OHSU Moore Institute for Nutrition & Wellness OHSU School of Medicine. Diane Stadler, PhD, RD Graduate Programs in Human Nutrition
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1 OHSU Moore Institute for Nutrition & Wellness OHSU School of Medicine Diane Stadler, PhD, RD Graduate Programs in Human Nutrition
2 Moore Institute for Nutrition & Wellness There is no question that a nutritious, wellbalanced, whole-foods-based diet is: the foundation for optimal growth and development throughout infancy, childhood and adolescence the cornerstone for promotion of wellness and prevention and treatment of disease
3 Moore Institute for Nutrition & Wellness Despite this understanding, there is no more urgent population- based need than to improve the diets and the health of people living within and beyond the United States.
4 OHSU Moore Institute for Nutrition & Wellness
5 OHSU Moore Institute for Nutrition & Wellness
6 Founding Principle Reducing the prevalence of chronic diseases throughout life starts by promoting healthy, nutrientrich diets based on wholesome foods before conception, during pregnancy and lactation, and in infancy and early childhood.
7 Developmental Origins of Health and Disease OHSU is recognized internationally as a leader in the exploration of the developmental origins of health and disease, which includes the vital relationships between maternal prenatal diet, fetal health and adult onset disease.
8 Impact of Maternal Nutrition on Infant Health Susceptibility to adult-onset diseases can be increased by intrauterine exposure Inadequate fetal nutrition due to poor maternal protein, or vitamin/ mineral intake IUGR risk of adult onset hypertension, DM, stroke Over-nutrition LGA with fat stores risk of adult onset disease Kunz, et al. Sem Fet Neon Med. 2007;12:71-77
9 Example: % of Men and Women who Died of Heart Disease in One County of England (1989) 100% David Barker, MD, PhD Weight at Birth (pounds)
10 Risk Ratio Example: Association between birth weight and risk of developing type 2 diabetes Odds ratio for impaired glucose intolerance or type 2 diabetes according to birth weight among 370 men aged 64 years born Heretfordshire, adjusted for adult BMI Risk Ratio of 8:1 among babies with 5.5 lb birth weight Birth weight Hales & Barker, BMB 2001
11 Our organization reflects our priorities External Advisory Board Mark Richardson Dean, School of Medicine Director s Corporate Partners Panel Jonathan Purnell, Associate Director Kent Thornburg, Director David Barker, Director International Collaborations Irene Barhyte, Director of Finance International Board Co-chairs Research Oversight Committee Moore Institute Steering Committee Larry Wallack, Chair Public Health & Policy Committee Susan Bagby, Chair Community Outreach Committee Diane Stadler, Chair Nutrition Education Committee Kathleen McFall, Chair Media & Marketing Committee Rachel Bristol, Chair Moore Nutrition Consortium of Oregon
12 Founding Research Projects Improving Adolescent Awareness of the Epigenetics of Generational Nutrition The Pregnancy Exercise & Nutrition (PEN) Program Nutrient-Rich, Whole-Food Dietary Intervention in Pregnant Women with ADHD
13 Improving Adolescent Awareness of the Epigenetics of Generational Nutrition Jackilen Shannon, Ph.D., RD Public Health and Preventive Medicine, CROET Scientist Leverage Let s Get Healthy!, an established education and research exhibit at Oregon Health & Science University (OHSU), as a tool for subject recruitment, intervention delivery, and data collection. Create a NEW epigenetics module to educate middle school students about a whole-foods diet and epigenetics. Evaluate effectiveness of the module in modifying knowledge, attitudes and intended behaviors with pre-post evaluation as well as fair statistics.
14 The Pregnancy Exercise & Nutrition (PEN) Program Linn Goldberg, M.D., Health Promotion & Sports Medicine Develop and implement a 20-session workplace administered, team and web-based educational program to reduce risk factors for gestational diabetes. Builds on the OHSU Health Team Healthy U employee wellness program Focuses on healthy nutrition, stress reduction and regular physical activity during pregnancy. Assesses outcomes of intervention and controls participants (15 women in each group) with respect to weight gain and health outcomes during pregnancy and birth and infant outcomes within 4 months.
15 Nutrient-Rich, Whole-Food Dietary Intervention in Pregnant Women with ADHD Joel Nigg, Ph.D., Pediatric Psychiatry Assess nutrient intake, dietary compliance and effectiveness of changing diet in pregnant women with ADHD. Assess change in maternal symptoms of ADHD, depression, and anxiety 1 and 2 months after initiating the intervention diet compared to standard of care. Evaluate biological and behavioral outcomes in offspring to 3 months of age. Infant physical and perinatal health assessed through birth weight, APGAR scores, perinatal presentation, growth parameters and infant feeding practices Infant neural development assessed by MRI Infant temperament assessed by standard observational methods.
16 Upcoming & Ongoing Initiatives Intervention trials in rural communities K-12 nutrition/ culinary science curriculum Interdisciplinary nutrition curriculum for health professional Creation of Moore Nutrition Consortium International summit on maternal nutrition Over-arching public media and marketing campaign
17 American Institute for Cancer Research: Annual Conference Transgenerational Effects of Diet--Implications for Cancer Prevention Transgenerational epigenetic effects on phenotypic variation and disease risk--joseph Nadeau, PhD, Institute for Systems Biology Maternal protein restriction induces transgenerational epigenetic and phenotypic changes in the offspring--karen Lillycrop, PhD, U Southampton, Southampton, UK Generational effects of maternal high-fat diet--tracy Bale, PhD, U Penn Effects of methyl donor nutrition on transgenerational obesity--robert Waterland, PhD, Baylor College of Medicine Epigenetic transgenerational inheritance alters stress responses in a sexually dimorphic manner--david Crews, PhD, UT-Austin
18 OHSU Moore Institute for Nutrition & Wellness
Early Diet = Lifelong Health for Generations
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