibrohistiocytoma, see Dermatofibroma Fibromatosis, 517f, 520f, 723 Fibrosarcoma, 513f, 517f, 525, 636, 723 FISH, 51, 120, 138, 140, 166, 187, 188, 219, 278, 317, 336, 423, 436, 468, 470, 514, 536, 548, 572, 634, 654, 678

3 Index 749 Flat nevus, 29, 31, 32, 34, 43f Fluorescence in situ hybridization, see FISH Follicular melanoma, 590, 603f, 604f Fontana Masson, see Masson Fontana gna-q mutation, 116, 119, 120, 140, 237, 537 GNA11 mutation, 119, 120, 140, 237, 537, 569, 570, 572, 581 Generalized melanocytosis, 114 Generalized melanosis, 116, 721 Genital area, see Nevus on genital skin, Melanoma on genital skin Giant blue nevus, 120, 121, 141 Giant congenital nevus, 79 Giant melanosomes, 7, 30 Giant Spitz nevus, 189 Gingiva, 15, 16, 329, 663, 722 Glans, 16, 132f, 654, 656 Granular cell nevus, 52, 355, 358, 372f Granulomatous Spitz nevus, 186 Groin, 339 Halo congenital nevus, 80 Halo dermatitis (eczema), 375 Halo nevus, 385, 389f-398f Halo phenomenon, 80, 114, 385, 388f Hemangioma, 51, 155, 156, 186, 597 Hemangiopericytoma-like metastatic melanoma, 592 Hemangiopericytoma-like nevus, 102f HMB45, 120, 138, 140, 166, 356, 358, 377, 401, 424, 439, 483, 512, 514 Horizontal growth phase, see Radial growth phase Hutchinson s sign, 16, 18, 121, 305, 637, 638 Hyalinizing Spitz nevus, 187, 202f Hypermelanized polypoid melanoma, 589 Hypermelanotic nevus, 39f, 49 Hypermelanotic simple lentigo, 31 Hyperpigmented melanoma, see Animal-type melanoma Hyperpigmented Spitz nevus, 156, 163, 186 Hypopigmented blue nevus, 121, 127f, 128f, 139, 148f, 150f Hypopigmented Reed nevus, 220, 232f Hypospadia, 81 Immunostaining, 4, 419 Incidental nevus, 53 Inclusions, 52, 74f Inflammatory metastatic melanoma, 722 Inflammatory skin diseases, 375 Ink spot lentigo, 18, 25f In transit metastatic melanoma, 721 Inter-observer variability, 741 Intradermal melanoma, see Primary intradermal melanoma Intradermal melanoma on a congenital nevus, 77, 621 Intradermal nevus, 34 Intradermal Spitz nevus, 159 Intraepidermal Spitz nevus, 168f, 169f, 430, 485 Intranuclear inclusions, 52, 74f Introitus, 16, 653 Inverted type A nevus, 53 Irregular distribution of the pigment, 416 Ito nevus, see nevus of Ito, 114, 570 Jentigo, 31, 38f, 330 Jessner lymphocytic infiltrate, 513 Junctional anomalies in nevi, 91, 93f-96f Junctional nevus, 32, 42f Junctional Spitz nevus, 157 Juvenile conjunctival nevus, 358 Juvenile melanoma, see Spitz nevus Kamino bodies, 148, 157, 159, 163, 170f, 182f, 218, 277, 286, 305, 481, 482, 502 Keratoacanthoma, 188, 590 Labial lentigo, 15 Labia majores, 315, 653 Labia minores, 315, 653 Labial melanosis, 20f Lamellar fibroplasia, 276, 280f, 283f, 284f, 316, 340, 348f, 672f, 703 Large nests, 51, 68f, 69f, 416 Lateral margins, 2, 415 Lentiginous melanocytic hyperplasia, 82, 90f Lentiginous melanoma (of elderly), 6, 7, 32, 276, 423, 431f-432f Lentiginous melanoma of mucous membranes, 654, 665, 676 Lentigo maligna, 415, 418, 421, 422, 437, 440f, 441f, 457, 511 Lentigo-maligna-melanoma, 437, 438, 442f, 444f, 447 Lentigo senilis, 31 Lentigo simplex, 5, 7, 15, 31, 29, 37f-41f, 274, 329, 424, 431 Lichen planus-like keratosis, 387, 424, 439, 702, 711 Lichen sclerosus et atrophicus, 375, 376, 381f, 382, 653, 655, 375 Lichen simplex chronicus, 7, 13f Linear blue nevus, 121 Lips, 15, 20f, 527, Lymphatic invasion 159, 452, 726 Lymphocytic-like melanocytes, 513 Malignant blue nevus, 545f, 569 Malignant melanoma, see Melanoma Malignant peripheral nerve sheath tumor, 459, 515, 529, 596, 723 MANIAC, 302 Masson Fontana stain, 127, 303, 377, 387, 598, 722 Masson neuronevus, 139, 140 Maturation, 3 Melan-A, 6, 8, 16, 18, 120, 138, 166, 387, 422, 424, 439, 458, 512, 591, 593 Melanoacanthoma, 329, 331, 338f, 358, 424, 665, 666 Melanoblasts, 29, 47, 49, 98 Melanocytes type A, B, C, 103f, 115 Melanocytic hyperplasia, 3, 5, 8, 8f-14f, 15, 114, 378, 403f, 438, 635, 663, 666 Melanocytic macules, 15 Melanocytoma, benign melanocytoma, 257, 260f-272f differential diagnosis with epithelioid blue nevus, 257 melanoma, 259, 536, 560 (malignant) melanocytoma 547, 550f-558f Melanoma arising in a pre-existent nevus, 619, 623f-631f Melanoma arising in blue nevus, 569, 573f-580f Melanoma in children, 79, 100, 50, 486f, 505f-510f Melanoma in situ, dysplastic nevus, differential diagnosis with, 424 lentiginous intrabasal proliferation, 423 Melanoma in situ of the vulva, 654, 657f-661f Melanoma in situ on a compound Unna nevus, 422 Melanoma in situ on the conjunctiva, 676, 680f-682f Merkel cells carcinoma, differential diagnosis with, 424 Paget disease, differential diagnosis with, 424 Melanoma of male urethra, 655 Melanoma of the oral cavity, 663, 688f-674f

4 750 Index Melanoma on a compound nevus, 619, 623f, 624f, 627f, 630f Melanoma on a congenital nevus, 621 Melanoma on acral skin, 633, 640f-649f Melanoma on common nevus, 619, 623f-632f, 688f Melanoma on dermal melanocytosis, 569 Melanoma on genital skin, 653, 657f-662f Melanoma on male genitalia, 653, 655 Melanoma on palms and soles, see Melanoma on acral skin Melanoma on the conjunctiva, 675, 680f-688f Melanoma on vulvar melanosis, 653, 654 Melanoma resembling blue nevus, 535, 538f-546f Melanoma with a plexiform pattern, 581, 583f, 588f Melanoma with aberrant immunophenotype, 598 Melanoma with clear cell, 594, 612f-614 Melanoma with carcinoid-like, paraganglioma-like and haemangiopericytoma-like patterns, 592, 606f Melanoma with intermixed epithelial component, 592, 608f, 610 Melanoma with monster cell, 595 Melanoma with neural differentiation, 527 Melanoma with neuroblastic, ganglioneuroblastic differentiation, 596 Melanoma with neuroendocrine differentiation, 596 Melanoma with osteocartilagineous differentiation, 597 Melanoma with plasmacytic features, 597 Melanoma with prominent pigment synthesis, see Animal-type melanoma Melanoma with pseudoacantholytic features, 591 Melanoma with pseudoepitheliomatous hyperplasia, 590 Melanoma with pseudoglandular features, 591 Melanoma with regression, see Regressing melanoma Melanoma with spindled cell, see Spindle cell melanoma Melanoma with Spitz features, see Spitzoid melanoma Melanonichia striata, 17, 24f, 121, 304, 305, 637, 638 Melanophages, see Tumoral melanosis Melanosis oculi, 359 Melanosis of conjunctiva, 355, 675 Melanosis of nail bed, 17, 637 Melanotic macules, 5, 15c, 17, 638, 650f, 653, 664, 666 Melanotic macules on the vulva, 16 Melanotic schwannoma, 139, 549, 724 MELTUMP, 581 Meningeal melanocytosis, 113 Merkel cell carcinoma, 419, 424, 447, 595, 724 Merkel cells like metastatic melanoma, 724 Metaplastic ossification, 47 Metastatic carcinoma, 447, 595, 724, 728f Metastatic (cutaneous) melanoma, 721, 726f-740f Metastatic (cutaneous) melanoma with spindle cells, 457 Metastatic epidermotropic mammary carcinoma, 424 Metastatic epidermotropic melanoma, 723 Metastatic melanoma on mucous membranes, 665, 676 Metastasizing benign blue nevus, 571 Meyerson nevus, 375, 378f, 380f, 419 Meyerson phenomenon, 80 Miescher nevus, 8, 29, 35, 36, 46f, 51, 58f, 59f, 62f, 78 Miliary metastatic melanoma, 722 Milk line nevi, 339, 342f Minimal deviation melanoma, 467, 67f Mitoses, as a clue, 418 Mitotic rate, 482, 503, 571, 572, 591, 595, 620, 689, 725, 741 as a prognostic factor, 745 Mitotically active nevus, 51 Mongolian spot, 81, 82, 113, 114, 120, 385 melanoma on, 569 Monsel reaction, 447 Monster cells, 51, 72f, 73f, 180f, 541, 595 Mostly nested melanoma, 51, 75f, 322, 423, 434, 436, 447, 471f, 472f Mucin, 33, 48, 51, 57f, 70f, 80, 99, 139, 143, 152f, 176, 186, 197f, 237, 250f, 356, 512, 528, 596, 597, 618f, 724 Multinucleated giant cell, 139, 381f, 638 Multiple melanoma 156, 277, 653, 663, 723 Mycosis fungoides, 48, 419, 424, 703 Myxoid blue nevus, 139, 152f Myxoid melanoma, 237, 513, 597, 618f, 724 Myxoid Spitz nevus, 186, 188, 197f n-ras mutation 47, 77, 236, 451, 481, 537, 654, 723 Naked nodules, 100 Nail bed and matrix melanotic macule, 17, 637 Nail bed melanomas, 637 Nail matrix nevi, 304 Nanta osteonevus, 47, 56f Nasal mucosa, 676 Nested melanoma, 32, 51, 75, 322, 351, 423, 434f, 436f, 471f, 472f Neural differentiation, 81, 99, 140, 438, 527, 528, 529, 531f-534f, 571 in desmoplastic melanoma, 511, 512, 513, 514 in melanoma, 527, 532f-534f in nevi, 49, 63f, 78, 79 Neuroblastoma, 529, 595, 621 Neurocristic hamartoma, 81, 111f, 141, 571 Neurocutaneous melanosis, 81, 572 Neuroepithelioma, 621 Neurofibroma, 49, 51, 64, 78, 79, 80, 112, 121, 127, 139, 167, 385, 511, 513, 514, 529, 597 Neurofibromatosis, 79, 596, 597, 529 Neurofibromatosis and congenital nevus, 79 Neurofibrosarcoma, 529, 621, 458, Neuronevus, see Masson neuronevus Neurothekeoma, 167, 184, 452, 529, 531, 533, 584, 598 Neurotization of melanocytic nevus, 49, 63f Neurotropic melanoma, 16, 63, 527, 531f-534f, 597, 667, 743 Neurotropism, 141,185, 438, 457, 512, 527, 529, 531f-534f, 689, 744 Nevoid melanoma, 4, 35, 44, 47, 50, 86, 283, 382f, 400, 415, 419, 446, 467, 471f, 636, 642f-647f in situ, 423 on nevus, 44, 47, 621 Nevoid metastatic melanoma, 723, 729f-732f Nevus combined with inflammatory skin diseases, 375, 379f-384f Nevus combined with lichen sclerosus et atrophicus, 376, 381f Nevus fuscoceruleus acromio-deltoideus, 114 Nevus fuscoceruleus ophthalmo-maxillaris, 113 Nevus fuscoceruleus zigomaticus, 114 Nevus in the oral cavity, 329, 332f-337f Nevus incipiens, 31, 38f-39f Nevus on acral skin, 301, 307f-310f Nevus on genital skin, 315, 318f-328f, 653 Nevus on nail apparatus, 304 Nevus on skin affected by psoriasis, 377 Nevus on special sites, 339, 342f-352f Nevus on the conjunctiva, 355, 360f-374f Nevus on the milk line, 340, 348f Nevus sebaceous, 81 Nevus spilus, 82, 90f Nevus with adipocytic metaplasia, 49 Nevus with large spindle and or epithelioid cells, see Spitz nevus Nevus with mucin, 48, 57f, 59 Nevus with pagetoid cells, 52, 75

5 Index 751 Nipple, nevus on the, 19, 342f, 418, 424 Nodular pattern melanoma, 451, 454f-456f Nodule in acquired nevus, 97 Nodule in congenital nevus, 97 Oculo-dermal-melanocytosis, 113 Oral melanosis, 15, 663 Oral Spitz nevus, 330 Osteocartilagineous melanoma, 597 Osteonevus of Nanta, 47, 56f Ota nevus, 82, 113, 359 melanoma on, 569 p16, 166, 483, 514, 620 p75 NGFR, 458, 511, 512, 513, 515, 528 Paget disease, 52, 75, 168, 284, 418, 424, 446, 503, 654, 678 Pagetoid cells, 75f, 446, 635, 654 Pagetoid dyskeratosis, 418, 424 Pagetoid melanocytes, 52, 75f, 284f, 287, 438, 498f, 503, 614f Pagetoid Spitz nevus, 157, 423 Pagetoid spread in nevi, 2, 33, 52, 80, 90, 158, 164, 218, 287, 302, 304, 308f, 311f, 316, 330, 340, 356, 376, 387, 400 in melanoma 421, 422, 431, 433f, 447, 452, 482, 635, 638, 654, 675, 724 Palate, 2, 16, 329, 331, 334, 589, 663, 664, 722 Palpebral conjunctiva, 355, 676, 680f PAM, see Primary acquired melanosis Papillated nevoid melanoma, 467, 468 Penile melanosis (penile melanotic macula), 17, 22f, 23f Penile melanotic macula, 17, 22f-23f Penis, 17, 22f-23f, 82, 132f, 315, 326f, 655 Perls stain, 115, 447 Permanganate, 122, 124f Persistent melanoma, see Recurrent melanoma Persistent nevus, 49, 399, 689, 692 Phakomatosis pigmentovascularis, 81, 82 Pigmented epithelioid melanocytoma, see Benign melanocytoma and Melanocytoma Pigmented spindle cell nevus, see Reed nevus Pilar neurocristic hamartoma, 81 Placenta, 722 Plaque type blue nevus, 121 Plasmacytic melanoma, 597 Plexiform pattern of melanoma, 237, 251, 252, 496f, 529, 548, 581, 583f-581f Plexiform Spitz nevus, 186, 585 Polypoid melanoma, 70f, 210f, 589 Polypoid nevus of pregnancy, 339, 340, 353f Polypoid Spitz nevus, 187, 188, 210f, 212f, 396, 590 Pregnancy, 18, 34, 50, 115, 156, 277, 315, 339, 353f, 355, 359 Prepuce, 316, 655 Primary acquired melanosis (PAM), 355, 675, 677 Primary dermal melanoma (intradermal melanoma), 100f, 590, 592, 605f, 691, 724, Prognostic factors, 741 Proliferative nodules in congenital and acquired nevi, 67, 79, 97, 100, 101f-112f, 208f, 209f, 288, 620 Prurigo nodularis, 7, 13f, 590 Pseudoacantholytic melanoma, 591 Pseudoepitheliomatous hyperplasia, 122, 330, 358, 373f, 442f, 590, 702 Pseudoinclusions, 50, 236, 358, 429, 597 Pseudonest, 8, 424, 439 Pseudonevoid melanoma, see Nevoid melanoma Pseudosarcomatous melanoma, 457, 511 Pseudovascular lacunae, 48, 59f Psoriasis, 17, 26f, 355, 377, 383f, 385 Puberty, melanocytic nevus and, 33, 34, 81, 82, 113, 141, 235, 274, 277, 302, 501 Pulverocytes, 52, 277, 284f, 503, 583, 590 PUVA therapy, 5, 7, 11f, 15, 17, 19, 26f Racial melanosis, 359, 424, 675, 677, 678 Radial growth phase, 445, 743 Recurrent melanoma, 7, 156, 187, 399, 401, 404f, 463f, 689, 693f-697f Recurrent nevus, 5, 248f, 357, 377, 404f, 399, 400, 690, 703 Recurrent Spitz nevus, 187, 201f Reed nevus, 39, 80, 156, 170, 198f, 199f, 188, 217, 221f-234f, 285, 286, 295f, 340, 342f, 429f, 438, 548, 696, 703 differential diagnosis with Clark nevus, 273, 275, 277, 278 differential diagnosis with melanoma, 458, 460f, 461f, 483, 484, 497f, 498f, 499f Regressing melanoma, 186, 189, 196, 218, 376, 386, 387, 393, 424, 439, 699, 705f-711f Regressing melanoma on a nevus, 624f, 702 Regressing Spitz nevus, 388, 396f Reticulated melanotic macule of the trunk, 18 Reticulohistiocytoma, 167 Rhabdoid cells, 99, 595, 616f Rhabdoid melanoma, 74, 99, 595, 614f, 724 Rhabdomyosarcoma, 99, 595, 621 Satellite metastasis, 696, 721, 735 Scale crust, 165, 379f, 380f, 400 Scalp, 32, 47, 78, 80, 81, 115, 120, 138, 141, 235, 257, 274, 277, 340, 351f, 352f, 417, 447, 511, 536, 560, 569, 570, 595, 721 atypical nevi on, 339, 351f, 352f Scar, 12f, 49, 187, 345f, 340, 379, 383f-385f, 444f, 511, 512, 516f, 664, 689, 690, 694f-696f, 722, 724 Schwannian differentiation, 33, 35, 47, 53, 77, 78, 79, 80, 99, 100, 150f, 458, 529, 533f, 571 Sclerosing nevus, 283f, 399, 401, 408f-413f, 703 Sclerotic blue nevus, 139, 514, 528 Scrotum, 315 Sebaceous carcinoma, 418, 424, 447, 678 Sebaceous glands, 35, 78, 120 Selective advantage of growth, 417 Signet ring cell melanoma, 596 Silhouette, 2, 29, 34, 35, 44, 596, 630f, 705f, 722 Simple lentigo, see Lentigo simplex Skin tag, 34, 425, 589 Small cell melanoma, 595, 615f Smoker s melanosis, 16 Solar damage, 185, 219, 220, 447, 482, 514 SOX-10, 18, 192, 281, 422, 458, 512, 513, 528, 598, 611f, 708f, 728 SPARK nevus, 186, 200f, 277 Special cutaneous sites, 273, 315, 339, 356, 417, 422, 424 Speckled lentiginous nevus see Nevus spilus Spindle cell melanoma, 447, 457, 463f-465f, 512, 527, 734f differential diagnosis with blue nevus, 121, 138 differential diagnosis with Reed nevus, 217, 219, 220, 229f, 230f, 232f on acral skin 635, 712f Spitz nevus, 155, 168f-184f adnexal structures, involvement in, 158

6 752 Index age in patients with, 160 epidermal hyperplasia in, 165 expansive nodules in, 165 halo phenomenon in, 189, 214f, 388, 396f Spitz nevus on special sites on acral skin, 304, 311f on oral cavity, 330, 336f Spitz nevus variants agminate Spitz nevus, 190 angiomatoid Spitz nevus, 186, 196f atypical Spitz nevus, 189, 215f, 216f ballooning Spitz nevus, 189, 213f combined Spitz nevus, 188, 205f congenital Spitz nevus, 190 desmoplastic Spitz nevus, 185, 191f, 192f granulomatous Spitz nevus, 186, 194f hyalinizing Spitz nevus, 187, 202f hyperpigmented Spitz nevus,186, 198f, 199f intradermal Spitz nevus, 188, 202f intraepidermal Spitz nevus, 157, 168f, 169f myxoid, 186, 197f oral Spitz nevus, 330, 336f nodular intradermal, 188, 208f, 209f pagetoid Spitz nevus, 157, 168f, 169f plexiform Spitz nevus, 186, 194f polypoid Spitz nevus, 188, 210f, 212f, 396f recurrent Spitz nevus, 187, 201f regressing Spitz nevus, 189, 214f, 396f spitzoid lentigo, 23f, 31, 40f, 157, 168f, 169f tubular Spitz nevus, 188 verrucous Spitz nevus, 187 with BAP-1 mutation, 188, 206f with features of Clark nevus, 186, 200f with pseudoepitheliomatous hyperplasia, 187, 204f Spitz nevus with spindle cells, 172f, 177f Spitz Sophie, 155, 162, 179f, 501 Spitzoid melanoma, 481, 485f-499f Spitzoid melanoma of childhood, 501, 505f-510f Spitzoid metastatic melanoma, 723, 733f Splaying, 78, 79, 84f, 236, 330 Spongiotic dermatitis, 7, 80, 375, 379f, 380f, 385 Squamomelanocytic tumor, 592, 608f Squamous cell carcinoma, 156, 188, 204f, 356, 358, 373f, 375, 403, 452, 590, 592, 638, 653, 666, 678 Subungual melanoma, 637 Sun nevus, 114 Sunburn, 50, 53, 121, 156, 277 Superficial spreading pattern of melanoma, 445, 447, 449f, 450f, 452 Sutton nevus, see halo nevus Symmetry, 99, 232f, 725 as diagnostic criterium, 2, 3, 415 in Spitz nevus, 161, 164 Syringoma, 48, 61f, 598 Trichostasis spinulosa, 48 Tubular Spitz nevus, 188 Tumor thickness in melanoma prognosis, 741 Tumoral melanosis, 88, 122, 131, 141, 149f, 236, 387, 482, 561, 700, 701, 718f-720f, 721, 724 Type A, B, C nevus cell, 68f,103f, 53 Ulceration, 77, 79, 100, 161, 165, 387, 401, 446, 451, 483, 513, 560, 571, 621, 666, 677, 689, 700 as a prognostic factor, 741, 742, 745f Umbilicus, 217, 339, 340, 345f Unna nevus, 29, 34, 44f, 45f variants, 47, 50, 51, 52, 57f, 340, 410 differential diagnosis with melanoma, 468, 470f melanoma on papillomatous nevus, 630 Unusual forms of melanoma, 589 Urethral meatus, 564, 655 Vaginal melanoma, 653 Vascular embolism, 744, 723 Verrucous melanoma, 188, 589, 590, 633, 717 Verrucous pseudonevoid melanoma, 467 Verrucous Spitz nevus, 156 Vertical growth phase, 159, 188, 445, 452, 595, 663 as a prognostic factor, 742, 743 Volar skin, see Nevi and Melanoma on acral skin Von Recklinghausen s disease, 80, 529, 597 Vulvar melanoma, see Melanoma on genital skin Vulvar melanoma in situ, 653 Vulvar melanoma on nevus, 653 Vulvar melanosis, 17, 653 Vulvar melanotic macules, 16, 17, 21f, 653 Vulvar nevus, 315 Xeroderma pigmentosum, 7, 30, 675 Zitelli nevus, 468, 473f Tardy or tardive congenital nevi, 32, 77 Toker cells, 418 Tongue, 15, 329, 330, 663, 665, 722 Tonsils, 667, 722 Toxic epidermolytic necrolysis, 378 Transplacental metastatic melanoma, 722 Trauma, 114, 121, 139, 156, 159, 163, 276, 381, 400, 401, 406f, 469, 482, 633, 637, 666, 742 Traumatized nevus, 2, 49, 377, 399, 401, 406f, 702