NEW DRUGS. edited by JOHN FEELY MD FRCPI

Transcription

1 2 NEW DRUGS edited by JOHN FEELY MD FRCPI Professor of Pharmacology and Therapeutics, Trinity College, and Consultant Physician, St James's Hospital, Dublin Published by the British Medical Journal Tavistock Square, London WC1H 9JR

2 Contents Page Drug handling and response 1, MD, FRCPI, professor of pharmacology and therapeutics, Trinity College, Dublin 2, and consultant physician, St James's Hospital, Dublin 8 Martin J Brodie, MD, FRCP, consultant clinical pharmacologist, Epilepsy Research Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow Gil 6NT Therapeutic drug monitoring and clinical trials 15 Martin J Brodie, Adverse reactions to drugs 29 D N Bateman, MD, FRCP, consultant physician and reader in therapeutics S Chaplin, MSc, MPS, staff pharmacist, Northern Regional Drug Information Unit, Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU Adverse drug interactions 40 Martin J Brodie, Prescribing for infants and children 56 George W Rylance, MRCP, consultant in paediatrics and paediatric clinical pharmacology, Children's Hospital, Birmingham B16 8ET Prescribing for the elderly 65 Cameron G Swift, PhD, FRCP, professor of health care of the elderly, King's College School of Medicine and Dentistry, London SE5 8RX Nitrates and antianginal drugs 74 Derek Maclean, PhD, FRCP, senior lecturer, Department of Clinical Pharmacology and Pharmacology, Ninewells Hospital and Medical School, Dundee DD1 9SY

3 Calcium antagonists 80 Terence Pringle, MD, FRCPI, consultant cardiologist, Ninewells Hospital and Medical School, Dundee DD1 9SY Derek Maclean, P Adrenoceptor antagonists (0 blockers) 92 Derek Maclean Angus MacConnachie, BSC, MRPS, principal pharmacist, Department of Clinical Pharmacology and Pharmacology, Ninewells Hospital and Medical School, Dundee DD1 9SY Angiotensin converting enzyme inhibitors 106 Alasdair Breckenridge, MD, FRCP, professor of clinical pharmacology, University of Liverpool, New Medical Building, Liverpool, L69 3BX Diuretic treatment 114 Derek Maclean, Angus MacConnachie Thrombolytic treatment 128 Terence Pringle,, Derek Maclean Antiarrhythmic drugs 134 W S Hillis, FRCP, senior lecturer B Whiting, MD, FRCP, professor, University Department of Medicine and Therapeutics, Stobhill General Hospital, Glasgow GL1 3UW Drugs in cerebral and peripheral arterial disease 150 Gordon D O Lowe, MD, FRCP, senior lecturer and consultant physician, University Department of Medicine, Royal Infirmary, Glasgow G31 2ER Asthma and allergic rhinitis 164 K Fan Chung, MD, MRCP, senior lecturer Peter J Barnes, DM, FRCP, professor, Department of Thoracic Medicine, National Heart & Lung Institute, Royal Brompton Hospital, London SW3 6LY

4 Chronic obstructive airways disease and respiratory infections 181 K Fan Chung, Peter J Barnes Peptic ulceration 199 Donald G Weir, MD, FRCPI, regius professor of physic, Trinity College Medical School, St James's Hospital, Dublin 8 Gall stones 217 Ian A D Bouchier, MD, FRCP, professor of medicine, University Department of Medicine, Royal Infirmary, Edinburgh EH3 9YW Insulin 234 J Niall MacPherson, FRCP, consultant, Crosshouse Hospital, Kilmarnock KA2 OBE Oral hypoglycaemic agents 250 Norman R Peden, MA, FRCPEd, consultant physician and endocrinologist, Falkirk and District Royal Infirmary, Falkirk FK1 5QE Vitamin D metabolites and analogues, bisphosphonates, danazol, and bromocriptine 263 Colin R Paterson, DM, FRCP, senior lecturer, Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY Lipid lowering drugs 277 Patricia O'Connor, MRCPI, lecturer, department of pharmacology and therapeutics, Trinity College, Dublin 2, and Lipid Clinic, St James's Hospital, Dublin 8 James Shepherd, MD, MRCPath, professor, Department of Pathological Biochemistry, Royal Infirmary, Glasgow G32 2ER Anxiolytics and hypnotics 293 Brian R Ballinger, FRCPEd, FRCPsych, consultant psychiatrist, Royal Dundee Liff Hospital, Liff, Dundee DD2 5NF

5 Antidepressant drugs 301 Brian R Ballinger, Anticonvulsant drugs 309 D L W Davidson, FRCPEd, consultant neurologist, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY Centrally acting drugs 323 D N Bateman, S Chaplin Non-steroidal analgesic and anti-inflammatory drugs 330 George Nuki, FRCP, professor of rheumatology, University of Edinburgh, Rheumatic Diseases Unit, Northern General Hospital, Edinburgh EH5 2DR Thomas Pullar, MD, MRCP, honorary consultant rheumatologist, Yorkshire Regional Health Authority, senior lecturer in clinical pharmacology, University of Leeds, and honorary consultant physician, General Infirmary, Leeds LSI 3EX Controlling symptoms in advanced cancer 345 T D Walsh, MSC, FACP, director, Palliative Care Service, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA T S West, OBE, MB, medical director, St Christopher's Hospice, London SE26 6DZ Acne and psoriasis 359 G M Murphy, MD, MRCPI, consultant dermatologist, Beaumont Hospital, Dublin 9 M W Greaves, MD, FRCP, professor, Institute of Dermatology, St Thomas's Hospital, London SE1 7EH Anti-infectives 369 Roger Finch, FRCP, FRCPath, consultant and senior lecturer in microbial diseases, University of Nottingham, City Hospital, Nottingham NG5 1PB

6 Antiviral and antifungal drugs 381 P G Davey, MD, MRCP, senior lecturer in clinical pharmacology and infectious diseases, Ninewells Hospital and Medical School, Dundee DD1 9SY Drug overdosage and poisoning 400 L F Prescott, MD, FRCPEd, consultant physician and professor of clinical pharmacology, Regional Poisoning Treatment Centre and University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh EH3 9YW Index 411