Amino Acid Nutrition + Testing. Nutrition-based pathology testing to match your requirements for supplementation

Size: px

Start display at page:

Download "Amino Acid Nutrition + Testing. Nutrition-based pathology testing to match your requirements for supplementation"

Cecilia Hensley
5 years ago
Views:

1 Amin Acid Nutritin + Testing Nutritin-based pathlgy testing t match yur requirements fr supplementatin

Imprving General Health & Wellbeing thrugh Testing and matching Amin Acid Supplementatin This prgram aims t imprve an individual s general health, wellbeing and vitality by determining key nutrient

2 Imprving General Health & Wellbeing thrugh Testing and matching Amin Acid Supplementatin This prgram aims t imprve an individual s general health, wellbeing and vitality by determining key nutrient deficiencies thrugh examinatin f urine and prviding a prgram f nutrient supplementatin specifically designed fr specific health and lifestyle requirements. The urine analysis determines whether the excretin f amin acids was representative f 1. nrmal functining f the bdy 2. lng term impacts n health assciated with lng term chrnic illness r extensive and prlnged physical exertin extensive verwrk and prlnged tiredness 3. shrt term impacts frm recent events such as recvery frm acute infectins respnses t stresses recvery frm muscle and bdy injuries Althugh numerus nutritinal supplements are cmmercially available, the current prgram is distinctive as it: Takes int accunt the unique nutritinal requirements f peple as a result f differing cmbinatins f general health, lifestyle and nutritinal issues. Allws fr rapid nutrient uptake and dispersal thrughut the bdy. The supplements have been scientifically designed t ptimise uptake and maximise utilisatin by the bdy. A range f the amin acid supplements have been designed t match the 3 majr categries f health determined by the urine assay and aligned with either Wrklad demands Physical exercise demands Supprt f illness and injury recvery

yur bdy. If yu are in heavy training, then yur bdy will require certain types f amin acids, vitamins and nutrients t supprt the functins assciated with the sprt.

3 Clean Nutrient Supprt fr Athletes. Optimum Perfrmance All tissues and rgans are affected by rigrus exercise. Bichemical testing can help yu t maximise yur perfrmance by; Identifying yur specific nutrient requirements, Assessing levels f tissue damage, Assisting yu t select the best supplements required by yur bdy. If yu are in heavy training, then yur bdy will require certain types f amin acids, vitamins and nutrients t supprt the functins assciated with the sprt. These functins range frm nerve firing fr crdinatin, t specific nutrients required fr supprting energy metablism and building muscle prteins. The needs f tday s athlete ften extend beynd the nrmal dietary intake and therefre apprpriate supplementatin culd lead t greater perfrmance benefit. Tailring yur specific nutrient intake t YOUR wn sprts and genetic requirements culd lead t a mre efficient training prgram with greater perfrmance achievement. The nly way t identify YOUR sprting nutritinal requirements is t have a urine. This will enable us t cmpile yur tailr-made nutrient supprt system.

4 Amin acids are required fr: Prtein synthesis Recvery frm illness Brain functin Hrmne prductin Energy metablism Amin acids have many metablic rles in the bdy including brain and nerve functin, hrmne synthesis as well as representing the building blcks f prtein. Thrughut the day, the bdy cntinuusly manufactures millins f prteins assciated with muscle structure and functin. Amin acids are thus vital fr gd bdy perfrmance. Urine analysis testing is used t identify metablic imbalances which may assist in clinical diagnsis and prvide a baseline f individual bichemistry fr planning, implementing and tracking patient management. Amin acid deficits can arise frm prlnged illness, pr diet, extensive exercise regimes as well as aging prcesses and may cntribute twards a pr health status.. Tailring a specific amin acid intake t a patient s individual requirements can lead t better health and quality f life fr the general ppulatin and, in the case f athletes, imprved perfrmance. Individual requirements are different as a result f a myriad f factrs including age, lifestyle, genetics, fd and medicinal intake, sleep patterns and training schedules. Fr example, amin acid depletin is a significant prblem in chrnic pain and fatigue disrders. Falls in amin acid levels are assciated with increased symptm severity in chrnic illnesses and increasing duratin f the illness is assciated with a prgressive lss f amin acids in the urine. Alteratins in amin acid metablism can be identified with urine analysis and a cmprehensive, accurate supplementatin prgram can be implemented. Prviding a patient with nutritinal supprt based n labratry tests prvides the best pssible apprach t clinical nutritinal management.

5 Disruptin f the capacity t prduce new prteins can have significant impact n bdy perfrmance and functin. Many amin acids which are nt deemed essential t receive frm the diet (ie the bdy can manufacture them) can becme Cnditinally Essential Nutrients during illness r injury when the hst respnse, r repair mechanisms, may result in unusual metablic demands n the bdy which must be met t cntinue nrmal functining. Selected prtein fds, fruits and vegetables culd ptentially be used t prvide the additinal demands f varius amin acids and this culd frm the basis f nutritinal supprt. The difficulty is t match the patient's specific requirements t the apprpriate plant/animal extract. In additin, digestive capacity is ften reduced in the aging individual as well as under times f intense exercise, stress r prlnged illness. This impact n the stmach can lead t inadequate prtein digestin and thus may render the fd supplement apprach ineffective. Fatigue Reviva is designed t be rapidly absrbed, by-passing the need fr digestin. The mst effective clinical apprach is t directly identify the nutrient deficits and prvide scientifically designed frmulatins which can be absrbed by the bdy withut requiring active digestin. This can be dne in cnjunctin with cnsidering the patient s clinical status and diagnsis int accunt.

Intrducing the Urine Test The urine testing prcedure can identify anmalies in the excretin f amin

amin acids in the urine can reflect deficits in the bdy High levels f amin acids in the urine can

respnses The benefit f amin acid supplementatin has been nted in several published studies The

6 Intrducing the Urine Test The urine testing prcedure can identify anmalies in the excretin f amin identify deficits in amin acid hmestasis and suggest crrespnding amin acid frmulatins Lw levels f amin acids in the urine can reflect deficits in the bdy High levels f amin acids in the urine can reflect either specific high dietary intakes (supplements) r perids f excessive lsses via catablic respnses The benefit f amin acid supplementatin has been nted in several published studies The advantages f amin acid supprt are well dcumented fr critically ill patients Amin acid supprt can enhance recvery fr athletes

7 Intrducing the Reprt: The reprt prvides the cncentratins f amin acids measured in the urine samples prvided. The cncentratins are prvided in universally accepted standard frmat f mles (micrmles) per liter. The amin acids and related metablites are listed n the left and the cncentratins in mles L -1 are prvided in the adjacent bxes. The buttns indicate whether the patient results are "average" r relatively lw r high cmpared t the healthy subjects. The urine analysis can be used t assist in determining whether the excretin f amin acids was representative f 1. nrmal functining f the bdy 2. lng term impacts n health assciated with lng term chrnic illness extensive / prlnged physical exertin extensive verwrk prlnged tiredness 3. shrt term impacts frm recent events such as recvery frm acute infectins respnses t stresses recvery frm muscle and bdy injuries Reprt Cmments: The reprt prvides 3 sectins f autmated cmments which respnd t levels f amin acids in the urine sample: Essential Amin Acids: Leucine and Isleucine are imprtant amin acids that help regulate amin acid hmestasis in the bdy. If these are lw, then this is usually assciated with a net deficit in essential amin acids. Catablism Marker: A high level f Tyrsine in the urine can be indicative f an nging catablic respnse in the bdy as result f an infectin r recvery frm intense exercise. Sft Tissue Damage: Prline and hydrxy-prline are abundant cmpnents f cnnective tissues. Damage t these tissues is ften reflected with the excretin f these amin acids. The reference ranges f values are prvided t the right f the buttn displays t shw the variance assciated with the values fr urinary cncentratins. The urinary metablites have been gruped int 4 types f excretry prducts: Essential Amin Acids these are amin acids that cannt be synthesized by the human bdy and must be derived frm the diet. Nn-essential Amin Acids these can be made by the bdy frm ingested fd substrates. Sme f the amin acids may becme cnditinally essential under certain cnditins such as prlnged illness r exercise stress when the bdy s capacity t synthesis these amin acids cannt keep up with demand. Amin Acid Derivatives these cmpunds represent precursr r breakdwn prducts f the amin acids and can smetimes prvide valuable insight fr anmalies in hmestasis. Dipeptides these represent 2 amin acids jined tgether which can smetimes have specific functins within the bdy. This is grwing field f interest. DR Bilab disclaims any respnsibility fr the use f these tests by clinicians fr either diagnsis r the design f patient management schedules.

Amin Acids - Selected Functins - Clinical Guide BCAAs (leucine, isleucine & valine): rle in neurtransmissin as a result f BCAAs rle in brain glutamate and glutamine synthesis.

8 Amin Acids - Selected Functins - Clinical Guide BCAAs (leucine, isleucine & valine): rle in neurtransmissin as a result f BCAAs rle in brain glutamate and glutamine synthesis. BCAAs, in particular leucine, are believed t act as nitrgen dnrs fr glutamine and glutamate synthesis within the CNS. Methinine: within brain synthesis f S-adensylmethinine (SAM). Phenylalanine: precursr f tyrsine & catechlamines (DOPA, dpamine, nrepinephrine, epinephrine); precursr f phenylethylamine which has neurpharmaclgical effects; elevated levels txic t neurlgical systems resulting in defective cgnitive abilities/learning disabilities. Histidine: precursr f brain histamine which is a neurtransmitter Tryptphan: synthesis f sertnin & melatnin. Asparagine: precursr f aspartate. Leucine: prmtes wund healing. Phenylalanine: increased excretin may accmpany infectin & trauma. Histidine: precursr f histamine which mediates inflammatry & allergic reactins; antiinflammatry actin. NEUROLOGICAL: Vital functins in neurtransmissin IMMUNE: Energy, regulatin and recvery Aspartic acid: excitatry neurtransmitter. Glutamic acid: excitatry neurtransmitter; glutamatergic neurns are invlved in brain functins including learning and memry; glutamate precursr f the inhibitry neurtransmitter GABA. Glycine: inhibitry neurtransmitter. Ornithine: urea cycle intermediate thus invlved in remval f highly txic ammnia. Inherited defects in urea cycle enzymes can result in brain damage. Serine: invlved in phsphlipid prductin present in cell membranes as a cnstituent f the phsphlipid phsphatidylserine which is the precursr t phsphatidylethanlamine. Tyrsine: precursr f catechlamines (DOPA, dpamine, nrepinephrine, epinephrine); may reduce effects f stress/fatigue n cgnitive perfrmance. Methinine: reductin f histamine levels. Threnine: frmatin f glycprteins; may be required by thymus gland. Glutamine: may be cnditinally essential during injury & infectin acts as immunmdulatr. GASTROINTESTINAL: Immune prtectin, energy and regulatin BCAAs (leucine, isleucine & valine): invlved in synthesis f glutamine required fr intestinal nutritin. Histidine: rle in gastrintestinal functin as a precursr f histamine which stimulates release f HCl; enhances absrptin f zinc.. MUSCULOSKELETAL: Energy, grwth, regulatin BCAAs (leucine, isleucine & valine): cnstituents f tissue prteins; invlved in regulatin f prtein metablism; cmpnents f cllagen. Leucine: invlved in prtein synthesis & regulatin f prtein catablism; alternate t glucse as surce f energy fr muscles; may prmte muscle Tryptphan: synthesis f piclinic acid. Glutamine: required fr intestinal nutritin as energy surce fr gastrintestinal entercytes. Glycine: frmatin f bile salts. Lysine: cnnective tissue cnstituent cllagen & elastin. Methinine: cnnective tissue cmpnent. Hydrxyprline & Prline: cnstituents f cnnective tissue prteins. anablism in aging. Implicatins f Altered Excretin Cytkine mediated respnses t trauma, stress and infectin lead t prtelysis and increased amin acid excretin. Activatin f the immune system during infectin results in a catablic state with muscle tissue breakdwn and release f amin acids fr prductin f defence mlecules. This respnse is evidenced by typical sickness behaviur. If the catablic state becmes chrnic, eg during a lng-term persistent infectin, cntinual activatin f the immune system may result in cellular malnutritin, a decrease in the pl f available amin acids and decreased urinary amin acid levels. In rder t maintain the bdy s prtein stres during stress, dietary amin acid requirements may increase. Altered amin acid metablism may result in muscle prtein lss and eventually in malnutritin if amin acid stres d nt meet the bdy s needs. In varius cnditins including stress, prlnged fatigue, pathgenic challenge and strenuus exercise digestive functin may als be adversely affected reducing prtein absrptin. Amin acid supplementatin circumvents reduced digestive capacity as amin acids are readily absrbed. Altered excretin f ttal amin acid levels may indicate prblems with kidney functin. Aminaciduria may ccur despite nrmal plasma amin acid levels due t perturbed renal reabsrptin. NOTE: Altered urinary amin acid levels may nt reflect plasma/tissue levels. Due t bdy s ability t sustain amin acid hmestasis, circulating plasma levels f many amin acids may be maintained during perids f stress etc.

9 Implicatins f Altered Excretin Essential & nn-essential amin acids Cytkine mediated respnses t trauma, stress and infectin lead t prtelysis and an increase in amin acid excretin. As a cnsequence f the activatin f the immune system during infectin a catablic state ccurs, resulting in a breakdwn f muscle tissue t release amin acids fr use in the cnstructin f defence mlecules. This respnse is evidenced by typical sickness behaviur (fever, lss f appetite etc). If the catablic state becmes chrnic, such as in the case f a lngterm persistent infectin, the cntinual activatin f the immune system may result in cellular malnutritin and a decrease in the pl f available amin acids. This will be evidenced by a decrease in urinary amin acid levels. Under stress higher nutritinal input f amin acids may be required t maintain the bdy s prtein stres. Changes in amin acid metablism assciated with stress may result in muscle prtein lss and eventually in malnutritin if amin acid stres d nt meet the bdy s requirements. Higher free radical prductin ccurs in respnse t stress. Glutathine prvides perxidative prtectin and requires precursr amin acids cysteine, glutamate/glutamine and glycine. Altered excretin f ttal amin acid levels may indicate prblems with kidney functin. Aminaciduria may ccur despite nrmal plasma amin acid levels due t perturbed renal reabsrptin. Within the brain and muscle txic ammnia is cnverted t nntxic glutamine. Glutamine is synthesized frm glutamate and ammnia. Glutamine in the kidney supplies majrity f excreted ammnia. Branched-chain amin acids Fllwing stress, infectin, trauma, cytkine-mediated events, BCAAs are released frm the tissues. The BCAAs released frm tissue prteins are deaminated prviding an energy surce as well as amin grups which allw fr the synthesis f glucgenic alanine, glutamine and glutamate. Perturbatin f energy metablism may ccur as a result f a reductin in amin acids available fr TCA cycle xidatin r glucnegenesis affecting cellular energy prductin. Altered brain functin/neurtransmissin as a result f BCAAs rle in brain glutamate and glutamine synthesis. BCAAs, in particular leucine, are believed t act as nitrgen dnrs fr glutamine and glutamate synthesis within the CNS. Glutamatergic neurns are invlved in numerus brain functins including learning and memry. During exercise a transient catablic state ccurs which is reversed during recvery. During exercise prtein degradatin increases whilst prtein synthesis decreases and this results in an increase in the available stre f amin acids t be utilized t prvide energy fr wrking muscles. The BCAAs are the main amin acids which are xidized by skeletal muscle. Pr nutritin may result in an increase in the catablism f BCAAs. In severe catablic states BCAA nutritin may play a beneficial rle - sme studies have shwn maintenance f plasma amin acid levels, increased skeletal muscle prtein synthesis and decreased catablism. NOTE: Changes in the urinary levels f amin acids may nt reflect plasma r tissue levels. Due t the bdy s ability t sustain amin acid hmestasis, circulating plasma levels f many amin acids may be maintained during perids f stress etc. Abbreviatins: BBB bld-brain-barrier; BCAA branched-chain amin acid; GABA gammaaminbutyric acid; TCA tricarbxylic acid.

10 Testing fr amin acid requirements DRBilab Specialized Amin Acid supprt Fatigue Reviva Dr Bilab Unit 1, 31 Pendlebury Rd CARDIFF NSW

SPECIALIZED PRODUCTS FROM AMINO ACIDS [LIPPINCOTT S ] Deeba S. Jairajpuri

SPECIALIZED PRODUCTS FROM AMINO ACIDS [LIPPINCOTT S 285-290] Deeba S. Jairajpuri CATECHOLAMINES Dpamine, nrepinephrine, and epinephrine are bilgically active amines that are cllectively termed catechlamines.