David L. Wolgin Professor and Chair

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1 David L. Wolgin Professor and Chair Research Interests Mechanisms of drug tolerance and sensitization Role of inhibition in learned tolerance to stimulants Addiction to psychostimulants Chronic use of psychostimulants like amphetamine and cocaine induces behavioral and neural adaptations resulting in either tolerance or sensitization. My students and I are interested in how behavioral and pharmacological variables interact to produce these phenomena. For example, both the acquisition and loss of tolerance to the anorexic effect of amphetamine is contingent on behavioral experience. To understand the mechanism of this effect, we used intraoral delivery of a milk solution to dissociate the consummatory phase of feeding from the appetitive phase. This behavioral analysis revealed that amphetamine suppresses food intake by inducing stereotyped movements that are incompatible with feeding, not by suppressing appetite, as is commonly thought. By making intraoral infusions of milk contingent on maintaining a stationary head posture, we demonstrated that rats can learn to inhibit stereotyped movements in order to feed. Such learning represents an interaction between the behavioral and pharmacological effects of the drug. We are currently exploring the neural mechanisms by which rats learn to inhibit stereotypy. Our results have important implications for understanding psychostimulant addiction. Learning to cope with the adverse side effects of drugs during the early stages of drug abuse allows the individual to maintain a normal lifestyle while gradually escalating the dose. This increases the risk of more serious side effects (paranoia, neurotoxicity) and delays the seeking of treatment. This research is supported by the National Institute on Drug Abuse. Pertinent References Carlton, P.L. & Wolgin, D.L. Contingent tolerance to the anorexigenic effects of amphetamine. Physiology and Behavior, 1971, 7, Wolgin, D.L. & Hughes, K.M. Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia. Psychopharmacology, 1997, 132,

2 Wolgin, D.L. Contingent tolerance to amphetamine hypophagia: New insights into the role of environmental context in the expression of stereotypy. Neuroscience & Biobehavioral Reviews, 2000, 24, Wolgin, D.L. & Jakubow, J.J. Tolerance to amphetamine hypophagia: A microstructural analysis of licking behavior in the rat. Behavioral Neuroscience, 2003, 117, Wolgin, D.L. & Jakubow, J.J. Tolerance to amphetamine hypophagia: A real-time depiction of learning to suppress stereotyped movements in the rat. Behavioral Neuroscience, 2004, 118, Teaching Experience Undergraduate Psychopharmacology Biological Bases of Behavior Psychology of Motivation Research Methods in Psychology Laboratory in Psychobiology Directed Independent Research Graduate Seminar in Physiological Psychology Psychopharmacology Models of Behavioral Tolerance Methods in Psychobiology Directed Independent Research Biographical Information Address Education Department of Psychology Florida Atlantic University Boca Raton, Florida Telephone: (561) FAX: (561) WOLGINDL@FAU.EDU B.A. Rutgers University, New Brunswick, NJ, 1967 M.A. Vanderbilt University, Nashville, TN, 1968 Ph.D. Rutgers University, New Brunswick, NJ, 1973 Postdoctoral: University of Pennsylvania and University of Illinois

3 Professional Affiliations American Society for Pharmacology and Experimental Therapeutics Eastern Psychological Association European Behavioural Pharmacology Society Federation of European Neuroscience Societies International Behavioral Neuroscience Society (Fellow) International Brain Research Organization Society for Neuroscience Society for Stimulus Properties of Drugs Society for the Study of Ingestive Behavior Publications Carlton, P.L. & Wolgin, D.L. Contingent tolerance to the anorexigenic effects of amphetamine. Physiology and Behavior, 1971, 7, Huber, H., Wolgin, D.L. & Williams, J.M. A simple tailshock electrode for restrained rats. Behavioral Research Methods and Instrumentation, 1971, 3, 56. Teitelbaum, P., & Wolgin, D.L. Neurotransmitters and the regulation of food intake. Progress in Brain Research, 1975, 42, Wolgin, D.L., Cytawa, J., & Teitelbaum, P. The role of activation in the regulation of food intake. In: Hunger: Basic Mechanisms and Clinical Implications. D. Novin, W. Wrywicka & G. Bray (Eds.), Raven Press, New York, 1976, pp Teitelbaum, P., Wolgin, D.L., De Ryck, M. & Marin, O. Bandage-backfall reaction: Occurs in infancy, hypothalamic damage and catalepsy. Proceedings of the National Academy of Science, 1976, 73, Wolgin, D.L. & Teitelbaum, P. The role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat. Journal of Comparative and Physiological Psychology, 1978, 92, Golani, I., Wolgin, D.L., & Teitelbaum, P. A proposed natural geometry of recovery from akinesia in the lateral hypothalamic rat. Brain Research, 1979, 164, Wolgin, D.L., Hein, A. & Teitelbaum, P. Recovery of forelimb placing after lateral hypothalamic damage in the cat: Parallels and contrasts with development. Journal of Comparative and Physiological Psychology, 1980, 94,

4 Wolgin, D.L. Motivation, activation and behavioral integration. In: The Expression of Knowledge. R.L. Isaacson & N.E. Spear (Eds.), Plenum Press, New York, 1982, pp Wolgin, D.L. Tolerance to amphetamine anorexia: Role of learning versus body weight settling point. Behavioral Neuroscience, 1983, 97, Wolgin, D.L. & Kehoe, P. Cortical KC1 reinstates forelimb placing reflexes following damage to the internal capsule. Physiology and Behavior, 1983, 31, Wolgin, D.L. & Salisbury, J.J. Amphetamine tolerance and body weight set point: A dose-response analysis. Behavioral Neuroscience, 1985, 99, Wolgin, D.L. & Bonner, R. A simple, computer-assisted system for measuring latencies of contact placing. Physiology and Behavior, 1985, 34, Wolgin, D.L. Forelimb placing and hopping reflexes in haloperidol- and morphinetreated cataleptic rats. Behavioral Neuroscience, 1985, 99, Salisbury, J.J. & Wolgin, D.L. Role of anorexia and behavioral activation in amphetamine-induced suppression of feeding: Implications for understanding tolerance. Behavioral Neuroscience, 1985, 99, Wolgin, D.L., Thompson, G.B., & Oslan, I.A. Tolerance to amphetamine: Contingent suppression of stereotypy mediates recovery of feeding. Behavioral Neuroscience, 1987, 101, Wolgin, D.L., Oslan, I.A., & Thompson, G.B. Effects of "anorexia" on appetitive and consummatory behavior. Behavioral Neuroscience, 1988, 102, Pellis, S.M., O'Brien, D.P., Pellis, V.C., Teitelbaum, P., Wolgin, D.L., & Kennedy, S. Escalation of feline predation along a gradient from avoidance through "play" to killing. Behavioral Neuroscience, 1988, 102, (Reprinted in J.P.J. Pinel, Current research in biopsychology. Allyn & Bacon, Boston, 1991, pp ) Wolgin, D.L. The role of instrumental learning in behavioral tolerance to drugs. In: Psychoactive drugs: Tolerance and sensitization. A.J. Goudie & M.W. Emmett- Oglesby (Eds.). Humana Press, Clifton, N.J., 1989, pp Wolgin, D.L. & Thompson, G.B. Contingent suppression of tolerance to the "anorexigenic" effect of haloperidol. Behavioral Neuroscience, 1989, 103,

5 Wolgin, D.L. Contingent suppression of tolerance to haloperidol: A dose-response analysis. Pharmacology Biochemistry & Behavior, 1990, 35, Wolgin, D.L. & Wade, J.V. Effect of lithium chloride-induced aversion on appetitive and consummatory behavior. Behavioral Neuroscience, 1990, 104, Wolgin, D.L. & Benson, H.D. Tolerance to morphine "anorexia" is not contingent on experience with food while in the drugged state. Behavioral Neuroscience, 1990, 104, Wolgin, D.L. & Benson, H.D. Role of associative and nonassociative mechanisms in tolerance to morphine "anorexia." Pharmacology Biochemistry & Behavior, 1991, 39, Wolgin, D.L. & Moore, J.A. Sensitization to haloperidol-induced suppression of milk intake: Effect of interdose interval. Psychopharmacology, 1992, 107, Wolgin, D.L. & Dalzell, L. Sensitization of haloperidol-induced hypophagia is contingent on behavioral experience with food. Behavioural Pharmacology, 1992, 3, Wolgin, D.L. & Kinney, G.G. Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia. Journal of Pharmacology and Experimental Therapeutics, 1992, 262, Wolgin, D.L. Development and reversal of sensitization to amphetamine-induced hypophagia: Role of temporal, pharmacological, and behavioral variables. Psychopharmacology, 1995, 117, Wolgin, D.L. & Wade, J.V. Learned suppression of stereotypy in amphetaminetreated rats: Implications for understanding tolerance to amphetamine 'anorexia.' Behavioural Pharmacology, 1995, 6, Wolgin, D.L. & Hertz, J.M. Effects of acute and chronic cocaine on milk intake, body weight, and activity in bottle- and cannula-fed rats. Behavioural Pharmacology, 1995, 6, Wolgin, D.L. & Hughes, K.M. Effect of sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia. Psychopharmacology, 1996, 126,

6 Wolgin, D.L. & Hughes, K.M. Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia. Psychopharmacology, 1997, 132, Hughes, K.M., Popi, L. & Wolgin, D.L. Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: Instrumental contingencies regulate the expression of sensitization. Psychopharmacology, 1998, 140, Hughes, K.M., Popi, L. & Wolgin, D.L. Loss of tolerance to amphetamine-induced hypophagia in rats: Homeostatic readjustment versus instrumental learning. Pharmacology Biochemistry & Behavior, 1999, 64, Wolgin, D.L. Contingent tolerance to amphetamine hypophagia: New insights into the role of environmental context in the expression of stereotypy. Neuroscience & Biobehavioral Reviews, 2000, 24, Wolgin, D.L. & Hughes, K.M. Long term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests. Pharmacology Biochemistry & Behavior, 2001, 70, Wolgin, D.L. Effects of chronic amphetamine on the appetitive and consummatory phases of feeding. Appetite, 2002, 38, Hughes, K.M. & Wolgin, D.L. Changes in behavioral contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued tests while drugged. Behavioural Pharmacology, 2002, 13, Wolgin, D.L. & Jakubow, J.J. Tolerance to amphetamine hypophagia: A microstructural analysis of licking behavior in the rat. Behavioral Neuroscience, 2003, 117, Wolgin, D.L. & Jakubow, J.J. Tolerance to amphetamine hypophagia: A real-time depiction of learning to suppress stereotyped movements in the rat. Behavioral Neuroscience, 2004, 118, Recent Presentations Wolgin, D.L. & Benson, H.D. Tolerance to morphine-induced "anorexia" is not mediated by Pavlovian conditioning. Third International Meeting of the European Behavioural Pharmacology Society, Noordwijkerhout, The Netherlands, 1990.

7 Wolgin, D.L. & Kinney, G.G. Effect of prior sensitization of stereotypy on tolerance to amphetamine-induced hypophagia. Joint Meeting of the British Association for Psychopharmacology and the European Behavioural Pharmacology Society, Cambridge, England, Wolgin, D.L., Moore, J. & Dalzell, L. Sensitization of haloperidol-induced hypophagia: Role of interdose interval and behavioral experience. Society for Neuroscience meeting, Anaheim, CA, Wolgin, D.L. Is amphetamine-induced stereotypy involuntary? Colloquium presented at the Departments of Psychology and Zoology, Tel Aviv University, Tel Aviv, Israel, Wolgin, D.L. Development and reversal of sensitization to amphetamine anorexia: Role of temporal, behavioral, and pharmacological variables. Society for Neuroscience Meeting, Washington, D.C., Wolgin, D.L. & Wade, J.V. Differential reinforcement of immobility in amphetamine-treated rats: Implications for understanding tolerance. Society for Neuroscience Meeting, Miami Beach, FL, Wolgin, D.L. Appetite suppression: Why amphetamines don't work. Invited speaker, The Herrick Neuroscience Lecture, Denison University, Granville, OH, Hughes, K.M. & Wolgin, D.L. Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia. Society for Neuroscience Meeting, San Diego, CA, Wolgin, D.L. Are psychostimulants anorexigenic? Invited speaker, Sixth Biennial Meeting of the European Behavioural Pharmacology Society, Sardinia, Italy, Hughes, K.M. & Wolgin, D.L. Role of behavioral and pharmacological variables in the retention of tolerance to amphetamine hypophagia. Society for Neuroscience Meeting, Washington, D.C., Hughes, K.M. & Wolgin, D.L. Behavioral contingencies, not pharmacological exposure, determine the retention and reacquisition of tolerance to amphetamine hypophagia. FASEB Summer Research Conference, Copper Mountain, CO, 1997.

8 Hughes, K.M. & Wolgin, D.L. Sensitization of oral stereotypy blocks tolerance to amphetamine hypophagia. Society for Neuroscience Meeting, New Orleans, LA, Hughes, K.M., Popi, L. & Wolgin, D.L. Contingent loss of tolerance to amphetamine hypophagia. Society for Neuroscience Meeting, Los Angeles, CA, Wolgin, D.L. Can tolerance to amphetamine hypophagia be forgotten over time? First International Meeting of the Behavioral Pharmacology Society and European Behavioural Pharmacology Society, Boston, MA, Hughes, K.M. & Wolgin, D.L. Changes in behavioral contingencies without disrupted drug exposure can produce a loss of tolerance to amphetamine hypophagia in rats. Society for Neuroscience Meeting, Miami Beach, FL, Hughes, K.M. & Wolgin, D.L. Recovery from anorexia is not a prerequisite for feeding in amphetamine intoxicated rats. Society for Neuroscience Meeting, New Orleans, LA, Wolgin, D.L. Amphetamine tolerance: Homeostatic and operant conditioning models. Invited speaker, ASPET Symposium on Behavioral Tolerance: Evolving Concepts. Experimental Biology 2001 Meeting, Orlando, FL, Jakubow, J.J. & Wolgin, D.L. A microstructural analysis of licking behavior in the rat. Eastern Psychological Association Meeting, Washington, D.C., Wolgin, D.L. & Jakubow, J.J. Tolerance to amphetamine hypophagia: A real time analysis of learning to suppress stereotyped movements. Society for Neuroscience Meeting, San Diego, CA, Hughes, K.M. & Wolgin, D.L. Long term retention of tolerance to amphetamine hypophagia following cessation of drug injections and feeding tests. Society for Neuroscience Meeting, San Diego, CA, Wolgin, D.L. Effects of chronic amphetamine and other anorexigenic psychostimulants on the appetitive and consummatory phases of feeding. Invited speaker, Columbia University Seminar on Appetitive Behavior, New York, NY, Wolgin, D.L. & Jakubow, J.J. Effects of chronic amphetamine administration on licking behavior in the rat. Society for Neuroscience Meeting, Orlando, FL, 2002.

9 Wolgin, D.L. & Jakubow, J.J. Rapid loss of tolerance to amphetamine hypophagia following changes in the contingencies of reinforcement. Society for Neuroscience Meeting, New Orleans, LA, 2003.

DAVID N. KEARNS, PH.D.

DAVID N. KEARNS, PH.D. Psychology Department American University Washington, DC 20016 Phone: 202-885-1725 Email: kearns@american.edu EDUCATION 2005 American University Washington, DC Ph.D., Psychology