CELL AND SYSTEMS PHYSIOLOGY Spring 2011-Page 1 I. CELL PHYSIOLOGY

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1 Spring 2011-Page 1 I. CELL PHYSIOLOGY CELL AND SYSTEMS PHYSIOLOGY GS Course Schedule, Spring :00 3:00 P.M., Tuesdays and Thursdays R.649 Medical School Extension (MSE) Course Director: Edgar T. Walters, Ph.D. Tu 10 January INTRODUCTION TO PHYSIOLOGY Walters 1:00 1:30 Function, homeostasis, systems integration 1:30 3:00 P.M. CELL MEMBRANE STRUCTURE AND TRANSMEMBRANE Abebe TRANSPORT Fluid compartments and homeostasis Cell membrane composition and structure Transmembrane transport Th 12 January SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA Dubinsky 1:00 3:00 P.M. Structure and function of epithelia Epithelial solute and water transport II. INTERCELLULAR COMMUNICATION AND COORDINATION Tu 17 January DISCUSSION: PHYSIOLOGICAL DYSFUNCTION 1:00 2:00 P.M. Cystic Fibrosis Dubinsky 2:00 3:00 P.M. INTRODUCTION TO ENDOCRINE CONTROL Lichtenberger Organization of the endocrine control system Types of hormonal communication Th 19 January RESTING MEMBRANE POTENTIAL Walters 1:00 3:00 P.M. Electrolyte diffusion and diffusion potentials Electrochemical equilibrium and the Nernst Equation Genesis of resting membrane potential Tu 24 January ACTION POTENTIAL Walters 1:00 3:00 P.M. Ionic basis Conduction Regulation of excitability Th 26 January SYNAPTIC TRANSMISSION Walters 1:00 3:00 P.M. Postsynaptic mechanisms Presynaptic mechanisms Regulation of synaptic function and memory Tu 31 January SENSORY PHYSIOLOGY Walters 1:00 3:00 P.M. General features Specialized senses

2 Spring 2011-Page 2 Th 2 February MOTOR PHYSIOLOGY Walters 1:00 2:00 P.M. Organization of reflexes 2:00 3:00 P.M. DISCUSSION: PHYSIOLOGICAL DYSFUNCTION Walters Neuronal reactions to injury Tu 7 February EXAMINATION I Staff 1:00 3:00 P.M. III. MUSCLE SYSTEMS AND CONTRACTION Th 9 February OVERVIEW OF MUSCLE SYSTEM 1:00 3:00 P.M. SKELETAL MUSCLE Berdeaux Molecular basis of contraction Muscle mechanics Tu 14 February CARDIAC AND SMOOTH MUSCLE Walters, Li 1:00 3:00 P.M. Functional diversity Cardiac muscle and cardiac function Smooth muscle and hollow organs IV. THE CARDIOVASCULAR SYSTEM AND REGULATION OF BLOOD FLOW/PRESSURE Th 16 February HEMODYNAMICS Morris 1:00 3:00 P.M. Flow, pressure, and velocity Resistance, viscosity, and capacitance Tu 21 February THE CARDIAC PUMP Weems 1:00 3:00 P.M. Morphology and function of the heart Determinants of cardiac performance Th 23 February CARDIAC OUTPUT Weems 1:00 3:00 P.M. Cardiac function curves Venous return and mean circulatory filling pressure Tu 28 February REGULATION OF ARTERIAL PRESSURE AND 1:00 3:00 P.M. REGIONAL BLOOD FLOW Weems Regulation of arterial blood pressure Th 1 March CAPILLARY EXCHANGE & PATHOPHYSIOLOGY Morris 1:00 3:00 P.M. The microcirculation Capillary-interstitial fluid exchange Regulation of regional circulations 5 9 March SPRING BREAK!

3 Spring 2011-Page 3 Tu 13 March EXAMINATION II Staff 1:00 3:00 P.M V. THE RENAL SYSTEM AND REGULATION OF FLUID/ELECTROLYTE BALANCE Th 15 March ELEMENTS OF RENAL FUNCTION O'Neil 1:00 3:00 P.M. Gross morphology and special structural/functional relations Glomerular filtration and renal blood flow Tu 20 March MECHANISMS OF ELECTROLYTE AND WATER TRANSPORT O'Neil 1:00 3:00 P.M. Cellular mechanisms of NaCl and water transport The counter-current multiplier system Th 22 March REGULATION OF FLUID AND ELECTROLYTE BALANCE O'Neil 1:00 3:00 P.M. Regulation of extracellular fluid osmolality Regulation of NaCl reabsorption and extracellular fluid volume Regulation of K balance VI. THE RESPIRATORY SYSTEM AND REGULATION OF GAS BALANCE Tu 27 March PULMONARY VENTILATION AND GAS TRANSPORT Johnston 1:00 3:00 P.M. Mechanics of ventilation Alveolar ventilation Th 29 March CONTROL OF VENTILATION AND REGULATION OF 1:00 3:00 P.M. O 2 AND CO 2 BALANCE Johnston Pulmonary circulation and gas transport Regulation of ventilation Tu 3 April DISCUSSION: PHYSIOLOGICAL DYSFUNCTION Johnston Respiratory pathophysiology Th 5 April EXAMINATION III Staff 1:00 3:00 P.M. VII. THE GASTROINTESTINAL SYSTEM AND REGULATION OF DIGESTION/ABSORPTION Tu 10 April GASTROINTESTINAL ENDOCRINOLOGY Lichtenberger 1:00 3:00 P.M. GI hormones and control of GI function GASTROINTESTINAL SECRETION I Regulation of gastric secretion Th 12 April GASTROINTESTINAL SECRETION II Lichtenberger 1:00 2:00 P.M. Regulation of biliary and pancreatic secretion 2:00 3:00 P.M. DISCUSSION: PHYSIOLOGICAL DYSFUNCTION Lichtenberger Gastric ulcers and gut barrier malfunction Tu 17 April THE ENTERIC NERVOUS SYSTEM AND MOTILITY Hu

4 Spring 2011-Page 4 1:00 3:00 P.M. Enteric nervous system organization and function Motility and GI function Th 19 April DIGESTION AND ABSORPTION OF NUTRIENTS Morris 1:00 3:00 P.M. Structural/functional relations in the intestine Regulation of digestion and absorption of specific nutrient VIII. INTEGRATION/DISINTEGRATION OF PHYSIOLOGICAL SYSTEMS Tu 24 April FUNCTIONAL INTEGRATION AND DISINTEGRATION Morris 1:00 2:45 P.M. OF PHYSIOLOGICAL SYSTEMS 2:45-3:00 P.M. COURSE FEEDBACK Walters EXAMINATION IV: TAKE-HOME COMPREHENSIVE Staff

5 Spring 2011-Page 5 Course Director Edgar T. Walters, Ph.D. Room: MSB 4.118, Phone: Edgar.T.Walters@uth.tmc.edu Educational Programs Coordinator Patricia McFarland Room: MSB 4.102, Phone: Patricia.McFarland@uth.tmc.edu Textbooks: Recommended Human Physiology: From Cells to Systems, L. Sherwood, 7 th edition, Brooks/Cole: Belmont, CA, 2010 Fundamentals of Medical Physiology, J. Michael, Thieme Medical, NY, Useful Essential Medical Physiology, L.R. Johnson, 3 rd edition. Elsevier-Academic Press: San Diego Case Files in Physiology, Toy, Weisbrodt, Dubinsky, O Neil, Walters, Harms, 2 nd edition, McGraw-Hill, Principles of Physiology, R.M. Berne & M.N. Levy, 3 rd edition. Mosby: St. Louis Medical Physiology, W.F. Boron & E.L. Boulpaep, 1 st edition. Saunders: Philadelphia Lending Policy The above textbooks (and others) can be checked out from Dr. Walters in room MSB Each book can be kept overnight or over the weekend, but must be returned by noon the following workday. If Dr. Walters is not available, the book can be returned to Patricia McFarland in MSB We have only 1 copy of the Sherwood and Michael textbooks to lend, so please be considerate to your classmates and return the book promptly.

6 Spring 2011-Page 6 Lecturer Office Telephone Extension Dr. Alemayehu Gorfe Abebe MSB 7538 Dr. Rebecca Berdeaux R366 MSE 5653 Dr. William P. Dubinsky S330H SRB 3665 Dr. Hongzhen Hu MSB 7525 Dr. Richard A. Johnston MSB 6485 Dr. Yi-Ping Li R376 MSE 6498 Dr. Lenard M. Lichtenberger MSB 6320 Dr. Andrew Morris MSB 6514 Dr. Roger G. O'Neil MSB 6316 Dr. Edgar T. Walters MSB 6314 Dr. William A. Weems G.520/G.500D MSB 5224/3503 EXAMS Weight Style 1 to 3: 22% each in-class, closed-book, short essay 4: 34% take-home, open-book, essay Exams cover discussion materials as well as lectures. CLASS PARTICIPATION An important part of a scientist's training is learning how to participate in active discussions about scientific subjects. We expect all students to interact with each faculty member during both the lectures and the discussion sessions, orally answering questions posed by the lecturer and asking questions of the lecturer and other discussants. To facilitate interactions and learning within the classroom, students are expected to show attentive, respectful behavior (e.g., no eating or chewing gum, no texting, no listening to MP3 players, etc.). At the end of each block the lecturer will record whether each student participated actively in class discussions during that block. Demonstration of active class participation will contribute to the final grades as indicated below. GRADING: Without class participation With participation A % % B % % C % % F Less than 66.5% Less than 64.5%