Basic Electrophysiology. Transmembrane Ion-Transfer Modes
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1 1. מי מהבאים יוצא דופן? א- I ca ב- I k ג- Ryanodin receptor ד- Na/K ATPase pump ה- Ca/Na exchanger Basic Electrophysiology Michael Eldar Heart Institute Sheba Medical Center Ceasaria, 2004 התשובה ג' Transmembrane Ion-Transfer Modes Opie LH, The Heart 1998:75 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:40 Inward Rectifier Ik1 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:69 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:70 1
2 Channel Pore Model Voltage-Gated Sodium channel Opie LH, The Heart 1998:76 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:64 2. מי מהתעלות הבאות האחראית העיקרית לשלב II של פוטנציאל הפעולה החדרי? Channels Open in Bursts I ca,l I na I k I k1 I k,ach א- ב- ג- ד- ה- התשובה א' Opie LH, The Heart 1998:81 Whalley DW et al, PACE 1995;18:1561 Berne & Levy,Physiology 1998:30 2
3 Berne & Levy,Physiology 1998:335 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:43 Tetrodotoxin effect on Action Potential 100 mv Berne & Levy,Physiology 1998:339 Berne & Levy,Physiology 1998:330 Normal Automaticity 3. אחת מהפרעות הקצב להלן נגרמת עקב..Abnormal automaticity איזו היא? א- ב- ג- ד- ה- PAT עקב הרעלת דיגוקסין TdP מקינידין RVOT VT במאמץ AVNRT AIVR Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:199 התשובה הנכונה ה' 3
4 ACh and Automaticity Normal Automaticity I k decay I f Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:202 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:55 Abnormal automaticity - Depolarized myocytes ( mv) - ph - [O 2 ] - [K+] o Acceleration of Normal Automaticity Control Threshold MDP Slope Phase 4 Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:201 Abnormal automaticity Clinical Arrhythmias - Myocardial infarction minutes hours - AIVR - [K+] o - Ischemia - Injury currents Depolarization-induced Automaticity Low High Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:206 4
5 Triggered Activity 4. המשפטים הבאים מתייחסים ל Activity-.Triggered אחד אינו נכון, מהו? - activity arising from membrane potential oscillations during or immediately following an AP - Should occur following a previous AP (spontaneous or driven) א- ב- ג- ד- ה- DAD גדלים עקב טכיקרדיה LQT3 נגרם בשל מוטציה בתעלת אשלגן TdP מתרופות נגרם מחסימת תעלת אשלגן מחויב להיגרם ע"י פוטנציאל פעולה קודם עודף יונים חיוביים בתא גורם להארכת QT התשובה הנכונה ב' DAD Characteristics - Induction - fast train -1 ES - CI / CL of initiating stimulus/li CI of triggered response - Termination -1 ES - ODP Triggered Activity Zipes & Jaliffe, Cardiac Electrophysiology1995:208 DAD Digoxin induced DAD Clinical Arrhythmias - Dig. Intoxication - atrial tach: - VT -Accelerated VT during AMI -Reperfusion induced arrhythmias -Congenital LQTS -Exercise (catecholamine, camp dependent) induced RVOT VT Rate-Dependence of DAD s Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:211 5
6 Quinidine-induced EAD s Early Afterdepolarization (EAD) Pathophysiology Outward current and/or Inward current Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998:215 EAD Clinical arrhythmias - TDP - acquired LQTS - congenital LQTS EAD Pathophysiology -AP prolongation Ik, Ik1, Ito I NA, Ica, electrogenic Na Ca exchanger AP Plateau - Currents sensitivity - Net depolarizing current - Ica, L (window) - Genotype and ECG LQTS- net outward current I,II,V,VI III Viskin,, Lancet 99;354:1625 6
7 המשפטים הבאים מתי יחסים ל.REENTRY אחד אינו נכון, מהו? א- המנגנון השכיח ביותר לאריתמיות באדם ב- אחראי לאריתמיה בתסמונת ברוגדה ג- אחראי עיקרי לVT לאחר אוטם ישן ד- אחראי ל TdP ב LQTS מולד ה- אזור הולכה אטית אינו תנאי הכרחי התשובה הנכונה ד'.5 Acquired EAD - hypokalemia ( K conductance) - Acidosis - Bradycardia - Ik blockers - AAD - Phenothiazine - Antihistamines - Antibiotics - antidepressants Reentry Unidirectional block 1. Increase in sinus rate 2. Rapid or premature atrial pacing 3. Retrograde activation from VPC 4. Autonomic influence 5. AAD 6. Ischemia Circus Movement Reentry 1. Intact anatomic circuit 2. Unidirectional block (onset) 3. Area of slow conduction 4. Wavelength of tach. < length of circuit 7
8 Resetting EPS-Diagnosis Reentry 1. Continuous electric activity 2. Inducibility/termination by electric stimulation 3. Inverse relationship of C.I. of initiating extrastimulus/1 st tachycardia beat 4. Entrainment (resetting) by external stimuli Reentry circuit WPW Syndrome Leading Circus Reentry Leading Circle Jalife et al. Basic Cardiac Electrophysiology for the Clinician, 1998: Cannot be interrupted by disrupting the circuit 2. No fully excitable gap - unstable - insensitive to electrical stimulation 3. Short cycle length 8
9 K + channel opener rate Yan Gan-Xin, Circulation 1999;100:1660 Viskin, Prog Cardiovasc Dis 1998;41:17 Phase II Reentry Phase II Reentry Di Diego, Circulation 1993;88:1177 Clinical Reentry Tachyarrhythmias Definite AVNRT AVRT A Flutter Post MI VT BBR VT Probable A Fibrillation PVT VF 9
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