Ascend Clinical Reference Ranges (July 2018) Chemistry
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1 24 Hour Urine Creatinine mg/24 hr (Male) Kinetic Alkaline Picrate (Jaffe Reaction) for 24 hour Urine Creatinine Clearence (Creatinine ml/min/1.73m^2 Clearance) (Female) (Male) (Female) 24 Hour Urine Urea Nitrogen g/24 hr 7-16 Urease/GLDH A/G Ratio Ratio > 0.9; high ratio is usually clinically insignificant Albumin g/dl Bromocresol Green (BCG) Alkaline Phosphatase IU/L p-nitrophenyl Phosphate; IFCC ALT (SGPT) IU/L 7-52 UV/NADH; IFCC Aluminum µg/l 1-20 Inductively Coupled Plasma Mass Agilent Spectrometry (ICP-MS) Anion Gap meq/l 3-14 AST (SGOT) IU/L UV/NADH; IFCC Bilirubin, Direct mg/dl Diazonium Salt, DPD Bilirubin, Total mg/dl Diazonium Salt, DPD BUN (Blood Urea Nitrogen) mg/dl 7-25 Urease/GLDH Beckman Coulter AU680/AU5800 Calcium mg/dl Arsenazo III Calcium, Adjusted Total (with Albumin) mg/dl Calcium Phosphorus Product (CA*PO4) mg^2/dl^2 <55.0 Calcium Phosphorus Product, Adjusted mg^2/dl^2 <55.0 (CA*PO4, Adjusted) Calcium, Ionized mmol/l Ion Selective Electrode (ISE), Direct (Undiluted) Chloride meq/l Ion Selective Electrode (ISE), Indirect (Diluted) Cholesterol mg/dl Normal: Enzymatic Optimal: < 200 Borderline: Higher Risk: > 239 Nova 8 Cholesterol/HDL Ratio Ratio Optimal: < 3.3 Higher Risk: > 6.2 Chemistry Creatinine Kinetic Alkaline Picrate (Jaffe Reaction) for Creatinine CO2 (Bicarbonate or Carbon Dioxide) meq/l Enzymatic (Phosphoenolpyruvate Carboxylase) C-Reactive Protein (CRP) mg/l Immunoturbidimetric Creatine Kinase (CPK) IU/L UV/NADPH; IFCC (Creatine Phosphate/NADPH) Ranges subject to change without notice. Please refer to patient's laboratory report. Page 1 of 6
2 Creatinine mg/dl See Table Below Kinetic Alkaline Picrate (Jaffe Reaction) Ferritin ng/ml Male: Female: Folate ng/ml Gamma Glutamyl Transferase (GGT) IU/L 9-64 Glutamyl-carboxy-p-nitroanilide; IFCC Globulin g/dl Glucose mg/dl Hexokinase-UV/NAD HDL mg/dl Male: mg/dl; Female: mg/dl Direct - No Pretreatment, Enzymatic (Accelerator Selective Detergent) Desirable: > 59 Higher Risk: < 40 Hemoglobin A1C (Glycohemoglobin) High-Performance Liquid Chromatography Bio-Rad D-100 (HPLC) Iron µg/dl TPTZ (Tripyridyltriazine) Kt/V Jindal N/A The HD Adequacy Work Group feels this formula should not be used to measure delivered dose of Hemodialysis. - Jindal Formula Beckman Coulter AU680/AU5800 Kt/V Natural Log N/A The K/DOQI recommendations are: - Daugirdas II Formula Beckman Coulter AU680/AU5800 Prescribed dose of hemodialysis - Kt/V of 1.3 Delivered dose of hemodialysis - Kt/V > 1.2 Kt/V Equilibrated N/A See Kt/V Standard for recommendations - Leypoldt Formula Beckman Coulter AU680/AU5800 Kt/V Standard N/A The K/DOQI recommendations are: - Leypoldt Formula Beckman Coulter AU680/AU5800 Minimum Kt/V Standard of 2.0 per week LDH, Plasma IU/L Lactate-Pyruvate (NAD); IFCC Ranges subject to change without notice. Please refer to patient's laboratory report. Page 2 of 6
3 LDL, Calc mg/dl Optimal: < Friedewald Formula Above Optimal: Borderline High: High: Very High: > 189 Magnesium mg/dl Colorimetric (Xylidyl Blue) npna g/kg/day Providers should strive to achieve an npna of greater than - Modified Bergstrom Formula or equal to 0.9 g/kg/day. npna valid only if protein loss < 15 g/day. Phosphorus mg/dl UV; Phosphomolybdate Complex Potassium (K) meq/l Ion Selective Electrode (ISE), Crown-Ether Membrane Prealbumin mg/dl Immunoturbidimetric Protein, Total g/dl Biuret; Blanked Protein, Total, 24 hr Urine w/ Creatinine mg/g Creatinine 0-84 Protein, Total, Random Urine w/ Creatinine mg/dl Urine Protein, Random: 5-25 (Male) Pyrogallol Red Urine Protein, Random: 5-24 (Female) mg/g Creatinine Urine Protein, Random with Creatinine: PSA, Total ng/ml PTH, Intact pg/ml Suggested (KDIGO) ESRD maintenance range is two to nine times the upper normal limit (80.1 pg/ml) for the laboratory. Recirculation Study Recirculation results should average zero (-5 to +5) in patients with unimpaired accesses. Recirculation exceeding 10 should prompt investigation of its cause. If access recirculation values exceed 20, correct placement of needles should be confirmed before conducting further studies. Elevated levels of access recirculation should be investigated using angiography (fistulography) to determine whether stenotic lesions are impairing access blood flow. Residual Urea Clearance (KrU) ml/min N/A Sodium (NA) meq/l Ion Selective Electrode (ISE), Crown-Ether Membrane T3, Free pg/ml T3, Total ng/dl T4, Free (FT4) ng/dl Hypothyroid: < 0.89 Hyperthyroid: > 1.76 Ranges subject to change without notice. Please refer to patient's laboratory report. Page 3 of 6
4 T4, Total (Thyroxine) ug/dl Thyroid Stimulating Hormone (TSH) µiu/ml Hyperthyroid: < 0.35 Hypothyroid: > 5.50 TIBC, Calculated ug/dl Transferrin mg/dl Immunoturbidimetric Transferrin Saturation Triglycerides mg/dl Optimal: < 150 Enzymatic (Glycerol Phosphate Oxidase); Colorimetric (without Glycerol Blank with Borderline High: High: Serum Blank) URR (Urea Reduction Rate), Uric Acid mg/dl Very High: > 499 The K/DOQI recommendations are: Prescribed dose of hemodialysis - URR > or = to 70 Delivered dose of hemodialysis - URR > or = to (Male) (Female) Uricase Beckman Coulter AU680/AU5800 Urine Creatinine (Random) mg/dl N/A Kinetic Alkaline Picrate (Jaffe Reaction) Urine Protein (Random) mg/dl see 24-hour urine Total Protein Pyrogallol Red Urine Protein, Random with Creatinine mg/g Creatinine see 24-hour urine Total Protein Pyrogallol Red for Urine Protein Urine Urea Nitrogen (Random) mg/dl N/A Urease/GLDH Vitamin B12 pg/ml Deficient: Vitamin D 25-OH (Vitamin D, 25-Hydroxy) ng/ml See Table Below VLDL Cholesterol mg/dl Optimal: < 30 Borderline High: High: Very High: > 99 Zinc µg/l Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Agilent Ranges subject to change without notice. Please refer to patient's laboratory report. Page 4 of 6
5 Hematology Basophils (Male) Eosinophils (Female) (Male) (Female) Fluid Cell Count WBC/µL <50 and Manual Hematocrit (HCT) (Male) Direct Current Sheath Flow Hemoglobin (HGB) g/dl (Female) (Male) Cyanide-free Sodium Lauryl Sulfate (SLS) (Female) Hemoglobin Immature Granulocytes (IG) HGB x 3 Lymphocytes g/dl (Male) (Female) (Male) MCH pg (Female) (Male) MCHC MCV g/dl fl (Female) (Male) (Female) (Male) Monocytes Neutrophils (Female) (Male) (Female) (Male) Platelets K/µL (Female) (Male), Direct Current RBC M/uL (Female) (Male) Sheath Flow Direct Current Sheath Flow RDW Reticulocytes (Female) (Male) (Female) (Male) (Female) Reticulocyte HE pg WBC K/µL (Male) (Female) Ranges subject to change without notice. Please refer to patient's laboratory report. Page 5 of 6
6 Coagulation Prothrombin Time (PT) seconds Optical Clot Detection Sysmex CA-1500/CS-2500 INR Ratio Therapeutic Ranges Low Dose Anticoagulant: High Dose Anticoagulant: Sysmex CA-1500/CS-2500 Immunology / Serology Hep B Surface Ab Quant miu/ml >=10: Antibodies present (Probable Immunity) <10: Antibodies not present (No Immunity) Chemiluminescent Sandwich Immunoassay Siemens Advia Centaur XPT Hep B Surface Ag N/A Negative Chemiluminescent Sandwich Immunoassay Siemens Advia Centaur XPT Hep B Core Ab, IgM N/A Negative Chemiluminescent Sandwich Immunoassay Siemens Advia Centaur XPT Hep B Core Ab, Total N/A Negative Chemiluminescent Sandwich Immunoassay Siemens Advia Centaur XPT Hep C Virus Ab N/A Non-Reactive Chemiluminescent Sandwich Immunoassay Siemens Advia Centaur XPT HIV12 Ab and p24 Ag N/A Non-Reactive Chemiluminescent Sandwich Immunoassay Siemens Advia Centaur XPT Therapeutic Drugs (TDMs) Digoxin ng/ml Enzyme Immunoassay Phenytoin, Total (Dilantin) µg/ml Enzyme Immunoassay Vancomycin, Peak µg/ml Enzymatic Mediated Immuno Technique (EMIT) Vancomycin, Random µg/ml Peak: Enzymatic Mediated Immuno Technique (EMIT) Trough: Vancomycin, Trough µg/ml Enzymatic Mediated Immuno Technique (EMIT) KDOQI Guidelines for Chronic Kidney Disease: GFR (Glomerular Filtration Rate) ml/min/1.73 m2 Stage 1: >89 Formula based on four parameter MDRD (Modification of Diet in Renal Disease) Stage 2: Stage 3: equation using an IDMS (Isotope Dilution Mass Spectometry) - Traceable Calibration for Creatinine Stage 4: Stage 5: <15 Ranges subject to change without notice. Please refer to patient's laboratory report. Page 6 of 6
Ascend Clinical Reference Ranges (November 2018) Chemistry
24 Hour Urine Creatinine mg/24 hr 800-2000 (Male) 600-1800 (Female) Kinetic Alkaline Picrate (Jaffe Reaction) for Creatinine 24 hour Urine Creatinine Clearence (Creatinine ml/min/1.73m^2 85-125 (Male)
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