CONTENTS SINGLE STANDARDS New psychoactive substances (NPS) 29-52

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3 toxicology Toxicology covers a wide range of disciplines, including therapeutic drug monitoring, clinical toxicology, forensic toxicology (drug driving, criminal and coroners), drugs in sport and work place drug testing, as well as academia and research. Those working in the field have a professional interest in the detection and measurement of alcohol, drugs, poisons and their breakdown products in biological samples, together with the interpretation of these measurements. Abuse and misuse of drugs is one of the biggest problems facing our society today. Acute poisoning remains one of the commonest medical emergencies, accounting for 10-20% of hospital admissions for general medicine [Dargan & Jones, 2001]. Many offenders charged with violent crimes, or victims of violent crime may have been under the influence of drugs at the time the act was committed. The use of mind-altering drugs in the work place, or whilst in control of a motor vehicle places others in danger [Drummer, 2001]. Performance enhancing drugs in sport make for an uneven playing field and distract from the core ethic of sportsmanship. Patterns of drug abuse around the world are constantly evolving. They vary between geographies; from one country to another and even from region to region or population to population within countries. With a European presence, a wide reaching network of global customers and distributors, and activate participation in relevant professional societies, Chiron is well positioned to develop and deliver relevant, and current standards to meet customer demand in this challenging field.

4 CONTENTS SINGLE STANDARDS 1-4 Anaesthetics 4 Antibiotics 5 Anticancer 5 Anticoagulants 6 Anticonvulsants / Antiepileptics Antidiabetics 10 Antidyskinetic / Antimuscarinics / Antiparkinsonian 11 Antiemetics Antifungals 12 Antihistamines Anti-impotence 13 Anti-insomnia Antimalarial 14 Antimicrobial 14 Antipsycotics Antiretrovirals 16 Barbiturates Cannabinoids (Phyto) Cocaine and related compounds Contrast media 25 Enzymes 25 Ephedrines Ethanol and related compounds Gastrointestinal drugs Neurotransmitters 29 New psychoactive substances (NPS) Amphetamines Methamphetamines Methylenedioxyphenethylamines 33 2C Phenethylamines (psychedelics) 34 Benzofuries (APBs and APDBs) 35 Indanes Piperazines Designer forms of pharmaceuticals 47

5 Quinazolinones 47 Methylphenidate related compounds Other pharmaceuticals Synthetic opioids 49 GHB and GBL 49 Diarylethylamines 50 Aryl cyclohexylamines 50 Tryptamines Plant chemicals 51 Miscellaneous NPS Nicotine and related compounds Obstetrics Respiratory agents (including methylxanthines) Vitamins 61 DRUG MIXTURES Amphetamines 62 Anticonvulsants / Antiepileptics Cocaine 64 Congener alcohols 64 Opiates 64 Pharmaceutical residues 65 X-ray Contrast media 66 Z-Drugs 66 CALIBRATION SETS Amphetamines and Opiates 67 Benzoylecgonine and 67 THC-acid 67 Zopiclone, Zolpidem and 6-MAM 67 INDEX Alphabetical category index 68-89

6 1 SINGLE STANDARDS Aceclofenac ME Aceclofenac µg/ml methanol 1 ml ME Aceclofenac Imp. I (1-(2,6-Dichlorophenyl)indolin-2-one) µg/ml methanol 1 ml MG Aceclofenac Imp. I (1-(2,6-Dichlorophenyl)indolin-2-one) neat neat 10 mg Acetaminophen (Paracetamol) K-ME Acetaminophen µg/ml methanol 1 ml MG Acetaminophen neat neat 500 mg K-ME Acetaminophen-d3 (acetamide-d3 ) µg/ml methanol 1 ml MG Acetaminophen-d3 (acetamide-d3 ) neat neat 10 mg MG Acetaminophen-d3 (acetamide-d3 ) neat neat 100 mg ME Acetaminophen-d4 (phenyl-d4 ) µg/ml methanol 1 ml K-ME Acetaminophen-d4 (phenyl-d4 ) µg/ml methanol 1 ml MG Acetaminophen-d4 (phenyl-d4 ) neat neat 10 mg MG Acetaminophen-d4 (phenyl-d4 ) neat neat 100 mg ME Acetaminophen Imp. B (N -(4-Hydroxyphenyl)-propionamide) µg/ml methanol 1 ml MG Acetaminophen Imp. B (N -(4-Hydroxyphenyl)-propionamide) neat neat 100 mg MG Acetaminophen Imp. E (1-(4-Hydroxyphenyl)ethanone) neat neat 100 mg K-ME Acetaminophen Imp. F (4-Nitrophenol) µg/ml methanol 1 ml MG Acetaminophen Imp. F (4-Nitrophenol) neat neat 100 mg ME Acetaminophen Imp. H (N,O- Diacetyl-4-aminophenol) µg/ml methanol 1 ml MG Acetaminophen Imp. H (N,O- Diacetyl-4-aminophenol) neat neat 100 mg MG Acetaminophen Imp. I (1-(2-Hydroxyphenyl)ethanone, 2-Hydroxyacetophenone) neat neat 100 mg K-ME Acetaminophen Imp. J (4'-Chloroacetanilide) µg/ml methanol 1 ml MG Acetaminophen Imp. J (4'-Chloroacetanilide) neat neat 100 mg K-ME Acetaminophen Imp. K (4-Aminophenol) µg/ml methanol 1 ml MG Acetaminophen Imp. K (4-Aminophenol) neat neat 500 mg Acetylsalicylic acid (Aspirin) K-ME Acetylsalicylic acid µg/ml methanol 1 ml MG Acetylsalicylic acid neat neat 100 mg MG Acetylsalicylic acid neat neat 500 mg K-ME Acetylsalicylic acid Imp. A (4-Hydroxybenzoic acid) µg/ml methanol 1 ml MG Acetylsalicylic acid Imp. A (4-Hydroxybenzoic acid) neat neat 100 mg K-ME Acetylsalicylic acid Imp. B (4-Hydroxyisophthalic acid, 4-Hydroxybenzene-1,3-dicarboxylic acid) µg/ml methanol 1 ml MG K-ME MG Acetylsalicylic acid Imp. B (4-Hydroxyisophthalic acid, 4-Hydroxybenzene-1,3-dicarboxylic acid) Acetylsalicylic acid Imp. C (Salicylic acid, 2-Hydroxybenzoic acid) Acetylsalicylic acid Imp. C (Salicylic acid, 2-Hydroxybenzoic acid) neat neat 100 mg µg/ml methanol 1 ml neat neat 500 mg

7 2 continued Acetylsalicylic acid (Aspirin) ME Acetylsalicylic acid Imp. D (Acetylsalicylsalicylic acid) µg/ml methanol 1 ml MG Acetylsalicylic acid Imp. D (Acetylsalicylsalicylic acid) neat neat 10 mg MG Acetylsalicylic acid Imp. D (Acetylsalicylsalicylic acid) neat neat 25 mg MG Acetylsalicylic acid Imp. D (Acetylsalicylsalicylic acid) neat neat 100 mg ME Acetylsalicylic acid Imp. F (O- Acetylsalicylic anhydride) µg/ml methanol 1 ml MG Acetylsalicylic acid Imp. F (O- Acetylsalicylic anhydride) neat neat 100 mg ME 2-(2,4-Dihydroxybenzoyl)benzoic acid µg/ml methanol 1 ml K-ME Salicylic acid (2-Hydroxybenzoic acid) µg/ml methanol 1 ml MG Salicylic acid (2-Hydroxybenzoic acid) neat neat 500 mg K-ME Salicylic acid-d4 (3,4,5,6-d4 ) µg/ml methanol 1 ml K-MEx10 Salicylic acid-d4 (3,4,5,6-d4 ) µg/ml methanol 1 ml MG Salicylic acid-d4 (3,4,5,6-d4 ) neat neat 10 mg K-ME Salicylic acid-d6 (perdeuterated) µg/ml methanol 1 ml K-MEx10 Salicylic acid-d6 (perdeuterated) µg/ml methanol 1 ml K-10MG Salicylic acid-d6 (perdeuterated) neat neat 10 mg K-ME Salicylic acid Imp. C (Phenol) µg/ml methanol 1 ml G Salicylic acid Imp. C (Phenol) neat neat 1 g G 4-Aminosalicylic acid neat neat 1 g Diclofenac K-ME Diclofenac µg/ml methanol 1 ml K-ME Diclofenac-d4 (phenyl-d4 ) µg/ml methanol 1 ml MG Diclofenac-d4 (phenyl-d4 ) neat neat 5 mg Ethenzamide (2-Ethoxybenzamide) K-ME Ethenzamide µg /ml methanol 1 ml MG Ethenzamide neat neat 10 mg MG Ethenzamide neat neat 100 mg Etoricoxib (Arcoxia) MG Etoricoxib neat neat 10 mg Hydroxychloroquine MG Hydroxychloroquine (2-((4-(7-Chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol) neat neat 100 mg MG Hydroxychloroquine sulfate 2-((4-(7-Chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol neat neat 100 mg sulfate Ibuprofen K-ME (± )- Ibuprofen µg/ml methanol 1 ml MG (± )- Ibuprofen neat neat 100 mg MG (± )- Ibuprofen neat neat 500 mg K-ME (±)- Ibuprofen-d3 (α-methyl-d3 ) µg/ml methanol 1 ml K-IO (±)- Ibuprofen-d3 (α-methyl-d3 ) µg/ml isooctane 1 ml ME Ibuprofen Imp. B ((2RS )-2-(4-Butylphenyl)propanoic acid) µg/ml methanol 1 ml MG Ibuprofen Imp. B ((2RS )-2-(4-Butylphenyl)propanoic acid) neat neat 100 mg ME Ibuprofen Imp. B ((2RS )-2-(4-Butylphenyl)propanoic acid) µg/ml methanol 1 ml MG Ibuprofen Imp. B ((2RS )-2-(4-Butylphenyl)propanoic acid) neat neat 100 mg ME Ibuprofen Imp. C ((2RS )- 2-[4-(2-Methylpropyl)phenyl]propanamide) µg/ml methanol 1 ml K-ME Ibuprofen Imp. D ((2RS )- 2-(4-Methylphenyl)propanoic acid) µg/ml methanol 1 ml MG Ibuprofen Imp. D ((2RS )- 2-(4-Methylphenyl)propanoic acid) neat neat 100 mg

8 3 continued Ibuprofen ME Ibuprofen Imp. D2 ((1-Hydroxyethyl)-4-(2-methylpropyl)benzene) µg/ml methanol 1 ml MG Ibuprofen Imp. D2 ((1-Hydroxyethyl)-4-(2-methylpropyl)benzene) neat neat 100 mg ME Ibuprofen Imp. E (1-[4-(2-Methylpropyl)phenyl]ethanone) µg/ml methanol 1 ml MG Ibuprofen Imp. E (1-[4-(2-Methylpropyl)phenyl]ethanone) neat neat 25 mg MG Ibuprofen Imp. E (1-[4-(2-Methylpropyl)phenyl]ethanone) neat neat 100 mg ME Ibuprofen Imp. F2 (Methyl-2-[4-(2-methylpropyl)phenyl]propanoate) µg/ml methanol 1 ml MG Ibuprofen Imp. F2 (Methyl-2-[4-(2-methylpropyl)phenyl]propanoate) neat neat 100 mg ME Ibuprofen Imp. N ((2RS )-2-(4-Ethylphenyl)propanoic acid) µg/ml methanol 1 ml MG Ibuprofen Imp. N ((2RS )-2-(4-Ethylphenyl)propanoic acid) neat neat 25 mg MG Ibuprofen Imp. N ((2RS )-2-(4-Ethylphenyl)propanoic acid) neat neat 100 mg ME Ibuprofen Imp. P ((2RS )- 2-[4-(2-Methylpropyl)phenyl]propan-1-ol) µg/ml methanol 1 ml MG Ibuprofen Imp. P ((2RS )- 2-[4-(2-Methylpropyl)phenyl]propan-1-ol) neat neat 25 mg MG Ibuprofen Imp. P ((2RS )- 2-[4-(2-Methylpropyl)phenyl]propan-1-ol) neat neat 100 mg ME Ibuprofen Imp. S (4-Isobutylbenzoic acid) µg/ml methanol 1 ml MG Ibuprofen Imp. S (4-Isobutylbenzoic acid) neat neat 100 mg MG Ibuprofen Imp. U (4-Acetylbenzoic acid) neat neat 100 mg ME Ibuprofen Imp. W (2-Methyl-1-[4-(1-methylethyl)phenyl]-1-propanone) µg/ml methanol 1 ml MG Ibuprofen Imp. W (2-Methyl-1-[4-(1-methylethyl)phenyl]-1-propanone) neat neat 25 mg MG Ibuprofen Imp. W (2-Methyl-1-[4-(1-methylethyl)phenyl]-1-propanone) neat neat 100 mg ME (2RS )-2-(4-n -Propylphenyl)propanoic acid µg/ml methanol 1 ml MG (2RS )-2-(4-n -Propylphenyl)propanoic acid neat neat 25 mg MG (2RS )-2-(4-n -Propylphenyl)propanoic acid neat neat 100 mg Ketoprofen MG Ketoprofen neat neat 10 mg Meclofenamic acid (Meclomen, Meclofenamate sodium) MG Meclofenamic acid sodium salt neat neat 10 mg Medetomidine MG Medetomidine hydrochloride neat neat 50 mg Mefenamic acid MG Mefenamic acid neat neat 10 mg Meloxicam K-DS Meloxicam µg/ml DMSO 1 ml MG Meloxicam neat neat 10 mg Mesalazine K-ME Mesalazine µg/ml methanol 1 ml MG Mesalazine neat neat 100 mg G Mesalazine neat neat 1 g ME N -Propionyl mesalazine-d5 (propionyl-d5 ) µg/ml methanol 1 ml Naproxen ME (+)-(S)- Naproxen µg/ml methanol 1 ml K-ME (+)-(S)- Naproxen µg/ml methanol 1 ml MG (+)-(S)- Naproxen neat neat 100 mg MG (±) -Naproxen-d3 (α-methyl-d3 ) neat neat 10 mg MG Naproxen Imp. I ((6-Methoxy-2-naphthyl)acetic acid) neat neat 100 mg

9 4 continued Naproxen ME Naproxen Imp. L (2-Acetyl-6-methoxynaphthalene) µg/ml methanol 1 ml MG Naproxen Imp. L (2-Acetyl-6-methoxynaphthalene) neat neat 100 mg ME Naproxen Imp. M (2-Methoxynaphthalene) µg/ml methanol 1 ml MG Naproxen Imp. M (2-Methoxynaphthalene) neat neat 100 mg MG Naproxen Imp. N (2-Bromo-6-methoxynaphthalene) neat neat 100 mg Phenacetin (4-Ethoxyacetanilide) K-AN Phenacetin µg/ml acetonitrile 1 ml MG Phenacetin neat neat 10 mg Phenazone (Antipyrine) MG Phenazone neat neat 10 mg ME Phenazone-d3 (2-N- methyl-d3 ) µg/ml methanol 1 ml MG Phenazone-d3 (2-N- methyl-d3 ) neat neat 10 mg Phenylbutazone (Fenylbutazon) K-ME Phenylbutazone µg/ml methanol 1 ml MG Phenylbutazone neat neat 10 mg Propyphenazone (4-Isopropylantipyrine) ME Propyphenazone µg/ml methanol 1 ml MG Propyphenazone neat neat 10 mg MG Propyphenazone neat neat 100 mg ME Propyphenazone-d3 (N -methyl-d3 ) µg/ml methanol 1 ml MG Propyphenazone-d3 (N -methyl-d3 ) neat neat 10 mg Anaesthetics Gammahydroxybutyrate (GHB) K-ME Sodium gammahydroxybutyrate µg/ml methanol 1 ml MG Sodium gammahydroxybutyrate neat neat 100 mg ME Sodium gammahydroxybutyrate-d6 (2,2,3,3,4,4- d6) µg/ml methanol 1 ml K-ME Sodium gammahydroxybutyrate-d6 (2,2,3,3,4,4- d6) µg/ml methanol 1 ml MG Sodium gammahydroxybutyrate-d6 (2,2,3,3,4,4- d6) neat neat 10 mg K-ME Sodium gammahydroxybutyrate-1,4-13c (unlabelled) 1000 µg/ml methanol 1 ml MG Sodium gammahydroxybutyrate-1,4-13c (unlabelled) neat neat 10 mg Ketamine ME (± )- Ketamine hydrochloride µg base/ml methanol 1 ml K-ME (± )- Ketamine hydrochloride µg base/ml methanol 1 ml MG (± )- Ketamine hydrochloride neat neat 10 mg MG (± )- Ketamine hydrochloride neat neat 50 mg MG (± )- Ketamine hydrochloride neat neat 100 mg ME (+)-(S)- Ketamine hydrochloride µg base/ml methanol 1 ml ME (±)- Ketamine-d4 hydrochloride (phenyl-d4 ) µg base/ml methanol 1 ml ME (± )- Norketamine hydrochloride µg base/ml methanol 1 ml Lignocaine (Lidocaine) MG Lignocaine hydrochloride neat neat 100 mg K-ME Lignocaine-d10 hydrochloride (N,N- di(ethyl-d5 )) µg base/ml methanol 1 ml K-ME Lignocaine-d10 (N,N- di(ethyl-d5 )) µg/ml methanol 1 ml Propofol (2,6-Diisopropylphenol) K-ME Propofol µg/ml methanol 1 ml MG Propofol neat neat 100 mg MG Propofol neat neat 250 mg K-MEx2 Propofol-d18 (perdeuterated) µg/ml methanol 1 mlx2 Thiopental K-ME Thiopental µg/ml methanol 1 ml MG Thiopental neat neat 10 mg

10 5 Antibiotics Amikacin MG Amikacin neat neat 100 mg 4-Aminosalicylic acid (PAS) G 4-Aminosalicylic acid neat neat 1 g Cefotaxime MG Cefotaxime sodium salt neat neat 100 mg Chlortetracycline MG Chlortetracycline hydrochloride neat neat 10 mg Ciprofloxacin MG Ciprofloxacin neat neat 10 mg MG Ciprofloxacin hydrochloride neat neat 100 mg W Ciprofloxacin-d8 hydrochloride (piperazine-d8 ) µg base/ml water 1 ml MG Ciprofloxacin Imp. C neat neat 10 mg Clarithromycin MG Clarithromycin neat neat 10 mg MG Clarithromycin neat neat 100 mg G Clarithromycin neat neat 1 g G Clarithromycin neat neat 2 g Cloxacillin MG Cloxacillin sodium neat neat 100 mg Erythromycin MG Erythromycin neat neat 10 mg MG Erythromycin ethyl succinate neat neat 10 mg Norfloxacin (Baccidal, Sebercim) MG Norfloxacin neat neat 100 mg Isoniazid MG Isoniazid neat neat 250 mg Meropenem MG Meropenem trihydrate neat neat 100 mg Penicillin G (Benzylpenicillin G) MG Penicillin G sodium Salt neat neat 100 mg Piperacillin MG Piperacillin sodium Salt neat neat 100 mg Sulfadiazine MG Sulfadiazine neat neat 100 mg ME 4-Hydroxysulfadiazine µg/ml methanol 1 ml ME 4-Hydroxysulfadiazine µg/ml methanol 1 ml MG 4-Hydroxysulfadiazine neat neat 1 mg MG 4-Hydroxysulfadiazine neat neat 5 mg Sulfamethoxazole ME Sulfamethoxazole µg/ml methanol 1 ml MG Sulfamethoxazole neat neat 100 mg ME Sulfamethoxazole-d4 (phenyl-d4 ) µg/ml methanol 1 ml Tazobactam MG Tazobactam neat neat 100 mg Tetracycline MG Tetracycline hydrochloride neat neat 100 mg Trimethoprim MG Trimethoprim neat neat 100 mg MG Trimethoprim Imp. K (Aniline) neat neat 100 mg ML Trimethoprim Imp. K (Aniline) neat neat 1 ml ME Trimethoprim Imp. K (Aniline) µg/ml methanol 1 ml MEX5 Trimethoprim Imp. K (Aniline) µg/ml methanol 1 ml K-ME Aniline-d5 (perdeuterated) µg/ml methanol 1 ml Tobramycin MG Tobramycin neat neat 100 mg Anticancer Allopurinol MG Allopurinol neat neat 100 mg MG Allopurinol Imp. A (5-Amino-1H-pyrazole-4-carboxamide) neat neat 100 mg MG 3-Amino-4-pyrazolecarboxamide hemisulfate neat neat 100 mg Busulfan (Myleran) K-ME Busulfan µg/ml methanol 1 ml MG Busulfan neat neat 10 mg

11 6 Anticoagulants EDTA (Ethylenediaminetetraacetic) MG EDTA-d neat neat 100 mg Rivaroxaban (BAY ) MG Rivaroxaban neat neat 10 mg MG Rivaroxaban neat neat 50 mg Warfarin K-ME Warfarin µg/ml methanol 1 ml MG Warfarin neat neat 10 mg ME Warfarin-d5 (phenyl-d5 ) µg/ml methanol 1 ml MG Warfarin-d5 (phenyl-d5 ) neat neat 10 mg Anticonvulsants / Antiepileptics Allopurinol MG Allopurinol neat neat 100 mg MG Allopurinol Imp. A (5-Amino-1H-pyrazole-4-carboxamide) neat neat 100 mg MG 3-Amino-4-pyrazolecarboxamide hemisulfate neat neat 100 mg Carbamazepine (Tegretol) K-ME Carbamazepine µg/ml methanol 1 ml MG Carbamazepine neat neat 10 mg MG Carbamazepine neat neat 100 mg K-ME Carbamazepine-d10 (rings-d10 ) µg/ml methanol 1 ml MG Carbamazepine-d10 (rings-d10 ) neat neat 5 mg K-ME Carbamazepine-10,11-epoxide µg/ml methanol 1 ml K-ME Carbamazepine-10,11-epoxide-d10 (rings-d10 ) µg/ml methanol 1 ml MG Carbamazepine-10,11-epoxide-d10 (rings-d10 ) neat neat 5 mg IO Carbamazepine Imp. B (9-Methylacridine) µg/ml isooctane 1 ml MG Carbamazepine Imp. B (9-Methylacridine) neat neat 100 mg MG Carbamazepine Imp. D (5H-Dibenz[b,f]azepine, Iminostilbene) neat neat 100 mg K-IO Carbamazepine Imp. E (10,11-Dihydro-5H-dibenz[b,f] -azepine, Iminodibenzyl) µg/ml isooctane 1 ml MG Carbamazepine Imp. E (10,11-Dihydro-5H-dibenz[b,f] -azepine, Iminodibenzyl) neat neat 100 mg Gabapentin (Neurontin) K-ME Gabapentin µg/ml methanol 1 ml MG Gabapentin neat neat 10 mg MG Gabapentin neat neat 25 mg MG Gabapentin neat neat 100 mg G Gabapentin neat neat 1 g K-ME Gabapentin-d4 (aminomethyl- d2 ; acetic- d2 acid) µg/ml methanol 1 ml MG Gabapentin-d4 (aminomethyl- d2 ; acetic- d2 acid) neat neat 5 mg MG Gabapentin-d4 (aminomethyl- d2 ; acetic- d2 acid) neat neat 10 mg ME Gabapentin-d10 (cyclohexyl-d10 ) µg/ml methanol 1 ml Lacosamide MG (+)-(2R)- Lacosamide-d3 (methoxy-d3) neat neat 10 mg Lamotrigine (Lamictal) ME Lamotrigine µg/ml methanol 1 ml K-ME Lamotrigine µg/ml methanol 1 ml MG Lamotrigine neat neat 10 mg MG Lamotrigine neat neat 25 mg MG Lamotrigine neat neat 100 mg UG Lamotrigine-2N-glucuronide neat neat ca. 10µg Levetiracetam (Keppra) ME (-)-(S)- Levetiracetam µg/ml methanol 1 ml ME (-)-(S)- Levetiracetam-d6 (pyrrolidone-d6) µg/ml methanol 1 ml MG (-)-(S)- Levetiracetam-d6 (pyrrolidone-d6) neat neat 10 mg ME Etirazetam (racemic form) µg/ml methanol 1 ml ME Etirazetam-d6 (racemic form) (pyrrolidine-d6 ) µg/ml methanol 1 ml Oxcarbazepine ME Oxcarbazepine µg/ml methanol 1 ml K-ME Oxcarbazepine µg/ml methanol 1 ml MG Oxcarbazepine neat neat 10 mg

12 7 Anticonvulsants / Antiepileptics continued Phenobarbital (Luminal) K-ME Phenobarbital µg/ml methanol 1 ml MG Phenobarbital neat neat 10 mg ME Phenobarbital-d5 (ethyl-d5 ) µg/ml methanol 1 ml Phenytoin (5,5-Diphenylhydantoin) K-ME Phenytoin µg/ml methanol 1 ml MG Phenytoin neat neat 100 mg ME Phenytoin-d10 (di(phenyl-d5 )) µg/ml methanol 1 ml K-ME Phenytoin-d10 (di(phenyl-d5 )) µg/ml methanol 1 ml MG Phenytoin-d10 (di(phenyl-d5 )) neat neat 10 mg MG Phenytoin-d10 (di(phenyl-d5 )) neat neat 25 mg Pregabalin (Lyrica) ME (+)-(S)- Pregabalin µg/ml methanol 1 ml K-ME (+)-(S)- Pregabalin µg/ml methanol 1 ml MG (+)-(S)- Pregabalin neat neat 10 mg MG (+)-(S)- Pregabalin neat neat 50 mg MG (+)-(S)- Pregabalin neat neat 100 mg ME (+)-(S)- Pregabalin-d4 ( aminomethyl- d2 ; hexanoic- 2, 2- d2 acid) µg/ml methanol 1 ml K-ME (+)-(S)- Pregabalin-d4 ( aminomethyl- d2 ; hexanoic- 2, 2- d2 acid) µg/ml methanol 1 ml MG (+)-(S)- Pregabalin-d4 ( aminomethyl- d2 ; hexanoic- 2, 2- d2 acid) neat neat 10 mg MG (+)-(S)- Pregabalin-d4 ( aminomethyl- d2 ; hexanoic- 2, 2- d2 acid) neat neat 25 mg Primidone (2-Deoxyphenobarbital) K-ME Primidone µg/ml methanol 1 ml MG Primidone neat neat 100 mg Stiripentol MG Stiripentol neat neat 100 mg Topiramate (Topimax) MG Topiramate neat neat 50 mg MG Topiramate neat neat 100 mg K-ME Topiramate µg/ml methanol 1 ml ME Topiramate-d12 (diiso propylidene- d12 ) µg/ml methanol 1 ml MG Topiramate-d12 (diiso propylidene- d12 ) neat neat 5 mg MG Topiramate-d12 (diiso propylidene- d12 ) neat neat 10 mg Valproic acid (2-Propylpentanoic acid) K-ME Valproic acid µg/ml methanol 1 ml MG Valproic acid neat neat 10 mg MG Valproic acid neat neat 100 mg ME Valproic acid-d4 (2- (propyl- 1, 1- d2 ) pentanoic- 3, 3- d2 acid) µg/ml methanol 1 ml K-ME Valproic acid-d4 (2- (propyl- 1, 1- d2 ) pentanoic- 3, 3- d2 acid) µg/ml methanol 1 ml MG Valproic acid-d4 (2- (propyl- 1, 1- d2 ) pentanoic- 3, 3- d2 acid) neat neat 10 mg K-ME Valproic acid-d6 (2- (propyl- 3, 3, 3- d3 ) pentanoic- 5, 5, 5- d3 acid) µg/ml methanol 1 ml MG Valproic acid-d6 (2- (propyl- 3, 3, 3- d3 ) pentanoic- 5, 5, 5- d3 acid) neat neat 10 mg MG Valproic acid-d6 (2- (propyl- 3, 3, 3- d3 ) pentanoic- 5, 5, 5- d3 acid) neat neat 25 mg MG Valproic acid-d15 (perdeuterated-cooh) neat neat 10 mg Zonisamide MG Zonisamide neat neat 50 mg ME Zonisamide-13C6 (ring-13c6 ) µg/ml methanol 1 ml MG Zonisamide-13C6 (ring-13c6 ) neat neat 1 mg MG Zonisamide-13C6 (ring-13c6 ) neat neat 5 mg Amitriptyline (Elavil) K-ME Amitriptyline hydrochloride µg base/ml methanol 1 ml MG Amitriptyline hydrochloride neat neat 10 mg MG Amitriptyline hydrochloride neat neat 100 mg ME Amitriptyline-d3 hydrochloride (N -methyl-d3 ) µg base/ml methanol 1 ml K-ME Amitriptyline-d3 hydrochloride (N -methyl-d3 ) µg base/ml methanol 1 ml MG Amitriptyline-d3 hydrochloride (N -methyl-d3 ) neat neat 10 mg ME Amitriptyline Imp. A (Dibenzosuberone) µg/ml methanol 1 ml MG Amitriptyline Imp. A (Dibenzosuberone) neat neat 100 mg ME Amitriptyline Imp. B (Cyclobenzaprine hydrochloride) µg base/ml methanol 1 ml MG Amitriptyline Imp. B (Cyclobenzaprine hydrochloride) neat neat 100 mg K-ME Amitriptyline Imp. C (Nortriptyline hydrochloride) µg base/ml methanol 1 ml MG Amitriptyline Imp. C (Nortriptyline hydrochloride) neat neat 10 mg MG Amitriptyline Imp. C (Nortriptyline hydrochloride) neat neat 100 mg

13 8 continued Amitriptyline (Elavil) ME Nortriptyline-d3 hydrochloride (N -methyl-d3 ) µg base/ml methanol 1 ml K-ME Nortriptyline-d3 hydrochloride (N -methyl-d3 ) µg base/ml methanol 1 ml MG Nortriptyline-d3 hydrochloride (N -methyl-d3 ) neat neat 10 mg ME Amitriptyline Imp. D (5-(3-Dimethylaminopropyl)-10,11-dihydro-5Hdibenzo[a,d] µg/ml methanol 1 ml cyclohepten-5-ol) Chlorpromazine (Largactil) K-ME Chlorpromazine hydrochloride µg base/ml methanol 1 ml MG Chlorpromazine hydrochloride neat neat 50 mg MG Chlorpromazine hydrochloride neat neat 100 mg ME Chlorpromazine-d6 oxalate (N,N- dimethyl-d6 ) (free base) 100 µg/ml methanol 1 ml Clomipramine (Anafranil) ME Clomipramine hydrochloride µg base/ml methanol 1 ml K-ME Clomipramine hydrochloride µg base/ml methanol 1 ml MG Clomipramine hydrochloride neat neat 10 mg MG Clomipramine hydrochloride neat neat 25 mg MG Clomipramine hydrochloride neat neat 50 mg MG Clomipramine hydrochloride neat neat 100 mg ME Clomipramine-d6 hydrochloride (N,N -dimethyl-d6 ) µg base/ml methanol 1 ml K-ME Clomipramine-d6 hydrochloride (N,N -dimethyl-d6 ) µg base/ml methanol 1 ml ME Desmethylclomipramine hydrochloride (Norclomipramine HCl) µg base/ml methanol 1 ml K-ME Desmethylclomipramine hydrochloride (Norclomipramine HCl) µg base/ml methanol 1 ml MG Desmethylclomipramine hydrochloride (Norclomipramine HCl) neat neat 10 mg Citalopram (Cipramil) ME (± )- Citalopram hydrobromide µg/ml methanol 1 ml K-ME (± )- Citalopram hydrobromide µg/ml methanol 1 ml MG (± )- Citalopram hydrobromide neat neat 10 mg ME (±)- Citalopram-d4 hydrobromide (4- fluorophenyl- d4) µg/ml methanol 1 ml K-ME (±)- Citalopram-d4 hydrobromide (4- fluorophenyl- d4) µg/ml methanol 1 ml MG (±)- Citalopram-d4 hydrobromide (4- fluorophenyl- d4) neat neat 5 mg K-ME (±)- Desmethylcitalopram hydrochloride µg base/ml methanol 1 ml Desipramine K-ME Desipramine hydrochloride (Imipramine HCl EP Imp A) µg base/ml methanol 1 ml Dosulepin (Dothiepin) K-ME Dosulepin µg/ml methanol 1 ml Doxepin (Deptran) ME Doxepin hydrochloride (cis+trans ) (as trans ) 100 µg base/ml methanol 1 ml K-ME Doxepin hydrochloride (cis+trans ) (as trans ) 1000 µg base/ml methanol 1 ml MG Doxepin hydrochloride (cis+trans ) (as trans ) neat neat 10 mg MG Doxepin hydrochloride (cis+trans ) (as trans ) neat neat 25 mg ME Doxepin-d3 hydrochloride (N -methyl-d3 ) (cis+trans) (as trans ) 100 µg base/ml methanol 1 ml K-ME Doxepin-d3 hydrochloride (N -methyl-d3 ) (cis+trans) (as trans ) 1000 µg base/ml methanol 1 ml MG Doxepin-d3 hydrochloride (N -methyl-d3 ) (cis+trans) (as trans ) neat neat 10 mg K-ME Desmethyldoxepin hydrochloride (Nordoxepin HCl) µg base/ml methanol 1 ml MG Desmethyldoxepin hydrochloride (Nordoxepin HCl) neat neat 10 mg MG Desmethyldoxepin hydrochloride (Nordoxepin HCl) neat neat 25 mg Duloxetine MG Duloxetine hydrochloride neat neat 25 mg MG Duloxetine hydrochloride neat neat 50 mg MG Duloxetine hydrochloride neat neat 100 mg Fluoxetine (Prozac) K-ME Fluoxetine µg/ml methanol 1 ml MG Fluoxetine neat neat 10 mg MG Fluoxetine neat neat 50 mg MG Fluoxetine neat neat 100 mg K-ME Fluoxetine hydrochloride µg base/ml methanol 1 ml MG Fluoxetine hydrochloride neat neat 10 mg ME Fluoxetine-d5 hydrochloride (phenyl-d5 ) µg base/ml methanol 1 ml MG Fluoxetine-d5 hydrochloride (phenyl-d5 ) neat neat 10 mg ME Norfluoxetine hydrochloride µg base/ml methanol 1 ml MG Norfluoxetine hydrochloride neat neat 10 mg

14 9 continued Fluoxetine (Prozac) ME Norfluoxetine-d5 (propyl- 1, 1, 2, 2, 3- d5 ) µg/ml methanol 1 ml MG Norfluoxetine-d5 (propyl- 1, 1, 2, 2, 3- d5 ) neat neat 5 mg Flupentixol K-ME Flupentixol dihydrochloride (cis+trans ) µg base/ml methanol 1 ml MG Flupentixol dihydrochloride (cis+trans ) neat neat 10 mg K-ME cis-(z)- Flupentixol dihydrochloride µg base/ml methanol 1 ml MG cis-(z)- Flupentixol dihydrochloride neat neat 10 mg Fluvoxamine MG Fluvoxamine maleate neat neat 50 mg MG Fluvoxamine maleate neat neat 100 mg Imipramine K-ME Imipramine hydrochloride µg base/ml methanol 1 ml MG Imipramine hydrochloride neat neat 10 mg Meprobamate (Miltown, Equianil, Meprospan) ME Meprobamate µg/ml methanol 1 ml MG Meprobamate neat neat 10 mg ME Meprobamate-d µg/ml methanol 1 ml MG Meprobamate-d neat neat 10 mg Mianserin K-ME Mianserin hydrochloride µg base/ml methanol 1 ml MG Mianserin hydrochloride neat neat 10 mg ME Mianserin-d3 hydrochloride (methyl-d3 ) µg base/ml methanol 1 ml MG Mianserin-d3 hydrochloride (methyl-d3 ) neat neat 5 mg ME Desmethylmianserin (Normianserin) µg/ml methanol 1 ml Mirtazapine (Zispin) ME Mirtazapine µg/ml methanol 1 ml K-ME Mirtazapine µg/ml methanol 1 ml MG Mirtazapine neat neat 10 mg MG Mirtazapine neat neat 25 mg MG Mirtazapine neat neat 100 mg ME Mirtazapine-d3 (methyl-d3 ) µg/ml methanol 1 ml MG Mirtazapine-d3 (methyl-d3 ) neat neat 1 mg MG Desmethylmirtazapine hydrochloride (Normirtazapine HCl) (freebase) neat neat 10 mg Moclobemide MG Moclobemide neat neat 10 mg Paroxetine (Seroxat) K-ME (-) -(3S,4R )-Paroxetine hydrochloride hemihydrate µg base/ml methanol 1 ml MG (-) -(3S,4R )-Paroxetine hydrochloride hemihydrate neat neat 10 mg ME (-) -(3S,4R )-Paroxetine-d6 maleate (methylene-d2, alpha-n - piperazine-d4) µg/ml methanol 1 ml MG (-) -(3S,4R )-Paroxetine-d6 maleate (methylene-d2, alpha-n - piperazine-d4) neat neat 5 mg Phenibut (Fenibut, Phenybut) MG Phenibut hydrochloride neat neat 10 mg Sertraline (Zoloft) ME (+)- (1S,4S )- Sertraline hydrochloride µg base/ml methanol 1 ml K-ME (+)- (1S,4S )- Sertraline hydrochloride µg base/ml methanol 1 ml MG (+)- (1S,4S )- Sertraline hydrochloride neat neat 10 mg MG (+)- (1S,4S )- Sertraline hydrochloride neat neat 25 mg MG (+)- (1S,4S )- Sertraline hydrochloride neat neat 100 mg ME (±)-cis- Sertraline-d3 hydrochloride (N -methyl-d3 ) µg base/ml methanol 1 ml ME (±)-cis- Sertraline-d3 hydrochloride (N -methyl-d3 ) µg base/ml methanol 1 ml Trazodone (Molipaxin) K-ME Trazodone hydrochloride µg base/ml methanol 1 ml MG Trazodone hydrochloride neat neat 10 mg Trimipramine (Surmontil) K-ME Trimipramine maleate µg/ml methanol 1 ml MG Trimipramine maleate neat neat 10 mg ME Trimipramine-d3 maleate (N -methyl-d3 ) (free base) 100 µg/ml methanol 1 ml MG Trimipramine-d3 maleate (N -methyl-d3 ) (free base) neat neat 10 mg Venlafaxine (Effexor) K-ME Venlafaxine hydrochloride µg base/ml methanol 1 ml MG Venlafaxine hydrochloride neat neat 10 mg MG Venlafaxine hydrochloride neat neat 50 mg

15 10 continued Venlafaxine (Effexor) MG Venlafaxine hydrochloride neat neat 100 mg MG Venlafaxine hydrochloride neat neat 250 mg ME Venlafaxine-d6 hydrochloride (N,N -dimethyl-d3 ) µg base/ml methanol 1 ml K-ME Venlafaxine-d6 hydrochloride (N,N -dimethyl-d3 ) µg base/ml methanol 1 ml MG Venlafaxine-d6 hydrochloride (N,N -dimethyl-d3 ) neat neat 5 mg ME O- Desmethylvenlafaxine µg/ml methanol 1 ml MG O- Desmethylvenlafaxine neat neat 10 mg Antidiabetics Glibenclamide (Glyburide) MG Glibenclamide neat neat 10 mg Gliclazide MG Gliclazide neat neat 10 mg Glimepiride MG Glimepiride neat neat 10 mg Glipizide MG Glipizide neat neat 10 mg Metformin (Glucophage) K-ME Metformin hydrochloride µg base/ml methanol 1 ml MG Metformin hydrochloride neat neat 10 mg MG Metformin hydrochloride neat neat 100 mg MG Metformin hydrochloride neat neat 250 mg G Metformin hydrochloride neat neat 1 g G Metformin hydrochloride neat neat 5 g G Metformin hydrochloride neat neat 10 g ME Metformin HCl Imp. A µg/ml methanol (Dicyanodiamide, Cyanoguanidine) 1 ml MG Metformin HCl Imp. A neat neat (Dicyanodiamide, Cyanoguanidine) 10 mg MG Metformin HCl Imp. A neat neat (Dicyanodiamide, Cyanoguanidine) 100 mg MG Metformin HCl Imp. A neat neat (Dicyanodiamide, Cyanoguanidine) 250 mg ME Metformin HCl Imp. C (2,4-Diamino-6-dimethylamino-1,3,5-triazine, µg/ml methanol N,N -Dimethyl-1,3,5-triazine-2,4,6-triamine) 1 ml MG Metformin HCl Imp. C (2,4-Diamino-6-dimethylamino-1,3,5-triazine, neat neat N,N -Dimethyl-1,3,5-triazine-2,4,6-triamine) 100 mg ME Metformin HCl Imp. D µg/ml methanol (1,3,5-Triazine-2,4,6-triamine, Melamine) 1 ml MG Metformin HCl Imp. D neat neat (1,3,5-Triazine-2,4,6-triamine, Melamine) 100 mg ME Metformin HCl Imp. D-15N3 (triamine-15n3) (1,3,5-Triazine-2,4,6-triamine-15N3, (Melamine-15N3 (triamine µg/ml methanol 15N3 )) 1 ml K-MX Metformin HCl Imp. F (Dimethylamine) µg/ml methanol/water 1 ml ME Metformin HCl Imp. F TMA-free µg/ml (Dimethylamine) methanol 1 ml ME N,N -Dimethylguanidine µg/ml methanol 1 ml MG N,N -Dimethylguanidine neat neat 25 mg MG N,N -Dimethylguanidine neat neat 100 mg MG N,N -Dimethylguanidine neat neat 250 mg Tolbutamide K-AN Tolbutamide µg/ml acetonitrile 1 ml MG Tolbutamide neat neat 10 mg

16 11 Antidyskinetic / Antimuscarinics / Antiparkinsonian Apomorphine K-ME Apomorphine hydrochloride µg base/ml methanol 1 ml MG Apomorphine hydrochloride neat neat 10 mg Atropine MG (±)-Atropine-d neat neat 10 mg Biperiden MG Biperiden (Mixture of diastereomers) neat neat 10 mg MG Biperiden Hydrochloride (Mixture of diastereomers) neat neat 10 mg Carisoprodol K-ME Carisoprodol µg/ml methanol 1 ml MG Carisoprodol neat neat 10 mg MG Carisoprodol neat neat 10 mg MG Carisoprodol neat neat 10 mg G Carisoprodol neat neat 10 mg Creatinine MG Creatinine-d3 (methyl-d3 ) neat neat 10 mg Orphenadrine K-ME Orphenadrine hydrochloride µg base/ml methanol 1 ml MG Orphenadrine hydrochloride neat neat 10 mg Piracetam K-AN Piracetam µg/ml acetonitrile 1 ml MG Piracetam neat neat 100 mg K-AN Piracetam-d8 (perdeuterated-nh2) µg/ml acetonitrile 1 ml MG Piracetam-d8 (perdeuterated-nh2) neat neat 10 mg Procyclidine MG Procyclidine hydrochloride neat neat 10 mg Tetrabenazine K-ME Tetrabenazine µg/ml methanol 1 ml MG Tetrabenazine neat neat 25 mg G Tetrabenazine neat neat 1 g Antiemetics Bromopride K-ME Bromopride µg/ml methanol 1 ml Chlorpromazine (Largactil) K-ME Chlorpromazine hydrochloride µg base/ml methanol 1 ml MG Chlorpromazine hydrochloride neat neat 50 mg MG Chlorpromazine hydrochloride neat neat 100 mg ME Chlorpromazine-d6 oxalate (N,N -dimethyl-d6 ) µg/ml methanol 1 ml Cyclizine MG Cyclizine neat neat 10 mg Dexamethasone K-ME Dexamethasone µg/ml methanol 1 ml MG Dexamethasone neat neat 100 mg Diphenhydramine K-ME Diphenhydramine hydrochloride µg base/ml methanol 1 ml MG Diphenhydramine hydrochloride neat neat 10 mg Haloperidol (Haldol) K-ME Haloperidol µg/ml methanol 1 ml MG Haloperidol neat neat 50 mg ME Haloperidol-d4 (chlorophenyl-d4 ) µg/ml methanol 1 ml Mirtazapine (Zispin) ME Mirtazapine µg/ml methanol 1 ml K-ME Mirtazapine µg/ml methanol 1 ml MG Mirtazapine neat neat 10 mg MG Mirtazapine neat neat 25 mg MG Mirtazapine neat neat 100 mg ME Mirtazapine-d3 (methyl-d3 ) µg/ml methanol 1 ml MG Mirtazapine-d3 (methyl-d3 ) neat neat 1 mg MG Desmethylmirtazapine hydrochloride (Normirtazapine HCl) (freebase) neat neat 10 mg

17 12 Antiemetics continued Olanzapine (Zyprexa) AN Olanzapine µg/ml acetonitrile 1 ml K-AN Olanzapine µg/ml acetonitrile 1 ml MG Olanzapine neat neat 10 mg MG Olanzapine neat neat 250 mg MG Olanzapine neat neat 100 mg MG Olanzapine neat neat 250 mg G Olanzapine neat neat 1 g AN Olanzapine-d3 (N-methyl-d3 ) µg/ml acetonitrile 1 ml ME Olanzapine 10-N -β-d-glucuronide µg/ml methanol 1 ml Promethazine (Phenergan) MG Promethazine hydrochloride neat neat 10 mg MG Promethazine hydrochloride neat neat 100 mg Propofol (2,6-Diisopropylphenol) K-ME Propofol µg/ml methanol 1 ml MG Propofol neat neat 100 mg MG Propofol neat neat 250 mg K-ME Propofol-d18 (perdeuterated) µg/ml methanol 1 ml Scopolamine (Hyosine) ME (-)-Scopolamine hydrobromide trihydrate µg base/ml methanol 1 ml Antifungals Fluconazole K-ME Fluconazole µg/ml methanol 1 ml MG Fluconazole neat neat 100 mg MG Fluconazole-d4 (bismethylene-d4 ) neat neat 5 mg Flucytosine K-ME 5-Flucytosine µg/ml methanol 1 ml MG 5-Flucytosine neat neat 10 mg Itraconazole MG Itraconazole neat neat 100 mg Ketoconazole K-ME (±)- Ketoconazole µg/ml methanol 1 ml MG (±)- Ketoconazole neat neat 100 mg MG (±)- Ketoconazole-d4 (3,3,5,5-piperazine-d4) (cis- isomers) neat neat 5 mg Posaconazole MG Posaconazole neat neat 10 mg Terbinafine (Lamisil) MG Terbinafine hydrochloride neat neat 100 mg Triazole ME 1,2,4-Triazole-d3 (perdeuterated) µg/ml methanol 1 ml MEx5 1,2,4-Triazole-d3 (perdeuterated) µg/ml methanol 1 mlx5 Voriconazole MG (αr, βs)- Voriconazole neat neat 10 mg MG (± )- Voriconazole-d3 (difluorophenyl-d3 ) (unlabelled) neat neat 5 mg Antihistamines Cetirizine K-W Cetirizine dihydrochloride µg base/ml water 1 ml MG Cetirizine dihydrochloride neat neat 10 mg MG 4-Chlorobenzhydrol (Cetirizine impurity) neat neat 100 mg MG 4-Chlorobenzophenone (Cetirizine impurity) neat neat 100 mg Chlorpheniramine maleate K-ME Chlorpheniramine maleate (Chlorphenamine maleate) µg base/ml methanol 1 ml K-ME (+)-(S)- Chlorpheniramine maleate µg base/ml methanol 1 ml MG (+)-(S)- Chlorpheniramine maleate neat neat 10 mg MG Chlorphenamine maleate Imp. B N -(Pyridin-2-yl)pyridin-2-amine (2,2'-Dipyridylamine) neat neat 100 mg

18 13 Antihistamines continued Diphenhydramine K-ME Diphenhydramine hydrochloride (Orphenadrine hydrochloride Imp. D) µg base/ml methanol 1 ml MG Diphenhydramine hydrochloride (Orphenadrine hydrochloride Imp. D) neat neat 10 mg Doxylamine K-ME Doxylamine succinate µg base/ml methanol 1 ml Orphenadrine (o-methyldiphenhydramine) K-ME Orphenadrine hydrochloride µg base/ml methanol 1 ml MG Orphenadrine hydrochloride neat neat 10 mg Terfenadine MG Terfenadine neat neat 10 mg Trimeprazine (Alimemazine) MG Trimeprazine tartrate neat neat 10 mg Anti-impotence Sildenafil (Viagra) ME Sildenafil citrate µg base/ml methanol 1 ml K-ME Sildenafil citrate µg base/ml methanol 1 ml MG Sildenafil citrate neat neat 10 mg MG Sildenafil citrate neat neat 25 mg MG Sildenafil citrate neat neat 100 mg K-ME Sildenafil µg/ml methanol 1 ml MG Sildenafil neat neat 10 mg ME Sildenafil-d3 (N - methyl- d3 - piperazine) µg/ml methanol 1 ml MG Sildenafil-d3 (N - methyl- d3 - piperazine) neat neat 10 mg ME Sildenafil-d8 (piperazine-d8 ) µg/ml methanol 1 ml MG Sildenafil-d8 (piperazine-d8 ) neat neat 5 mg MG Sildenafil-d8 (piperazine-d8 ) neat neat 10 mg Tadalafil (Cialis) ME Tadalafil µg/ml methanol 1 ml K-ME Tadalafil µg/ml methanol 1 ml MG Tadalafil neat neat 10 mg MG Tadalafil neat neat 25 mg MG Tadalafil neat neat 100 mg Vardenafil (Levitra) ME Vardenafil dihydrochloride µg base/ml methanol 1 ml ME Vardenafil-d5 (N- ethyl-d5 ) µg/ml methanol 1 ml Anti-insomnia Clomethiazole (Chlormethiazole) MG Clomethiazole neat neat 10 mg Promethazine (Phenergan) MG Promethazine hydrochloride neat neat 10 mg MG Promethazine hydrochloride neat neat 100 mg Zaleplon ME Zaleplon µg/ml methanol 1 ml K-ME Zaleplon µg/ml methanol 1 ml MG Zaleplon neat neat 10 mg ME Zaleplon- d5 (N -ethyl-d5 ) µg/ml methanol 1 ml Zolpidem K-ME Zolpidem µg/ml methanol 1 ml MG Zolpidem neat neat 10 mg ME Zolpidem-d6 (N,N -dimethyl-d3 ) µg/ml methanol 1 ml MG Zolpidem-d6 (N,N -dimethyl-d3 ) neat neat 10 mg ME Zolpidem-13C6 (tolyl-13c6 ) µg/ml methanol 1 ml K-ME Zolpidem hemitartrate µg base/ml methanol 1 ml MG Zolpidem hemitartrate neat neat 10 mg MG Zolpidem hemitartrate neat neat 100 mg MG Zolpidem 6-carboxylic acid neat neat 10 mg MG Zolpidem phenyl-4-carboxylic acid neat neat 10 mg

19 14 Anti-insomnia continued Zopiclone (Imovan, Zimovan) K-AN (± )- Zopiclone µg/ml acetonitrile 1 ml MG (± )- Zopiclone neat neat 10 mg AN (±)- Zopiclone-d3 (N -methyl-d3 ) µg/ml acetonitrile 1 ml MG (±)- Zopiclone-d3 (N -methyl-d3 ) neat neat 5 mg K-AN (±)- Zopiclone-d4 (carboxypiperazine-3,3,5,5-d4 ) µg/ml acetonitrile 1 ml MG (±)- Zopiclone-d4 (carboxypiperazine-3,3,5,5-d4 ) neat neat 10 mg AN (±)- Zopiclone-d8 (piperazine-d8 ) µg/ml acetonitrile 1 ml K-AN (±)- Zopiclone-d8 (piperazine-d8 ) µg/ml acetonitrile 1 ml AN (±)- Zopiclone-13C4 ( piperazinyl-13c4) (unlabelled) 100 µg/ml acetonitrile 1 ml K-ME (±)- Zopiclone-N -oxide (Eszolpidem Imp. A) µg/ml methanol 1 ml MG (±)- Zopiclone-N -oxide (Eszolpidem Imp. A) neat neat 10 mg K-AN 2-Amino-5-chloropyridine (ACP) µg/ml acetonitrile 1 ml MG 2-Amino-5-chloropyridine (ACP) neat neat 10 mg MG 2-Amino-5-chloropyridine (ACP) neat neat 100 mg ME (±)- Norzopiclone hydrochloride (N -Desmethylzopiclone) µg base/ml methanol 1 ml MG (±)- Norzopiclone hydrochloride (N -Desmethylzopiclone) neat neat 10 mg Antimalarial Proguanil (Paludrine) MG Proguanil hydrochloride neat neat 10 mg MG Proguanil hydrochloride neat neat 100 mg MG Proguanil hydrochloride neat neat 250 mg ME Proguanil Imp. D (1,5-Bis-(1-methylethyl)-biguanide hydrochloride) µg base/ml methanol 1 ml MG Proguanil Imp. D (1,5-Bis-(1-methylethyl)-biguanide hydrochloride) neat neat 25 mg MG Proguanil Imp. D (1,5-Bis-(1-methylethyl)-biguanide hydrochloride) neat neat 100 mg ME Proguanil Imp. C (1,5-Bis-(4-chlorophenyl)-biguanide hydrochloride) µg base/ml methanol 1 ml MG Proguanil Imp. C (1,5-Bis-(4-chlorophenyl)-biguanide hydrochloride) neat neat 25 mg MG Proguanil Imp. C (1,5-Bis-(4-chlorophenyl)-biguanide hydrochloride) neat neat 100 mg Quinine K-ME Quinine hemisulfate µg base/ml methanol 1 ml MG Quinine hemisulfate neat neat 100 mg Antimicrobial Bronopol MG Bronopol neat neat 100 mg 2,2-Dibromo-2-cyanoacetamide (DBNPA) MG 2,2-Dibromo-2-cyanoacetamide neat neat 100 mg Hexadecyltrimethylammonium bromide (Cetrimonium bromide) K-ME Hexadecyltrimethylammonium bromide µg/ml methanol 1 ml G Hexadecyltrimethylammonium bromide neat neat 1 g Hexadecyltrimethylammonium chloride (Cetrimonium chloride) K-ME Hexadecyltrimethylammonium chloride µg/ml methanol 1 ml G Hexadecyltrimethylammonium chloride neat neat 1 g Isonicotinaldehyde (4-Pyridinecarboxaldehyde) MG Isonicotinaldehyde neat neat 10 mg Levamisole K-ME Levamisole µg/ml methanol 1 ml MG Levamisole neat neat 10 mg Povidone MG Povidone, PVP-polymer (PVP, E1201, Trade name: Betadine) neat neat 100 mg MG 1-Ethenylpyrrolidin-2-one (1-Vinylpyrrolidin-2-one) (Povidone Imp. A ) neat neat 100 mg Sulphathiazole (Sulfathiazole) MG Sulphathiazole neat neat 250 mg